Recent Patents on Nanotechnology最新文献

{"title":"Nanotheranostics: The Fabrication of Theranostics with Nanoparticles and their Application to Treat the Neurological Disorders.","authors":"Astha Singh, Aakriti Patel, Hema Chaudhary, Kiran Yadav, Neha Minocha","doi":"10.2174/1872210517666230718115651","DOIUrl":"10.2174/1872210517666230718115651","url":null,"abstract":"<p><strong>Background: </strong>Theranostics is a method that focuses on providing patient-centred care and is evolving as a targeted, safe, and effective pharmacotherapy. Nanotheranostics combines diagnosis and therapeutic modalities that bridge traditional treatment and personalised medicine. Theranostics provides novel ideas for nanotechnology. This review describes the current state of nanotechnology-based therapies used to treat neurological illnesses. Some patents on theranostics are also discussed in this review.</p><p><strong>Objective: </strong>This study aims to provide a more comprehensive review of the diagnosis and therapeutic properties of nanotheranostics, the present state of nanotechnology-based treatment of neurological disorders, and the future potential of theranostics.</p><p><strong>Methods: </strong>The phrase \"theranostics\" refers to a treatment strategy that integrates therapeutics and diagnostics to monitor treatment response and enhance drug efficacy and safety. Theranostics is a crucial component of personalised medicine and calls for significant advancements in predictive medicine. The term \"theranostics\" refers to a diagnosis that screens patients for potential adverse drug reactions and targets drug delivery depending on the test results. Theranostics treats neurological disorders (like brain tumours (glioma), Parkinson's disease, Alzheimer's disease, and neurovascular diseases). Many review articles on Google Scholar, PubMed, Google Patents, and Scopus were used to gather information for this review. Data acquired from many sources was compiled in this review to provide more information on theranostics.</p><p><strong>Results: </strong>The role of various nanocarrier systems as theranostic agents for neurological illnesses and the fabrication of nanomaterials for theranostics are discussed in this article after evaluating a substantial number of review articles.</p><p><strong>Conclusion: </strong>The distinctive intrinsic features of nanoparticles make them useful for functionalization and imaging. Theranostics in nuclear medicine include diagnostic imaging and therapy using the same molecule that is radiolabeled differently or the same medication at various doses. It is possible to determine if a patient will benefit from a given treatment by visualising potential targets. Targeted nuclear therapy has been shown to be beneficial in patients if chosen carefully and has a good safety profile.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"17-34"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double Bubble Electrospinning: Patents and Nanoscale Interface.","authors":"Muhammad Ali, Ya Li, Ji-Huan He","doi":"10.2174/0118722105259729231004040238","DOIUrl":"10.2174/0118722105259729231004040238","url":null,"abstract":"<p><p><p>Background: Bipolymeric nanofibers have gained significant attention in various fields due to their enhanced functionality, improved mechanical properties, and controlled release capabilities. However, the fabrication of these composite fibers with a well-defined polymer-polymer interface remains a challenging task. </p> <p> Methods: The double bubble electrospinning setup was developed and simulated using Maxwell 3D to analyze the electric field. PVP and PVA polymers were electrospun simultaneously to create bipolymer nanofibers with an interface. The resulting nanofibers were compared with nanofibers made from pure PVA, PVP, and a PVA/PVP blend. The characterization of the nanofibers was performed using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). </p> <p> Results: The SEM images showed the formation of PVA/PVP interfacial nanofibers aligned side by side, with a diameter of a few thousand nanometers on each side. By increasing the voltage from 20 kV to 40 kV during electrospinning, the diameter of the nanofibers on the PVA and PVP sides was successfully reduced by 60.8% and 66.3%, respectively. FTIR analysis confirmed the presence of both PVA and PVP in the bipolymeric interfacial nanofibers. TGA analysis demonstrated a weight retention of 14.28% compared to PVA, PVP, and the PVA/PVP blend even after degradation at 500°C. The Maxwell simulation of double bubble electrospinning revealed a stronger and more uniform electric field pattern at 40 kV compared to 20 kV. </p> <p> Conclusion: The study has demonstrated the potential of double bubble electrospinning for the fabrication of bipolymer nanofibers with an interface, opening new avenues and patents for the development of functional nanofibers.</p>.