Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

{"title":"Do <i>Colletotrichum gloeosporioides</i> and <i>Rhizopus stolonifer</i> induce alkaloidal and antifungal responses in <i>Annona muricata</i> seedlings?","authors":"Christian Anabi Riley-Saldaña,&nbsp;Ivan de-la-Cruz-Chacón,&nbsp;María Del Rocío Cruz-Ortega,&nbsp;Marisol Castro-Moreno,&nbsp;Alma Rosa González-Esquinca","doi":"10.1515/znc-2021-0297","DOIUrl":"https://doi.org/10.1515/znc-2021-0297","url":null,"abstract":"<p><p>The benzylisoquinoline alkaloids of <i>Annona muricata</i> have been isolated, but their physiological or ecological role is unknown. The objective was to explore whether these secondary metabolites are involved in defense against phytopathogenic fungi. To do this, the alkaloidal response of 6-leaf seedlings of <i>A. muricata</i> was analyzed, previously inoculated with <i>Colletotrichum gloeosporioides</i> and <i>Rhizopus stolonifer</i>. Before and after inoculation, alkaloidal extracts of roots, stems, and leaves were obtained, and the antifungal activity was evaluated <i>in vitro</i>. The alkaloids anonaine, reticuline, nornuciferine, assimilobine, and coreximine were identified. <i>C. gloeosporioides</i> caused variable increases in the production of anonaine, reticuline and nornuciferine (10-1200%), while <i>R. stolonifer</i> only stimulated the increase of nornuciferin and anonaine (10%) in the stems and leaves. The alkaloidal extracts of inoculated seedlings increased the antifungal activity, both against the pathogen elicitor and against the second target pathogen. These findings suggest that the alkaloids participate in the antifungal defense mechanism.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 1-2","pages":"57-63"},"PeriodicalIF":2.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sesquiterpenoids from <i>Tithonia diversifolia</i> (Hemsl.) A. Gray induce apoptosis and inhibit the cell cycle progression of acute myeloid leukemia cells.","authors":"Trinh Thi Thuy,&nbsp;Nguyen Thi Thuy Linh,&nbsp;Ba Thi Cham,&nbsp;Nguyen Thi Hoang Anh,&nbsp;Tran Duc Quan,&nbsp;Nguyen Thanh Tam,&nbsp;Le Thi Hong Nhung,&nbsp;Do Thi Thao,&nbsp;Nguyen Phi Hung,&nbsp;Vu Dinh Hoang,&nbsp;Sabrina Adorisio,&nbsp;Domenico V Delfino","doi":"10.1515/znc-2021-0154","DOIUrl":"https://doi.org/10.1515/znc-2021-0154","url":null,"abstract":"<p><p>Three sesquiterpene lactones (<b>1-3</b>) were isolated from the aerial part of <i>Tithonia diversifolia</i> (Hemsl.) A. Gray grown in the Hoa Binh province in Viet Nam. The structures of these three sesquiterpene lactones were identified as tagitinin A (<b>1</b>), 1<i>β</i>-hydroxytirotundin 3-O-methyl ether (<b>2</b>), and tagitinin C (<b>3</b>) by analyzing spectroscopic data. For the first time, compound <b>2</b> was isolated from <i>T. diversifolia</i> growing in Viet Nam. Furthermore, contrary to existing literature, we determined that compound <b>1</b> was the major isolate. Compounds <b>1</b> and <b>3</b> significantly decreased numbers of acute myeloid leukemia OCI-AML3 cells by promoting apoptosis and causing cell cycle arrest at G0/G1 phase at concentrations as low as 2.5 μg/mL (compound <b>1</b>) and 0.25 μg/mL (compound <b>3</b>). Additionally, all three compounds showed cytotoxic activity against five human cancer cell lines (A549, T24, Huh-7, 8505, and SNU-1), with IC₅₀ values ranging from 1.32 ± 0.14 to 46.34 ± 2.74 μM. Overall, our findings suggest that compounds <b>1</b> and <b>3</b> may be potential anti-cancer therapeutics and thus warrant further study.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 1-2","pages":"65-72"},"PeriodicalIF":2.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Santalum</i> Genus: phytochemical constituents, biological activities and health promoting-effects.","authors":"Javad Sharifi-Rad,&nbsp;Cristina Quispe,&nbsp;Aknur Turgumbayeva,&nbsp;Zehra Mertdinç,&nbsp;Sena Tütüncü,&nbsp;Elif Feyza Aydar,&nbsp;Beraat Özçelik,&nbsp;Stępień-Warda Anna,&nbsp;Staniak Mariola,&nbsp;Anna Koziróg,&nbsp;Anna Otlewska,&nbsp;Hubert Antolak,&nbsp;Surjit Sen,&nbsp;Krishnendu Acharya,&nbsp;Natallia Lapava,&nbsp;Simin Emamzadeh-Yazdi,&nbsp;Miquel Martorell,&nbsp;Manoj Kumar,&nbsp;Elena Maria Varoni,&nbsp;Marcello Iriti,&nbsp;Daniela Calina","doi":"10.1515/znc-2022-0076","DOIUrl":"https://doi.org/10.1515/znc-2022-0076","url":null,"abstract":"<p><p><i>Santalum</i> genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, and valued as traditional medicine, rituals and modern bioactivities. Sandalwood