Recent Patents on Nanotechnology最新文献

{"title":"Nano-Rutin: A Promising Solution for Alleviating Various Disorders.","authors":"Gunjan Nautiyal, Neha Minocha, Shiv Kant Sharma, Kiran Yadav, Dhirender Kaushik, Parijat Pandey","doi":"10.2174/0118722105310674240822115457","DOIUrl":"10.2174/0118722105310674240822115457","url":null,"abstract":"<p><strong>Background: </strong>Rutin, often known as vitamin P, is a natural flavonoid compound, which offers a broad spectrum of therapeutic potentials. Rutin is metabolised to different compounds by the gut bacteria after consumption, therefore, very little is absorbed. Higher plants contribute to rutin synthesis in large quantities, and it may also be found in many fruits and fruity rinds, particularly citrus fruits and berries.</p><p><strong>Objective: </strong>The present paper highlights several studies and patents conducted on rutin along with its nanoformulations regarding its broad spectrum of therapeutic potentials.</p><p><strong>Methods: </strong>Numerous electronic databases, including Springer, PubMed, Science Direct, Pubchem, Google Patents etc. were searched to extract relevant published literature demonstrating rutin effectiveness in various ailments.</p><p><strong>Results: </strong>The reviewed literature showed that rutin and related flavonoids possess a variety of physiological properties that protects human beings, plants and animals. Antioxidant, anti-inflammatory, anti-allergic, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, cardioprotective, antibacterial, antiviral, antiprotozoal, antitumor, anti-hypertensive antiplatelet, antispasmodic and hypolipidemic, activities. Nanotechnology has been implemented for the improvement of the bioavailability of rutin using novel drug-delivery carriers.</p><p><strong>Conclusion: </strong>The study concludes that the development of rutin nanoformulations for multiple therapeutic approaches contributes towards enhanced aqueous solubility as well as tailored pharmacokinetics compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"592-608"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Patents on Solid Dispersions Emphasize Promising Benefits in Solubility Enhancement of Poorly Water-soluble Drugs.","authors":"Manisha Saini, Shailender Bhatt, Harish Dureja, Neeta Solanki","doi":"10.2174/0118722105229356231030065938","DOIUrl":"10.2174/0118722105229356231030065938","url":null,"abstract":"<p><strong>Background: </strong>In the development of drug delivery systems, drugs' solubility remains the most challenging constraint. Many newly synthesized chemical compounds are available, but they involve low solubility and poor permeability restrictions. Among various drug delivery systems, the utilization of solid dispersion technologies has become more focused due to their promising benefits.</p><p><strong>Objective: </strong>This technology has attracted extensive attention for dissolution rate improvement along with substantial bioavailability enhancement of poorly water-soluble drug candidates.</p><p><strong>Methods: </strong>Many approaches have been employed for preparing solid dispersions, such as the melting method, hot melt extrusion, solvent evaporation process, fusion and kneading method, spray drying technique, co-grinding and freeze drying, supercritical fluid technology, etc. Results: A wide variety of hydrophilic and hydrophobic materials are available as carriers, which are employed in the formulation of solid dispersions. Depending on the carrier characteristics, immediate- release solid dispersions and/or controlled-release solid dispersions can be formulated. Multiple hydrophilic materials have been explored for heightening dissolution features with enhanced bioavailability of poorly water-soluble drug molecules. The availability of commercially available products further validates the utility of solid dispersion technology in drug delivery systems.</p><p><strong>Conclusion: </strong>In the current manuscript, an attempt has been made to highlight the comprehensive development techniques, characterization techniques, recent solid dispersion technologies, clinical trial studies, and patented technology, along with studies heightening the dissolution behavior of numerous poorly aqueous soluble drugs. The major stability issues affecting the suitability of solid dispersions are also discussed.