Recent Patents on Nanotechnology最新文献

{"title":"Enhanced Anti-Proliferative Effect of Carboplatin in Ovarian Cancer Cells Exploiting Chitosan-Poly (Lactic Glycolic Acid) Nanoparticles.","authors":"Fatima Redah Alassaif,&nbsp;Eman Redah Alassaif,&nbsp;Amit Kumar Kaushik,&nbsp;Jeevitha Dhanapal","doi":"10.2174/1872210516666220111160341","DOIUrl":"https://doi.org/10.2174/1872210516666220111160341","url":null,"abstract":"<p><strong>Objective: </strong>The present article aimed to enhance the therapeutic efficacy of carboplatin (CP) using the formulation of chitosan-poly (lactic glycolic acid) nanoparticles (CS-PLGA NPs).</p><p><strong>Methods: </strong>Nanoparticles were synthesized by an ionic gelation method and were characterized for their morphology, particle size, and surface potential measurements by TEM and zeta sizer. This study was highlighted for the evaluation of drug entrapment, loading and in vitro drug release capabilities of the prepared nanoparticles by spectrophotometric analysis. The stability study was also conducted after 3 months for their particle size, zeta potential, drug loading and encapsulation efficiencies. Further, ovarian cancer cell line PEO1 was used to evaluate the toxicity and efficacy of nano-formulation by MTT assay. Additionally, the study was evaluated for apoptosis using flow cytometric analysis.</p><p><strong>Results: </strong>The CS-PLGA-CP NPs were uniform and spherical in shape. The particle size and zeta potential of CS-PLGA-CP NPs were measured to be 156 ±6.8 nm and +52 ±2.4 mV, respectively. High encapsulation (87.4 ± 4.5%) and controlled retention capacities confirmed the efficiency of the prepared nanoparticles in a time and dose-dependent manner. The cytotoxicity assay results also showed that CS-PLGA-CP NPs have a high efficiency on PEO1 cells compared to the free drug. The flow cytometric result showed 64.25% of the PEO1 cells were apoptotic, and 8.42% were necrotic when treated with CS-PLGA-CP NPs.</p><p><strong>Conclusion: </strong>Chitosan-PLGA combinational polymeric nanoparticles were not only steady but also non-toxic. Our experiments revealed that the chitosan-PLGA nanoparticles could be used as a challenging vehicle candidate for drug delivery for the therapeutic treatment of ovarian cancer.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 1","pages":"74-82"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9217287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Silver Nanoparticles of <i>Vernonia cinerea</i> Leaf Extract and their <i>In vitro</i> Cytotoxicity Activity against Neuroblastoma SHSY-5Y Cell Lines, Antimicrobial and Antioxidant Studies.","authors":"Narahari N Palei,&nbsp;S Navaneetha Krishnan,&nbsp;R Jayaraman,&nbsp;S Hemanth Reddy,&nbsp;Anna Balaji,&nbsp;Malay K Samanta,&nbsp;Bibhash C Mohanta","doi":"10.2174/1872210516666220520144453","DOIUrl":"https://doi.org/10.2174/1872210516666220520144453","url":null,"abstract":"<p><strong>Background: </strong>Green syntheses of silver nanoparticles using plant extracts have potential anti- cancer, antimicrobial, and antioxidant properties, among other aspects. The aim of the present patent study was to synthesize silver nanoparticles (AgNPs) using Vernonia cinerea plant extract.</p><p><strong>Methods: </strong>The AgNPs were successfully prepared and characterized using UV-Vis Spectrophotometer, particle size, Zeta potential, Transmission electron microscopy (TEM), Energy-dispersive x-ray analysis (EDAX), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectrometry. The in vitro cytotoxicity study was performed using neuroblastoma SHSY-5Y cell lines. Moreover, antimicrobial and antioxidant activity studies were also performed for AgNPs.</p><p><strong>Results: </strong>The size of AgNPs determined through the dynamic light scattering (DLS) technique was 49.5 nm and the zeta potential was -36.8 mV. The synthesized AgNPs were checked using UV-Visible spectroscopy at ƛmax 439 nm. The color was changed from green to dark brown, indicating the formation of AgNPs. The TEM study revealed that the nanoparticles were spherical in shape. The XRD pattern of AgNPs produced in this experiment was apparently crystalline. The results of FTIR study revealed that the majority of the obtained peaks correspond to the polyphenols, triterpenoids, and alkaloids which were abundant in the corresponding to the V. cinerea leaf extract and support to the formation of AgNPs. The cytotoxicity effect of the V. cinerea plant extract and biosynthesized AgNPs was found to be dosedependent. From the results of antimicrobial studies, it was reported that the gram negative bacteria were found to be more susceptible compared to the gram positive bacteria. Moreover, the results of antioxidant study revealed that the AgNPs showed good antioxidant activity (77.21%) in comparison to the V. cinerea plant extract (56.13%).