Polish Journal of Pathology最新文献

Thoracic SMARCA4-deficient undifferentiated tumour - a case of an aggressive neoplasm. 胸椎smarca4缺陷未分化肿瘤-侵袭性肿瘤1例。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149440

Gizem Teoman

引用次数: 0

Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors. c -末端紧张素样蛋白在乳腺癌中的表达及其与已知预后因素的相关性。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149282

Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq

{"title":"Expression of C-terminal tensin-like in breast carcinoma and its correlation with known prognostic factors.","authors":"Usma Arshad, Syeda Fatima Rizvi, Shahzada Khalid Sohail, Samina Qamar, Rahat Sarfraz, Maham Akhlaq","doi":"10.5114/pjp.2025.149282","DOIUrl":"https://doi.org/10.5114/pjp.2025.149282","url":null,"abstract":"C-terminal tensin-like (Cten) is a marker for poorly differentiated breast cancer. We evaluated the immunohistochemical expression of Cten in invasive breast carcinoma in our population and correlated it with known histopathologic prognostic variables. Fifty-seven specimens of modified radical mastectomy diagnosed as invasive ductal carcinoma were collected. The histopathologic findings were noted independent of the result of Cten. According to the results of Cten immunohistochemistry, the tumors were categorized as negative/mild, moderate, or high expression and were statistically corelated with histologic findings. In our study, 47 (82.5%) cases showed negative/mild expression, 2 (3.5%) cases showed moderate staining, and 8 (14%) cases showed strong expression of Cten. Positive Cten was present in pT4 stage tumors. Similarly, grade III tumor showed moderate expression in 2 (3.5%) cases and strong staining in 8 (14%) cases. Posi-tive expression of Cten was observed in cases with lymphovascular invasion (LVI) and high axillary lymph nodal involvement (N3). All these poor prognostic factors were significantly associated with moderate to high expression of Cten. We found that tumor size and extent, histologic grade, LVI, and lymph node status were significantly associated with Cten expression. C-terminal tensin-like can be used as marker of poor prognosis in breast carcinoma.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"10-15"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas? ARID1A表达缺失是否影响直肠癌新辅助放化疗反应？

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153970

Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan

{"title":"Does loss of ARID1A expression affect neoadjuvant chemoradiotherapy response in rectal carcinomas?","authors":"Nagehan O Barisik, Sibel Sensu, Sevinc H Keser, Yesim S Gurbuz, Ozgul Ozdemir, Ramazan O Yuceer, AylinE Gul, Nusret Erdogan","doi":"10.5114/pjp.2025.153970","DOIUrl":"https://doi.org/10.5114/pjp.2025.153970","url":null,"abstract":"This study evaluated the difference of ARID1A protein immunoexpression between responders and non-responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancers. The biopsies before neoadjuvant chemoradiotherapy and resection materials after me-sorectal excision were re-examined for conventional prognostic parameters, tumour re-gression score was determined, and survival data were evaluated. All parameters were statistically compared. Of the 117 cases, most (93%) were adenocarcinoma, 88% were moderately differentiat-ed and no response was seen in 28%. Before neoadjuvant therapy, low nuclear expression of ARID1A was noted in 49 (41.9%), while high expression was observed in 68 cases (58.1%). After neoadjuvant therapy, low expression was observed in 12 (10.7%) cases, while high expression was seen in 90 cases (80.3%). After neoadjuvant therapy a statis-tically lower ARID1A expression was noted in the absence of distant organ metastasis (p = 0.033). No statistically significant relationship was observed between ARID1A expression and overall survival or progression-free survival. ARID1A expression before neoadjuvant treatment had no statistically significant effect on response to neoadjuvant treatment and was not significantly associated with survival. More patients had significantly higher ARID1A expression in the post-treatment period than the pretreatment period. This may suggest that tumour cells with low ARID1A expression are more sensitive to neoadjuvant therapy.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"87-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population. 土耳其人群非小细胞肺癌TERT启动子突变的临床病理和预后相关性研究。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149380

Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz

{"title":"Investigation of clinicopathological and prognostic association of TERT promoter mutation in non-small cell lung cancer in a Turkish population.","authors":"Onur Dülger, Ilhan Yaylim, Ismail Yilmaz, Fatma Sen, Büge Öz","doi":"10.5114/pjp.2025.149380","DOIUrl":"https://doi.org/10.5114/pjp.2025.149380","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is characterized by a complex and heterogeneous molecular basis. Telomerase reverse transcriptase ( TERT ) gene promoter mutations have been implicated in various cancer types. We aimed to investigate the status of TERT promoter region mutations in NSCLCs and determine associations of clinicopathological connections, driver mutations, programmed death-ligand 1 (PD-L1) expression, and overall survival (OS) in the Turkish population. The study included 186 patients diagnosed with NSCLC at a tertiary care center pathology department between 2017 and 2022. TERT promoter mutations were present in 2.7% and associated with old age ( p = 0.015). The levels of PD-L1 expression were higher in TERT mutants ( p = 0.016). TERT mutants had shorter median OS than wild types ( p = 0.006) and TERT mutation was an independent risk factor ( p = 0.004). TERT and EGFR mutations may co-occur and be associated with shorter median OS in patients who continue to receive EGFR treatment ( p < 0.001). TERT promoter mutations were associated with high PD-L1 expression and adverse prognosis in NSCLC. In addition, they may play a major role in patients' poor clinical outcomes during EGFR therapy. In conclusion, TERT may be a significant parameter for future follow-up and treatment selection of NSCLC.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"38-46"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On interactions between fever, inflammation, and the autonomic nervous system. 发热、炎症和自主神经系统的相互作用。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149441

Beato Suwa

{"title":"On interactions between fever, inflammation, and the autonomic nervous system.","authors":"Beato Suwa","doi":"10.5114/pjp.2025.149441","DOIUrl":"10.5114/pjp.2025.149441","url":null,"abstract":"The pathologist Simon Samuel, one of the pioneers in the field of the autonomic nervous system during the 19 th century, contributed significantly to the understanding of the pathological mechanisms underlying inflammation. The remarkable advances in that field around the mid-19 th century fundamentally influenced future research of the last 170 years. In fact these findings are still connected with many novel studies on pathology today. Albert Eulenburg (1840-1917) is another scientist who contributed to the former advances in the autonomic nervous system and who closely cooperated with Samuel. Both scientists published articles and reviews in the German journal Schmidt's yearbooks edited by J. A. Winter (1816-1901). It is remarkable that Johann Ignaz Hoppe (1811-1891), an even earlier pioneer of the autonomic nervous system, also wrote articles for the same journal and obviously had influenced Samuel. Although regulations discriminating Jewish academics existed in Prussia (and later in the German Empire) until approximately 1888, Samuel was finally made assistant professor (außerordentlicher Professor) at Königsberg University (today Kaliningrad/Russian Federation) in 1874. An embarrassingly low position compared to the significance of his scientific contributions and to the implications of his work on future generations.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"47-53"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3. miR-21通过靶向PLD1和STAT3调控lps诱导的大鼠心肌细胞凋亡和炎症损伤。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153974

Rui Chen, Wei Xiong, Ruiying Liu, Sai Wan, Tao Huang, Jiajing Ai, Lingjing Ye, Qingping He

{"title":"miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3.","authors":"Rui Chen, Wei Xiong, Ruiying Liu, Sai Wan, Tao Huang, Jiajing Ai, Lingjing Ye, Qingping He","doi":"10.5114/pjp.2025.153974","DOIUrl":"https://doi.org/10.5114/pjp.2025.153974","url":null,"abstract":"This study aims to elucidate the role and molecular mechanism of microRNA-21 (miR-21) in LPS-induced inflammatory injury in H9c2 cardiomyocytes. H9c2 cardiomyocytes were treated with lipopolysaccharide (LPS) to establish an in vitro model. The expression of miR-21 was quantified using RT-qPCR, while protein levels were assessed via Western blot analysis. The impact of miR-21 on inflamma-tory response, cell proliferation, and apoptosis in LPS-treated H9c2 cells was evalu-ated using ELISA, CCK-8/EdU assays, and flow cytometry. TargetScan predictions and dual-luciferase reporter assays were employed to identify potential miR-21 tar-gets. The regulatory effects of miR-21 on inflammation, proliferation, and apop-tosis in cells were further examined following transfection with phospholipase D1 (PLD1) overexpression constructs or signal transducer and activator of transcription 3 (STAT3) activation. The expression levels of miR-21, PLD1, and p-STAT3 were significantly elevated in LPS-treated H9c2 cells. Knockdown of miR-21 markedly inhibited the LPS-induced inflammatory response, enhanced cell proliferation, and reduced apoptosis in H9c2 cells. PLD1 and STAT3 were confirmed as direct targets of miR-21. Overexpression of PLD1 or activation of STAT3 significantly reversed the protective effects of miR-21 downregulation in LPS-treated H9c2 cells. Downregu-lation of miR-21 protects cardiomyocytes against LPS-induced inflammatory injury and apoptosis by inhibiting PLD1 expression and STAT3 phosphorylation.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"131-140"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does SOX-2 expression have a prognostic value in triple-negative breast cancer? SOX-2表达在三阴性乳腺癌中有预后价值吗？