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"453-465"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50159140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Potential of Andrographolide and its Analogs in Colorectal Cancer: An Update","authors":"S Lakshmi, Geetha Birudala, Beda Durga Prasad, Praveen Kumar Kusuma, Moturi Anvesh Raj, Kranthi Kumar Kotha, Shaik Shakir Basha, Vinyas Mayasa, Sandeep Kanna, Vinod Kumar Nelson","doi":"10.2174/9789815256567124010013","DOIUrl":"https://doi.org/10.2174/9789815256567124010013","url":null,"abstract":"Colorectal cancer (CRC) is a highly prevalent and leading cause of death globally. Though well-developed treatment strategies are available, colorectal cancer is still a challenging health problem in developed and developing countries. Despite advanced treatment methods, all may not exterminate the tumor since most cases of CRCs are diagnosed at the last stage, and treatment-associated drug toxicity and resistance are major concerns. Therefore, it is imperative to discover anticancer drugs with less toxicity and no drug resistance. During the process of new drug discovery, medicinal plants and their derivatives play a significant role. This chapter/review explores andrographolides and their derivatives as potential anticancer drug candidates to combat colorectal cancer. This chapter describes the molecular mechanisms of colorectal cancer, potential drug targets in cancer, the anticancer potential of andrographolide derivatives in various malignancies, and its specific function in preventing CRC. This review provides concise information and possible clues for researchers to develop andrographolides, their derivatives and anticancer drugs to treat colorectal cancer.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"1 1","pages":"201-217"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymers: Backbone of Controlled Drug Delivery","authors":"Shweta H. Shahare, Hitesh V. Shahare, Nayana S. Baste, Atish S. Mundada","doi":"10.2174/9789815274165124010008","DOIUrl":"https://doi.org/10.2174/9789815274165124010008","url":null,"abstract":"The concept of a drug-delivery system (DDS) is not entirely new. Recent years have undoubtedly seen notable advancements in the identification and management of several illnesses. Medication administration to affected areas is an important part of DDS. A sufficient number of drug carriers are required to deliver an adequate amount of drug to the lesion. Polymers that expand and condense in reaction to pH levels outside of the body are being studied by researchers. The investigation is being carried out at a breakneck pace all over the world. Not only are advances in traditional technologies being made but innovations are also being developed and tested. The purpose of this chapter is to discuss a few of the polymer compounds that are utilized in controlled medication delivery systems. Both newcomers and scientists working in this fascinating field of applied polymer research will find the paper to be a valuable resource.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"1 1","pages":"87-127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Solid to Fluid: Novel Approaches in Neuromorphic Engineering.","authors":"Daniil Nikitin, Hynek Biederman, Andrei Choukourov","doi":"10.2174/0118722105305259240919074119","DOIUrl":"https://doi.org/10.2174/0118722105305259240919074119","url":null,"abstract":"<p><p>Neuromorphic engineering is rapidly developing as an approach to mimicking processes in brains using artificial memristors, devices that change conductivity in response to the electrical field (resistive switching effect). Memristor-based neuromorphic systems can overcome the existing problems of slow and energy-inefficient computing that conventional processors face. In the Introduction, the basic principles of memristor operation and its applications are given. The history of switching in sandwich structures and granular metals is reviewed in the Historical Overview. Particular attention is paid to the fundamental articles from the pre-memristor era (the 1960s-70s), which demonstrated the first evidence of resistive switching and predicted the filamentary mechanism of switching. Multi-dimensionality in neuromorphic systems: Despite the powerful computational abilities of traditional memristor arrays, they cannot repeat many organizational characteristics of biological neural networks, i.e., their multi-dimensionality. This part reviews the unconventional nanowire- and nanoparticle-based neuromorphic systems that demonstrate incredible potential for use in reservoir computing due to the unique spiking change in conductance similar to firing in neurons. Liquid-based neuromorphic devices: The transition of neuromorphic systems from solid to liquid state broadens the possibilities for mimicking biological processes. In this section, ionic current memristors are reviewed and, the working principles of which bring us closer to the mechanisms of information transmittance in real synapses. Nanofluids: A novel direction in neuromorphic engineering linked to the application of nanofluids for the formation of reconfigurable nanoparticle networks with memristive properties is given in this section. The Conclusion t summarizes the bullet points of the Review and provides an outlook on the future of liquid-state neuromorphic systems.