Recent Patents on Nanotechnology最新文献

{"title":"Magnetic Field Modulation Effect of Photoelectric Properties in Dye-sensitized Solar Cells with La_0.67(Ca,Ba)_0.33MnO₃ as Counter Electrodes.","authors":"Guanzhong Huo, Wenqing Lin, Ke Wang, Zhe Pei, Xuan Du, Shuiyuan Chen, Chao Su, Qingying Ye, Guilin Chen","doi":"10.2174/1872210518666230915142211","DOIUrl":"10.2174/1872210518666230915142211","url":null,"abstract":"<p><strong>Background: </strong>In recent years, many semiconductor materials with unique band structures have been used and also pursued patent protection as Pt counter electrode (CE) substitutes for dyesensitized solar cells (DSSCs), which makes the photoelectric properties of DSSCs possible to be modulated by electric field, magnetic field, and light field. In this work, La_0.67(Ca,Ba)_0.33MnO₃ (LCBMO) thin film is employed to act as CE in DSSCs.</p><p><strong>Methods: </strong>The experimental results indicate that short-circuit current density and photoelectric conversion efficiency present better stability when applying an external magnetic field to the DSSCs. Furthermore, both the exchange current density (J₀) and limit diffusion current density (J_lim) are largely enhanced by an external magnetic field. J₀ increases from -0.51 mA·cm^-2 to -0.65 mA·cm^-2, and J_lim increases from 0.2 mA·cm^-2 to 0.3 mA·cm^-2 when applying a magnetic field of 0.25 T.</p><p><strong>Results: </strong>The fitting results of the impedance test verify that the magnetic field reduces the value of R_ct.</p><p><strong>Conclusion: </strong>Both magnetic-field enhancing catalytic activity and CMR effect jointly promote the increase of photocurrent and finally improve the photovoltaic effect in DSSCs.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"140-147"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10339078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Enhance the Stability of Colloidal Quantum Well Light-Emitting Diodes.","authors":"Wenhui Fang, Baiquan Liu","doi":"10.2174/0118722105280923231215063047","DOIUrl":"10.2174/0118722105280923231215063047","url":null,"abstract":"<p><p>Colloidal quantum well light-emitting diodes (CQW-LEDs) show great potential for applications in displays and lighting due to their advantages, such as high color purity, spectral tunability and compatibility with flexible electronics, as demonstrated in relevant papers and patents. So far, attention has been mainly devoted to pursuing device efficiencies rather than achieving device stability, leading to the fact that the lifetime of CQW-LEDs is far from the demand for practical applications. In this perspective, various approaches to enhance the stability of CQW-LEDs have been discussed, including the synthesis of stable CQW materials, the selection of stable transport layers, the improvement of charge balance, and the introduction of advanced encapsulation techniques.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"313-318"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Drug Delivery System: Nanosponges.","authors":"Piyali Barik, Pooja Rani Bhaisal, Sonia Singh","doi":"10.2174/0118722105246668231012113121","DOIUrl":"10.2174/0118722105246668231012113121","url":null,"abstract":"<p><p>In recent years, nanotechnology has been the focus of study for the cure of different diseases, among which nanosponge delivery system is one of a kind. Nano sponges are tiny, highly porous, three-dimensional nanostructures with a size range of 250 nm^-1 μm in an amorphous or crystalline structure. Nanosponges usually act as an excipient or carrier of a drug in the different delivery systems. The type of polymers and cross-linkers, along with their concentration ratio, causes variation in nanosponges's dimension and encapsulation efficiency. Nanosponges have gained prominence in recent times due to their distinct ability to encapsulate both hydrophilic and lipophilic drugs within their internal cavity, thereby improving the solubility of drugs that have low water solubility. Virus-like size helps the nanosponges to circulate within the body without getting eliminated by the immune system until they stick to the targeted part of the body, which makes it the perfect candidate for a targeted drug delivery system and controlled delivery system as well because of its slow drug release property for a more extended period. Cyclodextrin-based nanosponges are the best choice for anticancer drug delivery as their small virus-like diameter helps them in passive targeting by enhancing the enhanced permeability and retention effect, allowing the anticancer drug to stay inside the tumour cell to show more significant therapeutic action on cancer, while for active targeting to the cancerous cell, nanosponges are attached with a ligand on it for receptor binding purpose. It can be used for drug delivery in many major diseases like brain-related diseases, diabetes, cancer, fungal, hypertension, etc., in different dosage forms, like oral, topical, hydrogel, parenteral, etc. and also provide valuable information of this novel drug delivery system in the field of patent area.