Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

{"title":"Revolutionizing the probiotic functionality, biochemical activity, antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H via <i>in-vitro</i> and <i>in-silico</i> approaches.","authors":"Gege Hu, Muhammad Naveed, Muhammad Aqib Shabbir, Abid Sarwar, Junaid Yousaf, Yang Zhennai, Tariq Aziz, Metab Alharbi, Abdulrahman Alshammari","doi":"10.1515/znc-2024-0074","DOIUrl":"https://doi.org/10.1515/znc-2024-0074","url":null,"abstract":"<p><p>This study presents a comprehensive genomic exploration, biochemical characterization, and the identification of antibiotic resistance and specialty genes of <i>Pediococcus acidilactici</i> BCB1H strain. The functional characterization, genetic makeup, biological activities, and other considerable parameters have been investigated in this study with a prime focus on antibiotic resistance and specialty gene profiles. The results of this study revealed the unique susceptibility patterns for antibiotic resistance and specialty genes. BCB1H had good <i>in vitro</i> probiotic properties, which survived well in simulated artificial gastrointestinal fluid, and exhibited acid and bile salt resistance. BCB1H didn't produce hemolysis and had certain antibiotic sensitivity, making it a relatively safe LAB strain. Simultaneously, it had good self-coagulation characteristics and antioxidant activity. The EPS produced by BCB1H also had certain antioxidant activity and hypoglycemic function. Moreover, the genome with a 42.4 % GC content and a size of roughly 1.92 million base pairs was analyzed in the genomic investigations. The genome annotation identified 192 subsystems and 1,895 genes, offering light on the metabolic pathways and functional categories found in BCB1H. The identification of specialty genes linked to the metabolism of carbohydrates, stress response, pathogenicity, and amino acids highlighted the strain's versatility and possible uses. This study establishes the groundwork for future investigations by highlighting the significance of using multiple strains to investigate genetic diversity and experimental validation of predicted genes. The results provide a roadmap for utilizing <i>P. acidilactici</i> BCB1H's genetic traits for industrial and medical applications, opening the door to real-world uses in industries including food technology and medicine.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In silico</i> molecular modeling and <i>in vitro</i> biological screening of novel benzimidazole-based piperazine derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.","authors":"Haseena Naz, Fazal Rahim, Rafaqat Hussain, Shoaib Khan, Wajid Rehman, Yousaf Khan, Tariq Aziz, Metab Alharbi","doi":"10.1515/znc-2024-0068","DOIUrl":"https://doi.org/10.1515/znc-2024-0068","url":null,"abstract":"<p><p>New series of benzimidazole incorporating piperazine moieties in single molecular framework has been reported. The structures of the synthesized derivatives were assigned by ¹H-NMR, ¹³C-NMR, and HR-MS techniques. The hybrid derivatives were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibition effect. All the synthesized analogs showed good to moderate inhibitory effect ranging from IC₅₀ value 0.20 ± 0.01 µM to 0.50 ± 0.10 µM for acetylcholinesterase and from IC₅₀ value 0.25 ± 0.01 µM to 0.70 ± 0.10 µM for butyrylcholinesterase except one that showed least potency with IC₅₀ value 1.05 ± 0.1 µM and 1.20 ± 0.1 µM. The differences in inhibitory potential of synthesized compounds were due to the nature and position of substitution attached to the main ring. Additionally, molecular docking study was carried out for most active in order to explore the binding interactions established by ligand (active compounds) with the active residues of targeted AChE & BuChE enzyme.