Recent Patents on Nanotechnology最新文献

{"title":"Untangling Breast Cancer: Trailing Towards Nanoformulations-based Drug Development.","authors":"Ravinder Verma, Kuldeep Kumar, Shailendra Bhatt, Manish Yadav, Manish Kumar, Priti Tagde, P S Rajinikanth, Abhishek Tiwari, Varsha Tiwari, Diksha Nagpal, Vineet Mittal, Deepak Kaushik","doi":"10.2174/1872210517666230731091046","DOIUrl":"10.2174/1872210517666230731091046","url":null,"abstract":"<p><p>All over the world, cancer death and prevalence are increasing. Breast cancer (BC) is the major cause of cancer mortality (15%) which makes it the most common cancer in women. BC is defined as the furious progression and quick division of breast cells. Novel nanotechnology-based approaches helped in improving survival rate, metastatic BC is still facing obstacles to treat with an expected overall 23% survival rate. This paper represents epidemiology, classification (non-invasive, invasive and metastatic), risk factors (genetic and non-genetic) and treatment challenges of breast cancer in brief. This review paper focus on the importance of nanotechnology-based nanoformulations for treatment of BC. This review aims to deliver elementary insight and understanding of the novel nanoformulations in BC treatment and to explain to the readers for enduring designing novel nanomedicine. Later, we elaborate on several types of nanoformulations used in tumor therapeutics such as liposomes, dendrimers, polymeric nanomaterials and many others. Potential research opportunities for clinical application and current challenges related to nanoformulations utility for the treatment of BC are also highlighted in this review. The role of artificial intelligence is elaborated in detail. We also confer the existing challenges and perspectives of nanoformulations in effective tumor management, with emphasis on the various patented nanoformulations approved or progression of clinical trials retrieved from various search engines.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"76-98"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9898278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutting-Edge Developments and Patent Trends in Microspheres Drug Delivery: A Comprehensive Overview.","authors":"Shailesh Sharma, Pankaj, Subhash Kumar, Neelam Sharma, Surajpal Verma","doi":"10.2174/0118722105296316240626071243","DOIUrl":"10.2174/0118722105296316240626071243","url":null,"abstract":"<p><p>Microspheres have emerged as innovative drug delivery platforms with significant potential to improve the therapeutic efficacy of drugs with limited aqueous solubility and prolong their release. This abstract provides an overview of recent developments and patents granted in microsphere research, highlighting key trends and innovative approaches. Recent studies have focused on various aspects of microspheres, including formulation techniques, materials selection, and their applications in drug delivery. Recent breakthroughs in polymer science have paved the way for the creation of innovative biodegradable and biocompatible materials for microsphere fabrication, improving drug encapsulation effectiveness and release dynamics. Notably, the integration of nanomaterials and functionalized polymers has enabled precise control over drug release rates and enhanced targeting capabilities. The utilization of microspheres for administering a diverse array of therapeutic substances, including anticancer drugs, anti-inflammatory agents, and peptides, has gained significant attention. These microspheres have demonstrated the potential to enhance drug stability, minimize dosing frequency and enhance patient adherence.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"434-452"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetology and Nanotechnology: A Compelling Combination.","authors":"Ritu Karwasra, Shivkant Sharma, Isha Sharma, Nida Shahid, Tarana Umar","doi":"10.2174/0118722105253055231016155618","DOIUrl":"10.2174/0118722105253055231016155618","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The convergence of diabetology and nanotechnology has emerged as a promising synergy with the potential to revolutionize the management and treatment of diabetes mellitus. Diabetes, a complex metabolic disorder affecting millions worldwide, necessitates innovative approaches to enhance monitoring, diagnosis, and therapeutic interventions. Nanotechnology, a burgeoning field that manipulates materials at the nanoscale, offers unprecedented opportunities to address the challenges posed by diabetes. This