Recent Patents on Nanotechnology最新文献

{"title":"Formulation Optimization and Characterization of Solid Lipid Nanoparticles of Apixaban.","authors":"Laukik Mulay, Namita Hegde, Abhishek Kanugo","doi":"10.2174/0118722105284862240506045944","DOIUrl":"10.2174/0118722105284862240506045944","url":null,"abstract":"<p><strong>Background: </strong>Unpredictable situations such as clotting of blood, deep vein thrombosis, and pulmonary embolism arise in the body, which is the leading cause of mortality. Such conditions generally arise after surgery as well as after treatment with oral anticoagulant agents. Apixaban is a novel oral anticoagulant widely recommended for the prevention and treatment of strokes and blood clots suffering from nonvalvular atrial fibrillation by suppressing factor Xa. Apixaban has a log P of 2.71 with poor solubility and reported maximum bioavailability of approximately 50%.</p><p><strong>Objective: </strong>Hence, the current research mainly focused on the improvement of solubility, bioavailability, and therapeutic efficacy of Apixaban via solid lipid nanoparticles (SLN).</p><p><strong>Methods: </strong>The SLN was developed using the hot-homogenization method using a high-pressure homogenizer. The drug-lipid compatibility study was assessed by the FTIR, and the thermal analysis was performed using differential scanning calorimetry (DSC). During the scrutiny of lipids, the highest solubility of Apixaban was estimated in the glyceryl monostearate, hence selected for the formulation. Moreover, the colloidal solution was stabilized by the polyethylene glycol 200. The Design of Expert software (Version 13, Stat-Ease) was implemented for the optimization analysis by considering the 3-independent factors and 2-dependent parameters. The Patents on the SLN are Indian 202321053691, U.S. Patent, 10,973,798B2, U.S. Patent, U.S. Patent 2021/0069121A1, U.S. Patent 2022/0151945A1.</p><p><strong>Results: </strong>Box-Behnken design was applied along with ANOVA, which showed a p-value less than 0.05 for the dependent parameters such as particle size and entrapment efficiency (p-value: 0.0476 and 0.0379). The optimized batch F10 showed a particle size of 167.1 nm, -19.5 mV zeta potential, and an entrapment efficiency of 87.32%. The optimized batch F10 was lyophilized and analyzed by Scanning electron microscopy (SEM), which showed a particle size of 130 nm. The solid powder was filled into the capsule for oral delivery.</p><p><strong>Conclusion: </strong>The marked improvement in solubility and bioavailability was achieved with F10- loaded Apixaban via Solid lipid nanoparticles. Moreover, the sustained released profile also minimizes the unseen complications that occur due to the clotting of blood.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"270-281"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development.","authors":"Manish Makhija, Deeksha Manchanda, Manu Sharma","doi":"10.2174/1872210518666230905155459","DOIUrl":"10.2174/1872210518666230905155459","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease marked by inflammation of synovium and generation of autoantibodies. Bone and cartilage are frequently damaged along with weakening of tendons and ligaments resulting in disability. An effective RA treatment needs a multi-disciplinary approach which relies upon pathophysiology that is still partially understood. In RA patients, inflammation was induced by pro-inflammatory cytokines including IL-1, IL-6 & IL-10. The conventional dosage regimens for treating RA have drawbacks such as ineffectiveness, greater doses, frequent dosing, relatively expensive and serious adverse effects. To formulate an effective treatment plan for RA, research teams have recently focused on producing several nanoformulations containing anti-inflammatory APIs with an aim to target the inflamed area. Nanomedicines have recently gained popularity in the treatment of RA. Interestingly, unbelievable improvements have been observed in current years in diagnosis and management of RA utilizing nanotechnology. Various patents and clinical trial data have been reported in relevance to RA treatment.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"56-75"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10199778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer.","authors":"Suchitra Nishal, Virender Kumar, Parmita Phaugat, Davinder Kumar, Naveen Khatri, Gajendra Singh","doi":"10.2174/1872210518666230907115056","DOIUrl":"10.2174/1872210518666230907115056","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most prevalent cancer among women. About 685K deaths were globally listed in 2020 by the World Health Organization. Nowadays, scientists prefer to use herbal medicines due to their low toxicity. Herbal medicines are used to overcome the toxicity effects of surgical removal, radio-chemo therapy and medication, which have a lot of risk of damaging the healthy tissues. To overcome this, enhance bioavailability and target specify, nano-formulation chemotherapy was introduced using herbal moiety for anticancer activity. The use of metallic nanoparticles (MNPs), particularly those made of silver, cobalt, zinc, and gold as contrast, antibacterial, anticancer, and drug delivery agents has revolutionised the medicinal field. Although MNPs can be made via exacting physical and chemical processes, a biological method utilising natural materials has been established recently.