European Geriatric Medicine最新文献

{"title":"Association between the 400-m walk test and sensor-based daily physical activity in frail and sarcopenic older adults.","authors":"Jana Rogler, Sebastian Krumpoch, Ellen Freiberger, Ulrich Lindemann, Robert Kob","doi":"10.1007/s41999-025-01262-4","DOIUrl":"https://doi.org/10.1007/s41999-025-01262-4","url":null,"abstract":"<p><strong>Purpose: </strong>Physical activity (PA) is recommended for frail and sarcopenic older adults as an essential means of preventing negative health outcomes and decline in functional abilities. Our objective was to examine the association between the time and/or stops during the 400-m walk test (400MWT) and average daily steps and walking cadence in a German cohort of frail and sarcopenic community-dwelling older adults.</p><p><strong>Methods: </strong>For this sub-study the German cohort of 104 frail and sarcopenic older adults (i.e., SPRINTT) aged 80.8 ± 5.2 years was divided into participants having made none or one stop or more than one stops, referred to as non-stoppers and multi-stoppers. The characteristics and general health state (physical function, disease state, concerns about falling) at first observation (FO) and individual last observation (LO) after at least 11 months (mean 24.5 ± 8.5 months) were examined. Daily PA represented by average daily steps and walking cadence was assessed over three to seven days at FO and LO using the activPAL3 micro. Time and stops made during the 400MWT and their association with daily PA were investigated using regression with bootstrapping.</p><p><strong>Results: </strong>Out of 104 frail and sarcopenic older adults, 84 non-stoppers (female: n = 54; 64.3%) had a median time in 400MWT of 509 s (Inter Quartile Range (IQR) 324-875), a median number of daily steps of 6537 (IQR 1841-19,488) and a median daily walking cadence of 73 steps/minute (IQR 53.3-88.9). 20 multi-stoppers (female: n = 12; 60%) showed a time of 703 s (IQR 479-898), 5642 steps (IQR 2470-11,458) and a cadence of 70.7 steps/minute (IQR 61.4-83.6). Time was significantly associated with average daily steps and walking cadence at both FO and LO, stops alone were not.</p><p><strong>Conclusion: </strong>Gait speed under laboratory conditions can be used in clinical settings and research to estimate daily PA, represented by average daily steps and cadence, in frail and sarcopenic older adults.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a web video-based positive word stimulation program for older patients with cardiac disease and subthreshold depression admitted to an acute care ward: a pilot randomized controlled trial.","authors":"Masataka Sakimoto, Hiroyuki Uchida, Takumi Igusa, Takuya Kobayashi, Aya Fukazawa, Chihaya Machida, Hirokuni Fujii, Keisuke Sekine, Minori Kurosaki, Kenji Tsuchiya, Senichiro Kikuchi, Kazuki Hirao","doi":"10.1007/s41999-025-01258-0","DOIUrl":"https://doi.org/10.1007/s41999-025-01258-0","url":null,"abstract":"<p><strong>Purpose: </strong>Major depressive disorder can exacerbate morbidity and hasten mortality from cardiac disorders among geriatric patients, so mitigation of subthreshold depression (StD) may help improve long-term outcome. Subliminal priming with supraliminal reward stimulation (SPSRS), in which subjects view videos with embedded positive words, may be an effective intervention strategy for StD symptom reduction. The purpose of this pilot randomized controlled trial (RCT) was to evaluate the feasibility of an SPSRS intervention for older patients with cardiac disease and StD admitted to acute care wards.</p><p><strong>Methods: </strong>Thirty older patients with cardiac disease and comorbid StD (79.2 ± 7.55 years, six female) were randomly assigned to the intervention (SPSRS) group (n = 15) or the control group (n = 15). The intervention group viewed 10-min videos containing positive word stimulation once per day for 5 consecutive days, while the control group viewed YouTube videos containing no positive word stimulation following the same protocol. The primary outcome was a change in score on the Japanese version of the Beck Depression Inventory-II (BDI-II).</p><p><strong>Results: </strong>There were no dropouts and no adverse events during the trial. Linear mixed models showed no significant improvement in BDI-II in the intervention group compared to the control group (P = 0.72).