</p><p><strong>Conclusion: </strong>Based on the results, it could be concluded that the green synthesized silver nanoparticles showed promising anticancer, antioxidant, and anti-bacterial activities as compared to the plain V. cineria plant extract.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"270-280"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Discursive Review of Recent Development and Patents on Glycerosomes.","authors":"Singh Ragini,&nbsp;Fatima Zeeshan,&nbsp;Srivastava Dipti,&nbsp;Awasthi Himani","doi":"10.2174/1872210516666220328124450","DOIUrl":"https://doi.org/10.2174/1872210516666220328124450","url":null,"abstract":"<p><strong>Background: </strong>To achieve a target-based drug delivery with minimal side effects, novel drug delivery systems are being continuously explored. Vesicular systems are one such system that can ameliorate the bioavailability of the encapsulated drug by delivering the drug at the targeted site and can minimize the side effect.</p><p><strong>Objective: </strong>The objective of this patent review is to provide a vivid description of glycerosomes and their applications. Glycerosomes are sphere-shaped versatile vesicles consisting of one or more phospholipid bilayers similar to liposomes but contain a high concentration of glycerol, which modifies the liposome bilayer fluidity. Glycerosomes can encapsulate both hydrophobic and hydrophilic drugs, which makes them the promising vehicle in the field of drug delivery.</p><p><strong>Conclusion: </strong>Most of the glycerosome formulations prepared were targeted for topical delivery and in particular, a cutaneous route where they have shown promising results. These vesicles are biocompatible and due to the high glycerol concentration, they have improved spreadability and penetrability. It is therefore imperative to explore the other topical routes such as ocular, vaginal, nasal, and rectal for delivery of drugs.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"183-189"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9384528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Bismuth Tungstate/Preoxidized Acrylonitrile/Acrylic Acid Copolymer Composite Nanofiber Membrane and Its Photocatalytic Properties.","authors":"Yinchun Fang,&nbsp;Xinhua Liu,&nbsp;Hongzhang Li,&nbsp;Yanchun Liu","doi":"10.2174/1872210516666220513094531","DOIUrl":"https://doi.org/10.2174/1872210516666220513094531","url":null,"abstract":"<p><strong>Background: </strong>In this patent article, a novel bismuth tungstate/preoxidized acrylonitrile/ acrylic acid (AN/AA) copolymer composite nanofiber membrane was prepared, which was used as the visible light catalyst.</p><p><strong>Methods: </strong>AN/AA copolymer was synthesized, which was electrospun with bismuth nitrate and sodium tungstate to prepare the composite nanofiber. Then the composite nanofiber was preoxidized to prepare the bismuth tungstate/preoxidized AN/AA composite nanofiber membrane containing adsorption moiety and photocatalytic active moiety.</p><p><strong>Results: </strong>The photocatalytic activity of bismuth tungstate/preoxidized AN/AA composite nanofiber membrane with different preoxidized temperature, heating rate, and holding time by catalytic degradation of methylene blue was investigated. The optimal preoxidized conditions were as follows: the preoxidized temperature was heated to 200 °C with the heating rate of 1°C/min and the holding time at this temperature was 12 h. The chemical structure and morphology of the composite nanofiber membrane were characterized by FTIR, XRD, and SEM.</p><p><strong>Conclusion: </strong>The bismuth tungstate/preoxidized AN/AA composite nanofiber membrane obtained good photocatalytic properties and reusability under visible light. The degradation rate of methylene blue by this visible light catalyst could reach 90.24% for 4.5 h, and the degradation rate remained 81.53% for 4.5 h after 5 reuses.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"144-149"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10655330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Polyvinylpyrrolidone on Polyvinylidene Fluoride/Hydroxyapatite- Blended Nanofiltration Membranes: Characterization and Filtration Properties.","authors":"Gunawan Setia Prihandana,&nbsp;Tutik Sriani,&nbsp;Muslim Mahardika","doi":"10.2174/1872210516666220302095010","DOIUrl":"https://doi.org/10.2174/1872210516666220302095010","url":null,"abstract":"<p><strong>Introduction: </strong>The application of polyvinylidene fluoride (PVDF) as a filtration membrane is limited due to its hydrophobicity. This paper elaborated on the fabrication process of nanofiltration PVDF membrane incorporating various quantities of hydrophilic polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) using a wet phase inversion method to improve its hydrophilicity.