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Optimization and Evaluation of Patented Solid Lipid Nanoparticles of Ambrisentan for Pulmonary Arterial Hypertension.","authors":"Harshada Shewale, Abhishek Kanugo","doi":"10.2174/0118722105302631240816115638","DOIUrl":"https://doi.org/10.2174/0118722105302631240816115638","url":null,"abstract":"<p><strong>Background: </strong>Ambrisentan is a new endothelin receptor antagonist extensively used to manage pulmonary or pulmonary arterial hypertension.</p><p><strong>Objective: </strong>The therapeutic efficacy of Ambrisentan is limited due to its reduced solubility, higher log P (3.4), and thus less bioavailability. The recent investigation was concentrated on the improvement of solubility, and bioavailability of Ambrisentan for the therapy of hypertension via solid lipid nanoparticles (SLN) administered orally.</p><p><strong>Methods: </strong>XRD evaluated the compatibility of Ambrisentan with lipids with FTIR, DSC, and crystalline nature. The SLN was developed by High-pressure homogenization method. The Glyceryl monostearate and Tween 80 indicated the highest solubility, hence selected. The optimization was performed with Box-Behnken Design considering the concentration of GMS (X1), Tween 80 (X2), stirring speed (X3) as independent factors and particle size (Y1), entrapment efficiency (Y2) as dependent factors. The Patents on the SLN are Indian 202321053691, U.S. Patent, 10,973,798B2, U.S. Patent 10,251,960B2, U.S. Patent 2021/0069121A1 and U.S. Patent 2022/0151945A1.</p><p><strong>Results: </strong>The optimized batch F1 showed particle size (130 nm), ZP (-18.9 mV), and entrapment efficiency (85.73 %). The dual release pattern (prompt and sustained) was achieved with the SLNloaded Ambrisentan for about 24 hours. The lyophilized sample was subjected to SEM, which also revealed a spherical shape of a colloidal dispersion with a particle size of 126 nm. Hence, the F1 batch is highly recommended for solid oral delivery and also for the pilot-plant scale-up.</p><p><strong>Conclusion: </strong>A marked improvement in the solubility and dissolution of Ambrisentan was attained with the SLN. Moreover, the sustained delivery via the oral route enabled the patient's comfort, compliance, and therapeutic efficacy.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper Electrodes Modified with Gold Nanoparticles Detect Two Hazardous Contaminants (As, Cd) in Raw Milk","authors":"Upama Das, Nikhil Kumar Daimari, Khairul Islam, Rajib Biswas","doi":"10.2174/0118722105316267240807072122","DOIUrl":"https://doi.org/10.2174/0118722105316267240807072122","url":null,"abstract":"Background: Milk contamination has been a longstanding global concern, with Heavy Metals (HM) like lead (Pb), mercury (Hg), arsenic (As), and cadmium (Cd) posing significant risks. These contaminants often infiltrate milk through contaminated water sources or during pasteurization. This study introduces a novel approach to detecting milk contaminants by analyzing the current– voltage (IV) characteristics of copper (Cu) electrodes modified with gold nanoparticle (AuNPs). Methods: Leveraging the exceptional conductivity of metal nanoparticles, electrons freely traverse the surface, facilitating electron movement across the copper substrate. Additionally, the nanoparticles serve as binding agents, aiding in the comparative detection of contaminants. This method enables the preliminary detection of two HM (As, Cd) by evaluating their current gains in milk supernatant samples at varying concentrations. Results: AuNPs deposited on Cu electrodes exhibited a linear IV trend, with a significant increase in current compared to bare electrodes. Spiked milk supernatant drops cast on the electrode system displayed a current gain, which was evaluated towards sensing application of HM ions in milk. The synthesized AuNPs underwent initial characterization using a UV-Vis spectrophotometer, revealing a prominent plasmonic peak around 520 nm, confirming nanoparticle formation. X-Ray Diffraction (XRD) analysis confirmed the Face-Centred Cubic (FCC) crystal structure. Conclusion: Notably, different concentrations (1 and 10 ppm) and types of HM (As, Cd, Hg, and Pb) in milk supernatant yielded varying current gains, providing insights specifically targeting As and Cd contamination. conclusion: Notably, different concentrations and types of heavy metals in milk supernatant yielded varying current gains, providing insights into specific heavy metal contamination.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"34 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142191414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of TiO2 Nanoparticles Influence on Tensile Properties and Thermal Stability of Dry and Wet Luffa-Epoxy Nanocomposites","authors":"K. Anbukarasi, D. Mala, N. Senthilkumar, S. Imran Hussain, S. Kalaiselvam","doi":"10.2174/0118722105295445240418064351","DOIUrl":"https://doi.org/10.2174/0118722105295445240418064351","url":null,"abstract":"Background: Recently, progress has been made toward understanding the efficiency of polymer composites with natural fibres. With the hope of enhancing the characteristics of polymer composites supplemented with natural fibres in a watery environment, TiO2 nanoparticles have been used to improve their performance in the field. Method: These nanoparticles were filled in luffa-epoxy components at 1, 3, and 5 % volume fractions. A combination of x-ray diffraction and Fourier