Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

{"title":"An update on the progress of microbial biotransformation of commercial monoterpenes.","authors":"Ruchika Mittal,&nbsp;Gauri Srivastava,&nbsp;Deepak Ganjewala","doi":"10.1515/znc-2021-0192","DOIUrl":"https://doi.org/10.1515/znc-2021-0192","url":null,"abstract":"<p><p>Monoterpenes, a class of isoprenoid compounds, are extensively used in flavor, fragrance, perfumery, and cosmetics. They display many astonishing bioactive properties of biological and pharmacological significance. All monoterpenes are derived from universal precursor geranyl diphosphate. The demand for new monoterpenoids has been increasing in flavor, fragrances, perfumery, and pharmaceuticals. Chemical methods, which are harmful for human and the environment, synthesize most of these products. Over the years, researchers have developed alternative methods for the production of newer monoterpenoids. Microbial biotransformation is one of them, which relied on microbes and their enzymes. It has produced many new desirable commercially important monoterpenoids. A growing number of reports reflect an ever-expanding scope of microbial biotransformation in food and aroma industries. Simultaneously, our knowledge of the enzymology of monoterpene biosynthetic pathways has been increasing, which facilitated the biotransformation of monoterpenes. In this article, we have covered the progress made on microbial biotransformation of commercial monoterpenes with a brief introduction to their biosynthesis. We have collected several reports from authentic web sources, including Google Scholar, Pubmed, Web of Science, and Scopus published in the past few years to extract information on the topic.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 5-6","pages":"225-240"},"PeriodicalIF":2.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioguided isolation of antiplasmodial secondary metabolites from <i>Persea americana</i> Mill. (Lauraceae).","authors":"Christine Claire Waleguele,&nbsp;Marthe Aimée Tchuente Tchuenmogne,&nbsp;Yannick Stéphane Fotsing Fongang,&nbsp;Jules Ngatchou,&nbsp;Jean Jules Kezetas Bankeu,&nbsp;Augustin Silvère Ngouela,&nbsp;Etienne Tsamo,&nbsp;Norbert Sewald,&nbsp;Rui Werner Maçedo Krause,&nbsp;Bruno Ndjakou Lenta","doi":"10.1515/znc-2021-0182","DOIUrl":"https://doi.org/10.1515/znc-2021-0182","url":null,"abstract":"<p><p>The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves of <i>Persea americana</i> Mill. led to the isolation of a new fatty alcohol, perseatriol (<b>1</b>), along with six known compounds (<b>2-7</b>). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity on <i>Plasmoduim falciparum</i> 3D7 with IC₅₀ values ranging from 0.76 to 10.5 μg/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminary <i>Plasmodium</i> lactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9'-Di-<i>O</i>-feruloyl-5,5'-dimethoxysecoisolariciresinol (<b>4</b>) turned out to be non-toxic and displayed the best activities on <i>P. falciparum</i> with an IC₅₀ value of 0.05 μM, comparable to the reference drug chloroquine with an IC₅₀ value of 0.03 μM. Furthermore, besides compound <b>4</b>, this work reports the first isolation of lutein (<b>2</b>) and scopoletin (<b>3</b>) from <i>P. americana</i>. The crude extracts of roots, stem bark, and leaves of <i>P. americana</i>, their fractions and compounds completely suppressed the growth of <i>P. falciparum</i>. The observed activity supports the use of <i>P. americana</i> in folk medicine for the treatment of malaria.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"125-131"},"PeriodicalIF":2.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, <i>in vitro</i> evaluation, and molecular docking as selective MAO-A inhibitor.","authors":"Derya Osmaniye,&nbsp;Ramazan Alaşan,&nbsp;Begüm Nurpelin Sağlık,&nbsp;Serkan Levent,&nbsp;Yusuf Özkay,&nbsp;Zafer Asım Kaplancıklı","doi":"10.1515/znc-2021-0223","DOIUrl":"https://doi.org/10.1515/znc-2021-0223","url":null,"abstract":"<p><p>MAO-A inhibitors are used in the treatment of depression. There are many studies showing that the thiazolyl-hydrazone structure is a pharmacophore structure for the MAO enzyme. In previous studies by our team, activity studies were carried out with thiazolyl-hydrazone derivatives containing pyrrolidine, morpholine, and piperazine. All of them were displayed MAO-A selective inhibition profile. Additionally, derivatives