Recent Patents on Nanotechnology最新文献

{"title":"Synthesis, Characterization, and Antibacterial Properties of ZnO Nanostructures Functionalized Flexible Carbon Fibers.","authors":"Ahmet Aykaç,&nbsp;Emine Özge Akkaş","doi":"10.2174/1872210516666220414103629","DOIUrl":"https://doi.org/10.2174/1872210516666220414103629","url":null,"abstract":"<p><strong>Background: </strong>Studies on the surface functionalization of flexible carbon fibers without any substrate by using cost-effective, fast, and practical processes that may provide antibacterial properties to carbon fiber have received great importance recently.</p><p><strong>Objective: </strong>The objective of this patent study is to obtain zinc oxide nanostructures functionalized carbon fibers by a facile, cheap, fast, and repeatable method, and to show their effective antibacterial activity.</p><p><strong>Methods: </strong>Electroplating and electrochemical anodization were used to synthesize zinc oxide nanostructures on carbon fiber surfaces, respectively, and their antibacterial properties were studied by zone inhibition test against Staphylococcus aureus and Pseudomonas aeruginosa.</p><p><strong>Results: </strong>The zinc oxide nanostructures on carbon fiber surfaces were successfully synthesized in minutes, and they exhibited effective antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. The morphological properties of the nanocomposite were studied using scanning electron microscopy, which showed that ZnO on the CF surface exhibits a flake-like nanostructure. Fourier transform infrared spectrophotometer, x-ray diffraction spectroscopy, Raman spectroscopy, and x-ray photoelectron spectroscopy were used to analyze the composite's compositional, structural, crystallographic, and spectral characteristics. The results from all analyses were in a good agreement, indicating that the wurtzite crystalline ZnO nanostructure was successfully produced on the CF surface.</p><p><strong>Conclusion: </strong>As a consequence, a method for the surface functionalization of carbon fiber using zinc oxide nanostructures has been developed that is feasible, low-cost, rapid, and repeatable. The flexible nanocomposite structure has a significant potential to be employed as a scaffold in sensor technology, wearable devices, and particularly in medical textiles due to its antibacterial and woven-able properties.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"119-130"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10656524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Nanotechnology in Photocatalysis Application.","authors":"Y M Hunge,&nbsp;A A Yadav,&nbsp;Seok-Won Kang,&nbsp;B M Mohite","doi":"10.2174/1872210516666220304162429","DOIUrl":"https://doi.org/10.2174/1872210516666220304162429","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 1","pages":"5-7"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Developments in Nano-Formulations Against Diabetes.","authors":"Swaralipi Choudhury,&nbsp;Prasun Patra","doi":"10.2174/1872210516666220622114505","DOIUrl":"https://doi.org/10.2174/1872210516666220622114505","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a life-threatening metabolic syndrome, but patient compliance is poor due to the pain and inconvenience caused by the subcutaneous injection of insulin and other macromolecular diabetic therapies. Current challenges in DM management are to optimize the use of available therapies and reduce complications. For clinical improvements, future therapies need to be easier to use, achieving tighter glycemic control, better safety profiles, and reduced manufacturing costs. The medical applications of nanotechnology are enormous and have been proven to be the best approach to improve compliance and clinical efficacy by overturning biopharmaceutical obstacles. Nanoformulations enhance the properties of conventional drugs and are specific to the targeted delivery site. The aim of the present review is to provide an overview of the application of nano-formulations in diabetes management. We analyze the current state of most of the available approaches which are in various stages of research and development. Herein, we review the developing role of nanotechnology in diabetes management and focus on the technologies that we feel are most likely to have an impact.