Polish Journal of Pathology最新文献_第10页

Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma. ALDH1和CD44阳性对早期声门喉癌放疗反应和预后的预测价值。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117177

Ozgur Surmelioglu, Kıvılcım Erdogan, Muhammed Dagkiran, Suleyman Ozdemir, Ozgur Tarkan, Aysun Uguz

{"title":"Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis in early-stage glottic laryngeal squamous cell carcinoma.","authors":"Ozgur Surmelioglu, Kıvılcım Erdogan, Muhammed Dagkiran, Suleyman Ozdemir, Ozgur Tarkan, Aysun Uguz","doi":"10.5114/pjp.2022.117177","DOIUrl":"https://doi.org/10.5114/pjp.2022.117177","url":null,"abstract":"To evaluate the predictive value of CD44 and aldehyde dehydrogenase 1 (ALDH1) expression for prognosis and radiotherapy (RT) response in patients with early-stage laryngeal cancer receiving RT. Forty-four patients with early-stage laryngeal cancer diagnosed between 2002 and 2016 were included in the study. The correlation between RT response and pre-treatment immunohistochemical ALDH1 and CD44 staining was evaluated. In addition, survival times were compared between groups. The mean age of the 44 patients was 59.8 ±9.0 (43-81) years and 41 were male. There were 20 patients in the non-recurrent group (all men) and 24 patients in the recurrent group (21 men). Immunohistochemical positivity for ALDH1 was found to be a significant risk factor for RT failure (p = 0.0001), whereas CD44 positivity (p = 0.114) and age group (p = 0.287) were not significant. ALDH1 positivity was identified as a significant predictor of DFS and RT sensitivity, while CD44 positivity did not differ according to RT response.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 1","pages":"43-49"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of spatial PD1 and PD-L1 expression in inflammatory bowel disease samples - a pilot study. 评估炎症性肠病样本中PD1和PD-L1的空间表达-一项初步研究

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117178

Kinga Szczepaniak, Wiktor Paskal, Zofia Kuśmierczyk, Jarosław Wejman, Joanna Ostrowska, Wiesław Tarnowski, Paweł Włodarski

{"title":"Evaluation of spatial PD1 and PD-L1 expression in inflammatory bowel disease samples - a pilot study.","authors":"Kinga Szczepaniak, Wiktor Paskal, Zofia Kuśmierczyk, Jarosław Wejman, Joanna Ostrowska, Wiesław Tarnowski, Paweł Włodarski","doi":"10.5114/pjp.2022.117178","DOIUrl":"https://doi.org/10.5114/pjp.2022.117178","url":null,"abstract":"Alterations of PD1/PD-L1 pathway may be associated with an excessive inflammatory response in the intestinal wall in inflammatory bowel diseases (IBD). To evaluate the expression of PD-1 and PD-L1 in 4 compartments of intestinal wall (mucosa, submucosa, muscularis propria and lymphatic follicles), high-resolution immunohistochemically stained slides were obtained from formalin-fixed paraffin-embedded samples of 10 Crohn's disease (CD), 9 ulcerative colitis (UC) and 10 unaffected individuals cases. The levels of expression were quantified using the QuPath software. PD-1 was detected in lymphatic follicles in affected and unaffected tissue samples and in inflammatory infiltration in IBD. There was no difference between groups neither in PD-1 overall expression nor in individual compartments, with the exception of the mucosal expression. It was higher in the mucosa of CD patients comparing to controls, however this difference was marginal (p = 0.0461). PD-L1 was expressed in endothelium and mesenteric nervous plexi, consistently in each group. There were no significant differences in PD-L1 immunoreactivity in context of histologic compartment nor clinical diagnosis. The results suggest that PD-1 and PD-L1 expression in intestinal tissue is heterogeneous in the analysed groups, thus it may be dependent on individual characteristics.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 1","pages":"50-59"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expressions of EZH2 and NOTCH3 pathway in osteosarcoma and their roles in osteosarcoma stem cells. EZH2和NOTCH3通路在骨肉瘤中的表达及其在骨肉瘤干细胞中的作用