is reported to possess a plethora of bioactive compounds such as essential oil and its components (α-santalol and β-santalol), phenolic compounds and fatty acids. These bioactives play important role in contributing towards biological activities and health-promoting effects in humans. Pre-clinical and clinical studies have shown the role of sandalwood extract as antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroleptic, antihyperglycemic, antihyperlipidemic, and anticancer activities. Safety studies on sandalwood essential oil (EO) and its extracts have proven them as a safe ingredient to be utilized in health promotion. Phytoconstituents, bioactivities and traditional uses established sandalwood as one of the innovative materials for application in the pharma, food, and biomedical industry.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 1-2","pages":"9-25"},"PeriodicalIF":2.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10849295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sakuranetin and its therapeutic potentials - a comprehensive review.","authors":"Md Junaid,&nbsp;Bristy Basak,&nbsp;Yeasmin Akter,&nbsp;Syeda Samira Afrose,&nbsp;Afsana Nahrin,&nbsp;Rashiduzzaman Emran,&nbsp;Md Shahinozzaman,&nbsp;Shinkichi Tawata","doi":"10.1515/znc-2022-0024","DOIUrl":"https://doi.org/10.1515/znc-2022-0024","url":null,"abstract":"<p><p>Sakuranetin (SKN), a naturally derived 7-<i>O</i>-methylated flavonoid, was first identified in the bark of the cherry tree (<i>Prunu</i>s spp.) as an aglycone of sakuranin and then purified from the bark of <i>Prunus puddum</i>. It was later reported in many other plants including <i>Artemisia campestris</i>, <i>Boesenbergia pandurata</i>, <i>Baccharis</i> spp., <i>Betula</i> spp., <i>Juglans</i> spp., and <i>Rhus</i> spp. In plants, it functions as a phytoalexin synthesized from its precursor naringenin and is the only known phenolic phytoalexin in rice, which is released in response to different abiotic and biotic stresses such as UV-irradiation, jasmonic acid, cupric chloride, L-methionine, and the phytotoxin coronatine. Till date, SKN has been widely reported for its diverse pharmacological benefits including antioxidant, anti-inflammatory, antimycobacterial, antiviral, antifungal, antileishmanial, antitrypanosomal, glucose uptake stimulation, neuroprotective, antimelanogenic, and antitumor properties. Its pharmacokinetics and toxicological properties have been poorly understood, thus warranting further evaluation together with exploring other pharmacological properties such as antidiabetic, neuroprotective, and antinociceptive effects. Besides, <i>in vivo</i> studies or clinical investigations can be done for proving its effects as antioxidant and anti-inflammatory, antimelanogenic, and antitumor agent. This review summarizes all the reported investigations with SKN for its health-beneficial roles and can be used as a guideline for future studies.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 1-2","pages":"27-48"},"PeriodicalIF":2.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10865912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covid-19 vaccines and neurological complications: a systematic review.","authors":"Fakhri Allahyari, Hamideh Molaee, Javad Hosseini Nejad","doi":"10.1515/znc-2022-0092","DOIUrl":"10.1515/znc-2022-0092","url":null,"abstract":"<p><p>The COVID-19 mainly causes respiratory disorders with high infection and severe morbidity and mortality. Neurologists have concerns about potential neurological side effects, profits, and timing of COVID-19 vaccines. This study aimed to review systematically research for the COVID-19 vaccine and neurological complications. Data was searched in Scopus, ISI web of knowledge, Medline, PubMed, Wiley, Embase, International Clinical Trials Registry Platform and Clinical Trials, Cochrane Library, and Google Scholar. Two reviewer authors individually searched and assessed the titles and abstracts of all articles. The third reviewer resolved disagreement between them. Data were documented regarding study location, study design, type of complications, number of patients, various types of COVID-19 vaccine, and type of neurological complications. Six studies in COVID-19 vaccine and neurological complications include two studies about neurological manifestations after the mRNA vaccines, four records about side effects of vector-based vaccine were included in the study. The main neurological complication associated mRNA vaccines were body