containing piperazine ring were most active. For this purpose, thiazolyl-hydrazone derivatives containing piperazine were synthesized, but this time an active group, formyl group, was added to the piperazine ring as a substituent. Based on this view, new thiazolyl-hydrazone compounds were synthesized, characterized, and screened for their <i>h</i>MAO-A and <i>h</i>MAO-B inhibitory activity by an <i>in vitro</i> fluorometric method. The structure of the compound was tried to be fully elucidated using 2D NMR technique. The compound including 2,4-dimethyl substituent (<b>3i</b>) were found to be the most effective agents in the series against MAO-A enzyme with the IC₅₀ value of 0.080 ± 0.003 µM. The docking study of compound <b>3i</b> revealed that there is a strong interaction between the active sites of <i>h</i>MAO-A and analyzed compound.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"167-175"},"PeriodicalIF":2.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39540481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary metabolites of downy birch buds (<i>Betula pubescens</i> Erch.).","authors":"Valery A Isidorov,&nbsp;Jolanta Nazaruk,&nbsp;Marcin Stocki,&nbsp;Sławomir Bakier","doi":"10.1515/znc-2021-0036","DOIUrl":"https://doi.org/10.1515/znc-2021-0036","url":null,"abstract":"<p><p>The subject of this study is the composition of low-molecular-weight metabolites in downy birch (<i>Betula pubescens</i>) buds and their participation in protection from various kinds of stress. Using the GC-MS, 640 compounds were detected, of which 314 were identified in downy birch buds for the first time. The volatile components detected using the SPME technique mainly consisted (about 70% of the total ionic current of the chromatogram, TIC) of mixtures of sesquiterpenoids. The exudate covering the buds, along with sesquiterpenoids (approximately 60% of TIC), included flavonoids (25% of TIC). The main part of the material extracted by supercritical carbon dioxide from buds comprised sesquiterpenoids and triterpenoids (47 and 28% of TIC, respectively). Via column chromatography, 25 known compounds (mainly flavonoids and triterpenoids) were isolated, most of which were first discovered in the buds of downy birch. Many compounds of these classes have strong biological activity and probably either directly or indirectly perform a protective function in birch buds. An assumption is made about the biological role of a number of secondary metabolites (such as volatile isomeric megastigmatriens and triterpene <i>seco</i>-acids) as well as about these compounds' possible means of biosynthesis, which were first discovered in the buds of downy birch.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"145-155"},"PeriodicalIF":2.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39533070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the development of probiotic supplemented confectioneries.","authors":"Eylül Şenöztop,&nbsp;Tuğçe Dokuzlu,&nbsp;Mine Güngörmüşler","doi":"10.1515/znc-2021-0081","DOIUrl":"https://doi.org/10.1515/znc-2021-0081","url":null,"abstract":"<p><p>Probiotics are living organisms that have beneficial effects on host by regulating the microbial balance of the intestinal system. While probiotics are naturally found in yogurt and other fermented foods, they can also be added to many products. Although mostly in dairy products, it is possible to see examples of food products supplemented by probiotics in bakeries, chocolates and confectioneries. Nowadays, the COVID-19 pandemic that the world suffers increased the demand for such functional food products including probiotics. Due to probiotics having potential effects on strengthening the immune system, confectioneries supplemented by probiotics were comprehensively discussed in this review together with the suggestion of a novel gelly composition. The suggested formulation of the product is a gel-like snack contains natural ingredients such as carrot, lemon juice and sugar provided from apples. This research review article provided a guide together with the recommendations for potential probiotic research in candy and confectionery industry.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 1-2","pages":"71-84"},"PeriodicalIF":2.