SARS-CoV-2细胞因子风暴综合征的研究进展

IF 2.1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Braira Wahid, Noshaba Rani, Muhammad Idrees
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引用次数: 2

摘要

截至2020年5月,严重急性呼吸综合征冠状病毒2型在全球范围内造成了严重破坏,共有5488825例确诊病例和349095例死亡,真正达到了21世纪大流行的期望。由于死亡的主要原因是急性呼吸窘迫综合征引起的呼吸衰竭,目前唯一的管理选择是支持性的,因为传播完全依赖于人与人之间的接触。2019冠状病毒病(COVID-19)患者应接受高度炎症检测,以筛选免疫抑制可增加生存机会的患者。随着越来越多的临床数据浮出水面,这表明轻度或重度细胞因子风暴患者的致命失败风险更大,因此这些细胞因子风暴应该成为抢救COVID-19患者的治疗目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytokine storm syndrome in SARS-CoV-2: a review.

After wreaking havoc on a global level with a total of 5,488,825 confirmed cases and 349,095 deaths as of May 2020, severe acute respiratory syndrome coronavirus 2 is truly living up to the expectations of a 21st-century pandemic. Since the major cause of mortality is a respiratory failure from acute respiratory distress syndrome, the only present-day management option is supportive as the transmission relies solely on human-to-human contact. Patients suffering from coronavirus disease 2019 (COVID-19) should be tested for hyper inflammation to screen those for whom immunosuppression can increases chances of survival. As more and more clinical data surfaces, it suggests patients with mild or severe cytokine storms are at greater risk of failing fatally and hence these cytokine storms should be targets for treatment in salvaging COVID-19 patients.

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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
55
期刊介绍: A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.
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