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 4","pages":"340-358"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tomato as a Natural Source of Dyes in the Food Industry: A Patent Data Analysis.","authors":"Vanessa de Lima Silva,&nbsp;Bruna Santos Leite,&nbsp;Fabiane do Espírito Santo de Jesus,&nbsp;Lissa Daltro Martins,&nbsp;Larissa Santos Assunção,&nbsp;Ingrid Lessa Leal,&nbsp;Nelson Barros Colauto,&nbsp;Giani Andrea Linde Colauto,&nbsp;Bruna Aparecida Souza Machado,&nbsp;Camila Duarte Ferreira Ribeiro","doi":"10.2174/1872210516666220523114141","DOIUrl":"https://doi.org/10.2174/1872210516666220523114141","url":null,"abstract":"BACKGROUND Foods that promote health benefits are being increasingly used. Innovative techniques, such as nanotechnology, have been used to improve functional properties, sensory characteristics, or the conservation of foods. OBJECTIVE The objective of this study was to identify the technological domain of patents for tomato products with or without nanotechnology and elucidate the technological advances associated with the recent use of tomatoes as a natural food dye in the food industry by exploring patent documents. METHODS AND RESULTS The search was conducted using the Espacenet and INPI databases. There was an increase in patent document applications employing nanotechnology in 2013, with a peak between 2017 and 2018. China is the lead country in the number of patent applications. In Brazil, the patent applications are variable, and the food industry is most involved in studies on tomatoes as a natural food dye. Most patent deposits using nanotechnology were from companies, and the main sources of the patent application were the food and pharmaceutical industries. CONCLUSION There is an increasing trend for the use of tomatoes as natural food dyes, produced with or without nanotechnology, and number of patents filed yearly. New technologies are being developed in several application areas.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 3","pages":"243-258"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9540111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocrystals: A Deep Insight into Formulation Aspects, Stabilization Strategies, and Biomedical Applications.","authors":"Deepika Purohit,&nbsp;Shivkant Sharma,&nbsp;Avneet Kaur Lamba,&nbsp;Sapna Saini,&nbsp;Neha Minocha,&nbsp;Neelam Vashist,&nbsp;Dhirender Kaushik,&nbsp;Parijat Pandey","doi":"10.2174/1872210516666220523120313","DOIUrl":"https://doi.org/10.2174/1872210516666220523120313","url":null,"abstract":"<p><strong>Background: </strong>Drugs with poor solubility exhibit hurdles in their formulation due to poor dissolution and low bioavailability. Nanocrystallization is a great technique for incorporating poorly soluble drugs and is associated with many benefits.</p><p><strong>Objective: </strong>The objective of the present review is to discuss formulation techniques for the generation of Nanocrystals (NCs) and illustrate the various advantages of NCs. It also explains commonly used stabilizers and guidelines for their safe use for enhancing NCs and provides a deep insight into various biomedical applications of NCs.</p><p><strong>Methods: </strong>The review was extracted from the study carried out in the general literature to emphasize the importance of NCs in various formulations.</p><p><strong>Results: </strong>NCs are a widely accepted approach to enhancing drug solubility. There are so many marketed products of nanocrystal drug formulations that are being used to treat life-threatening disorders. Two techniques can be used to formulate NCs, i.e., the bottom-up method and the top-down method. Their main biomedical applications are found in oral, parenteral, pulmonary, ocular, dermal, and mucosal formulations.</p><p><strong>Conclusion: </strong>In the present review, different formulation methods of NCs have been discussed in detail, followed by explaining the advantages and various targeted drug delivery systems covered by NCs formulations. The development of NCs-based formulation avoids the limitations of other systems used for targeted drug delivery.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 4","pages":"307-326"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanovaccine: A Hope to Triumph the Battle Against Novel Coronavirus Disease 2019 (COVID-19).","authors":"Anurag Singh,&nbsp;Anand Maurya,&nbsp;Gaurav Mishra,&nbsp;Rajendra Awasthi,&nbsp;Kamal Dua,&nbsp;Giriraj Kulkarni","doi":"10.2174/1872210515666210720130736","DOIUrl":"https://doi.org/10.2174/1872210515666210720130736","url":null,"abstract":"<p><strong>Background: </strong>The novel coronavirus 2019 (COVID-19) infection has caused the global emergence of coronavirus in humans during the last 12 months. Till May 11, 2021, the confirmed global COVID-19 cases and deaths reached 158551526 and 3296855, respectively.</p><p><strong>Methods: </strong>Goblet cells and ciliated cells in the nose act as the initial infection site of SARS-CoV-2. Thus, mucus immunity is important to protect from infection. The outburst of SARS-CoV-2 infection can be halted only when an effective vaccine will be developed.