Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences最新文献

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In silico molecular modeling and in vitro biological screening of novel benzimidazole-based piperazine derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. 作为潜在乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂的新型苯并咪唑基哌嗪衍生物的硅学分子建模和体外生物筛选。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-16 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0068
Haseena Naz, Fazal Rahim, Rafaqat Hussain, Shoaib Khan, Wajid Rehman, Yousaf Khan, Tariq Aziz, Metab Alharbi
{"title":"<i>In silico</i> molecular modeling and <i>in vitro</i> biological screening of novel benzimidazole-based piperazine derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.","authors":"Haseena Naz, Fazal Rahim, Rafaqat Hussain, Shoaib Khan, Wajid Rehman, Yousaf Khan, Tariq Aziz, Metab Alharbi","doi":"10.1515/znc-2024-0068","DOIUrl":"10.1515/znc-2024-0068","url":null,"abstract":"<p><p>New series of benzimidazole incorporating piperazine moieties in single molecular framework has been reported. The structures of the synthesized derivatives were assigned by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, and HR-MS techniques. The hybrid derivatives were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibition effect. All the synthesized analogs showed good to moderate inhibitory effect ranging from IC<sub>50</sub> value 0.20 ± 0.01 µM to 0.50 ± 0.10 µM for acetylcholinesterase and from IC<sub>50</sub> value 0.25 ± 0.01 µM to 0.70 ± 0.10 µM for butyrylcholinesterase except one that showed least potency with IC<sub>50</sub> value 1.05 ± 0.1 µM and 1.20 ± 0.1 µM. The differences in inhibitory potential of synthesized compounds were due to the nature and position of substitution attached to the main ring. Additionally, molecular docking study was carried out for most active in order to explore the binding interactions established by ligand (active compounds) with the active residues of targeted AChE & BuChE enzyme.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"85-94"},"PeriodicalIF":1.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential. 改性席夫碱附加 1,2,4-三唑杂化物支架的合成:阐明体外和硅学中 α 淀粉酶和 α 葡萄糖苷酶抑制剂的潜力。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-12 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0073
Shahzad Ahmad Abbasi, Fazal Rahim, Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Muhammad Taha, Tayyiaba Iqbal, Yousaf Khan, Syed Adnan Ali Shah
{"title":"Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the <i>in vitro</i> and <i>in silico</i> α-amylase and α-glucosidase inhibitors potential.","authors":"Shahzad Ahmad Abbasi, Fazal Rahim, Rafaqat Hussain, Wajid Rehman, Shoaib Khan, Muhammad Taha, Tayyiaba Iqbal, Yousaf Khan, Syed Adnan Ali Shah","doi":"10.1515/znc-2024-0073","DOIUrl":"10.1515/znc-2024-0073","url":null,"abstract":"<p><p>The current study involves the synthesis of Schiff bases based on 1,2,4-triazoles skeleton and assessing their α-amylase and α-glucosidase profile. Furthermore, the precise structures of the synthesized derivatives were elucidated using various spectroscopic methods such as <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and HREI-MS. Using glimepiride as the reference standard, the <i>in vitro</i> α-glucosidase and α-amylase inhibitory activities of the synthesized compounds were evaluated in order to determine their potential anti-diabetic properties. All analogues showed varied range of inhibitory activity having IC<sub>50</sub> values ranging from 17.09 ± 0.72 to 45.34 ± 0.03 μM (α-amylase) and 16.35 ± 0.42 to 42.31 ± 0.09 μM (α-glucosidase), respectively. Specifically, the compounds <b>1</b>, <b>7</b> and <b>8</b> were found to be significantly active with IC<sub>50</sub> values of 17.09 ± 0.72, 19.73 ± 0.42, and 23.01 ± 0.04 μM (against α-amylase) and 16.35 ± 0.42, 18.55 ± 0.26, and 20.07 ± 0.02 μM (against α-glucosidase) respectively. The obtained results were compared with the Glimepiride reference drug having IC<sub>50</sub> values of 13.02 ± 0.11 μM (for α-glucosidase) and 15.04 ± 0.02 μM (for α-amylase), respectively. The structure-activity relationship (SAR) studies were conducted based on differences in substituent patterns at varying position of aryl rings A and B may cause to alter the inhibitory activities of both α-amylase and α-glucosidase enzymes. Additionally, the molecular docking study was carried out to explore the binding interactions possessed by most active analogues with the active sites of targeted α-amylase and α-glucosidase enzymes.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"119-134"},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via in- silico innovation. 通过硅学创新,以人工智能驱动候选药物设计,重新定义碱蛋白尿治疗的新领域。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-12 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0075
Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Ali Zafar, Mahnoor Fatima, Imran Ali, Ayaz Ali Khan, Thamer H Albekairi