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the <i>in vitro</i> and <i>in silico</i> α-amylase and α-glucosidase inhibitors potential.","authors":"Shahzad Ahmad Abbasi, Fazal Rahim, Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Muhammad Taha, Tayyiaba Iqbal, Yousaf Khan, Syed Adnan Ali Shah","doi":"10.1515/znc-2024-0073","DOIUrl":"https://doi.org/10.1515/znc-2024-0073","url":null,"abstract":"<p><p>The current study involves the synthesis of Schiff bases based on 1,2,4-triazoles skeleton and assessing their α-amylase and α-glucosidase profile. Furthermore, the precise structures of the synthesized derivatives were elucidated using various spectroscopic methods such as ¹H-NMR, ¹³C-NMR and HREI-MS. Using glimepiride as the reference standard, the <i>in vitro</i> α-glucosidase and α-amylase inhibitory activities of the synthesized compounds were evaluated in order to determine their potential anti-diabetic properties. All analogues showed varied range of inhibitory activity having IC₅₀ values ranging from 17.09 ± 0.72 to 45.34 ± 0.03 μM (α-amylase) and 16.35 ± 0.42 to 42.31 ± 0.09 μM (α-glucosidase), respectively. Specifically, the compounds <b>1</b>, <b>7</b> and <b>8</b> were found to be significantly active with IC₅₀ values of 17.09 ± 0.72, 19.73 ± 0.42, and 23.01 ± 0.04 μM (against α-amylase) and 16.35 ± 0.42, 18.55 ± 0.26, and 20.07 ± 0.02 μM (against α-glucosidase) respectively. The obtained results were compared with the Glimepiride reference drug having IC₅₀ values of 13.02 ± 0.11 μM (for α-glucosidase) and 15.04 ± 0.02 μM (for α-amylase), respectively. The structure-activity relationship (SAR) studies were conducted based on differences in substituent patterns at varying position of aryl rings A and B may cause to alter the inhibitory activities of both α-amylase and α-glucosidase enzymes. Additionally, the molecular docking study was carried out to explore the binding interactions possessed by most active analogues with the active sites of targeted α-amylase and α-glucosidase enzymes.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via <i>in-</i> <i>silico</i> innovation.","authors":"Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Ali Zafar, Mahnoor Fatima, Imran Ali, Ayaz Ali Khan, Thamer H Albekairi","doi":"10.1515/znc-2024-0075","DOIUrl":"https://doi.org/10.1515/znc-2024-0075","url":null,"abstract":"<p><p>A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and phenylalanine that darkens the urine and accumulates in connective tissues which causes an agonizing arthritis. Employing the use of deep learning artificial intelligence (AI) drug design, this study aims to alleviate the current toxicity of the AKU drugs currently in use, particularly nitisinone, by utilizing the natural flavanol kaempferol molecule as a 4-hydroxyphenylpyruvate dioxygenase inhibitor. Kaempferol was employed to generate three effective <i>de novo</i> drug candidates targeting the enzyme 4-hydroxyphenylpyruvate dioxygenase using an AI drug design tool. We present novel AIK formulations in the present study. The AIK's (Artificial Intelligence Kaempferol) examination of drug-likeliness among the three led to its choice as a possible target. The toxicity assessment research of AIK demonstrates that it is not only safer to use than other treatments, but also more efficient. The docking of the AIGT with 4-hydroxyphenylpyruvate dioxygenase, which revealed a binding affinity of around -9.099 kcal/mol, highlights the AIK's potential as a therapeutic candidate. An innovative approach to deal with challenging circumstances is thus presented in this study by new formulations kaempferol that have been meticulously designed by AI. The results of the <i>in vitro</i> tests must be confirmed <i>in vivo</i>, even though AI-designed AIK is effective and sufficiently safe as computed.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics: a promising intervention for osteoporosis prevention and management.","authors":"Lakshay Panchal, Shivam Arora, Jhilam Pramanik, Kajol Batta, Akash Kumar, Bhupendra Prajapati","doi":"10.1515/znc-2024-0063","DOIUrl":"https://doi.org/10.1515/znc-2024-0063","url":null,"abstract":"<p><p>Osteoporosis (OP) is a systemic skeletal disease that is characterized by low bone mass and increased fracture risk. This article explores the potential of probiotics as an adjunctive approach for the prevention and management of OP. It has been well established that the gut microbiota (GM), a complex community of microbes, plays an important role in bone health. The gut dysbiosis is linked with a higher risk of OP. However, the consumption of probiotics in adequate amounts restores gut health thus improving bone health. Probiotics may influence bone metabolism through enhanced calcium absorption, reduced inflammation, and increased bone formation. The animal and human studies demonstrate the positive effects of probiotics on bone health parameters like reduced osteoclastogenesis, bone resorption markers, osteoblast, osteocyte apoptosis, and increased bone mineral density and expression of osteoprotegerin. The current evidence suggests that probiotics can be used as an adjunctive approach along with the existing therapies for the prevention and management of OP.