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"319-335"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progression in Nanocarrier based Techniques to Address Fungal Infections and Patent Status in Drug Development Process.","authors":"Ravi Pratap Singh, Raj Kumar Narang, Amrinder Singh","doi":"10.2174/1872210517666230727090314","DOIUrl":"10.2174/1872210517666230727090314","url":null,"abstract":"<p><p>Fungal infections are becoming one of the most common diseases in recent years, especially when it comes about dealing skin infections. Different drugs are available commercially with antifungal activity for topical application and are effective for treatment of mild to moderate fungal infections. However they lack dermal bioavailability due to their poor penetrability, and less retention at the site thereby resulting in poor efficacy. The remaining systemic treatment options available so far may cause adverse drug effects and many other complications. In recent years nano carrier based formulations promised to overcome the limitations of the conventional topical dosage forms. Lipid based nano carriers and their importance for potential use in delivery of antifungal agents for the treatment of superficial fungal infections have been well discussed in this review article. It comprises of different nano lipid systems involved in treatment of topical fungal infections, effect of different polymers on their size, stability, and their mechanistic action behind skin penetration and dermal retention of drug into deeper epidermal layers is also highlighted to depict recent efforts of researchers in this context. Further, addressing of the disease by novel drug delivery systems for the efficacious treatment, status of clinical trials, novel commercial formulations available for use in dermal drug delivery and patents claimed/granted in the respective fields have been discussed in detail.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"183-204"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9877114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Thermal Performance and Distillate of Conventional Solar Still via Copper Plate, Phase Change Material and CuO Nanoparticles.","authors":"Subramanian Kumaravel, Meenakshi Sunadaram Nagaraj, Govindarajan Bharathiraja","doi":"10.2174/0118722105275724231130100817","DOIUrl":"10.2174/0118722105275724231130100817","url":null,"abstract":"<p><strong>Background: </strong>The world is currently facing a growing concern regarding freshwater scarcity, which has arisen as a result of a complex interplay of various factors. Renewable energy-powered water desalination is a feasible solution to address freshwater scarcity.</p><p><strong>Methods: </strong>This patent study presents a comprehensive investigation of the performance of a conventional solar still (CSS) and its modified versions, such as a still with copper plates, a still with PCM and a still with PCM and 3 wt% CuO nanoparticles blend. The experiments were carried out concurrently under identical circumstances for the CSS and the proposed stills. Prior to usage, the CuO nanoparticles and their blend with PCM were characterized through various analyses.</p><p><strong>Results: </strong>The investigation showcased the copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM significantly improved the distillate production, achieving approximately 6.85 kg/m2/day. This represents an increment of approximately 23.42% compared to the still with copper plate and PCM and 69.14% related to the CSS.</p><p><strong>Conclusion: </strong>Moreover, the solar still with 3 wt% CuO nanoparticles blended with PCM demonstrated a thermal efficiency of 74.23% and an exergy efficiency of 9.75%. The production cost of distillate for all four stills remained at $0.03 per kg. These findings highlight the effectiveness of the proposed copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM as a viable method for producing potable water.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"483-497"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Optimization and Characterization of Solid Lipid Nanoparticles of Apixaban.","authors":"Laukik Mulay, Namita Hegde, Abhishek Kanugo","doi":"10.2174/0118722105284862240506045944","DOIUrl":"10.2174/0118722105284862240506045944","url":null,"abstract":"<p><strong>Background: </strong>Unpredictable situations such as clotting of blood, deep vein thrombosis, and pulmonary embolism arise in the body, which is the leading cause of mortality. Such conditions generally arise after surgery as well as after treatment with oral anticoagulant agents. Apixaban is a novel oral anticoagulant widely recommended for the prevention and treatment of strokes and blood clots suffering from nonvalvular atrial fibrillation by suppressing factor Xa. Apixaban has a log P of 2.71 with poor solubility and reported maximum bioavailability of approximately 50%.</p><p><strong>Objective: </strong>Hence, the current research mainly focused on the improvement of solubility, bioavailability, and therapeutic efficacy of Apixaban via solid lipid nanoparticles (SLN).