</p><p><strong>Results: </strong>Globally, over 100 different vaccines are under investigation, including DNA vaccines, RNA vaccines, inactivated virus vaccines, adenovirus-based vaccines, recombinant/subunit protein vaccines, peptide vaccines, virus-like particles, etc. Inactivated virus vaccines and mRNA, and adenovirus-based vaccines have moved fast into patent clinical trials.</p><p><strong>Conclusion: </strong>Vaccines containing spike protein of SARS-CoV as subunit could effectively prevent binding of coronavirus to the host cell and membrane fusion. Thus, spike protein can be used as a major target for subunit vaccine preparation.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 1","pages":"15-17"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Coupled-/soluble-Copper, Generating from Copper-doped Titanium Dioxide Nanotubes on Cell Response.","authors":"Pengyu Gao,&nbsp;Xiao Luo,&nbsp;Benli Yin,&nbsp;Zhisha Jiao,&nbsp;JunJi Piao,&nbsp;Ansha Zhao,&nbsp;Ping Yang","doi":"10.2174/1872210516666220114120412","DOIUrl":"https://doi.org/10.2174/1872210516666220114120412","url":null,"abstract":"<p><strong>Background: </strong>Endothelialization in vitro is a very common method for surface modification of cardiovascular materials. However, mature endothelial cells are not suitable because of the difficulty in obtaining and immunogenicity.</p><p><strong>Methods: </strong>In this patent work, we determined the appropriate amount of copper by constructing a copper- loaded titanium dioxide nanotube array that can catalyze the release of nitric oxide, compared the effects of coupled-/soluble-copper on stem cells, and then induced stem cells to differentiate into endothelial cells.</p><p><strong>Results: </strong>The results showed that it had a strong promotion effect on the differentiation of stem cells into endothelial cells, which might be used for endothelialization in vitro.</p><p><strong>Conclusion: </strong>SEM and EDS results prove that a high content of copper ions are indeed doped onto the surface of nanotubes with small amounts of Cu release. The release of NO confirms that the release of several samples within a period of time is within the physiological concentration.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"150-158"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Characterization of Polymeric Microsponge as a New Vehicle to Deliver Urea Topically.","authors":"Lalit Kumar,&nbsp;Rahul Kumar,&nbsp;Syed Basit Hussain,&nbsp;Shivali Kumari,&nbsp;Yash Pal","doi":"10.2174/1872210516666220422134046","DOIUrl":"https://doi.org/10.2174/1872210516666220422134046","url":null,"abstract":"<p><strong>Background: </strong>Topical delivery of therapeutic agents is considered beneficial due to various advantages like ease of administration, avoidance of the first-pass effect, and improved patient compliance. Therefore, scientists around the globe are exploring this route for the delivery of drugs nowadays.</p><p><strong>Objective: </strong>The present patent investigation aimed to prepare, optimize, and characterize the urealoaded microsponges for efficient topical delivery in vitro.</p><p><strong>Methods: </strong>Urea-loaded ethylcellulose microsponges were prepared using quasi emulsion solvent diffusion technique and optimized using Box-Behnken design (BBD). Furthermore, they were characterized in-vitro using various techniques like scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction analysis (XRD). In-vitro drug release and release kinetics analysis was also performed.</p><p><strong>Results: </strong>Urea-loaded microsponges were spherical and porous. Optimized urea loaded microsponges showed a minimum size (39.78 ± 1.98 μm), high entrapment (74.56 ± 2.8%), acceptable polydispersity index (PDI) (0.224 ± 0.081) and zeta potential (-21.9 ± 2.9 mV). These microsponges were capable of sustaining the release of urea for 24 h (91.21 ± 5.20%), and the mechanism of release was the combination of diffusion and erosion.</p><p><strong>Conclusion: </strong>The developed microsponge system could be beneficial for topical delivery of urea as it could reduce the dosing frequency of urea and increase patient compliance through its sustained release.