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"216-240"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138463947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide (GO) Layered Bioconjugates: An Effective Strategy for Delivering p53 Gene for Adenocarcinoma.","authors":"Dilpreet Singh","doi":"10.2174/0118722105290129240122104901","DOIUrl":"10.2174/0118722105290129240122104901","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"568-571"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid Nanophotonic Graphene Systems: A Transformative Innovation for Transdermal Drug Delivery.","authors":"Dilpreet Singh, Mandavi Pandey","doi":"10.2174/0118722105329862240919075834","DOIUrl":"10.2174/0118722105329862240919075834","url":null,"abstract":"<p><p>Transdermal Drug Delivery Systems (TDDSs) offer non-invasive administration and sustained drug release, enhancing patient compliance. However, the skin's natural barrier, particularly the stratum corneum, limits the effectiveness of TDDS for high molecular weight and hydrophilic substances. Innovations in material science, particularly hybrid nanophotonic graphene systems, present promising solutions. Nanophotonics generate localized photothermal effects to create microchannels in the skin, while graphene enhances permeability through its electrical and thermal conductivity. Hybrid nanophotonic systems, such as photonic crystals, plasmonic nanoparticles, metamaterials, quantum dots, nanowires, fiber optic nanosensors, and nanoantennas, offer precise control and real-time monitoring for applications in cancer therapy, chronic pain management, targeted drug delivery, and personalized medicine. This perspective examines the design, effectiveness, biocompatibility, and clinical implications of these hybrid systems, highlighting their potential to expand transdermal drug delivery and revolutionize treatment in personalized medicine. This particular formulation holds patentability, as supported by product patents that highlight the advancements in hybrid nanophotonic graphene systems for transdermal drug delivery.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"160-165"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-phase Hybrid Thermal Interface Alkali-treated E-Glass Fiber/MWCNT/Graphene/Copper Oxide Nanocomposites for Electronic Gadgets.","authors":"Swaminathan Ramu, Natarajan Senthilkumar, Balakrishnan Deepanraj","doi":"10.2174/0118722105296725240308094344","DOIUrl":"10.2174/0118722105296725240308094344","url":null,"abstract":"<p><strong>Introduction: </strong>Two-phase hybrid mode thermal interface materials were created and characterized for mechanical properties, thermal conductivity, and wear behaviour. Therefore, the ultimate goal of this current research was to use alkali-treated glass fibre and other allotropes to produce high-performance two-phase thermal interface materials that can be patented for engineering applications.</p><p><strong>Methods: </strong>Three different polymer composites were prepared to contain 20 vol.% alkalies (NaOH) treated e-glass fibre (E) and epoxy as a matrix with varying proportions of multi-walled carbon nanotube (MWCNT), graphene (G), copper oxide (C). The one-phase material contained epoxy+20%e-glass+1%MWCNT (EMGC1), the two-phase hybrid composite contained epoxy+20%e-glass+1%MWCNT+1%graphene+1%CuO (EMGC2), and two-phase material contained epoxy+20%e-glass+1%graphene+1%CuO (EMGC3). Vacuum bagging method was used for fabricating the composites.</p><p><strong>Results: </strong>The higher thermal conductivity observed was 0.3466 W/mK for EMGC2, the alkalitreated glass fibre/hybrid mode nanofillers epoxy matrix composite was mechanically tougher than the other two composites (EMGC1 & EMGC3). Scanning electron microscopy analysis revealed the fine filler dispersion and homogenous interaction with the glass fibre/epoxy resin composite of the upper and lower zone, which also revealed the defective zone, fibre elongation, fibre/filler breakages, and filler leached surfaces.</p><p><strong>Conclusion: </strong>Finally, it was concluded that the hybrid mode two-phased structure EMGC2 epoxy matrix composite replicated the maximum thermal conductivity, mechanical properties, and wear properties of the other two specimens.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"511-523"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patent Analysis on Nano Drug Delivery Systems.","authors":"Dengyu Li, Wen Luo, Shengwei Yin, Ying Wang, Yanqing Zhao, Shiwei Zhu, Junfeng Yu, Ping Yang, Lina Zhang, Zhuyan Xi","doi":"10.2174/0118722105293359240626070342","DOIUrl":"10.2174/0118722105293359240626070342","url":null,"abstract":"<p><strong>Background: </strong>A nano drug delivery system is an effective tool for drug delivery and controlled release, which is used for a variety of medical applications. In recent decades, nano drug delivery systems have been significantly developed with the emergence of new nanomaterials and nanotechnologies.</p><p><strong>Objective: </strong>This article aimed to provide insight into the technological development of nano drug delivery systems through patent analysis.</p><p><strong>Methods: </strong>3708 patent documents were used for patent analysis after retrieval from the Incopat patent database.