Recent Patents on Nanotechnology最新文献

{"title":"Recent Advancements in Novel Formulations of Anti-psoriatic Agents for Effective Delivery: Clinical Importance and Patent Survey.","authors":"Nikhil Dadwal, Balak Das Kurmi, Dilpreet Singh, Amrinder Singh","doi":"10.2174/1872210517666230601124620","DOIUrl":"10.2174/1872210517666230601124620","url":null,"abstract":"<p><strong>Background: </strong>An autoimmune-mediated dermatological ailment featuring recurrent episodes is acknowledged as psoriasis. Around the world, 2-3% of people suffer from this autoimmune skin condition.</p><p><strong>Objectives: </strong>The primary goal of the current review is to analyse and determine the effectiveness of conventional and emerging nano technological strategies to alleviate psoriasis and discuss future perspectives.</p><p><strong>Methods: </strong>A thorough search of numerous electronic databases, including Science Direct, Scopus, Google Scholar, Clinical Trials, Google Patents, Research Gate, and PubMed, yielded all the data used in this review paper about the management of psoriasis <i>via</i> various anti-psoriatic agent and nanotechnology approaches. Keywords such as topical, liposomes, niosomes, micro needles, clinical trials, patents, pathogenesis, biosimilars, cytokines, and other pertinent words were investigated.</p><p><strong>Results: </strong>Nano technological approaches are gaining prominence since they enable targeted delivery, rapid onset of action with limited systemic exposure. Researchers have investigated innovative, alternative therapeutic approaches that are both secure and efficient for treating psoriatic conditions. Further, the potential role of numerous psoriatic conventional therapies has been explored. The patents granted or in process to address psoriasis <i>via</i> topical route have been well explored. Modern nanotechnology has made it possible for pharmaceuticals to be delivered with improved physical, chemical, pharmacokinetic, and pharmacodynamic qualities. Despite extensive research complete cure for psoriasis is hampered.</p><p><strong>Conclusion: </strong>Relying on the extensive literature review, it can be inferred that nanoparticles based novel delivery strategies have the possibility of enhancing the pharmacological activity and eliminating or resolving problems associated with this ailment. The different drug delivery systems available for the treatment of psoriasis along with the clinical trials in different stages, patents in process and granted, the commercialized status of therapeutic molecules, and the future of research in this area have been thoroughly reviewed.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"259-277"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Complete Sojourn of Current Trends in Gastro-retentive Drug Delivery System: Recent Advances and Patent Survey.","authors":"Abhisek Dey, Amrinder Singh, Balak Das Kurmi, Dilpreet Singh","doi":"10.2174/1872210517666230331083346","DOIUrl":"10.2174/1872210517666230331083346","url":null,"abstract":"<p><p>The current work aims to provide a complete sojourn on gastro-retentive drug delivery system (GRDDS) along with formulation methods, polymer selection, and in vitro/ in vivo challenges with finished dosage forms. Ideally, a biopharmaceutical-hindered drug has a rapid clearance and erratic bioavailability due to its low aqueous solubility and permeability. Additionally, it also suffers from high first-pass metabolism and pre-systemic gut wall clearance. Gastro-retentive drug delivery systems have become an emerging technology where newer methodologies and scientific approaches have been used to provide the controlled release of drugs and provide a protective mechanism in the stomach. By the virtue of utilizing GRDDS as a dosage form, these formulations increase Gastroretention time (GRT) which prolongs the controlled release of the drug in the dosage form. GRDDS contribute to increased drug bioavailability and targeting at a site of action, which enhances therapeutic action and offers significant patient compliance. Furthermore, the present work also highlighted the critical role of polymers in favoring drug retention across GIT with the mechanism of gastro-retention and recommended concentration ranges. The emerging technology is also highlighted by the approved drug products and patented formulations in the recent decade which is depicted in a justified manner. GRDDS formulations have demonstrated clinical efficacy, which is supported by a compilation of patents for cutting-edge innovations in dosage forms that can be held in the stomach for an extended period of time.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"190-206"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9233841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Treatment Options of Pluronic in Designing Colloidal Nano and Microcarriers Carriers for Various Therapies","authors":"Ravinder Verma, Laxmi Rani, Sweta Kamboj, Rohit Kamboj, Tanu Kamboj, Shailendra Bhatt","doi":"10.2174/0118722105255391231018112747","DOIUrl":"https://doi.org/10.2174/0118722105255391231018112747","url":null,"abstract":"Poloxamers, commonly known as Pluronics, are a special family of synthetic tri-block copolymers with a core structure made of hydrophobic poly (propylene oxide) chains sandwiched by two hydrophilic poly (ethylene oxide) chains. It is possible to modify the mechanical, bioactive, and microstructural characteristics of Pluronics to simulate the behavior of different types of tissues. Additionally, they are auspicious drug carriers with the capacity to increase therapeutic agent availability and to design nano-drug formulations for various ailments. The nanoformulation composed of Pluronics is more susceptible to cancer cells due to their amphiphilic nature and feature of selfassembling into micelles. Today's expanding poloxamer research is creating new hopes that increase the possibility of new remedies for a brand-new nanomedicine age treatment. This article provides a concise overview of the classification, grading, and attributes of drug delivery systems (DDSs) as well as the potential for Pluronics to create micro and nanocarriers. We subsequently discuss its utility in drug delivery for cancer, gene therapy, anti-infective therapy, antioxidants, anti-diabetic drugs, anti-HIV, Alzheimer's disease, and antimicrobial drugs. This review also highlighted several patented formulations that contain various grades of Pluronics in one or more different ways. The recent findings in fundamental research in the field properly demonstrate the strong interest in these novel pharmaceutical strategies.