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coenzyme Q₁₀ supplementation affects cellular ionic balance: relevance to aging.","authors":"Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi","doi":"10.1515/znc-2024-0129","DOIUrl":"https://doi.org/10.1515/znc-2024-0129","url":null,"abstract":"<p><p>Aging results into disruptive physiological functioning and cellular processes that affect the composition and structure of the plasma membrane. The plasma membrane is the major regulator of ionic homeostasis that regulates the functioning of membrane transporters and exchangers. Coenzyme Q₁₀ is a lipid-soluble antioxidant molecule that declines during aging and age-associated diseases. The present study aims to explore the role of Coenzyme Q₁₀ supplementation to rats during aging on membrane transporters and redox biomarkers. The study was conducted on young and old male Wistar rats supplemented with 20 mg/kg b.w. of Coenzyme Q₁₀ per day. After a period of 28 days, rats were sacrificed and erythrocyte membrane was isolated. The result exhibits significant decline in biomarkers of oxidative stress in old control rats when compared with young control. The effect of Coenzyme Q₁₀ supplementation was more pronounced in old rats. The functioning of membrane transporters and Na⁺/H⁺ exchanger showed potential return to normal levels in the Coenzyme Q₁₀ treated rats. Overall, the results demonstrate that Coenzyme Q₁₀ plays an important role in maintaining redox balance in cells which interconnects with membrane integrity. Thus, Coenzyme Q₁₀ supplementation may play an important role in protecting age related alterations in erythrocyte membrane physiology.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robustanic acid as a glutaminase and Na⁺, K⁺-ATPase inhibitor from leaves of <i>Eucalyptus globulus</i>.","authors":"Atsumi Shimada, Hiroshi Ueno, Kohei Kawabata, Masanori Inagaki","doi":"10.1515/znc-2024-0071","DOIUrl":"https://doi.org/10.1515/znc-2024-0071","url":null,"abstract":"<p><p>This study was to compare glutaminase and Na⁺, K⁺-ATPase inhibitory activities of 20 herbal extracts and investigate the isolation, structural elucidation and those inhibitory activities of three triterpenes from the selected extract of <i>Eucalyptus globulus</i> Labill. Three triterpenes, ursolic acid (<b>1</b>), robustanic acid (<b>2</b>) and ursolic acid lactone (<b>3</b>), were identified by analyzing their NMR and MS spectral data and comparison of these with reported data. The IC₅₀ values of <b>1</b>-<b>3</b> and the control compound against glutaminase, 6-diazo-5-oxo-l-norleucine (DON), were 443 μM, 334 μM, 963 μM and 134 μM, respectively. The IC₅₀ values of <b>1</b>, <b>2</b> and the control compound against Na⁺, K⁺-ATPase and ouabain, were 180 μM, 56 μM and 0.5 μM, respectively. Compounds <b>1</b> and <b>2</b> may serve as potential lead compounds for the prevention and treatment of neurodegenerative and lifestyle-related diseases by targeting glutaminase and Na⁺, K⁺-ATPase. This is the first report on glutaminase and Na⁺, K⁺-ATPase inhibitory activities of 2.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of whey protein beverage incorporating encapsulated probiotic strain <i>Lactiplantibacillus rhamnosus</i> NCDC 347 and its physico-chemical characteristics.","authors":"Rishi Bhatia, Komal Chauhan, Neetu Kumra Taneja, Vikram Kumar, Garima Singh, Kuljinder Kaur, Harinder Singh Oberoi","doi":"10.1515/znc-2024-0105","DOIUrl":"https://doi.org/10.1515/znc-2024-0105","url":null,"abstract":"<p><p>In the present study, encapsulated strain <i>Lactiplantibacillus rhamnosus</i> NCDC 347 was used to prepare a novel whey protein-based beverage. The encapsulation process utilized skimmed milk powder matrix and evaluated strain viability, physico-chemical properties, sensory assessment, and shelf-life stability. Encapsulated <i>L. rhamnosus</i> NCDC 347 within skim milk powder maintained viability at 8.0 log CFU/g, forming spherical microcapsules with 1-12 µm