</p><p><strong>Objectives: </strong>This patent review article will offer a succinct explanation of the use of MNPs and its potential impact on herbal medicines in the future.</p><p><strong>Methods: </strong>Using PRISMA principles, this review systematically examines studies that concentrate on metal nanoparticles loaded with herbal compounds for the treatment of breast cancer. Various Databases were studied: PubMed, Elsevier, ScienceDirect, SpringerLink, Taylor & Francis Online, ACS Publications, Publishing Royal Society of Chemistry, and Future Medicines. Studies were selected if they were peer-reviewed primary studies published in the past 10 years.</p><p><strong>Results: </strong>We found that many herbal nano-formulations are more effective in breast cancer treatment than other types of formulations. Efficacy, safety and drug stability are also enhanced using nanoformulations.</p><p><strong>Conclusion: </strong>Nano-formulation is found to be more effective in the treatment of breast cancer.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"120-130"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-phase Hybrid Thermal Interface Alkali-treated E-Glass Fiber/MWCNT/Graphene/Copper Oxide Nanocomposites for Electronic Gadgets.","authors":"Swaminathan Ramu, Natarajan Senthilkumar, Balakrishnan Deepanraj","doi":"10.2174/0118722105296725240308094344","DOIUrl":"10.2174/0118722105296725240308094344","url":null,"abstract":"<p><strong>Introduction: </strong>Two-phase hybrid mode thermal interface materials were created and characterized for mechanical properties, thermal conductivity, and wear behaviour. Therefore, the ultimate goal of this current research was to use alkali-treated glass fibre and other allotropes to produce high-performance two-phase thermal interface materials that can be patented for engineering applications.</p><p><strong>Methods: </strong>Three different polymer composites were prepared to contain 20 vol.% alkalies (NaOH) treated e-glass fibre (E) and epoxy as a matrix with varying proportions of multi-walled carbon nanotube (MWCNT), graphene (G), copper oxide (C). The one-phase material contained epoxy+20%e-glass+1%MWCNT (EMGC1), the two-phase hybrid composite contained epoxy+20%e-glass+1%MWCNT+1%graphene+1%CuO (EMGC2), and two-phase material contained epoxy+20%e-glass+1%graphene+1%CuO (EMGC3). Vacuum bagging method was used for fabricating the composites.</p><p><strong>Results: </strong>The higher thermal conductivity observed was 0.3466 W/mK for EMGC2, the alkalitreated glass fibre/hybrid mode nanofillers epoxy matrix composite was mechanically tougher than the other two composites (EMGC1 & EMGC3). Scanning electron microscopy analysis revealed the fine filler dispersion and homogenous interaction with the glass fibre/epoxy resin composite of the upper and lower zone, which also revealed the defective zone, fibre elongation, fibre/filler breakages, and filler leached surfaces.</p><p><strong>Conclusion: </strong>Finally, it was concluded that the hybrid mode two-phased structure EMGC2 epoxy matrix composite replicated the maximum thermal conductivity, mechanical properties, and wear properties of the other two specimens.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"511-523"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patent Analysis on Nano Drug Delivery Systems.","authors":"Dengyu Li, Wen Luo, Shengwei Yin, Ying Wang, Yanqing Zhao, Shiwei Zhu, Junfeng Yu, Ping Yang, Lina Zhang, Zhuyan Xi","doi":"10.2174/0118722105293359240626070342","DOIUrl":"10.2174/0118722105293359240626070342","url":null,"abstract":"<p><strong>Background: </strong>A nano drug delivery system is an effective tool for drug delivery and controlled release, which is used for a variety of medical applications. In recent decades, nano drug delivery systems have been significantly developed with the emergence of new nanomaterials and nanotechnologies.</p><p><strong>Objective: </strong>This article aimed to provide insight into the technological development of nano drug delivery systems through patent analysis.</p><p><strong>Methods: </strong>3708 patent documents were used for patent analysis after retrieval from the Incopat patent database.