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"116 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135541456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INVASOMES: New Carriers for Transdermal Delivery of Anticancer Drugs","authors":"Lalit Kumar","doi":"10.2174/0118722105254232230920053519","DOIUrl":"https://doi.org/10.2174/0118722105254232230920053519","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136254093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on Recent Advances and Patents of Niosomes","authors":"Sushma Verma, Sakshi Saharawat","doi":"10.2174/0118722105259776231002071218","DOIUrl":"https://doi.org/10.2174/0118722105259776231002071218","url":null,"abstract":"Abstract: Niosomes are novel, self-assembled vesicular carriers that deliver both lipophilic and hydrophilic drugs at the specific site in a targeted way, enhancing bioavailability and extending therapeutic effects. Niosomes are a versatile drug delivery system with a diverse range of applications from gene to brain-targeted delivery and they are more attractive choices than liposomes as they are efficient at biodegrading. Niosome offers several advantages over conventional drug delivery systems, including enhanced stability, and also have gained a lot of focus in natural product delivery in recent years. This review provides a comprehensive view of niosomal research and recent advancements, including classification and fabrication methods, and their role in drug delivery and targeting. The description of the rise in niosomal formulation patents around the world is also elaborated along with the natural product delivery of niosomes which has recently gained significance. Patents on novel preparation, loading, and modification techniques have enhanced the importance of niosome in the pharmaceutical industry.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Selections","authors":"","doi":"10.2174/187221051703230215165620","DOIUrl":"https://doi.org/10.2174/187221051703230215165620","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135736237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Expression and Clinical Significance of Cat B and sICAM-1 in the GCF of Patients with Peri-implantitis","authors":"Jichao Lin,&nbsp;Yanjun Lin,&nbsp;Youcheng Yu,&nbsp;Qinglian Wang","doi":"10.2174/1872210517666230818161525","DOIUrl":"10.2174/1872210517666230818161525","url":null,"abstract":"<p><p>The article has been withdrawn at the request of the authors of the journal Recent Patents on Nanotechnology.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policiesmain.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be\u0000simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been\u0000published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is\u0000strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal\u0000right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By\u0000submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and\u0000when the article is accepted for publication.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10078160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo pharmacokinetic assessment and In-vitro characterization of strategically optimized Perphenazine-loaded nanostructured lipid carriers for nose-to-brain Targeting","authors":"Yogeeta O. Agrawal, T. Patil, K. Patil, N. Gujarathi, A. Gangwal, S. Goyal","doi":"10.2174/1872210517666230613150305","DOIUrl":"https://doi.org/10.2174/1872210517666230613150305","url":null,"abstract":"\u0000\u0000Perphenazine (PPZ) is a prevalent antipsychotic medication used to treat schizophrenia. After oral treatment, however, it shows substantial first-pass metabolism and decreased bioavailability.\u0000\u0000\u0000\u0000The goal of this research was to incorporate PPZ into nanostructured lipid carriers and thereby improve its bioavailability and brain targeting (PPZ-NLCs).\u0000\u0000\u0000\u0000PPZ-NLCs were formulated by a high-pressure homogenization methodology under heated conditions and optimized by applying a 23-full factorial design.\u0000\u0000\u0000\u0000The optimized PPZ-NLCs showed particle size 167.5 nm, PDI 0.277, Zeta Potential of -28.8 mV, and 98.6% EE. The drug release during In-vitro experiments of PPZ-NLCs exhibited a prolonged release profile of the drug best fitted into the Higuchi kinetic model. PPZ-NLCs when examined In-vivo pharmacokinetically a significant increase in t1/2, AUC0-∞, and Cmax was observed which indicates a greater bioavailability and a lesser elimination (Kel).\u0000\u0000\u0000\u0000These results suggested the superiority of NLCs in enhancing the bioavailability of PPZ drug and their suitability for successful brain targeting.\u0000","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46138263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Tapas K. Bandyopadhyay","doi":"10.2174/187221051702221121141420","DOIUrl":"https://doi.org/10.2174/187221051702221121141420","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135275270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Selections","authors":"","doi":"10.2174/187221051702221121151611","DOIUrl":"https://doi.org/10.2174/187221051702221121151611","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135275271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}