{"title":"Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via <i>in-</i> <i>silico</i> innovation.","authors":"Muhammad Naveed, Khushbakht Javed, Tariq Aziz, Ali Zafar, Mahnoor Fatima, Imran Ali, Ayaz Ali Khan, Thamer H Albekairi","doi":"10.1515/znc-2024-0075","DOIUrl":"10.1515/znc-2024-0075","url":null,"abstract":"<p><p>A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and phenylalanine that darkens the urine and accumulates in connective tissues which causes an agonizing arthritis. Employing the use of deep learning artificial intelligence (AI) drug design, this study aims to alleviate the current toxicity of the AKU drugs currently in use, particularly nitisinone, by utilizing the natural flavanol kaempferol molecule as a 4-hydroxyphenylpyruvate dioxygenase inhibitor. Kaempferol was employed to generate three effective <i>de novo</i> drug candidates targeting the enzyme 4-hydroxyphenylpyruvate dioxygenase using an AI drug design tool. We present novel AIK formulations in the present study. The AIK's (Artificial Intelligence Kaempferol) examination of drug-likeliness among the three led to its choice as a possible target. The toxicity assessment research of AIK demonstrates that it is not only safer to use than other treatments, but also more efficient. The docking of the AIGT with 4-hydroxyphenylpyruvate dioxygenase, which revealed a binding affinity of around -9.099 kcal/mol, highlights the AIK's potential as a therapeutic candidate. An innovative approach to deal with challenging circumstances is thus presented in this study by new formulations kaempferol that have been meticulously designed by AI. The results of the <i>in vitro</i> tests must be confirmed <i>in vivo</i>, even though AI-designed AIK is effective and sufficiently safe as computed.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"135-149"},"PeriodicalIF":1.8,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coenzyme Q10 supplementation affects cellular ionic balance: relevance to aging. 辅酶 Q10 补充剂影响细胞离子平衡:与衰老有关。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-07-05 Print Date: 2025-03-26 DOI: 10.1515/znc-2024-0129
Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi
{"title":"Coenzyme Q<sub>10</sub> supplementation affects cellular ionic balance: relevance to aging.","authors":"Parisha Srivastava, Sukanya Bhoumik, Arun K Yadawa, Rashmi Kesherwani, Syed Ibrahim Rizvi","doi":"10.1515/znc-2024-0129","DOIUrl":"10.1515/znc-2024-0129","url":null,"abstract":"<p><p>Aging results into disruptive physiological functioning and cellular processes that affect the composition and structure of the plasma membrane. The plasma membrane is the major regulator of ionic homeostasis that regulates the functioning of membrane transporters and exchangers. Coenzyme Q<sub>10</sub> is a lipid-soluble antioxidant molecule that declines during aging and age-associated diseases. The present study aims to explore the role of Coenzyme Q<sub>10</sub> supplementation to rats during aging on membrane transporters and redox biomarkers. The study was conducted on young and old male Wistar rats supplemented with 20 mg/kg b.w. of Coenzyme Q<sub>10</sub> per day. After a period of 28 days, rats were sacrificed and erythrocyte membrane was isolated. The result exhibits significant decline in biomarkers of oxidative stress in old control rats when compared with young control. The effect of Coenzyme Q<sub>10</sub> supplementation was more pronounced in old rats. The functioning of membrane transporters and Na<sup>+</sup>/H<sup>+</sup> exchanger showed potential return to normal levels in the Coenzyme Q<sub>10</sub> treated rats. Overall, the results demonstrate that Coenzyme Q<sub>10</sub> plays an important role in maintaining redox balance in cells which interconnects with membrane integrity. Thus, Coenzyme Q<sub>10</sub> supplementation may play an important role in protecting age related alterations in erythrocyte membrane physiology.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"95-102"},"PeriodicalIF":1.8,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Chitin structures and pathways as targets for biopesticides and drugs. 社论:作为生物农药和药物靶标的几丁质结构和途径。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-20 Print Date: 2024-05-27 DOI: 10.1515/znc-2024-2001
Klaus H Hoffmann
{"title":"Editorial: Chitin structures and pathways as targets for biopesticides and drugs.","authors":"Klaus H Hoffmann","doi":"10.1515/znc-2024-2001","DOIUrl":"10.1515/znc-2024-2001","url":null,"abstract":"","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"93-94"},"PeriodicalIF":1.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing microbial fuel cell performance through microbial immobilization. 通过微生物固定化提高微生物燃料电池的性能。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-14 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0175
Yana Mersinkova, Hyusein Yemendzhiev