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.149426

Ismail Guzelis, Betul Bolat Kucukzeybek, Merve Gursoy, Yeliz Yilmaz, Yuksel Kucukzeybek

{"title":"Does SOX-2 expression have a prognostic value in triple-negative breast cancer?","authors":"Ismail Guzelis, Betul Bolat Kucukzeybek, Merve Gursoy, Yeliz Yilmaz, Yuksel Kucukzeybek","doi":"10.5114/pjp.2025.149426","DOIUrl":"https://doi.org/10.5114/pjp.2025.149426","url":null,"abstract":"Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. At the cell of origin level, cancer stem cells (CSC) are the tumour initiators in breast cancer. SRY-box transcription factor 2 (SOX-2) is a CSC marker that plays a role in tumourigenesis. The objective of this study was to evaluate the association of SOX-2 expression with histopathological parameters and clinical outcomes in TNBC patients. The study included 95 TNBC cases. An in vitro diagnostic SOX-2 antibody was applied to the tumoural slides in a validated automated stainer. The expression of SOX-2 was defined as a SOX-2 H-score ≥ 1. The expression of SOX-2 was observed in 29 cases (30.5%). At a median follow-up of 76 months, SOX-2 expression was not associated with overall or disease-free survival. R-based statistical analysis determined a SOX-2 H-score cut-off of 2. Although the overall and disease-free survival rates of cases with an H-score ≥ 3 were lower than the others, the differences were not statistically significant. The percentage of SOX-2 staining is typically low, as only 1% of tumour cells exhibit CSC characteristics. In conclusion, the prognostic significance of SOX-2 could become clear in a larger group of TNBC patients using standardized methodologies.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 1","pages":"1-9"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High mobility group box 1 attenuates aortic stenosis by modulating macrophages to reduce valvular calcification. 高迁移率组1通过调节巨噬细胞减少瓣膜钙化来减轻主动脉狭窄。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153975

Dong Zhao, Yun Zhao, Li-Na Luan

{"title":"High mobility group box 1 attenuates aortic stenosis by modulating macrophages to reduce valvular calcification.","authors":"Dong Zhao, Yun Zhao, Li-Na Luan","doi":"10.5114/pjp.2025.153975","DOIUrl":"https://doi.org/10.5114/pjp.2025.153975","url":null,"abstract":"Our previous study demonstrated that HMGB1 may suppress M1 macrophage polarisation and mitigate the progression of calcific aortic valve disease (CAVD). However, the role of HMGB1 in regulating macrophage-mediated valvular calcifi-cation remains to be further explored. Serum samples from healthy individuals and CAVD patients with varying severity were collected and analysed by ELISA. Immunofluorescence staining of human heart tissue arrays assessed macrophage infiltration in calcified valves. A macro-phage-aortic valve interstitial cell (haVIC) co-culture system was used to examine the effects of reHMGB1-treated macrophages. RUNX2 and osteopontin mRNA expression were measured by RT-qPCR, and alkaline phosphatase (ALP) staining was performed to evaluate calcification. HMGB1 levels were significantly reduced in severe CAVD patients than controls. Immunofluorescence staining revealed increased CD68 expression in calcified valve samples, indicating macrophage infiltration. In the macrophage-haVIC co-culture system, macrophages pretreated with reHMGB1 led to reduced RUNX2 mRNA expression and lower ALP activity in haVICs, suggesting a potential inhibitory effect of HMGB1 on valvular calcification. HMGB1 may have the potential to suppress inflammation and mitigate aortic valve calcification, making it a promising therapeutic target for preventing the progression of aortic stenosis.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"141-150"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOXC1 expression profile in invasive breast carcinomas and its relationship with prognostic parameters. 浸润性乳腺癌中FOXC1表达谱及其与预后参数的关系

