Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

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Phytochemical profile and antioxidant capacity of the endemic species Bellevalia sasonii Fidan. 地方物种 Bellevalia sasonii Fidan 的植物化学成分和抗氧化能力。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-08-05 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0115
Metin Tekіn, İbrahim Selçuk Kuru
{"title":"Phytochemical profile and antioxidant capacity of the endemic species <i>Bellevalia sasonii</i> Fidan.","authors":"Metin Tekіn, İbrahim Selçuk Kuru","doi":"10.1515/znc-2024-0115","DOIUrl":"10.1515/znc-2024-0115","url":null,"abstract":"<p><p>The study investigated total phenolic-flavonoid content, antioxidant activity, and phytochemical compounds across various parts (bulb, stem, leaf, and flower) of the endemic <i>Bellevalia sasonii</i>, commonly known as hyacinth, belonging to the Asparagaceae family. Phenolic content was highest in bulb extracts (117.28 μg GAE) and lowest in stems (45.11 μg GAE). Conversely, leaf extracts exhibited the highest flavonoid content (79.44 μg QEs), while stems showed the lowest (22.77 μg QEs). When the antioxidant activities were compared, by DPPH method leaf = flower > bulb > stem; in ABTS and CUPRAC methods bulb > flower > leaf > stem, respectively. Considering the results in general, it was revealed that bulbs and flowers displayed higher activity, while stem exhibited lower activity compared to other parts. The phytochemical analysis identified 53 active substances, with 27 absent in any extract and 15 detected across all extracts. The distribution of phytochemicals varied among parts, with bulbs, stems, flowers, and leaves also different numbers. The LC-MS/MS analysis revealed prominent metabolites including fumaric acid in leaves, caffeic acid in bulbs, and cosmosiin and quinic acid in flowers. This study provides foundational insights into <i>B. sasonii</i>, an important endemic plant in Türkiye, laying the groundwork for future research on its medicinal and ecological roles.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"75-83"},"PeriodicalIF":1.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing psoriasis drug delivery through topical liposomes. 通过局部脂质体推进牛皮癣药物输送。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-23 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0118
Devesh U Kapoor, Rahul Garg, Rahul Maheshwari, Mansi Gaur, Deepak Sharma, Bhupendra G Prajapati
{"title":"Advancing psoriasis drug delivery through topical liposomes.","authors":"Devesh U Kapoor, Rahul Garg, Rahul Maheshwari, Mansi Gaur, Deepak Sharma, Bhupendra G Prajapati","doi":"10.1515/znc-2024-0118","DOIUrl":"10.1515/znc-2024-0118","url":null,"abstract":"<p><p>Psoriasis, recognized as a chronic inflammatory skin disorder, disrupts immune system functionality. Global estimates by the World Psoriasis Day consortium indicate its impact on approximately 130 million people, constituting 4 to 5 percent of the worldwide population. Conventional drug delivery systems, mainly designed to alleviate psoriasis symptoms, fall short in achieving targeted action and optimal bioavailability due to inherent challenges such as the drug's brief half-life, instability, and a deficiency in ensuring both safety and efficacy. Liposomes, employed in drug delivery systems, emerge as highly promising carriers for augmenting the therapeutic efficacy of topically applied drugs. These small unilamellar vesicles demonstrate enhanced penetration capabilities, facilitating drug delivery through the stratum corneum layer of skin. This comprehensive review article illuminates diverse facets of liposomes as a promising drug delivery system to treat psoriasis. Addressing various aspects such as formulation strategies, encapsulation techniques, and targeted delivery, the review underscores the potential of liposomes in enhancing the efficacy and specificity of psoriasis treatments.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"41-60"},"PeriodicalIF":1.8,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing the probiotic functionality, biochemical activity, antibiotic resistance and specialty genes of Pediococcus acidilactici BCB1H via in-vitro and in-silico approaches. 通过体外和体内方法革新酸性乳酸球菌 BCB1H 的益生菌功能、生化活性、抗生素抗性和特异基因。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-19 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0074
Gege Hu, Muhammad Naveed, Muhammad Aqib Shabbir, Abid Sarwar, Junaid Yousaf, Yang Zhennai, Tariq Aziz, Metab Alharbi, Abdulrahman Alshammari