</p><p><strong>Methods: </strong>The SLN was developed using the hot-homogenization method using a high-pressure homogenizer. The drug-lipid compatibility study was assessed by the FTIR, and the thermal analysis was performed using differential scanning calorimetry (DSC). During the scrutiny of lipids, the highest solubility of Apixaban was estimated in the glyceryl monostearate, hence selected for the formulation. Moreover, the colloidal solution was stabilized by the polyethylene glycol 200. The Design of Expert software (Version 13, Stat-Ease) was implemented for the optimization analysis by considering the 3-independent factors and 2-dependent parameters. The Patents on the SLN are Indian 202321053691, U.S. Patent, 10,973,798B2, U.S. Patent, U.S. Patent 2021/0069121A1, U.S. Patent 2022/0151945A1.</p><p><strong>Results: </strong>Box-Behnken design was applied along with ANOVA, which showed a p-value less than 0.05 for the dependent parameters such as particle size and entrapment efficiency (p-value: 0.0476 and 0.0379). The optimized batch F10 showed a particle size of 167.1 nm, -19.5 mV zeta potential, and an entrapment efficiency of 87.32%. The optimized batch F10 was lyophilized and analyzed by Scanning electron microscopy (SEM), which showed a particle size of 130 nm. The solid powder was filled into the capsule for oral delivery.</p><p><strong>Conclusion: </strong>The marked improvement in solubility and bioavailability was achieved with F10- loaded Apixaban via Solid lipid nanoparticles. Moreover, the sustained released profile also minimizes the unseen complications that occur due to the clotting of blood.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"270-281"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development.","authors":"Manish Makhija, Deeksha Manchanda, Manu Sharma","doi":"10.2174/1872210518666230905155459","DOIUrl":"10.2174/1872210518666230905155459","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease marked by inflammation of synovium and generation of autoantibodies. Bone and cartilage are frequently damaged along with weakening of tendons and ligaments resulting in disability. An effective RA treatment needs a multi-disciplinary approach which relies upon pathophysiology that is still partially understood. In RA patients, inflammation was induced by pro-inflammatory cytokines including IL-1, IL-6 & IL-10. The conventional dosage regimens for treating RA have drawbacks such as ineffectiveness, greater doses, frequent dosing, relatively expensive and serious adverse effects. To formulate an effective treatment plan for RA, research teams have recently focused on producing several nanoformulations containing anti-inflammatory APIs with an aim to target the inflamed area. Nanomedicines have recently gained popularity in the treatment of RA. Interestingly, unbelievable improvements have been observed in current years in diagnosis and management of RA utilizing nanotechnology. Various patents and clinical trial data have been reported in relevance to RA treatment.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"56-75"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10199778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer.","authors":"Suchitra Nishal, Virender Kumar, Parmita Phaugat, Davinder Kumar, Naveen Khatri, Gajendra Singh","doi":"10.2174/1872210518666230907115056","DOIUrl":"10.2174/1872210518666230907115056","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most prevalent cancer among women. About 685K deaths were globally listed in 2020 by the World Health Organization. Nowadays, scientists prefer to use herbal medicines due to their low toxicity. Herbal medicines are used to overcome the toxicity effects of surgical removal, radio-chemo therapy and medication, which have a lot of risk of damaging the healthy tissues. To overcome this, enhance bioavailability and target specify, nano-formulation chemotherapy was introduced using herbal moiety for anticancer activity. The use of metallic nanoparticles (MNPs), particularly those made of silver, cobalt, zinc, and gold as contrast, antibacterial, anticancer, and drug delivery agents has revolutionised the medicinal field. Although MNPs can be made via exacting physical and chemical processes, a biological method utilising natural materials has been established recently.</p><p><strong>Objectives: </strong>This patent review article will offer a succinct explanation of the use of MNPs and its potential impact on herbal medicines in the future.</p><p><strong>Methods: </strong>Using PRISMA principles, this review systematically examines studies that concentrate on metal nanoparticles loaded with herbal compounds for the treatment of breast cancer. Various Databases were studied: PubMed, Elsevier, ScienceDirect, SpringerLink, Taylor & Francis Online, ACS Publications, Publishing Royal Society of Chemistry, and Future Medicines. Studies were selected if they were peer-reviewed primary studies published in the past 10 years.</p><p><strong>Results: </strong>We found that many herbal nano-formulations are more effective in breast cancer treatment than other types of formulations. Efficacy, safety and drug stability are also enhanced using nanoformulations.