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153969

Özge Bozkurt Öztürk, Remzi Arslan

{"title":"FOXC1 expression profile in invasive breast carcinomas and its relationship with prognostic parameters.","authors":"Özge Bozkurt Öztürk, Remzi Arslan","doi":"10.5114/pjp.2025.153969","DOIUrl":"https://doi.org/10.5114/pjp.2025.153969","url":null,"abstract":"This study aimed to investigate the expression profile of FOXC1 in molecular sub-types of invasive breast cancer. Additionally, it sought to explore the association between FOXC1 expression and clinicopathological prognostic parameters to eval-uate its potential diagnostic and therapeutic implications. A total of 122 invasive breast carcinoma cases from excision specimens were an-alysed. Immunohistochemical staining for FOXC1 was performed, with nuclear expression > 1% considered positive. The correlation between FOXC1 expression, molecular subtypes, and prognostic parameters was examined. A significant negative correlation was found between FOXC1 expression and ER, PR, and HER2 in 122 cases, while FOXC1 expression was notably higher in the triple-negative breast cancer (TNBC) subtype. Additionally, FOXC1 expression showed a significant positive correlation with nuclear grade, histological grade, Ki67 index, and prognostic stage. FOXC1 expression was found to be higher in TNBCs compared to other molecular subtypes, and FOXC1 expression was negatively correlated with hormone recep-tors and HER2. On the other hand, FOXC1 was significantly associated with high proliferation index, high-grade tumour, and prognostic stage. These findings sug-gest that high FOXC1 expression may indicate aggressive behaviour and may be a predictive marker for poor prognosis.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"79-86"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological image analysis and enhanced diagnostic accuracy explainability for oral cancer detection. 组织病理学图像分析和提高口腔癌检测的诊断准确性。

IF 0.6 4区医学

Polish Journal of Pathology Pub Date : 2025-01-01 DOI: 10.5114/pjp.2025.153973

V P Gladis Pushparathi, Sylaja Vallee NarayanS R, Pratheeba R S, V Naveen

{"title":"Histopathological image analysis and enhanced diagnostic accuracy explainability for oral cancer detection.","authors":"V P Gladis Pushparathi, Sylaja Vallee NarayanS R, Pratheeba R S, V Naveen","doi":"10.5114/pjp.2025.153973","DOIUrl":"https://doi.org/10.5114/pjp.2025.153973","url":null,"abstract":"Deep learning (DL) has transformed medical imaging, particularly in the realm of oral cancer (OC) diagnosis using histopathological images. Timely detection of OC is es-sential for enhancing precision medicine and saving lives. However, incorrect diagnosis may impede effective treatment. In this study, we have proposed a DL model for OC classification, enhanced diagnosis decision-making and interpretability. We achieve this by starting with colour normalisation of histopathology images using the Vaha-dane 3-stain parameter normalisation and watershed segmentation method, followed by tiling and augmentation. Key features are selected using the weighted Fisher score (WFS) to address class imbalance. The U-Net classifier has been improved by using feature-based inputs instead of full images, reducing computational complexity and training time. The integration of Vahadane normalisation for consistent preprocessing across samples, WFS, and explainable artificial intelligence (XAI) addresses critical challenges in histopathological image analysis. The proposed model surpasses exist-ing approaches with a classification accuracy of 99.54%, and it outperforms Dense- Net201 and VGG10 in precision and reliability. The efficiency in handling imbal-anced datasets and explainability features make it suitable for early precise OC detec-tion, which can reduce diagnostic errors and enhance treatment outcomes.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"76 2","pages":"120-130"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0