{"title":"Revolutionizing the probiotic functionality, biochemical activity, antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H via <i>in-vitro</i> and <i>in-silico</i> approaches.","authors":"Gege Hu, Muhammad Naveed, Muhammad Aqib Shabbir, Abid Sarwar, Junaid Yousaf, Yang Zhennai, Tariq Aziz, Metab Alharbi, Abdulrahman Alshammari","doi":"10.1515/znc-2024-0074","DOIUrl":"10.1515/znc-2024-0074","url":null,"abstract":"<p><p>This study presents a comprehensive genomic exploration, biochemical characterization, and the identification of antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H strain. The functional characterization, genetic makeup, biological activities, and other considerable parameters have been investigated in this study with a prime focus on antibiotic resistance and specialty gene profiles. The results of this study revealed the unique susceptibility patterns for antibiotic resistance and specialty genes. BCB1H had good <i>in vitro</i> probiotic properties, which survived well in simulated artificial gastrointestinal fluid, and exhibited acid and bile salt resistance. BCB1H didn't produce hemolysis and had certain antibiotic sensitivity, making it a relatively safe LAB strain. Simultaneously, it had good self-coagulation characteristics and antioxidant activity. The EPS produced by BCB1H also had certain antioxidant activity and hypoglycemic function. Moreover, the genome with a 42.4 % GC content and a size of roughly 1.92 million base pairs was analyzed in the genomic investigations. The genome annotation identified 192 subsystems and 1,895 genes, offering light on the metabolic pathways and functional categories found in BCB1H. The identification of specialty genes linked to the metabolism of carbohydrates, stress response, pathogenicity, and amino acids highlighted the strain's versatility and possible uses. This study establishes the groundwork for future investigations by highlighting the significance of using multiple strains to investigate genetic diversity and experimental validation of predicted genes. The results provide a roadmap for utilizing <i>P. acidilactici</i> BCB1H's genetic traits for industrial and medical applications, opening the door to real-world uses in industries including food technology and medicine.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"103-118"},"PeriodicalIF":1.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico molecular modeling and in vitro biological screening of novel benzimidazole-based piperazine derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. 作为潜在乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂的新型苯并咪唑基哌嗪衍生物的硅学分子建模和体外生物筛选。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-16 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0068
Haseena Naz, Fazal Rahim, Rafaqat Hussain, Shoaib Khan, Wajid Rehman, Yousaf Khan, Tariq Aziz, Metab Alharbi
{"title":"<i>In silico</i> molecular modeling and <i>in vitro</i> biological screening of novel benzimidazole-based piperazine derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.","authors":"Haseena Naz, Fazal Rahim, Rafaqat Hussain, Shoaib Khan, Wajid Rehman, Yousaf Khan, Tariq Aziz, Metab Alharbi","doi":"10.1515/znc-2024-0068","DOIUrl":"10.1515/znc-2024-0068","url":null,"abstract":"<p><p>New series of benzimidazole incorporating piperazine moieties in single molecular framework has been reported. The structures of the synthesized derivatives were assigned by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HR-MS techniques. The hybrid derivatives were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibition effect. All the synthesized analogs showed good to moderate inhibitory effect ranging from IC<sub>50</sub> value 0.20 ± 0.01 µM to 0.50 ± 0.10 µM for acetylcholinesterase and from IC<sub>50</sub> value 0.25 ± 0.01 µM to 0.70 ± 0.10 µM for butyrylcholinesterase except one that showed least potency with IC<sub>50</sub> value 1.05 ± 0.1 µM and 1.20 ± 0.1 µM. The differences in inhibitory potential of synthesized compounds were due to the nature and position of substitution attached to the main ring. Additionally, molecular docking study was carried out for most active in order to explore the binding interactions established by ligand (active compounds) with the active residues of targeted AChE & BuChE enzyme.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"85-94"},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential. 改性席夫碱附加 1,2,4-三唑杂化物支架的合成:阐明体外和硅学中 α 淀粉酶和 α 葡萄糖苷酶抑制剂的潜力。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-12 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0073
Shahzad Ahmad Abbasi, Fazal Rahim, Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Muhammad Taha, Tayyiaba Iqbal, Yousaf Khan, Syed Adnan Ali Shah