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39523519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(<b>-</b>)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of <i>Agelanthus brunneus</i> (Engl.) Tiegh (LORANTHACEAE).","authors":"Moifo Kuete Thomas Wieland,&nbsp;Ambassa Pantaleon,&nbsp;Moungang Luciane Marlyse,&nbsp;Ngameni Bathelemy,&nbsp;Storr E Thomas,&nbsp;Ngadjui Tchaleu Bonaventure,&nbsp;Stephenson G Richard","doi":"10.1515/znc-2021-0143","DOIUrl":"https://doi.org/10.1515/znc-2021-0143","url":null,"abstract":"<p><p><i>Agelanthus brunneus</i> (Loranthaceae) is a hemiparasitic plant growing on <i>Senna siamea</i> (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (-)-brunneusine (<b>1</b>), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (<b>1-3</b>; <b>8-9</b> and <b>11-14</b>) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound <b>3</b> showed antibacterial activity with MICs ranging from 0.43 to 8.88.10³ µg/mL and MBCs from 0.43 to 3.55.10³ µg/mL. Compounds <b>9</b> and <b>14</b> showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 µg/mL. Only CLE, EAFL and compounds <b>14</b>, <b>2</b>, <b>8</b> and <b>9</b> showed bactericidal effects on all bacterial species tested.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"157-165"},"PeriodicalIF":2.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39465611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activities of some <i>Salvia</i> species.","authors":"Mehmet Doğan,&nbsp;Nurdan Akıcı,&nbsp;Mehmet Emin Diken,&nbsp;Serap Doğan,&nbsp;Begumhan Yilmaz Kardas,&nbsp;Tuncay Dirmenci","doi":"10.1515/znc-2021-0136","DOIUrl":"https://doi.org/10.1515/znc-2021-0136","url":null,"abstract":"<p><p>In this study, total phenolic, flavonoid and protein contents, antiradical capacities, antibacterial and cytotoxic properties of five different <i>Salvia</i> species (<i>Salvia macrochlamys</i> Boiss., <i>Salvia kronenburgii</i> Rech.f., <i>Salvia euphratica</i> Montbret. ex Aucher var. <i>euphratica</i>, <i>Salvia huberi</i> Hedge and <i>Salvia kurdica</i> Benth) were investigated. The total phenolic content of the species was in the range of 59.6 ± 20 to 150.1 ± 1.1 mg/g, total flavonoid content in the range of 20.4 ± 2.2 to 38.9 ± 4.1 mg/g, and total protein content in the range of 14.0 ± 0.5 to 22.0 ± 1.1 mg/g. Radical scavenging capacities of the <i>Salvia</i> species were determined in the range of 84.1 ± 4.5 to 96.8 ± 0.1%. Moreover, <i>Salvia</i> extracts showed powerful antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> bacteria. Cytotoxic effects of the samples on human lymphocytes were determined by MTS assay and <i>S. kronenburgii</i> and <i>S. euphratica</i> var. <i>euphratica</i> decreased the harmful effects of 2-hydroperoxy-2-methylpropane (tert-butyl hydroper-oxide, t-BOOH) at all time points tested. The highest amounts of rutin hydrate belong to <i>S. kronenburgii</i> and <i>S. euphratica</i> var. <i>euphratica</i>, and the highest amounts of luteolin-7-glucoside belong to <i>S. huberi</i> and <i>S. kronenburgii</i>. Vanillic acid was present only in <i>S. huberi</i> and <i>S. kurdica</i>.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"133-143"},"PeriodicalIF":2.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39435458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine storm syndrome in SARS-CoV-2: a review.","authors":"Braira Wahid,&nbsp;Noshaba Rani,&nbsp;Muhammad Idrees","doi":"10.1515/znc-2021-0062","DOIUrl":"https://doi.org/10.1515/znc-2021-0062","url":null,"abstract":"<p><p>After wreaking havoc on a global level with a total of 5,488,825 confirmed cases and 349,095 deaths as of May 2020, severe acute respiratory syndrome coronavirus 2 is truly living up to the expectations of a 21st-century pandemic. Since the major cause of mortality is a respiratory failure from acute respiratory distress syndrome, the only present-day management option is supportive as the transmission relies solely on human-to-human contact. Patients suffering from coronavirus disease 2019 (COVID-19) should be tested for hyper inflammation to screen those for whom immunosuppression can increases chances of survival. As more and more clinical data surfaces, it suggests patients with mild or severe cytokine storms are at greater risk of failing fatally and hence these cytokine storms should be targets for treatment in salvaging COVID-19 patients.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 1-2","pages":"65-69"},"PeriodicalIF":2.