Recent Patents on Nanotechnology最新文献

{"title":"Role of Nanoformulations in the Treatment of Lung Cancer.","authors":"Parijat Pandey, Gunjan Nautiyal, Deepika Purohit, Sneh Lata, Virender Kumar, Manish Makhija, Deeksha Manchanda, Neha Minocha, Sunil Kumar, Deepak Kaushik","doi":"10.2174/0118722105264531231205042817","DOIUrl":"https://doi.org/10.2174/0118722105264531231205042817","url":null,"abstract":"<p><p>Lung cancer is the second deadliest disease in the world. A major portion of deaths related to cancer are due to lung cancer in both males and females. Interestingly, unbelievable advances have occurred in recent years through the use of nanotechnology and development in both the diagnosis and treatment of lung cancer. Due to their in vivo stability, the nanotechnology-based pharmacological system gained huge attractiveness, solubility, absorption from the intestine, pharmacological effectiveness, etc. of various anticancer agents. However, this field needs to be utilized more to get maximum results in the treatment of lung cancer, along with wider context medicines. In the present review, authors have tried to concentrate their attention on lung cancer`s difficulties along with the current pharmacological and diagnostic situation, and current advancements in approaches based on nanotechnology for the treatment and diagnosis of lung cancer. While nanotechnology offers these promising avenues for lung cancer diagnosis and treatment, it is important to acknowledge the need for careful evaluation of safety, efficacy, and regulatory approval. With continued research and development, nanotechnology holds tremendous potential to revolutionize the management of lung cancer and improve patient outcomes. The review also highlights the involvement of endocrine systems, especially estrogen in lung cancer proliferation. Some of the recent clinical trials and patents on nanoparticle-based formulations that have applications in the treatment and diagnosis of lung cancer are also discussed.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation of Solid Lipid Nanoparticles Loaded with Rosiglitazone and Probiotic: Optimization and In-vitro Characterization","authors":"Nitish Kumar, Nidhi Tyagi, Sidharth Mehan, Alok Pratap Singh","doi":"10.2174/0118722105268801231203144554","DOIUrl":"https://doi.org/10.2174/0118722105268801231203144554","url":null,"abstract":"Introduction: In the present study, solid lipid nanoparticles loaded with Rosiglitazone and probiotics were prepared via solvent emulsification diffusion. As a lipid and surfactant, Gleceryl monostearate and Pluronic -68 were used in the formulation process. background: Nanotechnology is essential for developing novel methods for transporting potentially therapeutic and symptomatic substances to specific regions of the central nervous system. Since these formulations reduce the long-term adverse effects associated with the aberrant distribution of medications, they increase the drug concentration at the site of action, thereby enhancing therapeutic efficacy. Method: During characterization, it was determined that ingredient quantity variations significantly impacted Rosiglitazone loading capacity, particle size, polydispersity index, etc. In an optimized formulation of RSG-PB loaded SLNs, spherical particles with a mean particle size of 147.66±1.52 nm, PDI of 0.42±0.02, and loading capacity of 45.36±0.20 were identified. Result: Moreover, the developed SLNs had the potential to discharge the drug for up to 24 hours, as predicted by Higuchi's pharmacokinetic model. The SLNs were stable at 25⁰C/60%RH for up to 60 days. There was little to no change in particle size, PDI, or loading capacity. In addition, the number of probiotic bacteria was determined using the standard plate count procedure. Further, the antioxidant effect of the prepared formulation is evaluated using the DPPH assay method. Conclusion: This study concludes that the method used to fabricate RSG-probiotic-loaded SLNs is straightforward and yields favorable results regarding various parameters, including sustained release property, particle size, PDI, and percent drug loading stability. Furthermore, DPPH radical scavenging activity shows the high antioxidant potential of RSG-PB SLNs when compared to RSG and probiotics alone.","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"10 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139662459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide (GO) Layered Bioconjugates: An Effective Strategy for Delivering p53 Gene for Adenocarcinoma.","authors":"Dilpreet Singh","doi":"10.2174/0118722105290129240122104901","DOIUrl":"https://doi.org/10.2174/0118722105290129240122104901","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Lanthanum Oxide Based Double-Gate SOI MOSFET using Monte-Carlo Process.","authors":"Pattunnarajam Paramasivam, Naveenbalaji Gowthaman, Viranjay M