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.125534

Guangning Yan, Yangfan Lv, Xuwen Lai, Zhenlian Li, Danli Ye, Wei Wang, Yunfeng Qian, Haojie Yu, Zhuocai Wang

{"title":"Expressions of EZH2 and NOTCH3 pathway in osteosarcoma and their roles in osteosarcoma stem cells.","authors":"Guangning Yan, Yangfan Lv, Xuwen Lai, Zhenlian Li, Danli Ye, Wei Wang, Yunfeng Qian, Haojie Yu, Zhuocai Wang","doi":"10.5114/pjp.2022.125534","DOIUrl":"https://doi.org/10.5114/pjp.2022.125534","url":null,"abstract":"Osteosarcoma (OS) is the most common malignant bone tumour; however, the underlying mechanisms are mainly unknown. Enhancer of zeste homologue 2 (EZH2) and NOTCH pathway are important molecular signals related to carcinogenesis and tumour progression, but they are not fully understand in OS. Enhancer of zeste homologue 2, Notch3, HES1, and Nanog were detected on OS samples and statistically analysed. Expressions of these genes were investigate, and stem-like phenotype was verified in OS cells. This study found that higher EZH2 expression, Notch3 pathway, or Nanog were associated with tumour relapse and metastasis and a significantly shorter survival time. Moreover, the Notch3 pathway was activated in osteosarcoma stem cells. Enhancer of zeste homologue 2 overexpression could activate the Notch3 pathway and increase HES1 expression, leading to upregulated stem cell-related gene expression and self-renewal of OS cells. Our study demonstrates that EZH2, Notch3, and Nanog are important prognostic factors. Enhancer of zeste homologue 2 could maintain the self-renewal of OS cells, where the Notch3 pathway activation may be involved.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 4","pages":"343-351"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9593349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanog expression in patients with squamous cell carcinoma of oropharynx in relation to immunohistochemical score. 口咽鳞状细胞癌患者Nanog表达与免疫组织化学评分的关系。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2021.115662

Marta Kołodziej-Rzepa, Beata Biesaga, Dorota Słonina, Anna Mucha-Małecka

{"title":"Nanog expression in patients with squamous cell carcinoma of oropharynx in relation to immunohistochemical score.","authors":"Marta Kołodziej-Rzepa, Beata Biesaga, Dorota Słonina, Anna Mucha-Małecka","doi":"10.5114/pjp.2021.115662","DOIUrl":"https://doi.org/10.5114/pjp.2021.115662","url":null,"abstract":"This study aimed to compare prognostic potential of Nanog expression analysed by three immunohistochemical scores in the group of 63 squamous cell carcinomas of oropharynx. Immunoreactivity of Nanog expression was analyzed by semiquantitative score, immunoreactive score and H-score. For all three scores, the cut-off points for Nanog overexpression and its lack, allowing for optimal separation of overall and disease free survival curves, were search by minimal p-value method. In semiquantitative score, the best separation of overall and disease free survival curves was obtain by cut-off point lack of staining vs. week/moderate/strong staining, although statistical significance was not reach (OS: HR = 1.016, p = 0.081, DFS: HR = 6.876, p = 0.061). The cut-off points for immunoreactive score and H-score were, respectively: 1 (OS: HR = 6.977, p = 0.014, DFS: HR = 6.002, p = 0.019) and 50 (OS: HR = 6.977, p = 0.014, DFS: HR = 6.002, p = 0.019). The cut-off points found for these two scores allow to identify the same subgroups of patients with lack of Nanog expression (11.1%) and its overexpression (88.9%). All patients with tumors characterized by lack of Nanog overexpression identifying by immunoreactive score and H-score survived 5 years without evidence of cancer progression. In multivariate analysis Nanog immunoreactivity analysed by QRS and IRS was independent prognostic factor for OS (HR = 10.195, p = 0.024). Immunohistochemical score using to distinguish Nanog overexpression or its lack has influence on prognostic potential of this biomarker.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 1","pages":"60-71"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunohistochemical positive regulatory domain member 10 expression in soft tissue sarcomas. 免疫组化阳性调控域成员10在软组织肉瘤中的表达。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.124490