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39339995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition, antioxidant, and antimicrobial activities of two essential oils from Algerian propolis.","authors":"Safia Boulechfar,&nbsp;Amar Zellagui,&nbsp;Meltem Asan-Ozusaglam,&nbsp;Chawki Bensouici,&nbsp;Ramazan Erenler,&nbsp;İlyas Yildiz,&nbsp;Songul Tacer,&nbsp;Hasna Boural,&nbsp;Ibrahim Demirtas","doi":"10.1515/znc-2021-0028","DOIUrl":"https://doi.org/10.1515/znc-2021-0028","url":null,"abstract":"<p><p>This study aims to investigate the chemical composition, antioxidant, and antimicrobial activity of two essential oils (EOs) from Algerian propolis. The volatile constituents were analyzed by gas chromatography-mass spectrometry. Fifty components were identified from the oils. The major components were found to be: cedrol (17.0%), <i>β</i>-eudesmol (7.7%), and <i>α</i>-eudesmol (6.7%) in EO of propolis from Oum El Bouaghi (EOPO) whilst <i>α</i>-pinene (56.1%), <i>cis</i>-verbenol (6.0%), and cyclohexene,3-acetoxy-4-(1-hydroxy-1-methylethyl)-1-methyl (4.4%) in EO of propolis from Batna (EOPB). The antioxidant properties of EOPO and EOPB were determined using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS•+) and cupric reducing antioxidant capacity (CUPRAC assays), respectively. Both EOs had more cupric ion reducing ability than scavenging ABTS•+ radicals. The antimicrobial potential of the two EOs against eight pathogens was assayed by the agar diffusion method and the mode of action was determined by microdilution assay. The results revealed that EOPB was bactericidal for all tested pathogenic bacteria and fungicidal for <i>Candida albicans</i> ATCC 10231, whereas, EOPO showed bacteriostatic effect against <i>Escherichia coli</i> O157:H7 and <i>Pseudomonas aeruginosa</i> ATCC27853 and fungistatic effect against <i>C. albicans</i> ATCC 10231. Thus, the obtained results suggest the important use of propolis EOs as preservative agents.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 3-4","pages":"105-112"},"PeriodicalIF":2.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39311401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement.","authors":"Hadi Esmaeili Gouvarchin Ghaleh,&nbsp;Abdolkarim Hosseini,&nbsp;Hossein Aghamollaei,&nbsp;Mahdi Fasihi-Ramandi,&nbsp;Gholamhossein Alishiri,&nbsp;Ali Saeedi-Boroujeni,&nbsp;Kazem Hassanpour,&nbsp;Mohammad-Reza Mahmoudian-Sani,&nbsp;Gholamreza Farnoosh","doi":"10.1515/znc-2021-0101","DOIUrl":"https://doi.org/10.1515/znc-2021-0101","url":null,"abstract":"<p><p>The inflammasome as a multiprotein complex has a role in activating ASC and caspase-1 resulting in activating IL-1β in various infections and diseases like corona virus infection in various tissues. It was shown that these tissues are affected by COVID-19 patients. According to the current evidence, melatonin is not veridical while possessing a high safety profile, however, it possesses indirect anti-viral actions owing to its anti-oxidation, anti-inflammation, and immune improving properties. This study aims to assess the impacts of melatonin as the complementary treatments on oxidative stress agents and inflammasome activation in patients with COVID-19. Melatonin supplement (9 mg daily, orally) was provided for the patients hospitalized with a COVID-19 analysis for 14 days. For measuring IL-10, IL-1β, and TNF-α cytokines and malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD) level and the expression of <i>CASP1</i> and <i>ASC</i> genes, blood samples were gathered from the individuals at the start and termination of the therapy. Our findings indicated that melatonin is used as a complementary treatment to reduce the levels of TNF-α and IL-1β cytokines, MDA, and NO levels in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 cytokine possesses no considerable changes. The findings revealed that genes of <i>CASP1</i> and <i>ASC</i> were dysregulated by melatonin regulating the inflammasome complex. Based on the findings of the current study, it is found that melatonin can be effective as a medicinal supplement in decreasing the inflammasome multiprotein complex and oxidative stress along with beneficial impacts on lung cytokine storm of COVID-19 patients.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":"77 1-2","pages":"37-42"},"PeriodicalIF":2.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2021-0101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39281198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}