concavities. Probiotic addition to whey protein beverages maintained pH and acidity within desired ranges. Physico-chemical analysis showed protein content of 8.71 ± 0.21 % to 10.05 ± 0.42 %, fat content of 0.56 ± 0.24 % to 0.67 ± 0.13 %, viscosity of 5.14 pa/s, and total soluble solids (TSS) of 14.42 ± 0.31 to 16.16 ± 0.23° Brix. The shelf-life study revealed that the beverage remained stable for up to 90 days with no significant changes (<i>p</i> > 0.05) in sensory analysis. The sensory analysis scored the test sample's acceptability at 7.3 ± 0.41. The protein-rich probiotic drink exhibited favorable sensory qualities. Overall, incorporating encapsulated probiotic strain <i>L. rhamnosus</i> NCDC 347 into whey protein beverages could address daily protein requirements and enhance health.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xylatolides A and B, new 10-membered macrolides from the endophytic fungus <i>Xylaria</i> sp.","authors":"Pierre Roger Koliye, Achille Nouga Bissoue, Eitel Ngoh Misse Mouelle, Sylvie Kwanga Nguikwie, Claudine Victoire Zambo Owona, Viktor Emanuel Simons, Sergi Herve Akone, Luc Mbaze Meva'a, Rainer Kalscheuer","doi":"10.1515/znc-2023-0091","DOIUrl":"https://doi.org/10.1515/znc-2023-0091","url":null,"abstract":"<p><p>Chemical investigation of the fungal endophyte <i>Xylaria</i> sp. isolated from leaves of <i>Moringa oleifera</i>, collected in Cameroon, resulted in the previously undescribed 10-membered macrolide, and two known natural products. The structures of the xylatolides A and B were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis, featuring a 10-membered lactone core structure with oxygenated substituents and an unsubstituted 10-alkyl chain presenting seven carbon atoms. Compounds were screened for their cytotoxic potential against the human HepG2 hepatocellular carcinoma cells and HCT-116 cells (human colon carcinoma cell line). Moreover, the isolated compounds were also assayed against a small panel of sensitive strains including the bacterial species <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Mycobacterium tuberculosis</i> as well as against the fungal species <i>Candida albicans</i>. However, no significant activities were found.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from <i>Combretum molle</i> (Combretaceae).","authors":"Fawai Yakai, Amadou Dawe, Ibrayeva Manshuk, Vincent Taira, Albert Wangso, Angele Fanta, Chantal Doudja, Benoit Loura","doi":"10.1515/znc-2023-0087","DOIUrl":"https://doi.org/10.1515/znc-2023-0087","url":null,"abstract":"<p><p>A new compound, combrebisbibenzyl (<b>1</b>) as well as two sterols including stigmasterol (<b>2</b>) and 3-<i>O</i>-<i>β</i>-D-glucopyranoside of <i>β</i>-sitosterol (<b>3</b>) and seven triterpenoids namely mollic acid (<b>4</b>), oleanolic acid (<b>5</b>), ursolic acid (<b>6</b>), arjunglucoside I (<b>7)</b>, arjungenin (<b>8</b>), bellericagenin B (<b>9</b>) and combregenin (<b>10</b>) were isolated from the root of <i>Combretum molle</i>. Compounds <b>1</b>, <b>7</b> and <b>9,</b> AcOEt and MeOH extracts exhibited moderate antioxidant activity with an IC₅₀ value of 179.32, 185.21, 195.11 197.41 and 170.21 μg/mL, respectively, for reactive oxygen species inhibition and, inhibition percent value of 57.23, 64.52, 53.55, 67.42 and 65.04, respectively, for DPPH free-radical scavenging. The <b>E. MeOH</b> presented a moderate antibacterial activity against <i>Staphylococcus aureus</i> with DIZs value of 10.1 ± 0.2 from 800 μg/mL while the others tested strains were not sensitive. However, most of the tested bacteria, (<i>S. aureus</i>, <i>Escherichia coli</i> and <i>Salmonella typhimurium</i>) were moderately sensitive to <b>E. AcOEt</b> from 800 μg/mL with DIZs value of 8.2 ± 0.1. From the E. AcOEt, five of the isolated compounds were tested against four bacteria strains using the disc-dilusion method. The results showed that compound <b>1</b> and <b>2</b> exhibited very good antibacterial activity against all the tested bacteria at the concentration of 30 μg/mL with respective DIZ value of 22.2 and 25.4 for <i>E. coli</i>, 20.2 and 30.2 for <i>S. typhimurium</i>, 22.3 and 23.1 for <i>S. aureus</i> and, 22.1 and 24.1 for <i>Streptococcus faecalis</i>. This antibacterial activity significantly depends on the concentration.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}