(-)-褐藻碱，一种从褐藻叶中提取的新型水溶性抗菌酚类化合物。Tiegh(桑寄生科)。

IF 2.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2021-09-28 Print Date: 2022-03-28 DOI:10.1515/znc-2021-0143

Moifo Kuete Thomas Wieland, Ambassa Pantaleon, Moungang Luciane Marlyse, Ngameni Bathelemy, Storr E Thomas, Ngadjui Tchaleu Bonaventure, Stephenson G Richard

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引用次数: 1

摘要

龙舌兰是一种半寄生植物，生长在蕨草(豆科)上。对其叶和花的化学研究导致分离出一种新的酚类化合物，即(-)-brunneusine(1)，以及13种已知化合物。粗叶和粗花提取物(CLE和CFLE)及其乙酸乙酯组分(EAFL和EAFFL)和一些分离化合物(1-3;8-9和11-14)在水生环境中分离出的四种具有卫生重要性的细菌上进行了测试。除化合物3外，其余样品均表现出抗菌活性，mic值为0.43 ~ 8.88.103µg/mL, MBCs值为0.43 ~ 3.55.103µg/mL。化合物9和14在mic范围为0.43 ~ 27.77µg/mL时，对所有细菌都有较好的活性。只有CLE、EAFL和化合物14、2、8和9对所有被试细菌都有杀菌作用。

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(-)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE).

Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (-)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1-3; 8-9 and 11-14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.10³ µg/mL and MBCs from 0.43 to 3.55.10³ µg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 µg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.