Srivastava","doi":"10.2174/0118722105273476231201073651","DOIUrl":"https://doi.org/10.2174/0118722105273476231201073651","url":null,"abstract":"<p><strong>Introduction: </strong>This work proposes a Double-Gate (DG) MOSFET with a Single Material made of Silicon On-Insulator (SOI). The Lanthanum Oxide material with a high k-dielectric constant has been used as an interface between two gates and the channel. The Monte Carlo analysis has been used to determine the Conduction Band Energy (Ec) profiles and electron sheet carrier densities (ns) for a Silicon channel thickness (tsi) of 10 nm at 0.5 V gate drain-source voltages. The transverse electric fields are weak at the midchannel of DG SOI MOSFETs, where quantum effects are encountered. The Monte Carlo simulation has been confirmed to be effective for high-energy transport. A particle description reproduces the granularity property of the transport for nanoscale modeling.</p><p><strong>Methods: </strong>This work utilizes a Monte Carlo (MC) Simulation for the proposed Double Gate Single Material Silicon On Insulator MOSFET with (La2O3=2 nm) as dielectric oxide on upper and lower gate material. The electrical properties of the DG SOI MOSFETs with Lanthanum Oxide were analyzed using Monte Carlo simulation, including the conduction band energy, electric field, potential distribution, particle movement, and average velocity.</p><p><strong>Results: </strong>The peak electric field (E) simulation results and an average drift velocity (υavg) of 6Í105 V/cm and 1.6Í107 cm/s were obtained, respectively. The conduction band energy for the operating region of the source has been observed to be 4 % to the drain side, which obtained a value of -0.04 eV at the terminal end.</p><p><strong>Conclusion: </strong>This proposed patent design, such as double-gate SOI-based devices, is the best suggestion for significant scalability challenges. Emerging technologies reach the typical DG SOI MOSFET's threshold performance when their geometrical dimensions are in the nanometer region. This device based on nanomaterial compounds has been more submissive than conventional devices. The nanomaterials usage in the design is more suitable for downscaling and reducing packaging density.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wheatgrass (Triticum Aestivum) Extract Loaded Chitosan Solid Lipid Nanoparticles: Formulation, Physicochemical Characterisation and Cytotoxic Potential.","authors":"Neha Minocha, Parijat Pandey, Nidhi Sharma, Sangita Saini","doi":"10.2174/0118722105270861231128081639","DOIUrl":"https://doi.org/10.2174/0118722105270861231128081639","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of cancer is around the world, and is identified as a multifarious ailment. Amongst the most common reasons for cancer in the world is oxidative stress, and this can be overcome by taking the herbal plant wheatgrass in any form.</p><p><strong>Aim and objective: </strong>The aim of the present work is to formulate wheatgrass extract-loaded solid lipid nanoparticles using Box-Behnken design and to investigate the effect of formulation variables.</p><p><strong>Methods: </strong>Using the hot homogenisation method, the current work plan aimed to develop wheatgrassfilled chitosan solid lipid nanoparticles by means of a Box-Behnken design. This study investigated the effect of three formulation variables on particle size and entrapment efficiency, namely the sodium alginate concentration, the chitosan concentration, and the sonication time. Extraction of wheatgrass was done in a soxhlet extractor, using methanolic extract. Furthermore, the authors have examined recent patents associated with wheatgrass to enhance their comprehension of this herbal plant.</p><p><strong>Results: </strong>The hot homogenisation technique was used to prepare Triticum aestivum extract loaded with solid lipid nanoparticles (SLNs). For BBD, all formulations were analysed for particle size, which ranged from 394.4 to 911.2 nm, and for polydispersity index, which ranged from 0.527 to 1.0. Batch code BB SLN-8 was found to be the finest suitable because of a maximum loading capacity of 58.23 ±0.11 % (w/w), maximum entrapment efficiency of 55.12±0.17 % (w/w), and minimum particle size of 394.4nm by using sodium alginate as a surface stabiliser at sonication time ~ 10 min and having maximum percentage yield of 49.87%. During characterisation studies and MCF-6 cell line studies, it was found that wheatgrass has antioxidant potential and is potent against breast cancer.</p><p><strong>Conclusion: </strong>As an alternative medicine for cancer, wheatgrass is considered to be effective due to its high antioxidant content.