</p><p><strong>Methods: </strong>The membrane was fabricated by using the wet phase inversion method. It was then characterized in terms of water permeability, water contact angle, water content, surface energy, and surface porosity. Bacteria and Fe ions filtration was conducted to investigate the membrane filtration performance.</p><p><strong>Results: </strong>The PVDF/PVP/HA-blended membrane showed the highest water permeability (6,165 LMH/Bar), water content (45.2 %), and surface energy (104.1 mN/m) when 2 wt.% of PVP was introduced into the base polymer PVDF. This fabricated membrane, labeled as PVP 2.0, also showed the lowest contact angle (64°) and the highest surface porosity (42%).</p><p><strong>Conclusion: </strong>Overall, the PVP introduction patents into the polymeric membrane doping solution potentially improves membrane hydrophilicity and permeability.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 1","pages":"51-58"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10710689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progresses in Nano-Enabled Platforms for the Treatment of Vaginal Disorders.","authors":"Riya Patel,&nbsp;Bindu Kumari Yadav,&nbsp;Gayatri Patel","doi":"10.2174/1872210516666220628150447","DOIUrl":"https://doi.org/10.2174/1872210516666220628150447","url":null,"abstract":"<p><strong>Background: </strong>The most common vaginal disorders are within the uterus. According to the latest statistics, vaginal disorders occur in 50% to 60% of females. Although curative treatments rely on surgical therapy, still first-line treatment is a non invasive drug. Conventional therapies are available in the oral and parenteral route, leading to nonspecific targeting, which can cause dose-related side effects. Vaginal disorders are localized uterine disorders in which intrauterine delivery via the vaginal site is deemed the preferable route to mitigate clinical drug delivery limitations.</p><p><strong>Objective: </strong>This study emphasizes the progress of site-specific and controlled delivery of therapeutics in the treatment of vaginal disorders and systemic adverse effects as well as the therapeutic efficacy.</p><p><strong>Methods: </strong>Related research reports and patents associated with topics are collected, utilized, and summarized the key findings.</p><p><strong>Results: </strong>The comprehensive literature study and patents like (US 9393216 B2), (JP6672370B2), and (WO2018041268A1) indicated that nanocarriers are effective above traditional treatments and have some significant efficacy with novelty.</p><p><strong>Conclusion: </strong>Nowadays, site-specific and controlled delivery of therapeutics for the treatment of vaginal disorders is essential to prevent systemic adverse effects and therapeutic efficacy would be more effective. Nanocarriers have therefore been used to bypass the problems associated with traditional delivery systems for the vaginal disorder.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"208-227"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9171754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Silver Nanoparticles Using <i>Datura metel</i> Flower Extract Assisted by Ultrasound Method and Its Antibacterial Activity.","authors":"Is Fatimah,&nbsp;Habibi Hidayat,&nbsp;Bambang Nugroho,&nbsp;Saddam Husein","doi":"10.2174/1872210515666210614165105","DOIUrl":"https://doi.org/10.2174/1872210515666210614165105","url":null,"abstract":"<p><strong>Background: </strong>Green synthesis method of nanoparticles has been developed for several years. Besides providing environmental-friendly process, green synthesis of nanoparticles using plant extract provides synergistic effect of the secondary metabolite in such antibiotic activity. The study with an intensification process in nanoparticles formation is also gaining great attention. This research deals with the green synthesis of silver nanoparticles using Datura metel flower extract for the antibacterial agent. The use of ultrasound-assisted method for the synthesis was investigated.