</p><p><strong>Conclusion: </strong>Nano-formulation is found to be more effective in the treatment of breast cancer.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"120-130"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-phase Hybrid Thermal Interface Alkali-treated E-Glass Fiber/MWCNT/Graphene/Copper Oxide Nanocomposites for Electronic Gadgets.","authors":"Swaminathan Ramu, Natarajan Senthilkumar, Balakrishnan Deepanraj","doi":"10.2174/0118722105296725240308094344","DOIUrl":"10.2174/0118722105296725240308094344","url":null,"abstract":"<p><strong>Introduction: </strong>Two-phase hybrid mode thermal interface materials were created and characterized for mechanical properties, thermal conductivity, and wear behaviour. Therefore, the ultimate goal of this current research was to use alkali-treated glass fibre and other allotropes to produce high-performance two-phase thermal interface materials that can be patented for engineering applications.</p><p><strong>Methods: </strong>Three different polymer composites were prepared to contain 20 vol.% alkalies (NaOH) treated e-glass fibre (E) and epoxy as a matrix with varying proportions of multi-walled carbon nanotube (MWCNT), graphene (G), copper oxide (C). The one-phase material contained epoxy+20%e-glass+1%MWCNT (EMGC1), the two-phase hybrid composite contained epoxy+20%e-glass+1%MWCNT+1%graphene+1%CuO (EMGC2), and two-phase material contained epoxy+20%e-glass+1%graphene+1%CuO (EMGC3). Vacuum bagging method was used for fabricating the composites.</p><p><strong>Results: </strong>The higher thermal conductivity observed was 0.3466 W/mK for EMGC2, the alkalitreated glass fibre/hybrid mode nanofillers epoxy matrix composite was mechanically tougher than the other two composites (EMGC1 & EMGC3). Scanning electron microscopy analysis revealed the fine filler dispersion and homogenous interaction with the glass fibre/epoxy resin composite of the upper and lower zone, which also revealed the defective zone, fibre elongation, fibre/filler breakages, and filler leached surfaces.</p><p><strong>Conclusion: </strong>Finally, it was concluded that the hybrid mode two-phased structure EMGC2 epoxy matrix composite replicated the maximum thermal conductivity, mechanical properties, and wear properties of the other two specimens.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"511-523"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Patent Analysis on Nano Drug Delivery Systems.","authors":"Dengyu Li, Wen Luo, Shengwei Yin, Ying Wang, Yanqing Zhao, Shiwei Zhu, Junfeng Yu, Ping Yang, Lina Zhang, Zhuyan Xi","doi":"10.2174/0118722105293359240626070342","DOIUrl":"10.2174/0118722105293359240626070342","url":null,"abstract":"<p><strong>Background: </strong>A nano drug delivery system is an effective tool for drug delivery and controlled release, which is used for a variety of medical applications. In recent decades, nano drug delivery systems have been significantly developed with the emergence of new nanomaterials and nanotechnologies.</p><p><strong>Objective: </strong>This article aimed to provide insight into the technological development of nano drug delivery systems through patent analysis.</p><p><strong>Methods: </strong>3708 patent documents were used for patent analysis after retrieval from the Incopat patent database.</p><p><strong>Results: </strong>The number of patents on nano drug delivery systems has shown a rapid growth trend in the past two decades. At present, China and the United States have obvious contributions to the number of patents. According to the patent data, the nanomaterials used in nano drug delivery system are mainly inorganic nanomaterials, lipid-based nanomaterials, and macromolecules. In recent years, the highly cited patents (≥14) for nano drug delivery systems mainly involve lipid-based nanomaterials, indicating that their technology is mature and widely used. The inorganic nanomaterials in drug delivery have received increasing attention, and the number of related patents has increased significantly after 2016. The number of highly cited patents in the United States is 250, which is much higher than in other countries.</p><p><strong>Conclusion: </strong>Even after decades of development, nano drug delivery systems remain a hot topic for researchers. The significant increase in patents since 2016 can be attributed to the large number of new patents from China. However, according to the proportion of highly cited patents in total, China's patented technologies in nano drug delivery systems are not advanced enough compared to developed countries, including the United States, Canada, Germany, and France. In the future, research on emerging nanomaterials for nano drug delivery systems, such as inorganic nanomaterials, may focus on developing new materials and optimising their properties. The lipid-based and polymer- based nanomaterials can be continuously improved for the development of new nanomedicines.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"609-628"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}