Polish Journal of Pathology最新文献

Correct answer to the quiz. Check your diagnosis Cellular dermatofibroma. 测验的正确答案。检查你的诊断细胞性皮肤纤维瘤。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153980

Magdalena Justyna Kacperska-Olborska, Bogusław Olborski, Jerzy Ogłuszka

引用次数: 0

Thoracic SMARCA4-deficient undifferentiated tumour - a case of an aggressive neoplasm. 胸椎smarca4缺陷未分化肿瘤-侵袭性肿瘤1例。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149440

Gizem Teoman

引用次数: 0

Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors. c -末端紧张素样蛋白在乳腺癌中的表达及其与已知预后因素的相关性。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149282

Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq

{"title":"Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors.","authors":"Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq","doi":"10.5114/pjp.2025.149282","DOIUrl":"https://doi.org/10.5114/pjp.2025.149282","url":null,"abstract":"C-terminal tensin-like (Cten) is a marker for poorly differentiated breast cancer. We evaluated the immunohistochemical expression of Cten in invasive breast carcinoma in our population and correlated it with known histopathologic prognostic variables. Fifty-seven specimens of modified radical mastectomy diagnosed as invasive ductal carcinoma were collected. The histopathologic findings were noted independent of the result of Cten. According to the results of Cten immunohistochemistry, the tumors were categorized as negative/mild, moderate, or high expression and were statistically corelated with histologic findings. In our study, 47 (82.5%) cases showed negative/mild expression, 2 (3.5%) cases showed moderate staining, and 8 (14%) cases showed strong expression of Cten. Positive Cten was present in pT4 stage tumors. Similarly, grade III tumor showed moderate expression in 2 (3.5%) cases and strong staining in 8 (14%) cases. Posi-tive expression of Cten was observed in cases with lymphovascular invasion (LVI) and high axillary lymph nodal involvement (N3). All these poor prognostic factors were significantly associated with moderate to high expression of Cten. We found that tumor size and extent, histologic grade, LVI, and lymph node status were significantly associated with Cten expression. C-terminal tensin-like can be used as marker of poor prognosis in breast carcinoma.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"10-15"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas? ARID1A表达缺失是否影响直肠癌新辅助放化疗反应？

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153970

Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan

{"title":"Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas?","authors":"Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan","doi":"10.5114/pjp.2025.153970","DOIUrl":"https://doi.org/10.5114/pjp.2025.153970","url":null,"abstract":"This study evaluated the difference of ARID1A protein immunoexpression between responders and non-responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancers. The biopsies before neoadjuvant chemoradiotherapy and resection materials after me-sorectal excision were re-examined for conventional prognostic parameters, tumour re-gression score was determined, and survival data were evaluated. All parameters were statistically compared. Of the 117 cases, most (93%) were adenocarcinoma, 88% were moderately differentiat-ed and no response was seen in 28%. Before neoadjuvant therapy, low nuclear expression of ARID1A was noted in 49 (41.9%), while high expression was observed in 68 cases (58.1%). After neoadjuvant therapy, low expression was observed in 12 (10.7%) cases, while high expression was seen in 90 cases (80.3%). After neoadjuvant therapy a statis-tically lower ARID1A expression was noted in the absence of distant organ metastasis (p = 0.033). No statistically significant relationship was observed between ARID1A expression and overall survival or progression-free survival. ARID1A expression before neoadjuvant treatment had no statistically significant effect on response to neoadjuvant treatment and was not significantly associated with survival. More patients had significantly higher ARID1A expression in the post-treatment period than the pretreatment period. This may suggest that tumour cells with low ARID1A expression are more sensitive to neoadjuvant therapy.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"87-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population. 土耳其人群非小细胞肺癌TERT启动子突变的临床病理和预后相关性研究。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149380

Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz

{"title":"Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population.","authors":"Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz","doi":"10.5114/pjp.2025.149380","DOIUrl":"https://doi.org/10.5114/pjp.2025.149380","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is characterized by a complex and heterogeneous molecular basis. Telomerase reverse transcriptase ( TERT ) gene promoter mutations have been implicated in various cancer types. We aimed to investigate the status of TERT promoter region mutations in NSCLCs and determine associations of clinicopathological connections, driver mutations, programmed death-ligand 1 (PD-L1) expression, and overall survival (OS) in the Turkish population. The study included 186 patients diagnosed with NSCLC at a tertiary care center pathology department between 2017 and 2022. TERT promoter mutations were present in 2.7% and associated with old age ( p = 0.015). The levels of PD-L1 expression were higher in TERT mutants ( p = 0.016). TERT mutants had shorter median OS than wild types ( p = 0.006) and TERT mutation was an independent risk factor ( p = 0.004). TERT and EGFR mutations may co-occur and be associated with shorter median OS in patients who continue to receive EGFR treatment ( p < 0.001). TERT promoter mutations were associated with high PD-L1 expression and adverse prognosis in NSCLC. In addition, they may play a major role in patients' poor clinical outcomes during EGFR therapy. In conclusion, TERT may be a significant parameter for future follow-up and treatment selection of NSCLC.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"38-46"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural proximity, vascular remodeling, and perineural immune exclusion across the cervical neoplasia spectrum - a whole-slide, nerve-anchored spatial analysis of 135 cases. 神经接近、血管重构和神经周围免疫排斥贯穿宫颈肿瘤谱——135例全切片、神经锚定空间分析

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.158907

Giorgi-Jemal Gogitidze, Shota Kepuladze, George Burkadze

{"title":"Neural proximity, vascular remodeling, and perineural immune exclusion across the cervical neoplasia spectrum - a whole-slide, nerve-anchored spatial analysis of 135 cases.","authors":"Giorgi-Jemal Gogitidze, Shota Kepuladze, George Burkadze","doi":"10.5114/pjp.2025.158907","DOIUrl":"https://doi.org/10.5114/pjp.2025.158907","url":null,"abstract":"Cervical carcinogenesis unfolds within a complex tissue ecosystem. While epithelial biomarkers and HPV status inform risk, the contribution of local neural circuits and their relationship to angiogenesis and cytotoxic immunity remains insufficiently defined in cervical intraepithelial neoplasia (CIN). In a balanced, archival cohort (n = 135; 27 per group: normal, CIN1, CIN2, CIN3, squamous cell carcinoma - SCC), whole-slide images were analyzed using a pre-specified QuPath pipeline with fixed thresholds and area normalization. We created composite indices: a neuro-epithelial coupling index (NECI) integrating nerve density, caliber, PGP9.5 signal, and inverse nerve-basement membrane (BM) distance; a vascular remodeling index (VRI) integrating CD31/CD34 microvessel density, vascular endothelial growth factor, vessel caliber, and peribasement vessels. Cytotoxic access was captured by CD8 density within 0-50 µm of nerves (NACD50) NECI and VRI increased monotonically with grade (group medians, normal  SCC: NECI -1.29, -0.64, 0.00, 1.33, 3.54; VRI -1.35, -0.58, 0.00, 1.14, 2.06). Neurovascular progression index values differ between grades (-1.32, -0.64, 0.00, 1.24, 2.66). The minimum nerve-BM distance shortened stepwise. In contrast, nerve-adjacent CD8 access declined with grade: NACD50 fell (≈ 5, 8, 4, 2, 1 cells/mm²) and nerve-avoidance ratio decreased (≈ 0.9, 0.8, 0.6, 0.4, 0.3), indicating progressive perineural CD8 exclusion. Across the full histologic spectrum, neuro-epithelial proximity and vascular remodeling intensify, whereas cytotoxic access to the perineural niche declines. These nerve-anchored, spatially explicit metrics add a neural dimension to cervical carcinogenesis and nominate the 0-50 µm perineural zone as a quantifiable compartment for risk stratification and interventional trials. External validation and calibrated modeling are warranted.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 4","pages":"318-328"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic consistency of programmed death-ligand 1 immunohistochemistry - comparative analysis of SP142 and 22C3 clones in non-small cell lung cancer. 程序性死亡-配体1免疫组化诊断的一致性——SP142和22C3克隆在非小细胞肺癌中的比较分析。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.158889

