Polish Journal of Pathology最新文献_第3页

Correlation of programmed death cell ligand-1 expression in non-small cell lung cancer between small biopsy and surgical specimens. 非小细胞肺癌中程序性死亡细胞配体-1表达与小活检和手术标本的相关性

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2026-06-08 DOI: 10.5114/pjp.2026.161409

Jelena Aleksić, Dragana Tegeltija, Ivan Aleksić, Vesna Škuletić, Darko Mikić

{"title":"Correlation of programmed death cell ligand-1 expression in non-small cell lung cancer between small biopsy and surgical specimens.","authors":"Jelena Aleksić, Dragana Tegeltija, Ivan Aleksić, Vesna Škuletić, Darko Mikić","doi":"10.5114/pjp.2026.161409","DOIUrl":"10.5114/pjp.2026.161409","url":null,"abstract":"Immunotherapy with programmed death cell ligand-1 (PD-L1) antibodies is an essential treatment for non-small cell lung cancer (NSCLC), and immunohistochemical assessment of PD-L1 expression is required for therapeutic stratification. This study analyzed PD-L1 expression in paired small biopsy and surgical specimens from patients with NSCLC, including adenocarcinoma and squamous cell carcinoma. Associations with the histological type, pathological stage, and clinicopathological parameters were evaluated, and concordance between biopsies and corresponding resections was assessed. A five-year retrospective-prospective study included 102 patients. Programmed death cell ligand-1 expression was determined by immunohistochemistry using monoclonal antibody clone 28-8. Membranous staining in more than 1% of tumour cells was considered positive. No statistically significant difference in PD-L1 expression was found between small biopsy and surgical specimens (p = 0.790). Expression showed no significant association with patient age or gender. A significant association was observed between PD-L1 expression and smoking status in both specimen types (p = 0.012 and p = 0.019). Programmed death cell ligand-1 expression was not significantly related to the T descriptor (p = 0.548) or N descriptor (p = 0.617). A statistically significant correlation was identified between PD-L1 positivity and disease stage (p = 0.012). The high concordance of PD-L1 expression between biopsy and surgical material supports use of biopsies for immunotherapy planning in ineligible patients and confirms reliability of resection specimens for adjuvant treatment decisions.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"77 1","pages":"44-52"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148457471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical lymph node involvement in a rare case of Kikuchi-Fujimoto disease: a case report and literature review. 罕见菊池-藤本病不典型淋巴结累及1例报告及文献复习。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2026-06-08 DOI: 10.5114/pjp.2026.161721

Jakub Stanek, Jagoda Jakubik-Stanek, Dominik Paprocki, Piotr Król, Jarosław Jakubik

引用次数: 0

Prognostic impact of spread through air spaces and its association with KRAS mutation and histopathologic factors in resected colorectal lung metastases. 在切除的结直肠肺转移瘤中，通过空气空间扩散对预后的影响及其与KRAS突变和组织病理因素的关系。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2026-06-08 DOI: 10.5114/pjp.2026.161535

Gonca Gül Geçmen, Sevinç Hallaç Keser, Dilek Ece, Şermin Çoban Kökten, Berk Çimenoğlu, Ayşen Güler, Arif Pala, Sibel Sensu