{"title":"Enhancing microbial fuel cell performance through microbial immobilization.","authors":"Yana Mersinkova, Hyusein Yemendzhiev","doi":"10.1515/znc-2023-0175","DOIUrl":"10.1515/znc-2023-0175","url":null,"abstract":"<p><p>Bio-electrochemical Systems (BES), particularly Microbial Fuel Cells (MFC), have emerged as promising technologies in environmental biotechnology. This study focused on optimizing the anode bacterial culture immobilization process to enhance BES performance. The investigation combines and modifies two key immobilization methods: covalent bonding with glutaraldehyde and inclusion in a chitosan gel in order to meet the criteria and requirements of the bio-anodes in MFC. The performance of MFCs with immobilized and suspended cultures was compared in parallel experiments. Both types showed similar substrate utilization dynamics with slight advantage of the immobilized bio-anode considering the lower concentration of biomass. The immobilized MFC exhibited higher power generation and metabolic activity, as well. Probably, this is due to improved anodic respiration and higher coulombic efficiency of the reactor. Analysis of organic acids content supported this conclusion showing significant inhibition of the fermentation products production in the MFC reactor with immobilized anode culture.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"149-153"},"PeriodicalIF":1.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of Aspergillus flavus and Aspergillus fumigatus. 聚乙二醇(PEG)包覆的聚乳酸(PLGA)纳米颗粒可控地输送尼可霉素,抑制几丁质合成酶,防止黄曲霉和烟曲霉生长。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-07 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0185
Kamal Mayattu, Vandana Ghormade
{"title":"Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of <i>Aspergillus flavus</i> and <i>Aspergillus fumigatus</i>.","authors":"Kamal Mayattu, Vandana Ghormade","doi":"10.1515/znc-2023-0185","DOIUrl":"10.1515/znc-2023-0185","url":null,"abstract":"<p><p>Aspergillosis is one of the most common fungal infections that can threaten individuals with immune compromised condition. Due to the increasing resistance of pathogens to the existing antifungal drugs, it is difficult to tackle such disease conditions. Whereas, nikkomycin is an emerging safe and effective antifungal drug which causes fungal cell wall disruption by inhibiting chitin synthase. Hence, the study aims at the development of nikkomycin loaded PEG coated PLGA nanoparticles for its increased antifungal efficiency and inhibiting <i>Aspergillus</i> infections. The P-PLGA-Nik NPs were synthesized by w/o/w double emulsification method which resulted in a particle size of 208.3 ± 15 nm with a drug loading of 52.97 %. The NPs showed first order diffusion-controlled drug release which was sustained for 24 h. These nanoparticle's antifungal efficacy was tested using the CLSI - M61 guidelines and the MIC<sub>50</sub> defined against <i>Aspergillus flavus</i> and <i>Aspergillus fumigatus</i> was found to be >32 μg/ml which was similar to the nikkomycin MIC. The hyphal tip bursting showed the fungal cell wall disruption. The non-cytotoxic and non-haemolytic nature highlights the drug safety profile.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"155-162"},"PeriodicalIF":1.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities. 开发掺银氧化铜和壳聚糖纳米复合材料以增强抗菌活性。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-06-03 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0166
Yasir Anwar, Hisham Faiz Jaha, Mazhar Ul-Islam, Tahseen Kamal, Sher Bahadar Khan, Ihsan Ullah, Saleh M Al-Maaqar, Sameer Ahmed
{"title":"Development of silver-doped copper oxide and chitosan nanocomposites for enhanced antimicrobial activities.","authors":"Yasir Anwar, Hisham Faiz Jaha, Mazhar Ul-Islam, Tahseen Kamal, Sher Bahadar Khan, Ihsan Ullah, Saleh M Al-Maaqar, Sameer Ahmed","doi":"10.1515/znc-2023-0166","DOIUrl":"10.1515/znc-2023-0166","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) has emerged as a significant and pressing public health concern, posing serious challenges to effectively preventing and treating persistent diseases. Despite various efforts made in recent years to address this problem, the global trends of AMR continue to escalate without any indication of decline. As AMR is well-known for antibiotics, developing new materials such as metal containing compounds with different mechanisms of action is crucial to effectively address this challenge. Copper, silver, and chitosan in various forms have demonstrated significant biological activities and hold promise for applications in medicine and biotechnology. Exploring the biological properties of these nanoparticles is essential for innovative therapeutic approaches in treating bacterial and fungal infections, cancer, and other diseases. To this end, the present study aimed to synthesize silver@copper oxide (Ag@CuO) nanoparticles and its chitosan nanocomposite (Chi-Ag@CuO) to investigate their antimicrobial efficacy. Various established spectroscopic and microscopic methods were employed for characterization purposes, encompassing scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Subsequently, the antimicrobial activity of the nanoparticles was assessed through MIC (minimum inhibitory concentration), MBC (minimum bactericidal concentration), and well-disk diffusion assays against <i>Pseudomonas aeruginosa</i>, <i>Acinetobacter baumannii Staphylococcus aureus</i>, <i>Staphylococcus epidermidis</i>, and <i>Candida albicans</i>. The size of the CuO-NPs, Ag@CuO, and Chi-Ag@CuO NPs was found to be 70-120 nm with a spherical shape and an almost uniform distribution. The nanocomposites were found to possess a minimum inhibitory concentration (MIC) of 5 μg/mL and a minimum bactericidal concentration (MBC) of 250 μg/mL. Moreover, these nanocomposites generated varying clear inhibition zones, with diameters ranging from a minimum of 9 ± 0.5 mm to a maximum of 25 ± 0.5 mm. Consequently, it is evident that the amalgamation of copper-silver-chitosan nanoparticles has exhibited noteworthy antimicrobial properties in the controlled laboratory environment, surpassing the performance of other types of nanoparticles.