Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap. 从干细胞治疗组织再生和伤口愈合的现状到未来：弥合差距。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-05-23 DOI: 10.1515/znc-2025-0020

Kashvy R Morakhia, Aayushi C Shah, Mannat P Patel, Jainam K Shah, Rajanikant Patel, Mehul R Chorawala

{"title":"From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap.","authors":"Kashvy R Morakhia, Aayushi C Shah, Mannat P Patel, Jainam K Shah, Rajanikant Patel, Mehul R Chorawala","doi":"10.1515/znc-2025-0020","DOIUrl":"https://doi.org/10.1515/znc-2025-0020","url":null,"abstract":"Stem cell therapy has emerged as a groundbreaking approach in regenerative medicine, offering immense potential for tissue regeneration and wound healing. Stem cells, with their ability to self-renew and differentiate into specialized cell types, provide innovative therapeutic strategies for variety of medical conditions. Key stem cell types, including embryonic, induced pluripotent, and adult stem cells such as mesenchymal and hematopoietic stem cells, play pivotal roles in regenerative processes and wound repair. In tissue regeneration, stem cells replenish damaged or necrotic cells by differentiating into specialized cell types like bone, muscle, or nerve cells, thus restoring the structural and functional integrity of tissues. In wound healing, stem cells stimulate angiogenesis, generate new skin cells, and modulate immune responses to enhance repair. This multifaceted therapeutic potential has paved the way for clinical applications in cardiovascular, neurological, musculoskeletal, and autoimmune disorders, as well as skin and burn injuries. This review highlights recent advancements in stem cell therapy, exploring its clinical applications and addressing challenges such as immune rejection, ethical concerns, scalability, and the need for long-term clinical trials. The article underscores the importance of continued research to fully realize the transformative potential of stem cell therapy in modern medicine.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingolipids in medicinal mushrooms: structural insights, biological activities, and therapeutic potential. 药用蘑菇中的鞘脂：结构见解、生物活性和治疗潜力。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-05-01 DOI: 10.1515/znc-2024-0206

Yhiya Amen, Ahmed Othman, Kuniyoshi Shimizu

引用次数: 0

Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia. 芦笋精油的化学成分、抗胆碱酯酶活性及细胞毒性研究来自马来西亚的怀特。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-04-30 DOI: 10.1515/znc-2025-0053

Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Arwa R Althaher, Salam Ahmed Abed

{"title":"Chemical composition, anticholinesterase activity and cytotoxicity of the essential oil of Luvunga scandens (Roxb.) Wight from Malaysia.","authors":"Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Arwa R Althaher, Salam Ahmed Abed","doi":"10.1515/znc-2025-0053","DOIUrl":"https://doi.org/10.1515/znc-2025-0053","url":null,"abstract":"Luvunga scandens (Roxb.) Wight is identified as one of the vital folk medicinal plants in Malaysia. Despite its traditional use, the essential oil composition and bioactivities of L. scandens remain largely unexplored. This study investigates the essential oil composition, anticholinesterase activity, and cytotoxicity of L. scandens leaves. After the essential oil was extracted using hydrodistillation, GC-FID and GC-MS were used for analysis, identifying 35 components, representing 93.8 % of the total oil. The major components included germacrene D (17.8 %), γ-elemene (15.6 %), β-gurjunene (10.8 %), α-cadinol (5.3 %), α-humulene (4.9 %), and alloaromadendrene (4.5 %). With IC50 values of 78.5 and 95.2 μg/mL, the essential oil showed moderate inhibition of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). The cytotoxicity was evaluated using an MTT assay. The essential oil exhibited cytotoxicity against three cancer cell lines; HepG2, MCF7, and A549 with IC50 values of 70.2, 52.8, and 65.5 μg/mL, respectively. These findings provide new insights into the potential therapeutic applications of L. scandens essential oil, particularly in neurodegenerative diseases and cancer therapy.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review. 原生/改性右旋糖酐纳米凝胶在给药和眼部并发症管理中的应用综述

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-04-29 DOI: 10.1515/znc-2025-0014

