European Geriatric Medicine最新文献

{"title":"The relationship between depression and cardiovascular disease in older people: results from a large-scale epidemiological cohort study in Japan.","authors":"Kaoruko Komuro, Jin Komuro, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro, Masaki Ieda, Norihiko Takeda","doi":"10.1007/s41999-024-01128-1","DOIUrl":"10.1007/s41999-024-01128-1","url":null,"abstract":"<p><strong>Background: </strong>Depression is known to be associated with a greater risk of developing cardiovascular disease (CVD) in middle-aged people. However, it is not certain how depression would influence incident CVD in older people aged ≥ 75 years. We investigated the association between depression and CVD in older people.</p><p><strong>Methods: </strong>We analyzed 146,085 individuals aged ≥ 75 years including 7581 individuals (5.2%) with depression registered in the DeSC database from April 2014 to November 2022. We excluded those with a prior history of CVD. The incidence of composite CVD events, comprising ischemic heart disease (IHD), heart failure, and stroke was documented. A Cox proportional hazard regression analysis was conducted to estimate hazard ratios (HR) associated with the presence of depression.</p><p><strong>Results: </strong>The median age was 79 years and 41.0% were men. During the mean follow-up period of 3.4 ± 1.5 years, 39,552 composite CVD events (IHD: n = 10,916; heart failure: n = 26,719; stroke: n = 13,090) were recorded. Multivariable Cox regression analyses showed that older individuals with depression had a greater risk of composite CVD events than those without (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.24-1.34). The HR (95% CI) of depression was 1.26 (1.17-1.37) for IHD, 1.25 (1.19-1.31) for heart failure, and 1.30 (1.21-1.39) for stroke, respectively. While considering the limitations of real-world data, we conducted multiple sensitivity analyses, which confirmed the results of the primary analysis.</p><p><strong>Conclusions: </strong>The presence of depression was independently associated with a greater risk of developing CVD even in older individuals.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"673-680"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocratic considerations about statin treatment for patients over 75 years of age.","authors":"Timo E Strandberg, Athanase Benetos","doi":"10.1007/s41999-025-01160-9","DOIUrl":"10.1007/s41999-025-01160-9","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"393-395"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable sensors for monitoring caregivers of people with dementia: a scoping review.","authors":"Francesco Palmese, Ylenia Druda, Vittoria Benintende, Domenico Fuda, Marcello Sicbaldi, Paola Di Florio, Abdul Haleem Butt, Giorgio Bedogni, Lorenzo Chiari, Alessandro Silvani, Marco Domenicali","doi":"10.1007/s41999-024-01113-8","DOIUrl":"10.1007/s41999-024-01113-8","url":null,"abstract":"<p><strong>Purpose: </strong>Caregivers of people with dementia often face a demanding care burden that may lead to adverse physical and psychological outcomes. Wearable sensors are becoming a valuable tool for preventive care. We aimed to provide the first systematic map of the published evidence on the use of wearable sensors to monitor caregivers of people with dementia.</p><p><strong>Methods: </strong>We developed a scoping review protocol following the PRISMA-ScR guidelines. The searches were conducted on PubMed, Scopus, Web of Science, PsycInfo, and IEEE.</p><p><strong>Results: </strong>We identified 1394 articles and selected 37 reports. Sleep measures were the outcome most frequently evaluated (28/37). Among these reports, eight assessed the effectiveness of different interventions targeting both caregivers and care-receivers and found no improvement in caregivers' sleep; three compared the sleep of caregivers of people with dementia with controls, with conflicting results; five focused on depressive symptoms; and four associated these symptoms with shorter sleep duration and greater sleep fragmentation and sleep latency. A single device was used in 33 reports and sensors were most commonly placed at the wrist (33/37). Most studies monitored caregivers for 1 or more weeks (27/37).