</p><p><strong>Results: </strong>The number of patents on nano drug delivery systems has shown a rapid growth trend in the past two decades. At present, China and the United States have obvious contributions to the number of patents. According to the patent data, the nanomaterials used in nano drug delivery system are mainly inorganic nanomaterials, lipid-based nanomaterials, and macromolecules. In recent years, the highly cited patents (≥14) for nano drug delivery systems mainly involve lipid-based nanomaterials, indicating that their technology is mature and widely used. The inorganic nanomaterials in drug delivery have received increasing attention, and the number of related patents has increased significantly after 2016. The number of highly cited patents in the United States is 250, which is much higher than in other countries.</p><p><strong>Conclusion: </strong>Even after decades of development, nano drug delivery systems remain a hot topic for researchers. The significant increase in patents since 2016 can be attributed to the large number of new patents from China. However, according to the proportion of highly cited patents in total, China's patented technologies in nano drug delivery systems are not advanced enough compared to developed countries, including the United States, Canada, Germany, and France. In the future, research on emerging nanomaterials for nano drug delivery systems, such as inorganic nanomaterials, may focus on developing new materials and optimising their properties. The lipid-based and polymer- based nanomaterials can be continuously improved for the development of new nanomedicines.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"609-628"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide (GO) Layered Bioconjugates: An Effective Strategy for Delivering p53 Gene for Adenocarcinoma.","authors":"Dilpreet Singh","doi":"10.2174/0118722105290129240122104901","DOIUrl":"10.2174/0118722105290129240122104901","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"568-571"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Patents on Solid Dispersions Emphasize Promising Benefits in Solubility Enhancement of Poorly Water-soluble Drugs.","authors":"Manisha Saini, Shailender Bhatt, Harish Dureja, Neeta Solanki","doi":"10.2174/0118722105229356231030065938","DOIUrl":"10.2174/0118722105229356231030065938","url":null,"abstract":"<p><strong>Background: </strong>In the development of drug delivery systems, drugs' solubility remains the most challenging constraint. Many newly synthesized chemical compounds are available, but they involve low solubility and poor permeability restrictions. Among various drug delivery systems, the utilization of solid dispersion technologies has become more focused due to their promising benefits.</p><p><strong>Objective: </strong>This technology has attracted extensive attention for dissolution rate improvement along with substantial bioavailability enhancement of poorly water-soluble drug candidates.</p><p><strong>Methods: </strong>Many approaches have been employed for preparing solid dispersions, such as the melting method, hot melt extrusion, solvent evaporation process, fusion and kneading method, spray drying technique, co-grinding and freeze drying, supercritical fluid technology, etc. Results: A wide variety of hydrophilic and hydrophobic materials are available as carriers, which are employed in the formulation of solid dispersions. Depending on the carrier characteristics, immediate- release solid dispersions and/or controlled-release solid dispersions can be formulated. Multiple hydrophilic materials have been explored for heightening dissolution features with enhanced bioavailability of poorly water-soluble drug molecules. The availability of commercially available products further validates the utility of solid dispersion technology in drug delivery systems.</p><p><strong>Conclusion: </strong>In the current manuscript, an attempt has been made to highlight the comprehensive development techniques, characterization techniques, recent solid dispersion technologies, clinical trial studies, and patented technology, along with studies heightening the dissolution behavior of numerous poorly aqueous soluble drugs. The major stability issues affecting the suitability of solid dispersions are also discussed.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"216-240"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Rutin: A Promising Solution for Alleviating Various Disorders.","authors":"Gunjan Nautiyal, Neha Minocha, Shiv Kant Sharma, Kiran Yadav, Dhirender Kaushik, Parijat Pandey","doi":"10.2174/0118722105310674240822115457","DOIUrl":"10.2174/0118722105310674240822115457","url":null,"abstract":"<p><strong>Background: </strong>Rutin, often known as vitamin P, is a natural flavonoid compound, which offers a broad spectrum of therapeutic potentials. Rutin is metabolised to different compounds by the gut bacteria after consumption, therefore, very little is absorbed. Higher plants contribute to rutin synthesis in large quantities, and it may also be found in many fruits and fruity rinds, particularly citrus fruits and berries.</p><p><strong>Objective: </strong>The present paper highlights several studies and patents conducted on rutin along with its nanoformulations regarding its broad spectrum of therapeutic potentials.