Downregulated lncRNA LINC00908 correlates with a poor prognosis and increasing malignancy of gastric cancer.

IF 0.7 4区医学 Q4 PATHOLOGY

Polish Journal of Pathology Pub Date : 2024-01-01 DOI:10.5114/pjp.2024.141283

Chunyue Zhang, Yanmin Zhang, Yan Wang

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引用次数: 0

Abstract

Long non-coding RNA LINC00908 is a functional biomarker in regulating tumour progression. Its dysregulation in gastric cancer implies its potential functional role. Few studies have noted the functional role of LINC00908 in gastric cancer. The potential of LINC00908 to serve as a biomarker in gastric cancer was evaluated. A total of 113 paired gastric cancer tissues and normal tissues were collected from patients with gastric cancer. LINC00908 levels were evaluated by polymerase chain reaction, and its significance in disease progression and patients' prognosis was assessed. In vitro, the function of LINC00908 in tumour-related cellular processes was evaluated with CCK8 and Transwell assay. Significant downregulation of LINC00908 was observed in gastric cancer and was negatively associated with disease development and overall survival of patients. LINC00908 showed significant inhibitory effects on the proliferation, migration, and invasion of gastric cancer cells. Additionally, miR-627-3p was sponged by LINC00908 and therefore mediated the function of LINC00908 in gastric cancer cells. LINC00908 functioned as a prognostic biomarker and tumour suppressor of gastric cancer, providing a therapeutic target for gastric cancer.

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下调的lncRNA LINC00908与胃癌的不良预后和恶性程度增加有关。

长非编码 RNA LINC00908 是调控肿瘤进展的功能性生物标记物。它在胃癌中的失调意味着其潜在的功能性作用。很少有研究注意到 LINC00908 在胃癌中的功能作用。本研究评估了 LINC00908 作为胃癌生物标记物的潜力。研究人员从胃癌患者中收集了 113 例配对的胃癌组织和正常组织。通过聚合酶链反应评估了LINC00908的水平，并评估了其在疾病进展和患者预后中的意义。在体外，用 CCK8 和 Transwell 试验评估了 LINC00908 在与肿瘤相关的细胞过程中的功能。在胃癌中观察到 LINC00908 的显著下调，并与疾病发展和患者的总生存期呈负相关。LINC00908 对胃癌细胞的增殖、迁移和侵袭有明显的抑制作用。此外，miR-627-3p被LINC00908疏导，从而介导了LINC00908在胃癌细胞中的功能。LINC00908 可作为胃癌的预后生物标志物和肿瘤抑制因子，为胃癌的治疗提供了靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polish Journal of Pathology PATHOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.