The role of the CLL-1 protein in disease monitoring in patients diagnosed with acute myeloid leukaemia and myelodysplastic syndrome.

IF 0.7 4区医学 Q4 PATHOLOGY

Polish Journal of Pathology Pub Date : 2024-01-01 DOI:10.5114/pjp.2024.143228

Ewa Dobak, Sylwia Romana Jankowska-Szabłowska, Renata Guzicka-Kazimierczak, Paulina Poter, Elżbieta Urasińska, Katarzyna Karpińska-Łukaszewicz

引用次数: 0

Abstract

The normal subpopulation of CD34+CD38 - haematopoietic stem cells does not express CLL-1; therefore, the assessment of the expression of this protein can be used for the diagnosis of minimal residual disease. The aim of this study was to evaluate, using multi-colour flow cytometry, the level of CLL-1 protein expression on CD34+CD38- myeloid niche cells in acute myeloid leukaemia (AML) and myelodysplastic syndromepatients at the time of diagnosis and during disease monitoring on the example of 3 practical cases. The following conclusion was drawn: CD34+CD38-CLL-1+ cells in AML patients may serve as a biomarker to predict disease aggressiveness.

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CLL-1 蛋白在急性髓性白血病和骨髓增生异常综合征患者疾病监测中的作用。

CD34+CD38- 造血干细胞的正常亚群不表达 CLL-1；因此，评估该蛋白的表达可用于诊断极小残留病。本研究旨在以 3 个实际病例为例，使用多色流式细胞术评估急性髓性白血病（AML）和骨髓增生异常综合征患者在诊断时和疾病监测期间 CD34+CD38- 髓系龛细胞上 CLL-1 蛋白的表达水平。得出以下结论：急性髓性白血病患者体内的 CD34+CD38-CLL-1+ 细胞可作为预测疾病侵袭性的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polish Journal of Pathology PATHOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.