abstract explores the multifaceted interface between diabetology and nanotechnology, highlighting key areas of integration. Nanotechnology has paved the way for the development of advanced glucose monitoring systems with enhanced accuracy, sensitivity, and patient convenience. Miniaturized biosensors and implantable devices equipped with nanoscale materials enable continuous and real-time glucose monitoring, empowering individuals with diabetes to make timely and informed decisions about their dietary and insulin management. Furthermore, nanotechnology has facilitated breakthroughs in targeted drug delivery, addressing the limitations of conventional therapies in diabetes treatment. Nano-sized drug carriers can improve bioavailability, enable controlled release, and enhance the selectivity of therapeutic agents, minimizing side effects and optimizing treatment outcomes. Moreover, nanoengineered materials have opened avenues for tissue engineering and regenerative medicine, offering the potential to restore damaged pancreatic islets and insulin-producing cells. The amalgamation of diabetology and nanotechnology also holds promise for early disease detection and prevention. Nanoscale diagnostic tools, such as biomarker-based nanoprobes and lab-onchip devices, offer rapid and accurate detection of diabetes-related biomolecules, enabling timely interventions and reducing the risk of complications. However, this compelling combination also presents challenges that warrant careful consideration. Safety, biocompatibility, regulatory approval, and ethical implications are crucial factors that demand meticulous evaluation during the translation of nanotechnology-based solutions into clinical practice. In conclusion, the integration of diabetology and nanotechnology represents a transformative paradigm that has the potential to reshape the landscape of diabetes management. By harnessing the unique properties of nanoscale materials, researchers and clinicians are poised to usher in an era of personalized and precise diagnostics, therapeutics, and preventive strategies for diabetes mellitus. As advancements in nanotechnology continue to unfold, the journey towards realizing the full potential of this compelling combination remains an exciting frontier in medical science. This review has thoroughly and critically studied the usage of nanomedicine in the diagnosis, monitoring, and management of diabetes and its effects, providing a clear picture of their pot","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"4-16"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide, a Prominent Nanocarrier to Reduce the Toxicity of Alzheimer's Proteins: A Revolution in Treatment.","authors":"Dilpreet Singh, Balak Das Kurmi, Amrinder Singh","doi":"10.2174/0118722105292940240502114430","DOIUrl":"10.2174/0118722105292940240502114430","url":null,"abstract":"<p><p>Graphene oxide, a derivative of graphene, has recently emerged as a promising nanomaterial in the biomedical field due to its unique properties. Its potential as a nanocarrier in the treatment of Alzheimer's disease represents a significant advancement. This abstract outlines a study focused on utilizing graphene oxide to reduce the toxicity of Alzheimer's proteins, marking a revolutionary approach in treatment strategies. The pathological features of Alzheimer's disease, primarily focusing on the accumulation and toxicity of amyloid-beta proteins, have been described in this review. These proteins are known to form plaques in the brain, leading to neuronal damage and the progression of Alzheimer's disease. The current therapeutic strategies and their limitations are briefly reviewed, highlighting the need for innovative approaches. Graphene oxide, with its high surface area, biocompatibility, and ability to cross the blood-brain barrier, is introduced as a novel nanocarrier. The methodology involves functionalizing graphene oxide sheets with specific ligands that target amyloid-beta proteins. This functionalization facilitates the binding and removal of these toxic proteins from the brain, potentially alleviating the symptoms of Alzheimer's disease. Preliminary findings indicate a significant reduction in amyloid-beta toxicity in neuronal cell cultures treated with graphene oxide nanocarriers. The study also explores the biocompatibility and safety profile of graphene oxide in biological systems, ensuring its suitability for clinical applications. It calls for further research and filing patents for its translational potential and benefits of this nanotechnology paying the way for a new era in neurodegenerative therapy.