Polish Journal of Pathology最新文献_第9页

Vaginal metastasis of renal clear cell carcinoma: a case report emphasizing the role of immunohistochemistry in differential diagnosis in the absence of a clinical history. 肾透明细胞癌阴道转移一例报告:强调免疫组织化学在无临床病史的情况下鉴别诊断的作用。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.132229

Simona Stolnicu, Andrei Patrichi, Francisc Rozsnyai, Robert A Soslow

引用次数: 0

Granulomatous gastritis induced by chronic peanut ingestion. 长期食用花生诱发肉芽肿性胃炎

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.134029

Young Sub Lee, Inju Cho, Sung Hak Lee, Eun Sun Jung

引用次数: 0

Prognostic significance of a panel of two biomarkers (E-cadherin and CD105) in laryngeal cancer. 喉癌中两种生物标记物（E-cadherin 和 CD105）的预后意义。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2023-01-01 DOI: 10.5114/pjp.2023.134316

Elvir Zvrko, Ljiljana Vuckovic, Miodrag Radunovic

{"title":"Prognostic significance of a panel of two biomarkers (E-cadherin and CD105) in laryngeal cancer.","authors":"Elvir Zvrko, Ljiljana Vuckovic, Miodrag Radunovic","doi":"10.5114/pjp.2023.134316","DOIUrl":"10.5114/pjp.2023.134316","url":null,"abstract":"This study aimed to evaluate the clinicopathologic significance of the combined immunohistochemical expression of the epithelial-mesenchymal transition marker E-cadherin and the angiogenesis marker CD105 in laryngeal squamous cell carcinoma and assess correlation of their expression. Eighty-five patients who underwent complete resection as primary treatment were selected for this study. E-cadherin and CD105 expression levels were determined by immunohistochemistry. The receiver operating curve approach was applied to determine the cut-off value and separate patients with high and low expression of markers. The high-risk group (\"CD105 high\" and \"E-cadherin low\" expression) showed statistically significant correlations with age less than 66 years (p = 0.039), advanced T-status (T3-4) (p = 0.046), aggressive TNM stage (stage III-IV) (p = 0.003) and locoregional recurrence of disease (p = 0.004). In the Kaplan-Meier analyses, the high-risk group had significantly worse prognoses than other risk groups (log-rank test 2 = 9.415, p = 0.024). Spearman's correlation coefficient analysis showed a nonsignificant negative correlation between the expression of E-cadherin and CD105 (rho = -0.073, p = 0.505). Simultaneous consideration of E-cadherin and CD105 is a simple panel of markers to determine aggressive tumour phenotype with a higher risk of disease recurrence in patients with laryngeal cancer.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"74 4","pages":"225-231"},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of CD3, CD4 and CD8 in synovial lymphocytes of rheumatoid arthritis. CD3、CD4和CD8在类风湿关节炎滑膜淋巴细胞中的作用。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117173

Guangyi Xiong, Ting Lei, Shuhui Dong, Lina Xu, Mingshan Li, Ruilin Wang

{"title":"Roles of CD3, CD4 and CD8 in synovial lymphocytes of rheumatoid arthritis.","authors":"Guangyi Xiong, Ting Lei, Shuhui Dong, Lina Xu, Mingshan Li, Ruilin Wang","doi":"10.5114/pjp.2022.117173","DOIUrl":"https://doi.org/10.5114/pjp.2022.117173","url":null,"abstract":"In this study, the immunohistochemical EnVision method was applied to detect CD3, CD4 and CD8 in synovial tissues of 40 patients with rheumatoid arthritis (RA) and 10 patients with osteoarthritis (OA). In 92.5% (37/40) RA cases, lymphocytes were focally aggregated, and even germinal centers appeared, forming lymphoid follicle-like structures. The expression of CD3, CD4, and CD8 were high in synovial tissue of RA group, but low in OA group. The number of CD3, CD4+, and CD8+ lymphocytes in OA group were significantly lower than that in RA group (p < 0.05); CD4+lymphocytes in RA accounted for the majority, and mostly were focally distributed. The number of CD8+lymphocytes in the synovial tissue were small, and were mostly scattered. The number of CD4+lymphocytes were significantly higher than CD8+lymphocytes (p<0.05). Compared with the OA group, the number of CD4+T and CD8+T lymphocytes in RA group were higher, and the ratio of CD4/CD8 was higher in RA group (p < 0.05). In conclusion, the CD3, CD4 and CD8 with high level may promote the occurrence and development of RA. The ratio of CD4+/CD8+ may be used as a reference index for the diagnosis and prognosis of RA.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 1","pages":"21-26"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Laryngeal chondrosarcoma treated with conventional radiotherapy - case report and review of the literature. 常规放疗治疗喉软骨肉瘤病例报告及文献复习。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.119240

Agata Roch-Zniszczoł, Dorota Księżniak-Baran, Ewa Chmielik, Maria Goleń, Natalia Amrogowicz, Dorota Gabryś

引用次数: 0

The histopathologic checkpoints for thyroid core needle biopsy compared with resection sections. 甲状腺核心穿刺活检与切除切片的组织病理学检查点比较。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.125778