</p><p><strong>Methods: </strong>Numerous electronic databases, including Springer, PubMed, Science Direct, Pubchem, Google Patents etc. were searched to extract relevant published literature demonstrating rutin effectiveness in various ailments.</p><p><strong>Results: </strong>The reviewed literature showed that rutin and related flavonoids possess a variety of physiological properties that protects human beings, plants and animals. Antioxidant, anti-inflammatory, anti-allergic, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, cardioprotective, antibacterial, antiviral, antiprotozoal, antitumor, anti-hypertensive antiplatelet, antispasmodic and hypolipidemic, activities. Nanotechnology has been implemented for the improvement of the bioavailability of rutin using novel drug-delivery carriers.</p><p><strong>Conclusion: </strong>The study concludes that the development of rutin nanoformulations for multiple therapeutic approaches contributes towards enhanced aqueous solubility as well as tailored pharmacokinetics compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"592-608"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Tribological Characteristics of Titanium Grade-5 Alloy through HVOF Thermal-Sprayed WC-Co Nano Coatings by TOPSIS and Golden Jack Optimization Algorithm.","authors":"S Thirumalvalavan, G Perumal, N Senthilkumar, S Selvarasu","doi":"10.2174/0118722105306841240808092616","DOIUrl":"10.2174/0118722105306841240808092616","url":null,"abstract":"<p><strong>Background: </strong>Thermal spray coatings have emerged as a pivotal technology in materials engineering, primarily for augmenting the characteristics related to wear and tribology of metallic substrates.</p><p><strong>Methods: </strong>This study aims to develop into applying High-Velocity Oxygen Fuel (HVOF) thermalsprayed WC-Co nanocoatings on Titanium Grade-5 alloy (Ti64). The coating process, utilizing nano-sized WC-Co powder, undergoes systematic optimization of HVOF parameters, encompassing the flow rate of carrier gas, powder feed rate, and nozzle distance. Experimental assessments via Pin-on-Disc (PoD) tests encompass Loss of Wear (WL), Friction Coefficient (CoF), and Frictional Force (FF). Later, an exhaustive optimization of responses is conducted using the Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) method and the golden jack optimization algorithm (GJOA).</p><p><strong>Results: </strong>Outcomes show a substantial increase in WL, CoF, and FF with a rise in the carrier gas and powder feed rate. However, with increasing spraying distance of powder, the WL, CoF, and FF tend to lower due to higher bonding, which leads to increased wear resistance. The ideal parametric settings achieved from TOPSIS and GJOA are 245 mm of spray distance, 30 gpm rate of powder feed, and 11 lpm of carrier gas flow rate. The powder feed rate contributes 88.99% to the control action, as seen from ANOVA.</p><p><strong>Conclusion: </strong>The confirmation experiment presents that the WL, CoF, and FF output responses are 42.33, 27.97, and 9.38% less than the mean of experimental data. These results highlight the HVOF process in spraying WC-Co nanocoatings to fortify the durability and performance of Ti64 alloy that can be patented for diverse engineering applications.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"544-567"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Nanophotonic Graphene Systems: A Transformative Innovation for Transdermal Drug Delivery.","authors":"Dilpreet Singh, Mandavi Pandey","doi":"10.2174/0118722105329862240919075834","DOIUrl":"10.2174/0118722105329862240919075834","url":null,"abstract":"<p><p>Transdermal Drug Delivery Systems (TDDSs) offer non-invasive administration and sustained drug release, enhancing patient compliance. However, the skin's natural barrier, particularly the stratum corneum, limits the effectiveness of TDDS for high molecular weight and hydrophilic substances. Innovations in material science, particularly hybrid nanophotonic graphene systems, present promising solutions. Nanophotonics generate localized photothermal effects to create microchannels in the skin, while graphene enhances permeability through its electrical and thermal conductivity. Hybrid nanophotonic systems, such as photonic crystals, plasmonic nanoparticles, metamaterials, quantum dots, nanowires, fiber optic nanosensors, and nanoantennas, offer precise control and real-time monitoring for applications in cancer therapy, chronic pain management, targeted drug delivery, and personalized medicine. This perspective examines the design, effectiveness, biocompatibility, and clinical implications of these hybrid systems, highlighting their potential to expand transdermal drug delivery and revolutionize treatment in personalized medicine. This particular formulation holds patentability, as supported by product patents that highlight the advancements in hybrid nanophotonic graphene systems for transdermal drug delivery.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"160-165"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}