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Enhance the Stability of Colloidal Quantum Well Light- Emitting Diodes.","authors":"Wenhui Fang, Baiquan Liu","doi":"10.2174/0118722105280923231215063047","DOIUrl":"https://doi.org/10.2174/0118722105280923231215063047","url":null,"abstract":"<p><p>Colloidal quantum well light-emitting diodes (CQW-LEDs) show great potential for applications in displays and lighting due to their advantages, such as high color purity, spectral tunability and compatibility with flexible electronics. So far, attention has been mainly devoted to pursuing device efficiencies rather than achieving device stability, leading to the fact that the lifetime of CQW-LEDs is far from the demand for practical applications. In this perspective, various approaches to enhance the stability of CQW-LEDs have been discussed, including the synthesis of stable CQW materials, the selection of stable transport layers, the improvement of charge balance, and the introduction of advanced encapsulation techniques.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicular Nanocarriers: A Potential Platform for Topical/Transdermal Delivery of Antibiotics.","authors":"Mohit Chadha, Deepinder Singh Malik","doi":"10.2174/0118722105250901231201024930","DOIUrl":"https://doi.org/10.2174/0118722105250901231201024930","url":null,"abstract":"<p><strong>Background: </strong>Bacterial infections are becoming difficult to treat nowadays due to the development of resistance towards conventional treatments. Conventional topical formulations loaded with antibiotics display various disadvantages, like high dosing frequency, high toxicity, and poor patient compliance. The former limitations may sometimes lead to severe complications and hospitalization of patients. However, these can be overcome by employing vesicular nanocarriers for the delivery of antibiotics following the topical/transdermal route.</p><p><strong>Objective: </strong>The objective of this review paper was to summarize the role of vesicular nanocarriers, like liposomes, elastic liposomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions for topical/transdermal delivery of antibiotics, and patents associated with them.</p><p><strong>Methods: </strong>Literature for the present review was collected using various search engines, like PubMed, Google Scholar, and Google Patents.</p><p><strong>Results: </strong>Various literature investigations have revealed the in vitro and preclinical efficacy of vesicular nanocarrier systems in the delivery of antibiotics following the topical/transdermal route.</p><p><strong>Conclusion: </strong>Vesicular nanocarrier systems, via targeted delivery, may subside various side effects of antibiotics associated with conventional delivery, like high dosing frequency and poor patient compliance. However, their existence in the pharmaceutical market will be governed by effective clinical assessment and scale-up methodologies.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Thermal Performance and Distillate of Conventional Solar Still via Copper Plate, Phase Change Material and CuO Nanoparticles.","authors":"S Kumaravel, M Nagaraj, G Bharathiraja","doi":"10.2174/0118722105275724231130100817","DOIUrl":"https://doi.org/10.2174/0118722105275724231130100817","url":null,"abstract":"<p><strong>Background: </strong>The world is currently facing a growing concern regarding freshwater scarcity, which has arisen as a result of a complex interplay of various factors. Renewable energy-powered water desalination is a feasible solution to address freshwater scarcity.</p><p><strong>Methods: </strong>This study presents a comprehensive investigation of the performance of a conventional solar still (CSS) and its modified versions, such as a still with copper plates, a still with PCM and a still with PCM and 3 wt% CuO nanoparticles blend. The experiments were carried out concurrently under identical circumstances for the CSS and the proposed stills. Prior to usage, the CuO nanoparticles and their blend with PCM were characterized through various analyses.</p><p><strong>Results: </strong>The investigation showcased the copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM significantly improved the distillate production, achieving approximately 6.85 kg/m2/day. This represents an increment of approximately 23.42% compared to the still with copper plate and PCM and 69.14% related to the CSS.</p><p><strong>Conclusion: </strong>Moreover, the solar still with 3 wt% CuO nanoparticles blended with PCM demonstrated a thermal efficiency of 74.23% and an exergy efficiency of 9.75%. The production cost of distillate for all four stills remained at $0.03 per kg. These findings highlight the effectiveness of the proposed copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM as a viable method for producing potable water.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging and Non-imaging Analytical Techniques Used for Drug Nanosizing and their Patents: An Overview.","authors":"Vijay Agarwal, Meenakshi Bajpai","doi":"10.2174/0118722105243388230920013508","DOIUrl":"10.2174/0118722105243388230920013508","url":null,"abstract":"<p><strong>Background: </strong>Nanosizing is widely recognized as an effective technique for improving the solubility, dissolution rate, onset of action, and bioavailability of poorly water-soluble drugs. To control the execution and behavior of the output product, more advanced and valuable analytical techniques are required.