Tugce Kiran, Beril Guler

{"title":"The histopathologic checkpoints for thyroid core needle biopsy compared with resection sections.","authors":"Tugce Kiran, Beril Guler","doi":"10.5114/pjp.2022.125778","DOIUrl":"https://doi.org/10.5114/pjp.2022.125778","url":null,"abstract":"Introduction: The nuclear features that are thought to be classic indicators of thyroid nodules are not fully observed in core needle biopsies (CNB). The aim of this study was to evaluate the histopathological differences between CNB samples and resection sections.Material and methods: The haematoxylin and eosin-stained CNB and resection sections of thyroid nodules were retrospectively re-evaluated in terms of nuclear and architectural parameters. The evaluations were conducted by 2 pathologists. Statistical analysis was applied in 80 selected cases diagnosed as benign (n = 37) and papillary carcinoma/suspicious for papillary carcinoma (n = 43).Results: The nuclear findings in the CNB were more subtle than in the resection sections. The nuclei were smaller (measurements of the nuclear areas, major axes, and minor axes in CNB and resection sections were 52.62 µm2, 9.89 µm, 6.75 µm, 129.18 µm2, 14.53 µm, and 10.79 µm, respectively). Hypochromia was detected in 46.5% of the papillary carcinoma cases. Grooves and pseudoinclusions were the other nuclear features that could be detected. However, nuclear contour irregularity was the most reliable finding that could predict papillary carcinoma diagnosis in the CNB sections (v: 0.82, p < 0.001).Conclusions: We believe that the histopathological differences we found have an important place in diagnostics and should be emphasized, and new diagnostic algorithms should be developed.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 4","pages":"310-319"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical clinical presentation mimicking stroke in an adult patient caused by a rare diffuse leptomeningeal glioneuronal tumour. 一个罕见的弥漫性脑脊膜神经胶质细胞肿瘤引起的非典型临床表现。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.125822

Angelika Stapińska-Syniec, Anna Gogol, Albert Acewicz, Michał Sobstyl, Teresa Wierzba-Bobrowicz, Wiesława Grajkowska

引用次数: 1

Optimal DNA quality preservation process for comprehensive genomic testing of pediatric clinical autopsy formalin-fixed, paraffin-embedded tissues. 用于儿科临床尸检福尔马林固定石蜡包埋组织的全面基因组检测的最佳DNA质量保存工艺。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.124492

Noriko Watanabe, Tomohiro Umezu, Masashi Kyushiki, Kayoko Ichimura, Atsuko Nakazawa, Masahiko Kuroda

{"title":"Optimal DNA quality preservation process for comprehensive genomic testing of pediatric clinical autopsy formalin-fixed, paraffin-embedded tissues.","authors":"Noriko Watanabe, Tomohiro Umezu, Masashi Kyushiki, Kayoko Ichimura, Atsuko Nakazawa, Masahiko Kuroda","doi":"10.5114/pjp.2022.124492","DOIUrl":"https://doi.org/10.5114/pjp.2022.124492","url":null,"abstract":"Clinical autopsies are performed to reveal the process of the disease that caused patient death and validate the diagnosis and treatment decisions. In pediatric clinical autopsy, the feedback provided to bereaved families has a considerable social impact; however, pediatric diseases are diverse, which makes it difficult to elucidate them. Therefore, it is necessary to employ molecular biology techniques in addition to conventional methods. Formalin-fixed, paraffin-embedded (FFPE) tissues are routinely prepared. However, clinical autopsy FFPE tissue processing is not standardized, and it is unclear whether DNA from such tissues can be used for comprehensive genomic analysis. In this study, we evaluated the DNA quality of FFPE tissues from 15 recent autopsy cases at a single-center children's hospital using quantitative polymerase chain reaction [PCR (Q129/Q41)] and nanoelectrophoresis (DNA integrity number (DIN)). Good quality DNA was obtained from every organ type excluding bone marrow within 6 days of formalin fixation. Prolonged proteinase K digestion (48 h > 24 h > 1 h) and thicker tissue sections (10 µm > 1 µm) improved Q129/Q41; however, 24 h fixed FFPE tissues showed better DNA quality. We propose an optimal and feasible workflow for storing short-term fixed FFPE tissues as DNA-preserved FFPE tissues for future comprehensive genomic searches.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 3","pages":"255-263"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10652767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer. 非小细胞肺癌患者肿瘤组织中ANG-1表达和浓度的预后价值。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117176

Marzena Zalewska-Ziob, Brygida Adamek, Janusz Kasperczyk, Katarzyna Dobija-Kubica

{"title":"Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer.","authors":"Marzena Zalewska-Ziob, Brygida Adamek, Janusz Kasperczyk, Katarzyna Dobija-Kubica","doi":"10.5114/pjp.2022.117176","DOIUrl":"https://doi.org/10.5114/pjp.2022.117176","url":null,"abstract":"Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.","PeriodicalId":49692,"journal":{"name":"Polish Journal of Pathology","volume":"73 1","pages":"6-13"},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Glypican-3 immunostaining is associated with longer survival outcomes in colorectal carcinoma. Glypican-3免疫染色增加与结直肠癌患者更长的生存期相关。

IF 0.8 4区医学

Polish Journal of Pathology Pub Date : 2022-01-01 DOI: 10.5114/pjp.2022.117172

Jaudah Al-Maghrabi, Zuhoor Al-Mansouri, Abdullah Al-Harbi, Mourad Assidi, Abdelbaset Buhmeida, Wafaey Gomaa

引用次数: 1