</p><p><strong>Conclusion: </strong>Wearable sensors were mainly used to monitor sleep in informal caregivers of people with dementia based on wrist accelerometry for 1 or more weeks, with conflicting results. There is a need for targeted studies with adequate control groups to identify factors associated with sleep alterations in informal and formal caregivers of people with dementia, leveraging multi-sensor setups with the inclusion of autonomic nervous system metrics.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"473-483"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility within-subject RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during period of Immobility (IMMI).","authors":"Helal B Alqurashi, Tahir Masud, Adam Lee Gordon, Mathew Piasecki, Dominic O'Connor, Katie Robinson, John R F Gladman","doi":"10.1007/s41999-024-01133-4","DOIUrl":"10.1007/s41999-024-01133-4","url":null,"abstract":"<p><strong>Introduction: </strong>Neuromuscular electrical stimulation (NMES) is a potentially effective intervention to improve outcomes after a fragility fracture, but its feasibility in this group has not been established.</p><p><strong>Methods: </strong>A feasibility study was conducted in two phases: 1) in the hospital only, and 2) hospital, rehabilitation centres, and participants' homes. Patients with fragility fracture were randomised to receive NMES for 6 weeks/discharge either to the right or left leg, with the other leg serving as control. Patients who had no mobility issues had contraindications to NMES and were unable to give consent were excluded. NMES was applied to quadriceps and tibialis anterior muscles for 30 min, 3 days/week. Sessions were progressed to achieve 60 min, 5-7 days/week. Feasibility outcomes included participant characteristics, recruitment rate, tolerability, and number of NMES sessions. Clinical outcomes included muscle strength, and ADL at six months.</p><p><strong>Results: </strong>Overall, 1052 patients were identified, of whom 113 (11%) were eligible, and 29 (3%) were recruited (median Clinical Frailty Score 3, median Barthel ADL score 93/100). The recruitment rate was 0.45/week in phase 1 and 0.9/week in phase 2. Fifty-three percent achieved the target of 24 NMES sessions. However, 5/29 withdrew due to intolerance of NMES. Leg muscle strength improved in both treated and untreated legs, with marginally greater improvement observed in the tibialis anterior of treated legs.</p><p><strong>Conclusion: </strong>Although it would be feasible to evaluate the specific effect of NMES in fragility fracture patients in a multi-centre trial using home-based NMES, this would be possible only in a minority of mildly frail fragility fracture patients with little premorbid disability.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"635-643"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying both the 30-s and the 5-repetition sit-to-stand tests captures dissimilar groups and a broader spectrum of physical abilities in mobility-limited older individuals: results from the BIOFRAIL study.","authors":"P Hansen, H Nygaard, J Ryg, M T Kristensen, C Suetta","doi":"10.1007/s41999-024-01115-6","DOIUrl":"10.1007/s41999-024-01115-6","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to assess differences among older patients demonstrating low STS performance in the 30 s-STS and/or the 5r-STS.</p><p><strong>Methods: </strong>30 s-STS and 5r-STS were used to assess lower limb muscle strength and function in older adults. Analysis involved 376 patients (≥ 65 years) from a geriatric outpatient clinic for fall assessment.</p><p><strong>Results: </strong>The mean age of patients was 79.8 (± 6.1) years (67% female). In total, 40.6% had low STS performance with 9.3% presenting only low 30 s-STS, 9.8% only low 5r-STS, and 21.5% low STS performance in both tests. Patients with low STS performance in both tests had lower gait speed, were more often frail, and had more prior falls compared to patients with low STS performance in one test only.</p><p><strong>Conclusion: </strong>The two STS tests are not interchangeable, and the use of both STS tests capture a wider range of physical abilities in mobility-limited older adults.</p><p><strong>Clinical trial registration: </strong>NCT05795556.