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"131-143"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10665392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosponges- Versatile Platform as Drug Carrier.","authors":"Ujjwala Kandekar,&nbsp;Rohini Pujari,&nbsp;Neha Munot,&nbsp;Trushal Chorge,&nbsp;Krishnakumar Lone,&nbsp;Pallavi Kamble,&nbsp;Khandelwal Kishanchand","doi":"10.2174/1872210516666220905092202","DOIUrl":"https://doi.org/10.2174/1872210516666220905092202","url":null,"abstract":"<p><strong>Background: </strong>Recently, nano-drug delivery systems have become an integral part of the most novel drug delivery systems and have gained considerable importance owing to various advantages such as carriers for poorly soluble drugs, targeting molecules at the desired site, protection from degradation etc. Objective: One of the most studied areas of nanotechnology is nanosponges. The objective of this review was to extensively summarize the various strategies for the preparation, characterization and applications of nanosponges.</p><p><strong>Methods: </strong>In the current mini-review, we conducted a systemic search of the literature and patent inventions focusing on nanosponges. The summary of the search was inclusive of various aspects of nanosponges, such as drug characteristics to be considered while incorporating in nanosponges, other crucial additives during formulation of nanosponges, methods of preparation, characterization and applications of nanosponges in pharmaceuticals.</p><p><strong>Results: </strong>Nanosponges are nanocarriers for both lipophilic and hydrophilic drugs. These are prepared by different methods such as emulsion-solvent evaporation, solvent method, melting method, ultrasound assisted method etc., and all these methods were less time consuming, more economical and evaluated by sophisticated techniques available for routine analysis. These are among the most feasible alternative to address several formulation difficulties associated with the physicochemical properties of the drug. The porous nature and small particle size are vital properties of the nanosponges that contribute crucially to correcting the drawbacks of the drug. The properties of the nanosponges can be enhanced when combined with cyclodextrins. Extensive research work has been carried out in past to explore cyclodextrin based nanosponges. Besides, it is also used for smart targeting of tumors and for drug release in a sustainable pattern. Nanosponges can be prepared by simple methods. These can be tuned to release the drug by different routes so as to achieve the maximum benefits of the drug.</p><p><strong>Conclusion: </strong>Huge amount of research has been carried out on nanosponges as drug carrier. The method of preparation and characterization of nanosponges are quite economical and routinely available. Owing to potential benefits and probable applications, these can be used as efficient carriers for certain drugs. The authors expect that the current review will guide the investigation of the nanosponges as nanodrug delivery systems.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"91-103"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10668892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper and Zinc Co-doped Titanium Dioxide Nanotubes Arrays on Controlling Nitric Oxide Releasing and Regulating the Inflammatory Responses for Cardiovascular Biomaterials.","authors":"Benli Yin,&nbsp;Xiao Luo,&nbsp;Peng Yu Gao,&nbsp;Zhi Sha Jiao,&nbsp;Jun Ji Piao,&nbsp;An Sha Zhao,&nbsp;Ping Yang","doi":"10.2174/1872210515666211004103733","DOIUrl":"https://doi.org/10.2174/1872210515666211004103733","url":null,"abstract":"<p><strong>Background: </strong>Titanium dioxide (TiO₂) nanotubes arrays have shown tremendous application foreground due to their unique characters of structure and performance. However, the single bio-function is still the limit on cardiovascular biomaterials.</p><p><strong>Methods: </strong>The loadability function provides the possibility for the TiO₂ nanotubes arrays to realize composite multifunction. The copper can catalyze the release of nitric oxide to promote the proliferation of endothelium cells and improve the anticoagulant. Also, zinc can adjust the inflammatory responses to improve anti-inflammation.</p><p><strong>Results: </strong>In this patent work, we co-doped the copper and zinc onto TiO₂ nanotubes arrays to estimate the hemocompatibility, cytocompatibility and responses of inflammation. The results showed that copper and zinc could introduce better multi-biofunctions to the TiO₂ nanotubes arrays for the application in cardiovascular biomaterials.</p><p><strong>Conclusion: </strong>In summary, the NTs@Cu/Zn sample as a new composite material in this study had significant biocompatibility in vascular implantation and can be used as a potential material for polymer- free drug-eluting stents.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"17 2","pages":"165-172"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9232294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}