Ozge Mistik, Hamide Sayar

{"title":"Immunohistochemical positive regulatory domain member 10 expression in soft tissue sarcomas.","authors":"Ozge Mistik, Hamide Sayar","doi":"10.5114/pjp.2022.124490","DOIUrl":"https://doi.org/10.5114/pjp.2022.124490","url":null,"abstract":"Positive regulatory domain member (PRDM) proteins play a critical role in the transmission of signals that control cell proliferation and differentiation, and neoplastic transformation. Positive regulatory domain member 10 (tristanin) is a poorly studied member of PRDM protein family. Gene fusion transcripts containing PRDM10 were recently identified in low-grade undifferentiated pleomorphic sarcomas (UPS), and associated with pleomorphic morphology and low mitotic index. The aim of this study was to investigate the immunohistochemical staining of PRDM10 in a larger sample of soft tissue sarcomas. Therefore, the study included 118 soft tissue sarcomas from different classes, and PRDM10 antibody was applied to all of them. Immuno-histochemically, staining was observed in 22 (19%) cases, while 96 (81%) showed no staining. When PRDM10 expression was compared with clinico-pathological features, there was a statistically significant correlation between PRDM10 expression and myxoid changes, multi-nucleated giant cells, and surgical margin (p = 0.017, p = 0.034, p = 0.032, respectively). No statistically significant association was found between PRDM10 expression and other parameters. Based on the obtained data, it can be said that PRDM10-positive-stained tumors (tumors with PDRM10 expression) are mostly myxoid, containing multi-nucleated giant cells, and can be removed with well-circumscribed margins.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 3","pages":"223-232"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10652765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for central lymph node metastasis in papillary thyroid microcarcinoma - a retrospective study of 1433 cases from a single center. 甲状腺乳头状微癌中央淋巴结转移的危险因素——单中心1433例回顾性研究

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.124486

Yaoyuan Shen, Wenjing Pu, Hongrun Zhou, Mei Cui, Wei Zhao, Jin Ma, Chun Wang, Zhenzhu Sun

{"title":"Risk factors for central lymph node metastasis in papillary thyroid microcarcinoma - a retrospective study of 1433 cases from a single center.","authors":"Yaoyuan Shen, Wenjing Pu, Hongrun Zhou, Mei Cui, Wei Zhao, Jin Ma, Chun Wang, Zhenzhu Sun","doi":"10.5114/pjp.2022.124486","DOIUrl":"https://doi.org/10.5114/pjp.2022.124486","url":null,"abstract":"The purpose of this retrospective study was to evaluate the clinicopathological features of papillary thyroid microcarcinoma (PTMC) and the lymph node metastasis of PTMC. We retrospectively reviewed a total of 1433 patients with PTMC. The analysis data including demographics, tumor size, multifocality, bilateral, invasion capsule and Hashimoto's thyroiditis were collected from XinJiang, China. Univariate and multivariate analyses were performed to identify the clinicopathologic predictors of central lymph node metastasis: male gender [odds ratio (OR) = 2.358, p < 0.001], age ≤ 45 years (OR = 2.302, p 6.5 mm (OR = 2.388, p < 0.001), adjacent or invasion capsule (OR = 1.750, p = 0.002), Hashimoto's thyroiditis (OR = 0.501, p < 0.001). The optimal critical value of the number of dissected lymph nodes was found to be 8.5 using ROC analysis, with a sensitivity and specificity of 41.8% and 75.5%, respectively. This study suggests that evaluation of nodal metastasis is required to guide the surgical treatment of PTMC patients.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 3","pages":"191-197"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10707679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma. 在非小细胞肺癌中，Claudin 6与较短的生存期和较短的复发自由间隔有关。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117171

Ylermi Soini, Risto Pirinen, Kumi Takasawa, Makoto Osanai, Akira Takasawa

引用次数: 2

Immunohistochemical expression of PARP-1 in triple-negative endometrial cancer - a comparison of different score systems. PARP-1在三阴性子宫内膜癌中的免疫组织化学表达——不同评分系统的比较