Biswajit Basu, Suraj Mallick, Suman Dhauria, Pooja V Nagime, Sudarshan Singh

{"title":"Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review.","authors":"Biswajit Basu, Suraj Mallick, Suman Dhauria, Pooja V Nagime, Sudarshan Singh","doi":"10.1515/znc-2025-0014","DOIUrl":"https://doi.org/10.1515/znc-2025-0014","url":null,"abstract":"Ocular nanogels have emerged as a promising therapeutic approach, and nanotechnology has speed up the growth of the pharmaceutical and medical technology sectors. The physiological and anatomical barriers of the eye limit the use of traditional ocular preparations, which leads to low drug bioavailability and a brief retention period. This presents a serious problem for patients, doctors, and chemists. Nevertheless, nanogels can encapsulate medications within three-dimensional crosslinked polymeric networks and provide controlled and prolonged drug delivery by using particular structural layouts and unique preparation techniques, improving therapeutic efficacy and patient compliance. Dextran and its variants, a naturally occurring polysaccharide, have drawn a lot of interest in developing delivery systems for use in pharmaceutical and medical applications. Many dextran-based delivery systems with customized geometries and features have been fabricated recently, such as hydrogels, nanogels, magnetic nanoparticles, nanoemulsions, self-assembled micelles and nanoparticles, and microparticles. The review presents advancement and therapeutic potential of dextran-based nanogels for the treatment of various eye conditions, such as cataract, conjunctivitis, glaucoma, dry eye syndrome, age-related macular degeneration, and corneal ulcers. Moreover, the process for development and assessing these nanomedicines, emphasizing their safety and effectiveness as established by preclinical, toxicological, clinical assessments, and patent updates, has been elaborated.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotransformation of vinblastine into vincristine using a fungal endophyte Fusarium equiseti along with the assessment of its antiangiogenic properties. 利用真菌内生菌 Fusarium equiseti 将长春新碱生物转化为长春新碱，并评估其抗血管生成特性。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-24 DOI: 10.1515/znc-2024-0263

Gauri Srivastava, Ruchika Mittal, Nidhi Srivastava, Sarita Srivastava, Deepak Ganjewala

{"title":"Biotransformation of vinblastine into vincristine using a fungal endophyte Fusarium equiseti along with the assessment of its antiangiogenic properties.","authors":"Gauri Srivastava, Ruchika Mittal, Nidhi Srivastava, Sarita Srivastava, Deepak Ganjewala","doi":"10.1515/znc-2024-0263","DOIUrl":"https://doi.org/10.1515/znc-2024-0263","url":null,"abstract":"This study focuses on the microbial biotransformation of vinblastine to vincristine, a compound with enhanced anticancer efficacy compared to vinblastine utilizing a fungal endophyte Fusarium equiseti, isolated from Catharanthus roseus. Additionally, the antiangiogenic properties of the resulting vincristine were evaluated in vivo using the chick chorioallantoic membrane assay. The biotransformation was conducted in liquid medium containing vinblastine (0.6-2.4 mM), and F. equiseti spore suspension (50-150 µL) by incubating at 30 °C, pH 5.6, and 200 rpm for eight days. After the reaction was over, products were extracted using methanol and analyzed by LC-MS/MS. The results confirmed the production of vincristine from vinblastine in different sets of biotransformation reactions. In biotransformation reaction-1, which comprised of vinblastine (0.6 mM) and fungal inoculum 150 µL (82 × 104 spores/mL), 92 % of vinblastine was converted into vincristine on 8th day of incubation. The vincristine produced demonstrated significant antiangiogenetic properties in the chick chorioallantoic membrane assay in a dose-dependent manner. The antiangiogenic properties of vincristine produced was comparable to standard vincristine. Hence, the study revealed that F. equiseti present a viable alternative to produce vincristine from vinblastine. To our knowledge, this is the first report on F. equiseti highlighting its vinblastine biotransformation potential.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight the confirmation of benzothiazolidinone-derived thiadiazole scaffolds as promising antiurease and anti-Alzheimer agents: synthesis, in vitro, and in silico investigations. 揭示苯并噻唑烷酮衍生噻二唑支架作为抗尿毒症和抗老年痴呆药物的前景：合成、体外和硅学研究。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-21 DOI: 10.1515/znc-2024-0243

Shoaib Khan, Tayyiaba Iqbal, Tayyaba Zahoor, Rafaqat Hussain, Mohammad Shahidul Islam, Kholood A Dahlous