transform infrared spectroscopy was utilized to conduct the structural examinations. The nanoparticle spread was captured by field emission scanning electron microscopy. Result: Results show that dry nanocomposite's tensile strength and modulus have increased by 74% and, 13%, 137%, and 50% compared with epoxy and 40 vol% luffa-epoxy [E/L] composites, respectively. In wet nanocomposites, maximum reduction in tensile strength and modulus were observed as 27.4% and 16.54%, respectively. The diminished water absorption and thickness swelling percentage of nanocomposites were recorded as 98% and 91.8%, respectively. The onset temperature of these nanocomposites was scattered in the range of 379-393°C, with a maximum char residue of 38%. method: For uniform dispersal of nanoparticles, an ultrasonicator is used, and for the fabrication of nanocomposite, hand layup is adopted. Testing of composites is done as per the ASTM guidelines Conclusion: The increase in the percentage of residue indicates the effectiveness of epoxy's flame retardant, improved thermal stability, diminished water absorption [approximately 2%], and 95% retention of wet composites' tensile properties. These results provided data support for improving the application of nanocomposites in the automobile field. result: The tensile strength and modulus of dry nTiO2 nanocomposite have increased by 74% and 13%, 137% and 50% compared with epoxy and 40 vol% luffa-epoxy (E/L) composites, respectively. In wet nanocomposites, maximum reduction in tensile strength and modulus were observed as 27.4% and 16.54%, respectively. Diminished water absorption and thickness swelling percentage of nanocomposites were recorded as 98% and 91.8%, respectively conclusion: • nTiO2-filled luffa-epoxy nanocomposites have a low percentage of water absorption. Because the nTiO2 effectively contributed to decreasing the hydrophilic nature of luffa fibers. other: The generated luffa-epoxy nanocomposites could serve as an eco-friendly substitute for petroleum-based plastics used in car interiors","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"11 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140840372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on the Upgradation of Biomass-derived Hard Carbon Materials","authors":"Tengrui Wang, Ruyan Li, Qian Liu, Weichi Liu","doi":"10.2174/0118722105287471240221094548","DOIUrl":"https://doi.org/10.2174/0118722105287471240221094548","url":null,"abstract":": Sodium-ion battery is a promising alternative to lithium-ion battery because of its abundant raw material resources, low price, and high specific capacity. Amorphous carbon materials (hard carbon) have micropores and impurities, facilitating the intercalation of sodium ions to form \"quasi-metallic sodium,\" resulting in a high sodium storage capacity and a low sodium storage potential. Consequently, hard carbon is one of the most widely studied negative electrode materials. It can be prepared from biomass by thermochemical conversion and has the advantages of large specific capacity, low cost, good cycling stability, and renewability. This review focuses on the recent advances in biomass-based hard carbon materials. Firstly, the preparation methods of hard carbon, including precursor selection, pretreatment, drying methods, and carbonization processes, are summarized. Secondly, the effects of precursor composition and heteroatom doping structure and properties of hard carbon are examined, and the changes in carbon material pores during the activation process, as well as the selection of optimal drying method, pyrolysis temperature, carbonization temperature, activator dosage, and additive, are discussed. Thirdly, the impact of preparation methods on hard carbon's cost, efficiency, and stability is briefly summarized, and the relevant improvement measures and prospects are proposed. Finally, some insights are provided into preparing highperformance biomass-based anode materials for sodium-ion batteries.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"61 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics and Governance in the Metaverse: Navigating the Digital Frontier","authors":"Akashdeep Bhardwaj","doi":"10.2174/9789815238457124010011","DOIUrl":"https://doi.org/10.2174/9789815238457124010011","url":null,"abstract":"This chapter explores the ethical considerations and governance challenges associated with the metaverse, a virtual shared space where individuals interact and engage with digital entities. As the metaverse continues to evolve, it raises important questions surrounding user privacy, digital rights, virtual property, identity, and societal impact. Examining these ethical dimensions is essential to establish a framework that upholds values and principles for a fair and just metaverse. Key areas of focus include privacy and user consent, digital rights and virtual property, identity and authenticity, socioeconomic impact and access, and governance and regulation. By addressing these concerns, we can shape a metaverse that prioritizes individual autonomy, ethical principles, and the common good.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"1 1","pages":"242-258"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}