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"703-707"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plantar cutaneous sensation is independently associated with postural balance and lower limb motor function in older adults: the Shizuoka study.","authors":"Michitaka Kato, Kazuya Kito, Satoko Nakano, Wataru Nakano, Yasunari Kurita, Yoshihiro Tanaka, Nagato Kuriyama, Kazuya Seto, Etsuko Ozaki, Yasuharu Tabara","doi":"10.1007/s41999-024-01141-4","DOIUrl":"10.1007/s41999-024-01141-4","url":null,"abstract":"<p><strong>Purpose: </strong>A relationship between decreased plantar cutaneous sensation and impaired balance function has been reported in patients with peripheral neuropathy and diabetes. This cross-sectional study aimed to investigate the relationship between plantar sensation and postural balance, as well as the association between plantar sensation and sarcopenia-related motor function in community-dwelling older adults.</p><p><strong>Methods: </strong>The participants included 1659 community-dwelling older adults with a mean age of 74 ± 5 years, of which 43% were male patients. Plantar cutaneous sensation thresholds were assessed using an automatic plantar sensation testing device. Postural balance was measured using one-leg standing (OLS) time. Grip strength, five-time sit-to-stand (STS) time, and normal gait speed were measured as components of muscle strength and physical function related to sarcopenia. The skeletal muscle mass index (SMI) and leg phase angle were obtained using bioelectrical impedance analysis.</p><p><strong>Results: </strong>Age, sex, body mass index, and leg phase angle, but not SMI and grip strength, were independently associated with the plantar sensation threshold. Plantar sensation threshold was independently associated with the OLS time (P = 0.001) and STS time (P = 0.001) after adjusting for potential confounders. No significant association was found between plantar sensation threshold and normal gait speed (P = 0.741).</p><p><strong>Conclusion: </strong>Plantar sensation was independently associated with postural balance and lower limb function in community-dwelling older adults. The assessment of plantar sensation could be useful for identifying factors contributing to poor postural balance and lower limb motor function.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"625-634"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality following hip fracture surgery in patients with dementia: a Swedish multiple national register study.","authors":"Michael Axenhus, Sara J Hägg, Maria Eriksdotter, Margareta Hedström, Dorota Religa","doi":"10.1007/s41999-025-01163-6","DOIUrl":"10.1007/s41999-025-01163-6","url":null,"abstract":"<p><strong>Purpose: </strong>Hip fractures in older adults are a significant risk factor for morbidity and mortality, with the presence of dementia further complicating outcomes. The purpose of this study was to investigate the association between hip fractures and mortality of patients with dementia and dementia types in comparison to those without dementia following hip fracture surgery.</p><p><strong>Methods: </strong>Utilizing data from the Swedish Hip Fracture Register (SHR), Swedish Registry for Cognitive/Dementia Disorders (SveDem), National Patient Register (NPR), and National Prescribed Drug Register (PDR), we conducted a retrospective analysis of 111,353 patients aged 65 and older who underwent hip fracture surgery between 2010 and 2018. Patients were categorized into two cohorts: those with and without a known diagnosis of dementia prior to the hip fracture. Multivariable Cox regression analyses were used to evaluate mortality risk factors.</p><p><strong>Results: </strong>Of the study sample, 22% had dementia. Dementia patients exhibited higher mortality rates at 30 days with 13% vs. 6%, (p < 0.001), 4 months with 27% vs. 12%, (p < 0.001) and at 1 year with 39% vs. 20%, post-fracture (p < 0.001). Higher ASA grades, poor baseline walking ability, and long-term care residency were also associated with increased mortality. Parkinson's disease dementia was associated with a higher mortality compared to other dementias during the first 4 months post-operatively.</p><p><strong>Conclusion: </strong>Our findings revealed an association between dementia diagnosis and higher risk of mortality following hip fracture surgery. These findings underscore the need for specialized post-operative care. Involving specific post-operative geriatric competence, such as orthogeriatric or orthogeriatric models of care could potentially improve outcomes. Further research is needed to explore the impact of dementia severity and subtype on mortality.