</p><p><strong>Methods: </strong>Synthesis of silver nanoparticles (AgNPs) using Datura metel flower extract under ultrasound- assisted method has been conducted. Evaluation of the successful synthesis was done using UV-visible spectrophotometry, particle size analyzer, x-ray diffraction, and transmission electron microscopy. The prepared AgNPs were tested as an antibacterial against S. aureus, K. pneumoniae, S. pyogenes, and E. coli.</p><p><strong>Results: </strong>The ultrasound-assisted synthesis of AgNPs produces particles ranging from 25-70 nm in size; meanwhile, the reflux method demonstrated the size of 50-170 nm. These particles size represents the effect on the antibacterial activity as the ultrasound-assisted synthesized Ag NPs have higher inhibition zone towards all tested bacteria. Subsequently, these data presented the applicability of Ag NPs synthesis using an ultrasound method as a potential candidate for biomedical applications.</p><p><strong>Conclusion: </strong>The profile of UV-Visible spectra and particle size analyses demonstrated the applicability of the ultrasound technique to produce a smaller size of the nanoparticles with higher antibacterial activity.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 1","pages":"68-73"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9232270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passive Solar-driven Interfacial Evaporation Nanosystems: Beyond Desalination Towards Multiple Applications.","authors":"Minhao Sheng,&nbsp;Xiaoqing Bin,&nbsp;Yawei Yang,&nbsp;Wenxiu Que","doi":"10.2174/1872210516666220203093217","DOIUrl":"https://doi.org/10.2174/1872210516666220203093217","url":null,"abstract":"<p><p>Recently, passive solar-driven interfacial evaporation has become one of the fastest-growing technologies for solar energy utilization and desalination. Herein this patent, we provide an overview of other emerging and potential applications of evaporation nanosystems beyond desalination, i.e., electricity generation, organics rejection, and sterilization. These extended functions can be a benefit for energy and environmental issues.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"176-182"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9514938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Associate Board Member","authors":"E. Ghavanloo","doi":"10.2174/187221051704230410113823","DOIUrl":"https://doi.org/10.2174/187221051704230410113823","url":null,"abstract":"<jats:sec> <jats:title /> <jats:p /> </jats:sec>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68041251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid Lipid Nanoparticles: Peculiar Strategy to Deliver Bio-Proactive Molecules.","authors":"Neha Minocha,&nbsp;Nidhi Sharma,&nbsp;Ravinder Verma,&nbsp;Deepak Kaushik,&nbsp;Parijat Pandey","doi":"10.2174/1872210516666220317143351","DOIUrl":"https://doi.org/10.2174/1872210516666220317143351","url":null,"abstract":"<p><strong>Background: </strong>Novel Drug Delivery Systems (NDDS) provide numerous benefits compared to conventional dosage forms. Poor aqueous solubility, low bioavailability, frequent dosing, and particular hydrophilic lipophilic character of the drug are the biological factors associated with the traditional systems leading to the development of SLNs.</p><p><strong>Objective: </strong>For improving the solubility profile, enhancing the bioavailability, and attaining the best possible therapeutic effect of lipid inclined or aqueous inclined drug, formulating solid lipid nanoparticles is the best choice.</p><p><strong>Methods: </strong>Solid Lipid Nanoparticles (SLNs) have been projected as a colloidal carrier system with a size of 50-1,000 nm, collectively combining the benefits of other colloidal systems like liposomes, emulsions, etc., for delivering the drug at the target site. High absorption, high stability, and efficient drug packing enhance the pharmacokinetic and pharmacodynamic properties of the packed drug.</p><p><strong>Result: </strong>Solid Lipid Nanoparticles can be developed in different dosage forms and administered via routes such as nasal, rectal, oral, topical, vaginal, ocular, and parenteral. They have higher physicochemical stability and the batch size can be easily scaled up at a low cost. Lipophilic as well as hydrophilic drugs can be easily incorporated into solid lipid nanoparticles.</p><p><strong>Conclusion: </strong>In this manuscript, the authors have reviewed different aspects of solid lipid nanoparticles, major principles behind mechanism methods, recent patents, applications, and therapeutic potentials of solid lipid nanoparticles.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"228-242"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9165973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}