</p><p><strong>Results: </strong>The number of patents on nano drug delivery systems has shown a rapid growth trend in the past two decades. At present, China and the United States have obvious contributions to the number of patents. According to the patent data, the nanomaterials used in nano drug delivery system are mainly inorganic nanomaterials, lipid-based nanomaterials, and macromolecules. In recent years, the highly cited patents (≥14) for nano drug delivery systems mainly involve lipid-based nanomaterials, indicating that their technology is mature and widely used. The inorganic nanomaterials in drug delivery have received increasing attention, and the number of related patents has increased significantly after 2016. The number of highly cited patents in the United States is 250, which is much higher than in other countries.</p><p><strong>Conclusion: </strong>Even after decades of development, nano drug delivery systems remain a hot topic for researchers. The significant increase in patents since 2016 can be attributed to the large number of new patents from China. However, according to the proportion of highly cited patents in total, China's patented technologies in nano drug delivery systems are not advanced enough compared to developed countries, including the United States, Canada, Germany, and France. In the future, research on emerging nanomaterials for nano drug delivery systems, such as inorganic nanomaterials, may focus on developing new materials and optimising their properties. The lipid-based and polymer- based nanomaterials can be continuously improved for the development of new nanomedicines.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"609-628"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Nanotheranostics: The Fabrication of Theranostics with Nanoparticles and their Application to Treat the Neurological Disorders.","authors":"Astha Singh, Aakriti Patel, Hema Chaudhary, Kiran Yadav, Neha Minocha","doi":"10.2174/187221051902250224124215","DOIUrl":"https://doi.org/10.2174/187221051902250224124215","url":null,"abstract":"<p><p>The error was noted after the publication of the article titled 'Nanotheranostics: The Fabrication of Theranostics with Nanoparticles and their Application to Treat the Neurological Disorders'', published in Recent Patents on Nanotechnology, 2025, 1, 17-34 [1], that a part of the text was inadvertently omitted. The missing text has now been included as: The original article can be found online at: https://www.eurekaselect.com/article/132973 We regret the error and apologize to readers. Details of the error and a correction are provided here. Original: Nanotheranostic However, we may encounter more significant difficulties with their in vivo studies by invalidating their safety and efficacy before clinical applications. Corrected: Nanotheranostic systems are being utilised in addition to imaging and treatment to track pharmacokinetics, the dispersion of particles in the tissue, and drug accumulation at the target site. Using this cutting-edge technology, a thorough understanding of the pathophysiology of neurological illnesses has been attained. The manufacture and physiochemical characterisation of nanotheranostics has been the main foci of notable in vitro studies in the current situation. However, we may encounter more significant difficulties with their in vivo studies by invalidating their safety and efficacy before clinical applications.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"19 2","pages":"310"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation.","authors":"Berlin Grace Viswanathan Mariammal, David Wilson Devarajan, Siddikuzzaman, Viswanathan Singaram, Ragavi Ravichandran, Guruvayoorappan Chandrasekharan, Kathirvelan Chinnadurai","doi":"10.2174/0118722105246143231016105620","DOIUrl":"10.2174/0118722105246143231016105620","url":null,"abstract":"<p><strong>Background: </strong>The molecular drug all-trans retinoic acid (ATRA) acts on cancer cells via different molecular pathways, but its poor bioavailability in cancer cells limits its potency. Recently few patents have been published for the development of liposome-based drug for enhanced action. This study was, therefore, carried out to analyse the oncogene expressions in the lung tissue of benzo[ a]pyrene (B[a]P)-induced mice and compare between free ATRA and cationic liposome nanoformulation (lipo-ATRA) treatments.</p><p><strong>Objective: </strong>This study was designed to analyse the changes in the expression levels of epidermal growth factor receptor (EGFR) and B-Raf in the lung tissues of B[a]P-induced mice during the cancer development stage itself and to find the suppressive effect of free ATRA and lipo-ATRA.