</p><p><strong>Objective: </strong>The primary intent of this review manuscript was to furnish the understanding of imaging and non-imaging techniques related to nanosizing analysis by focusing on related patents. In addition, the study also aimed to collect and illustrate the information on various classical (laser diffractometry, photon correlation spectroscopy, zeta potential, laser Doppler electrophoresis, X-ray diffractometry, differential scanning calorimeter, scanning electron microscopy, transmission electron microscopy), new, and advanced analytical techniques (improved dynamic light scattering method, Brunauer-Emmett- Teller method, ultrasonic attenuation, biosensor), as well as commercial techniques, like inductively coupled plasma mass spectroscopy, aerodynamic particle sizer, scanning mobility particle sizer, and matrix- assisted laser desorption/ionization mass spectroscopy, which all relate to nano-sized particles.</p><p><strong>Methods: </strong>The present manuscript has taken a fresh look at the various aspects of the analytical techniques utilized in the process of nanosizing, and has achieved this through the analysis of a wide range of peer-reviewed literature. All summarized literature studies provide the information that can meet the basic needs of nanotechnology.</p><p><strong>Results: </strong>A variety of analytical techniques related to the nanosizing process have already been established and have great potential to weed out several issues. However, the current scenarios require more relevant, accurate, and advanced analytical techniques that can minimize the time and deviations associated with different instrumental and process parameters. To meet this requirement, some new and more advanced analytical techniques have recently been discovered, like ultrasonic attenuation technique, BET technique, biosensors, etc. Conclusion: The present overview certifies the significance of different analytical techniques utilized in the nanosizing process. The overview also provides information on various patents related to sophisticated analytical tools that can meet the needs of such an advanced field. The data show that the nanotechnology field will flourish in the coming future.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"494-518"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocrystal Materials for Resistive Memory and Artificial Synapses: Progress and Prospects.","authors":"Yingchun Chen, Dunkui Chen, Chi Zhang, Xian Zhang","doi":"10.2174/1872210517666230413092108","DOIUrl":"10.2174/1872210517666230413092108","url":null,"abstract":"<p><strong>Background: </strong>Resistive random-access memory (RRAM) is considered to be the most promising next-generation non-volatile memory because of its low cost, low energy consumption, and excellent data storage characteristics. However, the on/off (SET/RESET) voltages of RRAM are too random to replace the traditional memory. Nanocrystals (NCs) offer an appealing option for these applications since they combine excellent electronic/optical properties and structural stability and can address the requirements of low-cost, large-area, and solution-processed technologies. Therefore, the doping NCs in the function layer of RRAM are proposed to localize the electric field and guide conductance filaments (CFs) growth.</p><p><strong>Objective: </strong>The purpose of this article is to focus on a comprehensive and systematical survey of the NC materials, which are used to improve the performance of resistive memory (RM) and optoelectronic synaptic devices and review recent experimental advances in NC-based neuromorphic devices from artificial synapses to light-sensory synaptic platforms.</p><p><strong>Methods: </strong>Extensive information related to NCs for RRAM and artificial synapses and their associated patents were collected. This review aimed to highlight the unique electrical and optical features of metal and semiconductor NCs for designing future RRAM and artificial synapses.</p><p><strong>Results: </strong>It was demonstrated that doping NCs in the function layer of RRAM could not only improve the homogeneity of SET/RESET voltage but also reduce the threshold voltage. At the same time, it could still increase the retention time and provide the probability of mimicking the bio-synapse.</p><p><strong>Conclusion: </strong>NC doping can significantly enhance the overall performance of RM devices, but there are still many problems to be solved. This review highlights the relevance of NCs for RM and artificial synapses and also provides a perspective on the opportunities, challenges, and potential future directions.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"237-255"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9687973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}