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"137-148"},"PeriodicalIF":1.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring chitin: novel pathways and structures as promising targets for biopesticides. 探索甲壳素:作为生物杀虫剂有前途的目标的新途径和结构。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-05-20 Print Date: 2024-05-27 DOI: 10.1515/znc-2024-0027
Malkiet Kaur, Manju Nagpal, Gitika Arora Dhingra, Ankit Rathee
{"title":"Exploring chitin: novel pathways and structures as promising targets for biopesticides.","authors":"Malkiet Kaur, Manju Nagpal, Gitika Arora Dhingra, Ankit Rathee","doi":"10.1515/znc-2024-0027","DOIUrl":"10.1515/znc-2024-0027","url":null,"abstract":"<p><p>Chitin, the most prevalent polymer in nature, a significant structural polysaccharide that comes in second only to cellulose. Chitin is a crucial component of fungal cell walls and also present in many other creatures, such as viruses, plants, animals, insect exoskeletons, and crustacean shells. Chitin presents itself as a promising target for the development of biopesticides. It focuses on unraveling the unique structures and biochemical pathways associated with chitin, aiming to identify vulnerabilities that can be strategically leveraged for effective and environmentally sustainable pest control. It involves a comprehensive analysis of chitinase enzymes, chitin biosynthesis, and chitin-related processes across diverse organisms. By elucidating the molecular intricacies involved in chitin metabolism, this review seeks to unveil potential points of intervention that can disrupt essential biological processes in target pests without harming non-target species. This holistic approach to understanding chitin-related pathways aims to inform the design and optimization of biopesticides with enhanced specificity and reduced ecological impact. The outcomes of this study hold great promise for advancing innovative and eco-friendly pest management strategies. By targeting chitin structures and pathways, biopesticides developed based on these findings may offer a sustainable and selective alternative to conventional chemical pesticides, contributing to the ongoing efforts towards more environmentally conscious and effective pest control solutions.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"125-136"},"PeriodicalIF":1.8,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review. 揭示壳聚糖包覆脂质纳米颗粒在危重病药物输送中的潜力:综述。
IF 1.8 4区 生物学
Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2024-05-10 Print Date: 2024-05-27 DOI: 10.1515/znc-2023-0181
Ushasi Das, Devesh U Kapoor, Sudarshan Singh, Bhupendra G Prajapati
{"title":"Unveiling the potential of chitosan-coated lipid nanoparticles in drug delivery for management of critical illness: a review.","authors":"Ushasi Das, Devesh U Kapoor, Sudarshan Singh, Bhupendra G Prajapati","doi":"10.1515/znc-2023-0181","DOIUrl":"10.1515/znc-2023-0181","url":null,"abstract":"<p><p>Chitosan (CT), a natural, cationic, chemically stable molecule, biocompatible, biodegradable, nontoxic, polysaccharide derived from the deacetylation of chitin, has very uniquely surfaced as a material of promise for drug delivery and biomedical applications. For the oral, ocular, cutaneous, pulmonary, and nose-to-brain routes, CT-coated nanoparticles (CTCNPs) have numerous advantages, consisting of improved controlled drug release, physicochemical stability, improved cell and tissue interactions, and increased bioavailability and efficacy of the active ingredient. CTCNPs have a broad range of therapeutic properties including anticancer, antiviral, antifungal, anti-inflammatory, antibacterial properties, treating neurological disorders, and other diseases. This has led to substantial research into the many potential uses of CT as a drug delivery vehicle. CT has also been employed in a wide range of biomedical processes, including bone and cartilage tissue regeneration, ocular tissue regeneration, periodontal tissue regeneration, heart tissue regeneration, and wound healing. Additionally, CT has been used in cosmeceutical, bioimaging, immunization, and gene transfer applications. CT exhibits a number of biological activities, which are the basis for its remarkable potential for use as a drug delivery vehicle, and these activities are covered in detail in this article. The alterations applied to CT to obtain the necessary properties have been described.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":" ","pages":"107-124"},"PeriodicalIF":1.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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