aches, paresthesia, and difficulty walking, erythema migrans lesion, fatigue, myalgia, and pain in the left lateral deltoid region. The major neurological complication related to vector-based vaccines were urinary retention difficulty, feeding and ambulating, arm soreness, mild fatigue, chills, left-sided facial droop, headaches, a generalized epileptic seizure, hemianopia, and mild aphasia, acute somnolence and right-hand hemiparesis, acute transverse myelitis, deep vein thrombosis in her left leg, a vigilance disorder and a twitching, a severe immobilizing opsoclonus myoclonus syndrome, and encephalitis. A large spectrum of severe neurological unfavorable has been reported. These complications could occur as a result of molecular stimulation and later neuronal damage. Generally, the advantages of COVID-19 vaccination are dominant on the risks of a neurological complication at both individual and population levels. Future investigations will be required to find any relationship between neurological complications and COVID-19 vaccines principally as new strains of the virus and new vaccines are technologically advanced against them.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"78 1-2","pages":"1-8"},"PeriodicalIF":1.8,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10497455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and bioactivities of <i>Magnolia candollii</i> H.Keng essential oil.","authors":"Ahmad Azrul Hakim Yahaya,&nbsp;Wan Mohd Nuzul Hakimi Wan Salleh,&nbsp;Nurunajah Ab Ghani,&nbsp;Shamsul Khamis,&nbsp;Nurul Syafiqah Rezali,&nbsp;Mohd Afiq Aizat Juhari","doi":"10.1515/znc-2022-0100","DOIUrl":"https://doi.org/10.1515/znc-2022-0100","url":null,"abstract":"<p><p>Several <i>Magnolia</i> species have exhibited potent biological activities such as anti-inflammatory, anti-angiogenesis, anticonvulsant, anti-obesity, and antiviral activities. However, the <i>Magnolia candollii</i> from Malaysia has not been investigated yet. Hence, this study aims to investigate the chemical composition and bioactivities of the essential oil of <i>Magnolia candollii</i> H.Keng from Malaysia. The hydrodistillation process was used to produce the essential oil, and gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to analyse it. In total, 44 chemical components were identified in the bark oil, accounting for 98.4%. The major components of the essential oil were α-pinene (29.7%), elemol (10.2%), β-pinene (8.5%), β-caryophyllene (7.2%), α-terpineol (7.0%), guaiol (5.4%), and bulnesol (4.9%). Acetylcholinesterase and anti-inflammatory activities were also evaluated using the Ellman method and lipoxygenase enzyme, respectively, in which the essential oil showed moderate inhibitory activity against acetylcholinesterase (I%: 70.2%) and lipoxygenase (I%: 72.5%). Thus, the findings may be helpful for identifying the medicinal and therapeutic uses of the essential oil from the <i>Magnolia</i> genus.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 11-12","pages":"519-523"},"PeriodicalIF":2.0,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33439827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: an update on the progress of microbial biotransformation of commercial monoterpenes.","authors":"Ruchika Mittal,&nbsp;Gauri Srivastava,&nbsp;Deepak Ganjewala","doi":"10.1515/znc-2022-0114","DOIUrl":"https://doi.org/10.1515/znc-2022-0114","url":null,"abstract":"","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 7-8","pages":"363"},"PeriodicalIF":2.0,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10463758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on the progress of microbial biotransformation of commercial monoterpenes.","authors":"Ruchika Mittal,&nbsp;Gauri Srivastava,&nbsp;Deepak Ganjewala","doi":"10.1515/znc-2021-0192","DOIUrl":"https://doi.org/10.1515/znc-2021-0192","url":null,"abstract":"<p><p>Monoterpenes, a class of isoprenoid compounds, are extensively used in flavor, fragrance, perfumery, and cosmetics. They display many astonishing bioactive properties of biological and pharmacological significance. All monoterpenes are derived from universal precursor geranyl diphosphate. The demand for new monoterpenoids has been increasing in flavor, fragrances, perfumery, and pharmaceuticals. Chemical methods, which are harmful for human and the environment, synthesize most of these products. Over the years, researchers have developed alternative methods for the production of newer monoterpenoids. Microbial biotransformation