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"572-580"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicular Nanocarriers: A Potential Platform for Topical/Transdermal Delivery of Antibiotics.","authors":"Mohit Chadha, Deepinder Singh Malik","doi":"10.2174/0118722105250901231201024930","DOIUrl":"10.2174/0118722105250901231201024930","url":null,"abstract":"<p><p><p>Background: Bacterial infections are becoming difficult to treat nowadays due to the development of resistance towards conventional treatments. Conventional topical formulations loaded with antibiotics display various disadvantages, like high dosing frequency, high toxicity, and poor patient compliance. The former limitations may sometimes lead to severe complications and hospitalization of patients. However, these can be overcome by employing vesicular nanocarriers for the delivery of antibiotics following the topical/transdermal route. </p> <p> Objective: The objective of this review paper was to summarize the role of vesicular nanocarriers, like liposomes, elastic liposomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions for topical/transdermal delivery of antibiotics, and patents associated with them. </p> <p> Methods: Literature for the present review was collected using various search engines, like PubMed, Google Scholar, and Google Patents. </p> <p> Results: Various literature investigations have revealed the <i>in vitro</i> and preclinical efficacy of vesicular nanocarrier systems in the delivery of antibiotics following the topical/transdermal route. </p> <p> Conclusion: Vesicular nanocarrier systems, via targeted delivery, may subside various side effects of antibiotics associated with conventional delivery, like high dosing frequency and poor patient compliance. However, their existence in the pharmaceutical market will be governed by effective clinical assessment and scale-up methodologies.</p>.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"336-355"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturing Methods of Nanocomposites for Aerospace Application.","authors":"Ranjith Kannan","doi":"10.2174/187221051904241220142341","DOIUrl":"https://doi.org/10.2174/187221051904241220142341","url":null,"abstract":"","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"19 4","pages":"467"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress on One-dimensional Vanadium Pentoxide-based Nanomaterials for Advanced Energy Storage","authors":"Wei Ni","doi":"10.2174/0118722105349485241028104311","DOIUrl":"10.2174/0118722105349485241028104311","url":null,"abstract":"<p><p>One-dimensional (1D) vanadium-based nanostructures have advantageous properties and are showing emerging critical applications in the fields of catalysis, smart devices, and electrochemical energy storage. We herein timely gave an overview of the 1D vanadium pentoxide (V₂O₅)-based nanomaterials for these promising applications, especially regarding the merits of different synthetic methods, structures and properties combined with recent research frontiers in advanced energy storage, including batteries, supercapacitors and like. The high capacity, high rate and flexibility of 1D V₂O₅-based nanomaterials endow them with great potential in high-energy-density, high-power energy devices and specific/harsh environments. Finally, the directions and suggestions are provided for further development of this emerging and promising field.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials.","authors":"Navid Omidifar, Reza Masoumzadeh, Seyyed Amirreza Saghi, Ali Nikmanesh, Mansoureh Shokripour, Seyyed Mojtaba Mousavi, Yousef Nikmanesh, Ahmad Gholami","doi":"10.2174/0118722105285022240311062943","DOIUrl":"10.2174/0118722105285022240311062943","url":null,"abstract":"<p><p>The importance of early diagnosis of hepatitis B virus infection to treat and follow up this disease has led to many advances in diagnostic techniques and materials. Conventional diagnostic tests are not very useful, especially in the early stages of infection; it is therefore suggested that nanomaterials can enhance them by changing and strengthening their performance for a more accurate and rapid diagnosis. Electrochemical immunosensors with unique features such as miniaturization, low cost, specificity and simplicity have become a suitable and vital tool in the rapid diagnosis of hepatitis B since the patent. Different strategies have been presented, such as graphene oxide and gold nanorods (GO-GNRs), graphene oxide (GO), copper metal-organic framework/ electrochemically reduced graphene oxide (Cu-MOF/ErGO) composite, Label-free graphene oxide/ Fe₃O₄/Prussian Blue (GO/Fe₃O₄/PB) immunosensor, and graphene oxide-ferrocene-CS/Au (GOFc- CS/Au) nanoparticle layered electrochemical immunosensor. In this review, we discuss a group of the most widely used nanostructures, such as graphene and carbon nanotubes, which are used to develop electrochemical immunosensors for the early diagnosis of the hepatitis B virus.