</p><p><strong>Methods: </strong>Lung cancer was induced in mice by oral ingestion of 50mg/kg body weight B[a]P weekly twice for four consecutive weeks. Then, the mice were treated with free and lipo-ATRA (0.60 mg/kg) for 30 days via i.v injection. The EGFR and B-Raf gene expressions were analyzed in lung cells by reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>The RT-PCR gene band density and the relative quantity (RQ) values from qPCR revealed both EGFR and B-Raf genes to be significantly overexpressed in B[a]P control mice while having very low or no expression in normal mice. This indicates that they function as oncogenes in B[a]P-induced lung carcinogenesis. The lipo-ATRA treatment has shown a highly significant increase in RQ values for both EGFR and BRaf when compared to the free ATRA treatment.</p><p><strong>Conclusion: </strong>The study results have revealed the cationic lipo-ATRA treatment to have enhanced the bioavailability of ATRA in lung tissue due to its significant suppression action on EGFR-mediated oncogenes' expressions. Furthermore, the EGFR and BRaf could be the molecular targets of ATRA action in lung carcinogenesis.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"131-139"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Detailed Study on using Novel LM 25 Aluminium Alloy Hybrid Metal Matrix Nanocomposite for Nuclear Applications.","authors":"S C V Ramana Murty Naidu, Suresh Vellingiri, Paulraj Prabhu, Beporam Iftekhar Hussain, Abdul Rab Asary, Govindarajulu Padmanaban, Mukuloth Srinivasnaik, Kunnathur Periyasamy Yuvaraj","doi":"10.2174/0118722105286121240214062457","DOIUrl":"10.2174/0118722105286121240214062457","url":null,"abstract":"<p><strong>Aim: </strong>This article describes the use of graphite (Gr) and boron carbide (B4C) as multiple nanoparticle reinforcements in LM25 aluminum alloy. Because boron carbide naturally absorbs neutron radiation, aluminium alloy reinforced with boron carbide metal matrix composite has gained interest in nuclear shielding applications. The primary goal of the endeavor is to create composite materials with high wear resistance, high microhardness, and high ultimate tensile strength for use in nuclear applications. Patents on Gr and B4C can cover a wide range of subjects, including the synthesis and production methods of structural, armor materials, abrasives, and nuclear shielding.</p><p><strong>Background: </strong>Science and Technology have brought a vast change to human life. The human burden has been minimized by the use of innovation in developing new and innovative technologies. To improve the quality of human life, fresh, lightweight, and creative materials are being used, which play a vital role in science and technology and reduce the human workload. Composite materials made of metal are being used because they are lightweight. Neutron absorption, high ultimate strength, high wear resistance, high microhardness, high thermal and electrical conductivity, high vacuum environmental resistance, and low coefficient of thermal expansion under static and dynamic conditions are all demands for the hybrid metal matrix composites utilized in nuclear applications.</p><p><strong>Objective: </strong>Stir casting is used to create the novel LM 25 aluminum alloy/graphite and boron carbide hybrid nanocomposites. The mechanical properties such as ultimate tensile strength, yield strength, percentage of elongation, microhardness, and wear behavior are calculated. Three analyses are performed: microstructure, worn surface analysis, and fracture analysis of the tensile specimen.</p><p><strong>Methods: </strong>(1) Stir casting process. (2) Tensile, hardness, wear test. (3) Materials characterization - FESEM, optical microscopy, EDS.</p><p><strong>Results: </strong>The mechanical properties values are 308.76 MPa, 293.51 MPa, 7.8, 169.2 VHN, and 0.01854 mm3/m intended for ultimate tensile strength, yield strength, percentage of elongation, microhardness, and wear behavior, respectively. This implies that the synthesized composite may be used in nuclear applications successfully.</p><p><strong>Conclusion: </strong>The subsequent explanation was drawn from this investigative work: The LM 25/B4C/Gr hybrid nanocomposite was successfully manufactured by employing the stir casting technique. For nuclear shielding applications, these composites were prepared with three different weight percentages of nanoparticle reinforcements in 2,4,6% Boron carbide and constant 4 wt.% graphite. The microhardness values of the three-hybrid nanocomposite fabricated castings were determined to be 143.4VHN, 156.7VHN, and 169.2VHN, respectively. The hybrid nano composite's micro","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"498-510"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-coatings and Nanoscale Composites for Hazardous Environments.","authors":"N Senthilkumar","doi":"10.2174/187221051904241220142602","DOIUrl":"https://doi.org/10.2174/187221051904241220142602","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"19 4","pages":"524"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}