Li Liu , XiaoYi Yang , PengFei Wang , Yu Huang , Xing Huang
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引用次数: 0
Abstract
To reveal the penetration mechanism and present the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, the present study conducted experimental research on high-speed water-jet penetration into ballistic gelatin. The free jet dynamics of an air-powered needle-free injector that can emit up to 1.27 mL of liquid at once and the penetration dynamics were visualized to reveal the details of the penetration process. In the early unstable stage, the jet is emitted in the form of pulses, and the first jet pulse can rapidly generate an initial slender channel in gelatin in a very short time. In the subsequent stable stage, energy input produces dispersion and further increases the penetration depth slowly. Changing the driving pressure by the power source mainly changes the penetration depth increment by dispersion; while changing the nozzle diameter mainly affects the penetration depth in the initial stage. The central position of the dispersion area in the injection direction was firstly defined in the present work and it was found that an approximate linear relationship between this position and the maximum penetration depth exits for different nozzle diameters and driving pressures when injecting the same liquid dose. These research results can provide a basis for a thorough understanding of the penetration characteristics of high-speed micro-jet with injection volume larger than 0.3 mL into soft tissue, as well as the design and operation of the air-powered needle-free injector.
为了揭示注射量大于 0.3 mL 的高速微射流对软组织的渗透机理并呈现其渗透特性,本研究对高速水射流渗透弹道明胶进行了实验研究。通过对一次性可喷射 1.27 mL 液体的空气动力无针注射器的自由射流动力学和渗透动力学进行可视化研究,揭示了渗透过程的细节。在早期的不稳定阶段,射流以脉冲形式喷出,第一个射流脉冲能在极短的时间内迅速在明胶中生成一个初始细长通道。在随后的稳定阶段,能量输入产生分散,并进一步缓慢增加穿透深度。改变动力源的驱动压力主要是通过分散改变穿透深度的增加;而改变喷嘴直径主要影响初始阶段的穿透深度。本研究首次确定了分散区域在喷射方向上的中心位置,并发现在喷射相同剂量的液体时,不同喷嘴直径和驱动压力下该位置与最大穿透深度之间存在近似线性关系。这些研究成果为深入了解注射量大于 0.3 mL 的高速微射流在软组织中的穿透特性以及气动无针注射器的设计和操作提供了基础。
期刊介绍:
Medical Engineering & Physics provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes. Our focus encompasses the application of the basic principles of physics and engineering to the development of medical devices and technology, with the ultimate aim of producing improvements in the quality of health care.Topics covered include biomechanics, biomaterials, mechanobiology, rehabilitation engineering, biomedical signal processing and medical device development. Medical Engineering & Physics aims to keep both engineers and clinicians abreast of the latest applications of technology to health care.