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"166-182"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Carbon-Based Micro and Nano Electro-Mechanical Systems for Biotechnological Application.","authors":"M Mahalakshmi, D C Diana, R Ramachandran, Santosh Kumar Ravva, Babu Illuri, J Jeba Johannah, T Manikandan, A Jose Anand","doi":"10.2174/0118722105293232240826135124","DOIUrl":"https://doi.org/10.2174/0118722105293232240826135124","url":null,"abstract":"<p><p>The combination of carbon-based nanoelectromechanical systems (C-NEMS) and carbonbased microelectromechanical systems (C-MEMS) has become a promising new direction in biotechnology with a wide range of applications that could significantly improve medical research and healthcare. These carbon-based materials, which are highly suited for a variety of biotech applications, include graphene and carbon nanotubes (CNTs). They have special qualities including large surface area, superior electrical conductivity, and biocompatibility. The domain of medication delivery systems is where C-MEMS and C-NEMS are most prominently used. These materials address important issues with therapeutic effectiveness and patient comfort by providing a platform for targeted and regulated medication administration. Biosensors that use graphene and carbon nanotubes (CNTs) have become essential diagnostic instruments because they allow for the sensitive and realtime detection of analytes for biomarker monitoring and disease diagnosis. The incorporation of carbon- based materials into lab-on-a-chip (LOC) devices has transformed biotech tests by providing portable and quick analysis. Neural interfaces, drug screening, wearable health monitoring, diagnostics, imaging, tissue engineering and regenerative medicine, diagnostic imaging, diagnostic imaging, and imaging have all benefited greatly from the use of carbon-based materials. These wide-ranging applications of C-MEMS and C-NEMS highlight their potential to propel developments in science, medicine, healthcare and patents.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":"19 4","pages":"468-482"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Field Modulation Effect of Photoelectric Properties in Dye-sensitized Solar Cells with La_0.67(Ca,Ba)_0.33MnO₃ as Counter Electrodes.","authors":"Guanzhong Huo, Wenqing Lin, Ke Wang, Zhe Pei, Xuan Du, Shuiyuan Chen, Chao Su, Qingying Ye, Guilin Chen","doi":"10.2174/1872210518666230915142211","DOIUrl":"10.2174/1872210518666230915142211","url":null,"abstract":"<p><strong>Background: </strong>In recent years, many semiconductor materials with unique band structures have been used and also pursued patent protection as Pt counter electrode (CE) substitutes for dyesensitized solar cells (DSSCs), which makes the photoelectric properties of DSSCs possible to be modulated by electric field, magnetic field, and light field. In this work, La_0.67(Ca,Ba)_0.33MnO₃ (LCBMO) thin film is employed to act as CE in DSSCs.</p><p><strong>Methods: </strong>The experimental results indicate that short-circuit current density and photoelectric conversion efficiency present better stability when applying an external magnetic field to the DSSCs. Furthermore, both the exchange current density (J₀) and limit diffusion current density (J_lim) are largely enhanced by an external magnetic field. J₀ increases from -0.51 mA·cm^-2 to -0.65 mA·cm^-2, and J_lim increases from 0.2 mA·cm^-2 to 0.3 mA·cm^-2 when applying a magnetic field of 0.25 T.</p><p><strong>Results: </strong>The fitting results of the impedance test verify that the magnetic field reduces the value of R_ct.</p><p><strong>Conclusion: </strong>Both magnetic-field enhancing catalytic activity and CMR effect jointly promote the increase of photocurrent and finally improve the photovoltaic effect in DSSCs.</p>","PeriodicalId":49324,"journal":{"name":"Recent Patents on Nanotechnology","volume":" ","pages":"140-147"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10339078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}