is one of them, which relied on microbes and their enzymes. It has produced many new desirable commercially important monoterpenoids. A growing number of reports reflect an ever-expanding scope of microbial biotransformation in food and aroma industries. Simultaneously, our knowledge of the enzymology of monoterpene biosynthetic pathways has been increasing, which facilitated the biotransformation of monoterpenes. In this article, we have covered the progress made on microbial biotransformation of commercial monoterpenes with a brief introduction to their biosynthesis. We have collected several reports from authentic web sources, including Google Scholar, Pubmed, Web of Science, and Scopus published in the past few years to extract information on the topic.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 5-6","pages":"225-240"},"PeriodicalIF":2.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioguided isolation of antiplasmodial secondary metabolites from <i>Persea americana</i> Mill. (Lauraceae).","authors":"Christine Claire Waleguele,&nbsp;Marthe Aimée Tchuente Tchuenmogne,&nbsp;Yannick Stéphane Fotsing Fongang,&nbsp;Jules Ngatchou,&nbsp;Jean Jules Kezetas Bankeu,&nbsp;Augustin Silvère Ngouela,&nbsp;Etienne Tsamo,&nbsp;Norbert Sewald,&nbsp;Rui Werner Maçedo Krause,&nbsp;Bruno Ndjakou Lenta","doi":"10.1515/znc-2021-0182","DOIUrl":"https://doi.org/10.1515/znc-2021-0182","url":null,"abstract":"<p><p>The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves of <i>Persea americana</i> Mill. led to the isolation of a new fatty alcohol, perseatriol (<b>1</b>), along with six known compounds (<b>2-7</b>). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity on <i>Plasmoduim falciparum</i> 3D7 with IC₅₀ values ranging from 0.76 to 10.5 μg/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminary <i>Plasmodium</i> lactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9'-Di-<i>O</i>-feruloyl-5,5'-dimethoxysecoisolariciresinol (<b>4</b>) turned out to be non-toxic and displayed the best activities on <i>P. falciparum</i> with an IC₅₀ value of 0.05 μM, comparable to the reference drug chloroquine with an IC₅₀ value of 0.03 μM. Furthermore, besides compound <b>4</b>, this work reports the first isolation of lutein (<b>2</b>) and scopoletin (<b>3</b>) from <i>P. americana</i>. The crude extracts of roots, stem bark, and leaves of <i>P. americana</i>, their fractions and compounds completely suppressed the growth of <i>P. falciparum</i>. The observed activity supports the use of <i>P. americana</i> in folk medicine for the treatment of malaria.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"125-131"},"PeriodicalIF":2.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, <i>in vitro</i> evaluation, and molecular docking as selective MAO-A inhibitor.","authors":"Derya Osmaniye,&nbsp;Ramazan Alaşan,&nbsp;Begüm Nurpelin Sağlık,&nbsp;Serkan Levent,&nbsp;Yusuf Özkay,&nbsp;Zafer Asım Kaplancıklı","doi":"10.1515/znc-2021-0223","DOIUrl":"https://doi.org/10.1515/znc-2021-0223","url":null,"abstract":"<p><p>MAO-A inhibitors are used in the treatment of depression. There are many studies showing that the thiazolyl-hydrazone structure is a pharmacophore structure for the MAO enzyme. In previous studies by our team, activity studies were carried out with thiazolyl-hydrazone derivatives containing pyrrolidine, morpholine, and piperazine. All of them were displayed MAO-A selective inhibition profile. Additionally, derivatives containing piperazine ring were most active. For this purpose, thiazolyl-hydrazone derivatives containing piperazine were synthesized, but this time an active group, formyl group, was added to the piperazine ring as a substituent. Based on this view, new thiazolyl-hydrazone compounds were synthesized, characterized, and screened for their <i>h</i>MAO-A and <i>h</i>MAO-B inhibitory activity by an <i>in vitro</i> fluorometric method. The structure of the compound was tried to be fully elucidated using 2D NMR technique. The compound including 2,4-dimethyl substituent (<b>3i</b>) were found to be the most effective agents in the series against MAO-A enzyme with the IC₅₀ value of 0.080 ± 0.003 µM. The docking study of compound <b>3i</b> revealed that there is a strong interaction between the active sites of <i>h</i>MAO-A and analyzed compound.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"167-175"},"PeriodicalIF":2.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39540481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}