{"title":"Insight the confirmation of benzothiazolidinone-derived thiadiazole scaffolds as promising antiurease and anti-Alzheimer agents: synthesis, in vitro, and in silico investigations.","authors":"Shoaib Khan, Tayyiaba Iqbal, Tayyaba Zahoor, Rafaqat Hussain, Mohammad Shahidul Islam, Kholood A Dahlous","doi":"10.1515/znc-2024-0243","DOIUrl":"https://doi.org/10.1515/znc-2024-0243","url":null,"abstract":"Alzheimer's disease is a serious neurological disorder, and traditional therapies for Alzheimer's, like radiation and surgical procedures, as well as chemotherapeutics, are usually linked with multiple negative consequences. Finding a novel therapeutic anti-Alzheimer agent with high efficacy and minimal side effects, we have designed and synthesized benzothiazolidinone-derived thiadiazole-based Schiff base derivatives (1-15). Biological assessment of these compounds was carried out against acetylcholinesterase and butyrylcholinesterase, and all the derivatives showed varying degrees of inhibitory activity. Analog 8 (IC50 = 3.60 ± 0.20 and 4.10 ± 0.20 μM for acetylcholinesterase and butyrylcholinesterase, respectively) demonstrated spellbinding efficacy in contrast to standard donepezil (IC50 = 50 ± 0.10 and 8.10 ± 0.20 μM). The surpassing inhibition of analog 8 is due to highly reactive CF3 moiety at the para-position, inhibiting the enzymes via strong hydrogen bond. Analog 7 with IC50 value of 5.70 ± 0.10 and 6.20 ± 0.40 μM was also found with strong therapeutic potential than standard drug. The strong inhibition potential of lead compounds was also evaluated under enzyme kinetics and spellbinding potential was observed. Biological effectiveness of potent compounds was validated by visualizing the binding interactions via in silico molecular docking study and prediction of drug-likeness via ADME analysis. All the synthesized compounds were analyzed for their structural confirmation via 1HNMR, 13CNMR, and HREI-MS.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview. 姜黄素及其衍生物的潜力，对抗癌特性的现代见解：全面概述。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-21 DOI: 10.1515/znc-2024-0220

Rafi Ullah, Muhammad Siraj, Javed Iqbal, Banzeer Ahsan Abbasi

{"title":"Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview.","authors":"Rafi Ullah, Muhammad Siraj, Javed Iqbal, Banzeer Ahsan Abbasi","doi":"10.1515/znc-2024-0220","DOIUrl":"https://doi.org/10.1515/znc-2024-0220","url":null,"abstract":"Globally, cancer is the top cause of mortality, placing a heavy load on the medical system. One of the first known secondary metabolites is curcumin, a bioactive substance. This study aims to emphasize the chemopreventive and chemotherapeutic properties of curcumin and its derivatives, therefore, offering important insights for the possible creation of certain supplemental medications for the treatment of different cancers. Electronic Google databases, including Google scholar, ResearchGate, PubMed/Medline, and ScienceDirect, were searched to gather pertinent data about the chemopreventive and chemotherapeutic effects of curcumin and its derivatives. Various studies have revealed a diverse array of significant biological effects. The majority of investigations pertaining to the potential anticancer effects and associated processes are currently in the experimental preclinical stage and lack sufficient clinical trial data to validate their findings. Clinical research is further needed to clarify the molecular processes and specific targeted action of curcumin and its derivatives, as well as their potential for toxicity and side effects in humans, in order to open up new therapeutic avenues for treating cancer.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl. 揭示了挫折派挥发油的成分和生物活性。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-14 DOI: 10.1515/znc-2024-0227

Syarifah Nadhirah Wan Idrus, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Mohd Hafiz Arzmi, Carlos L Cespedes-Acuña

{"title":"Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl.","authors":"Syarifah Nadhirah Wan Idrus, Wan Mohd Nuzul Hakimi Wan Salleh, Abubakar Siddiq Salihu, Mohd Hafiz Arzmi, Carlos L Cespedes-Acuña","doi":"10.1515/znc-2024-0227","DOIUrl":"https://doi.org/10.1515/znc-2024-0227","url":null,"abstract":"This study aimed to investigate the chemical composition, and anticholinesterase and anti-tyrosinase activities of the essential oil extracted from the leaves of Piper frustratum Boerl., growing in Malaysia. Nineteen chemical components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS), accounting for 99.6 % of the essential oil. The identified major components include β-caryophyllene (12.6 %), β-asarone (10.7 %), myristicin (10.4 %), α-copaene (9.6 %), methyl eugenol (7.2 %), and β-cubebene (6.5 %). Anticholinesterase activity was assessed using the Ellman's method, while anti-tyrosinase activity was evaluated against mushroom tyrosinase. The essential oil demonstrated moderate inhibitory activity against acetylcholinesterase (IC50 value of 84.2 μg/mL), butyrylcholinesterase (IC50 value of 98.5 μg/mL), and tyrosinase (IC50 value of 95.4 μg/mL) enzymes. This study is the first to report the chemical composition and bioactivities of the essential oil obtained from P. frustratum, which may have implications on the characterization, pharmaceutical, and therapeutic applications of Piper essential oils.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New hydrazone derivatives: synthesis, characterization, carbonic anhydrase I-II enzyme inhibition, anticancer activity and in silico studies. 新的腙衍生物：合成，表征，碳酸酐酶I-II酶抑制，抗癌活性和硅研究。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-14 DOI: 10.1515/znc-2024-0226