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.125613

Michał Bulsa, Sylwia Romana Jankowska-Szabłowska, Elżbieta Urasińska

{"title":"Immunohistochemical expression of PARP-1 in triple-negative endometrial cancer - a comparison of different score systems.","authors":"Michał Bulsa, Sylwia Romana Jankowska-Szabłowska, Elżbieta Urasińska","doi":"10.5114/pjp.2022.125613","DOIUrl":"https://doi.org/10.5114/pjp.2022.125613","url":null,"abstract":"Endometrial cancer is the most common malignant neoplasm of the female reproductive system. The number of diagnosed cases is increasing every year. In recent years, the triple-negative phenomenon (TNP) has been identified as one of the determinants of shorter survival in endometrial cancer patients. The aim of the study was to compare the PARP-1 protein expression in triple-negative (TNEC) and non-triple-negative (NTNEC) endometrial cancer patients and determine the relationship between the PARP-1 protein expression in endometrial cancer cells and patient's overall survival depending on the adopted scale (H-SCORE < 75, H-SCORE < 50, Allred scale). The study involved 265 patients with histopathologically confirmed endometrial cancer. The patients were divided into 2 groups: patients with TNEC and patients with NTNEC. The study was conducted using a tissue microarray technique. Expression of PARP-1 protein was determined by immunohistochemistry. Protein expression evaluation was performed using virtual microscopy and the Image Scope computer image analysis system. The following conclusions were reached: total and individual levels of nuclear or cytoplasmic PARP-1 expression varied with the presence or absence of TNP, and PARP-1 nuclear expression at the 2+ level had a significant effect on the increased risk of death (according to H-SCORE < 75).","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 4","pages":"330-337"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual shaped mass filling the right cardiac chambers in a woman with a vascular malformation. 患有血管畸形的女性右心腔内的形状不寻常的肿块。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.124495

Cristian Podoleanu, Sorin Balos, Simona Stolnicu

引用次数: 0

Morphology of cells undergoing epithelial mesenchymal transition in microinvasive and early invasive oral squamous cell carcinom a - a light microscopic study. 微创和早期侵袭性口腔鳞状细胞癌中上皮间质转化的细胞形态——光镜研究。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.124491

Ketki Kalele, Vaishnavi Bhondekar, Shruti Dongare, Wasim Khan, Ashwini Shelotkar, Kaustubh Badukale, Kanchan Damare

{"title":"Morphology of cells undergoing epithelial mesenchymal transition in microinvasive and early invasive oral squamous cell carcinom a - a light microscopic study.","authors":"Ketki Kalele, Vaishnavi Bhondekar, Shruti Dongare, Wasim Khan, Ashwini Shelotkar, Kaustubh Badukale, Kanchan Damare","doi":"10.5114/pjp.2022.124491","DOIUrl":"https://doi.org/10.5114/pjp.2022.124491","url":null,"abstract":"The present study focuses on identification of cancer attributes of epithelial mesenchymal transition (EMT) at the earliest possible stage (microinvasion) under a light microscope by using hematoxylin and eosin stains, making it feasible for researchers to investigate such cases with ease without the use of extensive setups. The present study is the first in the English literature to define EMT features in micro-invasive and early invasive oral squamous cell carcinoma (OSCC) under a light microscope. This is a retrospective study of histological sections of 43 cases of OSCC from the Department of Oral Pathology and Microbiology. The data collected were later statistically analyzed. A total of 11 micro-invasive and 32 early invasive OSCC cases were assessed for core features of EMT. The predominant feature defining EMT found was dense inflammatory infiltrate in both microinvasive (91%) and early invasive OSCC (88%) followed by cell individualization in 82% of microinvasive and 75% of early invasive OSCC, which was then followed by other features. Reporting EMT in histopathological reports on a daily basis can aid in early diagnosis of OSCC as well as understanding carcinogenesis in early stages. Thereby, inclusion of EMT targeting therapeutics in early stages of OSCC can significantly alter the prognosis of cancer.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 3","pages":"244-254"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10665896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1