{"title":"Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the <i>in vitro</i> and <i>in silico</i> α-amylase and α-glucosidase inhibitors potential.","authors":"Shahzad Ahmad Abbasi, Fazal Rahim, Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Muhammad Taha, Tayyiaba Iqbal, Yousaf Khan, Syed Adnan Ali Shah","doi":"10.1515/znc-2024-0073","DOIUrl":"10.1515/znc-2024-0073","url":null,"abstract":"<p><p>The current study involves the synthesis of Schiff bases based on 1,2,4-triazoles skeleton and assessing their α-amylase and α-glucosidase profile. Furthermore, the precise structures of the synthesized derivatives were elucidated using various spectroscopic methods such as <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and HREI-MS. Using glimepiride as the reference standard, the <i>in vitro</i> α-glucosidase and α-amylase inhibitory activities of the synthesized compounds were evaluated in order to determine their potential anti-diabetic properties. All analogues showed varied range of inhibitory activity having IC<sub>50</sub> values ranging from 17.09 ± 0.72 to 45.34 ± 0.03 μM (α-amylase) and 16.35 ± 0.42 to 42.31 ± 0.09 μM (α-glucosidase), respectively. Specifically, the compounds <b>1</b>, <b>7</b> and <b>8</b> were found to be significantly active with IC<sub>50</sub> values of 17.09 ± 0.72, 19.73 ± 0.42, and 23.01 ± 0.04 μM (against α-amylase) and 16.35 ± 0.42, 18.55 ± 0.26, and 20.07 ± 0.02 μM (against α-glucosidase) respectively. The obtained results were compared with the Glimepiride reference drug having IC<sub>50</sub> values of 13.02 ± 0.11 μM (for α-glucosidase) and 15.04 ± 0.02 μM (for α-amylase), respectively. The structure-activity relationship (SAR) studies were conducted based on differences in substituent patterns at varying position of aryl rings A and B may cause to alter the inhibitory activities of both α-amylase and α-glucosidase enzymes. Additionally, the molecular docking study was carried out to explore the binding interactions possessed by most active analogues with the active sites of targeted α-amylase and α-glucosidase enzymes.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"119-134"},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via in- silico innovation. 通过硅学创新,以人工智能驱动候选药物设计,重新定义碱蛋白尿治疗的新领域。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-12 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0075
Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Ali Zafar, Mahnoor Fatima, Imran Ali, Ayaz Ali Khan, Thamer H Albekairi
{"title":"Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via <i>in-</i> <i>silico</i> innovation.","authors":"Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Ali Zafar, Mahnoor Fatima, Imran Ali, Ayaz Ali Khan, Thamer H Albekairi","doi":"10.1515/znc-2024-0075","DOIUrl":"10.1515/znc-2024-0075","url":null,"abstract":"<p><p>A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and phenylalanine that darkens the urine and accumulates in connective tissues which causes an agonizing arthritis. Employing the use of deep learning artificial intelligence (AI) drug design, this study aims to alleviate the current toxicity of the AKU drugs currently in use, particularly nitisinone, by utilizing the natural flavanol kaempferol molecule as a 4-hydroxyphenylpyruvate dioxygenase inhibitor. Kaempferol was employed to generate three effective <i>de novo</i> drug candidates targeting the enzyme 4-hydroxyphenylpyruvate dioxygenase using an AI drug design tool. We present novel AIK formulations in the present study. The AIK's (Artificial Intelligence Kaempferol) examination of drug-likeliness among the three led to its choice as a possible target. The toxicity assessment research of AIK demonstrates that it is not only safer to use than other treatments, but also more efficient. The docking of the AIGT with 4-hydroxyphenylpyruvate dioxygenase, which revealed a binding affinity of around -9.099 kcal/mol, highlights the AIK's potential as a therapeutic candidate. An innovative approach to deal with challenging circumstances is thus presented in this study by new formulations kaempferol that have been meticulously designed by AI. The results of the <i>in vitro</i> tests must be confirmed <i>in vivo</i>, even though AI-designed AIK is effective and sufficiently safe as computed.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"135-149"},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coenzyme Q10 supplementation affects cellular ionic balance: relevance to aging. 辅酶 Q10 补充剂影响细胞离子平衡:与衰老有关。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-05 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0129
Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi
{"title":"Coenzyme Q<sub>10</sub> supplementation affects cellular ionic balance: relevance to aging.","authors":"Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi","doi":"10.1515/znc-2024-0129","DOIUrl":"10.1515/znc-2024-0129","url":null,"abstract":"<p><p>Aging results into disruptive physiological functioning and cellular processes that affect the composition and structure of the plasma membrane. The plasma membrane is the major regulator of ionic homeostasis that regulates the functioning of membrane transporters and exchangers. Coenzyme Q<sub>10</sub> is a lipid-soluble antioxidant molecule that declines during aging and age-associated diseases. The present study aims to explore the role of Coenzyme Q<sub>10</sub> supplementation to rats during aging on membrane transporters and redox biomarkers. The study was conducted on young and old male Wistar rats supplemented with 20 mg/kg b.w. of Coenzyme Q<sub>10</sub> per day. After a period of 28 days, rats were sacrificed and erythrocyte membrane was isolated. The result exhibits significant decline in biomarkers of oxidative stress in old control rats when compared with young control. The effect of Coenzyme Q<sub>10</sub> supplementation was more pronounced in old rats. The functioning of membrane transporters and Na<sup>+</sup>/H<sup>+</sup> exchanger showed potential return to normal levels in the Coenzyme Q<sub>10</sub> treated rats. Overall, the results demonstrate that Coenzyme Q<sub>10</sub> plays an important role in maintaining redox balance in cells which interconnects with membrane integrity. Thus, Coenzyme Q<sub>10</sub> supplementation may play an important role in protecting age related alterations in erythrocyte membrane physiology.