Ulviye Acar Cevik, Hakan Ünver, Hayrani Eren Bostancı, Burak Tüzün, Nurten İrem Gedik, Ümit M Kocyigit

{"title":"New hydrazone derivatives: synthesis, characterization, carbonic anhydrase I-II enzyme inhibition, anticancer activity and in silico studies.","authors":"Ulviye Acar Cevik, Hakan Ünver, Hayrani Eren Bostancı, Burak Tüzün, Nurten İrem Gedik, Ümit M Kocyigit","doi":"10.1515/znc-2024-0226","DOIUrl":"https://doi.org/10.1515/znc-2024-0226","url":null,"abstract":"A new series of hydrazone derivatives (1a-1l) were prepared from a condensation reaction between different hydrazide derivatives and 3-formylbenzoic acid. Through the use of several spectral techniques, such as 1H-NMR, 13C-NMR, and elemental analysis, the structures of the compounds were clarified. The crystal structure of compound 1d was obtained by single-crystal X-ray crystallography. They were found to have inhibitory effects on the anticancer potentials and human carbonic anhydrase isoforms I and II. Compound 1d was found to be the strongest inhibitor, with IC50 values of 0.133 µM against hCA I. Also, compound 1l showed the highest inhibitory activity with IC50 values of 3.244 µM against hCA II. Moreover, their cytotoxic effects on rat glioma cell and colon adeno carcinoma cell lines were evaluated. According to the cytotoxicity results, compounds 1j and 1l exhibited the highest cytotoxicity on the HT29 cell, while compounds 1e, 1g, and 1l showed the strongest cytotoxic effect on C6 cell line. Compound 1l, which carries the methoxy substituent at the 3rd position on the phenyl ring, was effective against both cancer cells and showed the highest inhibitory effect on hCA II. The ADME/T properties and molecular docking of the molecules with the highest activity were examined.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents. 新型1,3,4-噻二唑类抗菌和抗生物膜剂的设计与合成。

IF 1.8 4区生物学

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2025-03-03 DOI: 10.1515/znc-2024-0294

Betül Kaya, Ulviye Acar Çevik, Pervin Soyer, Mehmet Taha Yıldız, Yusuf Özkay, Zafer Asım Kaplancıklı

{"title":"Design and synthesis of new 1,3,4-thiadiazoles as antimicrobial and antibiofilm agents.","authors":"Betül Kaya, Ulviye Acar Çevik, Pervin Soyer, Mehmet Taha Yıldız, Yusuf Özkay, Zafer Asım Kaplancıklı","doi":"10.1515/znc-2024-0294","DOIUrl":"https://doi.org/10.1515/znc-2024-0294","url":null,"abstract":"This study assessed the in vitro antibacterial and antibiofilm properties of new 1,3,4-thiadiazole derivatives. 1H NMR and 13C NMR analyses were employed to confirm the structure of the synthesized compounds, the characterization is followed by assessments of their efficacy against Bacillus subtilis NRRL B478, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, as well as for antifungal activity against Candida albicans ATCC 90028 and Candida krusei ATCC 6258, using the broth microdilution method. Notably, among the tested compounds, compound 4a exhibited the highest antimicrobial activity, with a minimal inhibitory concentration of 125 μg/mL against P. aeruginosa ATCC 27853 and significant antibiofilm activity, achieving 94 %, 98 % and 100 % biofilm inhibition at 250, 500 and 1,000 μg/mL, respectively. Besides, compound 4h achieved 81 %, 89 % and 98 % S. aureus ATCC 29213 biofilm inhibition at 250, 500 and 1,000 μg/mL, respectively, and displayed potent antibacterial activity against this bacterium. Finally, the theoretical ADME properties of the compounds 4a-4h were analyzed by calculations. This study has consolidated a base for the development of new antibacterial and antibiofilm agents and advanced our understanding of their potential mode of action against biofilm-associated infections.","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0