Integrated analysis of clinical indicators and mechanical properties in cancellous bone

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Jiapeng He , Zhen Pan , Guowei Zhou , Jiangming Yu , Dayong Li
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Abstract

Cancellous bone plays a critical role as a shock absorber in the human skeletal system. Accurate assessment of its microstructure and mechanical properties is crucial for osteoporosis diagnosis and treatment. However, various methods with different indicators are adopted currently in the clinical and laboratory assessments which lead to confusion and inconvenience for cancellous bone analysis. In the current work, correlations among clinical indicators including CT-derived Hounsfield Unit (HU) & bone mineral density (BMD), laboratory indicators (mass density & volume fraction), and mechanical properties (modulus & strength) are explored. The results show that different indicators can be linearly linked through the HU value which can be adopted as a good microstructure indicator of cancellous bone. Additionally, the impacts of cancellous bone specimen preparation on clinical CT imaging and mechanical properties are also investigated. The results indicate common marrow-removal treatment can lead to decrease in mean HU value, deviation in HU value distribution, while it will increase the modulus and strength. The current work provides a valuable insight into the cancellous properties based on comprehensive analysis on the clinical and laboratory assessments which is critical for accurate diagnosis and personalized treatment.
松质骨临床指标和机械性能的综合分析
松质骨在人体骨骼系统中扮演着减震器的重要角色。准确评估松质骨的微观结构和机械性能对骨质疏松症的诊断和治疗至关重要。然而,目前在临床和实验室评估中采用了各种不同指标的方法,导致松质骨分析的混乱和不便。本次研究探讨了临床指标(包括 CT 导出的 Hounsfield 单位(HU)及骨矿物质密度(BMD))、实验室指标(质量密度及体积分数)和机械性能(模量及强度)之间的相关性。结果表明,不同指标可通过 HU 值线性联系起来,HU 值可作为松质骨的良好微观结构指标。此外,还研究了松质骨标本制备对临床 CT 成像和机械性能的影响。结果表明,普通的去髓处理会导致平均 HU 值下降、HU 值分布偏差增大,而模量和强度则会增加。目前的研究基于对临床和实验室评估的综合分析,对松质骨特性提供了宝贵的见解,这对准确诊断和个性化治疗至关重要。
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来源期刊
Medical Engineering & Physics
Medical Engineering & Physics 工程技术-工程:生物医学
CiteScore
4.30
自引率
4.50%
发文量
172
审稿时长
3.0 months
期刊介绍: Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.
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