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"541-549"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of frailty index with incidence of chronic kidney disease: China Health and Retirement Longitudinal Study.","authors":"Lisha Zhang, Yan Zhang, Yanru He, Fuxue Deng, Jiahong Xue","doi":"10.1007/s41999-024-01148-x","DOIUrl":"10.1007/s41999-024-01148-x","url":null,"abstract":"<p><strong>Aim: </strong>Frailty is an important risk factor for a wide range of chronic diseases and for mortality risk. This study aims to explore the relationship between frailty and incidence of chronic kidney disease (CKD), particularly on the change and accumulation of frailty.</p><p><strong>Methods: </strong>Frailty status was assessed using the frailty index (FI, constructed by 31 items) and categorized as robust, pre-frail, and frail. The accumulation and change in frailty were assessed on the basis of frailty status at baseline and a second survey 4 years after baseline. Logistic regression was used to estimate the association between frailty and developing CKD.</p><p><strong>Results: </strong>A total of 3597 participants (mean age: 59.08 ± 8.94 years old, male: 49.9%) from CHARLS were included. Participants with pre-frailty or frailty status had a higher risk of developing CKD compared with robust participants (pre-frail vs robust, OR 1.78, 95% CI 1.37-2.32, p < 0.001; frail vs robust, OR 2.52, 95% CI 1.67-3.79, p < 0.001). Participants who had a robust status in the two surveys had a significantly lower risk of developing CKD (OR 0.51, 95% CI 0.36-0.75, p < 0.001) compared with those who never had a robust status.</p><p><strong>Conclusion: </strong>Frailty status is significantly associated with the incidence of CKD. The risk of CKD was lower in those who ever had a robust status than in participants who never had a robust status.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"681-688"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiving outcomes among informal caregivers of persons with multimorbidity and dementia: a scoping review.","authors":"Ruotong Liu, Katherine Peak, Em Trubits, Ana R Quiñones","doi":"10.1007/s41999-024-01150-3","DOIUrl":"10.1007/s41999-024-01150-3","url":null,"abstract":"<p><strong>Purpose: </strong>An emerging field of research involves caregiving outcomes for persons with Alzheimer's disease and related dementias (ADRD) and co-occurring multimorbidity (ADRD-multimorbidity). This scoping review aims to assess and synthesize the body of literature on caregiving outcomes among informal caregivers of individuals with ADRD-multimorbidity.</p><p><strong>Methods: </strong>We adhered to the scoping review framework by Arksey and O'Malley (2005) and Levac and colleagues (2010), which encompassed five steps: (1) identify the research question(s), delineate the inclusion and exclusion criteria, (2) search for relevant studies, (3) select studies, (4) chart the data, and (5) collate, summarize, and report results. Electronic databases including Ovid Medline, CINAHL, Embase, and PsycINFO were employed to identify relevant studies.</p><p><strong>Results: </strong>A total of 1,856 articles were identified and 29 were included in the final review. The majority of studies were quantitative, cross-sectional studies. The two most commonly examined caregiving outcomes were caregiver burden and psychological well-being. Most research on caregiver outcomes treated care recipients' cognitive impairment and chronic conditions separately, rather than exploring their interaction. Most studies examining caregiver burden utilized Zarit Burden Index and its variants. Specific psychological well-being outcomes displayed great variability across studies.</p><p><strong>Conclusion: </strong>Despite challenges in synthesizing the extensive variability in the way cognitive status, ADRD-multimorbidity, and caregiving outcomes were measured, included, and reported, this review underscores the intricate challenges of caregiving, especially when dealing with both cognitive impairments and co-occurring chronic conditions. This complexity underscores the need for a deeper understanding of the diverse needs facing caregivers of people with ADRD-multimorbidity.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"485-524"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing \"cognageism\" in geriatric surgery: ethical dilemmas and collaborative innovations for an aging world.","authors":"Pinar Soysal, Alixe H M Kilgour, Vincenza Frisardi","doi":"10.1007/s41999-025-01169-0","DOIUrl":"10.1007/s41999-025-01169-0","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"397-399"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}