Songül Şahin, Sule Ayla

{"title":"Diagnostic consistency of programmed death-ligand 1 immunohistochemistry - comparative analysis of SP142 and 22C3 clones in non-small cell lung cancer.","authors":"Songül Şahin, Sule Ayla","doi":"10.5114/pjp.2025.158889","DOIUrl":"https://doi.org/10.5114/pjp.2025.158889","url":null,"abstract":"Programmed death-ligand 1 (PD-L1) expression is a critical predictive biomarker for immune checkpoint inhibitor therapies in non-small cell lung cancer (NSCLC). Although various antibody clones are used for immunohistochemical (IHC) detection, differences in platforms and scoring algorithms raise concerns regarding analytical agreement at clinically relevant thresholds. This study evaluated the analytical concordance between VENTANA SP142, VENTANA 22C3, and DAKO 22C3 PD-L1 IHC assays in NSCLC, focusing on therapeutic decision-making thresholds. Non-small cell lung cancer samples from 205 patients were stained using VENTANA SP142, VENTANA 22C3, and DAKO 22C3 assays. Programmed death-ligand 1 expression was assessed in tumor cells using predefined thresholds (< 1%, 1-49%, ≥ 50%). Inter-assay agreement was evaluated using intraclass correlation coefficients (ICC). Strong analytical agreement (ICC > 0.90) was observed between SP142 and both DAKO and VENTANA 22C3 assays in the < 1% and 1-49% expression groups. Agreement decreased between VENTANA SP142 and DAKO 22C3 at the ≥ 50% threshold (ICC = 0.704). Conversely, concordance between VENTANA and DAKO 22C3 was high across all thresholds, particularly in the < 1% and ≥ 50% subgroups (ICC = 1.0 and 0.867, respectively). VENTANA and DAKO 22C3 assays demonstrate high analytical agreement. While SP142 is comparable at low expression levels, its reliability declines at higher thresholds. These findings underscore the necessity of standardized assay selection for accurate immunotherapy stratification in NSCLC.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 4","pages":"299-306"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracted: Histopathological image analysis and enhanced diagnostic accuracy explainability for oral cancer detection. 撤回：组织病理学图像分析和提高口腔癌检测的诊断准确性。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.159057

V P Gladis Pushparathi, Sylaja Vallee Narayan S R, Pratheeba R S, V Naveen

引用次数: 0

On interactions between fever, inflammation, and the autonomic nervous system. 发热、炎症和自主神经系统的相互作用。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149441

Beato Suwa

{"title":"On interactions between fever, inflammation, and the autonomic nervous system.","authors":"Beato Suwa","doi":"10.5114/pjp.2025.149441","DOIUrl":"10.5114/pjp.2025.149441","url":null,"abstract":"The pathologist Simon Samuel, one of the pioneers in the field of the autonomic nervous system during the 19 th century, contributed significantly to the understanding of the pathological mechanisms underlying inflammation. The remarkable advances in that field around the mid-19 th century fundamentally influenced future research of the last 170 years. In fact these findings are still connected with many novel studies on pathology today. Albert Eulenburg (1840-1917) is another scientist who contributed to the former advances in the autonomic nervous system and who closely cooperated with Samuel. Both scientists published articles and reviews in the German journal Schmidt's yearbooks edited by J. A. Winter (1816-1901). It is remarkable that Johann Ignaz Hoppe (1811-1891), an even earlier pioneer of the autonomic nervous system, also wrote articles for the same journal and obviously had influenced Samuel. Although regulations discriminating Jewish academics existed in Prussia (and later in the German Empire) until approximately 1888, Samuel was finally made assistant professor (außerordentlicher Professor) at Königsberg University (today Kaliningrad/Russian Federation) in 1874. An embarrassingly low position compared to the significance of his scientific contributions and to the implications of his work on future generations.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"47-53"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous pathological splenic rupture as a first manifestation of mantle cell lymphoma - a case report and literature review. 以套细胞淋巴瘤为首发表现的自发性病理性脾破裂1例报告并文献复习。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.156558

Antoni Knera, Wojciech Ciesielski, Adam Placek, Piotr Kruszyński, Marcin Braun, Julia Sołek, Janusz Strzelczyk, Adam Durczyński, Tomasz Klimczak, Piotr Hogendorf

引用次数: 0