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"95-102"},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Chitin structures and pathways as targets for biopesticides and drugs. 社论:作为生物农药和药物靶标的几丁质结构和途径。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-20 Print Date: 2024-05-27 DOI: 10.1515/znc-2024-2001
Klaus H Hoffmann
{"title":"Editorial: Chitin structures and pathways as targets for biopesticides and drugs.","authors":"Klaus H Hoffmann","doi":"10.1515/znc-2024-2001","DOIUrl":"10.1515/znc-2024-2001","url":null,"abstract":"","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"93-94"},"PeriodicalIF":1.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing microbial fuel cell performance through microbial immobilization. 通过微生物固定化提高微生物燃料电池的性能。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-14 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0175
Yana Mersinkova, Hyusein Yemendzhiev
{"title":"Enhancing microbial fuel cell performance through microbial immobilization.","authors":"Yana Mersinkova, Hyusein Yemendzhiev","doi":"10.1515/znc-2023-0175","DOIUrl":"10.1515/znc-2023-0175","url":null,"abstract":"<p><p>Bio-electrochemical Systems (BES), particularly Microbial Fuel Cells (MFC), have emerged as promising technologies in environmental biotechnology. This study focused on optimizing the anode bacterial culture immobilization process to enhance BES performance. The investigation combines and modifies two key immobilization methods: covalent bonding with glutaraldehyde and inclusion in a chitosan gel in order to meet the criteria and requirements of the bio-anodes in MFC. The performance of MFCs with immobilized and suspended cultures was compared in parallel experiments. Both types showed similar substrate utilization dynamics with slight advantage of the immobilized bio-anode considering the lower concentration of biomass. The immobilized MFC exhibited higher power generation and metabolic activity, as well. Probably, this is due to improved anodic respiration and higher coulombic efficiency of the reactor. Analysis of organic acids content supported this conclusion showing significant inhibition of the fermentation products production in the MFC reactor with immobilized anode culture.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"149-153"},"PeriodicalIF":1.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of Aspergillus flavus and Aspergillus fumigatus. 聚乙二醇(PEG)包覆的聚乳酸(PLGA)纳米颗粒可控地输送尼可霉素,抑制几丁质合成酶,防止黄曲霉和烟曲霉生长。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-07 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0185
Kamal Mayattu, Vandana Ghormade
{"title":"Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of <i>Aspergillus flavus</i> and <i>Aspergillus fumigatus</i>.","authors":"Kamal Mayattu, Vandana Ghormade","doi":"10.1515/znc-2023-0185","DOIUrl":"10.1515/znc-2023-0185","url":null,"abstract":"<p><p>Aspergillosis is one of the most common fungal infections that can threaten individuals with immune compromised condition. Due to the increasing resistance of pathogens to the existing antifungal drugs, it is difficult to tackle such disease conditions. Whereas, nikkomycin is an emerging safe and effective antifungal drug which causes fungal cell wall disruption by inhibiting chitin synthase. Hence, the study aims at the development of nikkomycin loaded PEG coated PLGA nanoparticles for its increased antifungal efficiency and inhibiting <i>Aspergillus</i> infections. The P-PLGA-Nik NPs were synthesized by w/o/w double emulsification method which resulted in a particle size of 208.3 ± 15 nm with a drug loading of 52.97 %. The NPs showed first order diffusion-controlled drug release which was sustained for 24 h. These nanoparticle's antifungal efficacy was tested using the CLSI - M61 guidelines and the MIC<sub>50</sub> defined against <i>Aspergillus flavus</i> and <i>Aspergillus fumigatus</i> was found to be >32 μg/ml which was similar to the nikkomycin MIC. The hyphal tip bursting showed the fungal cell wall disruption. The non-cytotoxic and non-haemolytic nature highlights the drug safety profile.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"155-162"},"PeriodicalIF":1.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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