{"title":"Prognostic impact of spread through air spaces and its association with KRAS mutation and histopathologic factors in resected colorectal lung metastases.","authors":"Gonca Gül Geçmen, Sevinç Hallaç Keser, Dilek Ece, Şermin Çoban Kökten, Berk Çimenoğlu, Ayşen Güler, Arif Pala, Sibel Sensu","doi":"10.5114/pjp.2026.161535","DOIUrl":"10.5114/pjp.2026.161535","url":null,"abstract":"Spread through air spaces (STAS) represents an independent prognostic factor for poor overall survival (OS) in patients with colorectal carcinoma who underwent pulmonary metastasectomy. This study aims to evaluate the prognostic impact of STAS and explore its associations with histopathologic features and KRAS mutation status/subtypes.We retrospectively analyzed 61 consecutive patients with colorectal cancer (CRC) who underwent pulmonary metastasectomy at a single tertiary center (May 2016 - July 2024). Histopathologic review assessed STAS and other histopathologic features. KRAS mutations were tested using a real-time polymerase chain reaction assay detecting 19 variants (codons 12, 13, 59, 61, 117, 146). Spread through air spaces was present in 37/61 cases (60.7%). Median OS was 1702 days (95% CI: 1495-NA) in STAS-negative and 1288 days (95% CI: 523-NA) in STAS-positive patients (log-rank p = 0.041). In univariable analysis, STAS remained an independent predictor of poorer OS in multivariable modeling (hazard ratio: 2.37; 95% CI: 1.17-4.80; p = 0.017). KRAS mutations (present in 44.3% of tested cases; common subtypes G12V and G12D) showed no significant association with STAS (p = 0.34) or with OS. Spread through air spaces is an independent poor prognostic factor in resected CRC pulmonary metastases, whereas KRAS mutation status and subtypes were not prognostic in this cohort.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"77 1","pages":"1-11"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148457479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pumilio2, but not Pumilio1, expression is significantly increased in high-grade and metastatic gastroenteropancreatic neuroendocrine neoplasms. 在高级别和转移性胃肠胰神经内分泌肿瘤中，Pumilio2的表达明显增加，而Pumilio1的表达则不明显。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2026-06-08 DOI: 10.5114/pjp.2026.161720

Patryk Kraiński, Andrzej Kluk, Jan Gruszczynski, Kacper Trębacz, Ewa Dwojak, Maciej Dorota, Paweł Antoni Kołodziejski, Aldona Wiesława Wozniak

{"title":"Pumilio2, but not Pumilio1, expression is significantly increased in high-grade and metastatic gastroenteropancreatic neuroendocrine neoplasms.","authors":"Patryk Kraiński, Andrzej Kluk, Jan Gruszczynski, Kacper Trębacz, Ewa Dwojak, Maciej Dorota, Paweł Antoni Kołodziejski, Aldona Wiesława Wozniak","doi":"10.5114/pjp.2026.161720","DOIUrl":"10.5114/pjp.2026.161720","url":null,"abstract":"Pumilio proteins (PUM1 and PUM2) are evolutionarily conserved RNA-binding proteins that regulate gene expression at the post-transcriptional level and have been implicated in tumourigenesis in various cancers. However, their role in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has not been previously investigated. This study aimed to evaluate the expression of PUM1 and PUM2 in GEP-NENs and determine their association with tumour grade and metastatic status. Transcriptomic data (GSE98894) were analyzed using GEO2R to assess differential gene expression in primary tumours, lymph node metastases, and distant meta- stases. Additionally, immunohistochemical analyses were performed on formalin- fixed paraffin-embedded samples, and protein expression was quantified using digital image analysis. Statistical comparisons were conducted across tumour sites and grades (G1-G3). At the mRNA level, PUM2 was significantly upregulated in distant metastases compared with primary tumours (log2FC = 0.151; adjusted p = 0.024), whereas PUM1 showed no significant difference. Protein-level analyses confirmed expression of both proteins in all samples; however, only PUM2 was significantly elevated in high-grade (G3) tumours compared to G1/G2. These findings suggest that PUM2, but not PUM1, is associated with tumour progression in GEP-NENs, although a causal role remains to be established.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"77 1","pages":"62-71"},"PeriodicalIF":0.8,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148457522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary granular cell tumor coexisting with interstitial lung disease - a rare case report. 肺颗粒细胞瘤合并间质性肺疾病1例

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2026-01-19 DOI: 10.5114/pjp.2025.158613

Zeynep Sagnak Yilmaz, Safak Ersoz, Elif Ozsagır, Kubra Ozturk Turker, Olcay Aycicek, Deha Cebi Ozturk

引用次数: 0

Correct answer to the quiz. Check your diagnosis Cellular dermatofibroma. 测验的正确答案。检查你的诊断细胞性皮肤纤维瘤。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153980

Magdalena Justyna Kacperska-Olborska, Bogusław Olborski, Jerzy Ogłuszka

引用次数: 0

Thoracic SMARCA4-deficient undifferentiated tumour - a case of an aggressive neoplasm. 胸椎smarca4缺陷未分化肿瘤-侵袭性肿瘤1例。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149440

Gizem Teoman

引用次数: 0

Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors. c -末端紧张素样蛋白在乳腺癌中的表达及其与已知预后因素的相关性。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149282

Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq

{"title":"Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors.","authors":"Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq","doi":"10.5114/pjp.2025.149282","DOIUrl":"https://doi.org/10.5114/pjp.2025.149282","url":null,"abstract":"C-terminal tensin-like (Cten) is a marker for poorly differentiated breast cancer. We evaluated the immunohistochemical expression of Cten in invasive breast carcinoma in our population and correlated it with known histopathologic prognostic variables. Fifty-seven specimens of modified radical mastectomy diagnosed as invasive ductal carcinoma were collected. The histopathologic findings were noted independent of the result of Cten. According to the results of Cten immunohistochemistry, the tumors were categorized as negative/mild, moderate, or high expression and were statistically corelated with histologic findings. In our study, 47 (82.5%) cases showed negative/mild expression, 2 (3.5%) cases showed moderate staining, and 8 (14%) cases showed strong expression of Cten. Positive Cten was present in pT4 stage tumors. Similarly, grade III tumor showed moderate expression in 2 (3.5%) cases and strong staining in 8 (14%) cases. Posi-tive expression of Cten was observed in cases with lymphovascular invasion (LVI) and high axillary lymph nodal involvement (N3). All these poor prognostic factors were significantly associated with moderate to high expression of Cten. We found that tumor size and extent, histologic grade, LVI, and lymph node status were significantly associated with Cten expression. C-terminal tensin-like can be used as marker of poor prognosis in breast carcinoma.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"10-15"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas? ARID1A表达缺失是否影响直肠癌新辅助放化疗反应？

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153970

Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan

{"title":"Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas?","authors":"Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan","doi":"10.5114/pjp.2025.153970","DOIUrl":"https://doi.org/10.5114/pjp.2025.153970","url":null,"abstract":"This study evaluated the difference of ARID1A protein immunoexpression between responders and non-responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancers. The biopsies before neoadjuvant chemoradiotherapy and resection materials after me-sorectal excision were re-examined for conventional prognostic parameters, tumour re-gression score was determined, and survival data were evaluated. All parameters were statistically compared. Of the 117 cases, most (93%) were adenocarcinoma, 88% were moderately differentiat-ed and no response was seen in 28%. Before neoadjuvant therapy, low nuclear expression of ARID1A was noted in 49 (41.9%), while high expression was observed in 68 cases (58.1%). After neoadjuvant therapy, low expression was observed in 12 (10.7%) cases, while high expression was seen in 90 cases (80.3%). After neoadjuvant therapy a statis-tically lower ARID1A expression was noted in the absence of distant organ metastasis (p = 0.033). No statistically significant relationship was observed between ARID1A expression and overall survival or progression-free survival. ARID1A expression before neoadjuvant treatment had no statistically significant effect on response to neoadjuvant treatment and was not significantly associated with survival. More patients had significantly higher ARID1A expression in the post-treatment period than the pretreatment period. This may suggest that tumour cells with low ARID1A expression are more sensitive to neoadjuvant therapy.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"87-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population. 土耳其人群非小细胞肺癌TERT启动子突变的临床病理和预后相关性研究。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149380

Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz

{"title":"Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population.","authors":"Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz","doi":"10.5114/pjp.2025.149380","DOIUrl":"https://doi.org/10.5114/pjp.2025.149380","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is characterized by a complex and heterogeneous molecular basis. Telomerase reverse transcriptase ( TERT ) gene promoter mutations have been implicated in various cancer types. We aimed to investigate the status of TERT promoter region mutations in NSCLCs and determine associations of clinicopathological connections, driver mutations, programmed death-ligand 1 (PD-L1) expression, and overall survival (OS) in the Turkish population. The study included 186 patients diagnosed with NSCLC at a tertiary care center pathology department between 2017 and 2022. TERT promoter mutations were present in 2.7% and associated with old age ( p = 0.015). The levels of PD-L1 expression were higher in TERT mutants ( p = 0.016). TERT mutants had shorter median OS than wild types ( p = 0.006) and TERT mutation was an independent risk factor ( p = 0.004). TERT and EGFR mutations may co-occur and be associated with shorter median OS in patients who continue to receive EGFR treatment ( p < 0.001). TERT promoter mutations were associated with high PD-L1 expression and adverse prognosis in NSCLC. In addition, they may play a major role in patients' poor clinical outcomes during EGFR therapy. In conclusion, TERT may be a significant parameter for future follow-up and treatment selection of NSCLC.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"38-46"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0