</p><p><strong>Conclusions: </strong>This pilot RCT supports the feasibility of the SPSRS intervention for older patients with cardiac disease and StD. A full-scale RCT would require a larger sample size, modifications to the content for this patient group, increased frequency of daily interventions, and a more sensitive depression symptom assessment tool.</p><p><strong>Trial registration: </strong>The University Hospital Medical Information Network (UMIN) Registered 8 September 2023 (UMIN000052155).</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cognitive reserve on the risk of cognitive frailty in older patients receiving maintenance hemodialysis: a cross-sectional study.","authors":"Ning-Ning Xia, Hong-Ying Wang, Jing Liu","doi":"10.1007/s41999-025-01260-6","DOIUrl":"https://doi.org/10.1007/s41999-025-01260-6","url":null,"abstract":"<p><strong>Background: </strong>Older patients undergoing hemodialysis may exhibit signs of cognitive frailty due to physiological degradation and the accumulation of toxins. This study aimed to explore the factors associated with both cognitive reserves and cognitive frailty in older patients receiving maintenance hemodialysis.</p><p><strong>Methods: </strong>Between February to December of 2023, older patients undergoing hemodialysis were selected from blood purification centers in Jiangsu Province, China, via convenience sampling. General data, dialysis data, biochemical indexes, GDS-5 scores, and cognitive reserve scores were collected. The patients were divided into two groups, namely, cognitively frail (74 patients) and non-cognitively frail (163 patients). Factors associated with cognitive frailty were analyzed via logistic regression, and ROC curve analysis was performed to evaluate the discriminative ability of cognitive reserve scores to identify cognitive frailty.</p><p><strong>Results: </strong>A total of 237 older patients receiving maintenance hemodialysis were included (61% male patients with a mean age of 70.8 ± 8.2 years), 31.2% of whom exhibited symptoms of cognitive frailty. Logistic regression showed that advanced age, longer dialysis durations, higher GDS-5 scores, lower cognitive reserve scores, and a history of inpatient admission within six months were independently associated with cognitive frailty. Each of these factors had a P value of < 0.05. The ROC curve analysis demonstrated that cognitive reserve scores had a strong discriminative ability to identify cognitive frailty, with an optimal cutoff value of 75.5 points, an AUC of 0.94, a sensitivity of 89.6%, and a specificity of 90.5%.</p><p><strong>Conclusion: </strong>Cognitive frailty is prevalent in older patients undergoing maintenance hemodialysis and is associated with multiple factors. Lower cognitive reserve scores were independently associated with cognitive frailty and demonstrated ideal discriminative ability to identify affected individuals. Nevertheless, longitudinal studies can be carried out to investigate the relevant underlying causal relationships.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational gaps and mild cognitive impairment among older workers.","authors":"Shoma Akaida, Osamu Katayama, Ryo Yamaguchi, Daiki Yamagiwa, Hiroyuki Shimada","doi":"10.1007/s41999-025-01253-5","DOIUrl":"https://doi.org/10.1007/s41999-025-01253-5","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between currently employed but unwilling to remain employed (occupational gaps) and mild cognitive impairment (MCI) in older workers.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on 2272 workers aged 65 years and older (mean age: 71.2 years, 52.2% male) who participated in a large community-based cohort study from 2017 to 2018. MCI was assessed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool, which measures four cognitive domains: memory, attention, executive function, and processing speed. Participants with a decline ≥ 1.5 standard deviations below the age- and education-adjusted norms in one or more domains were classified as having MCI. Occupational gaps were categorized into two groups based on self-reported willingness to work. Logistic regression analysis was performed with MCI as the dependent variable and occupational gaps as the independent variable, and adjusted for covariates.</p><p><strong>Results: </strong>Among older workers, 18.0% experienced MCI and 46.1% experienced occupational gaps. The proportion of individuals with occupational gaps was 44.2% in the non-MCI group and 54.6% in the MCI group, with a significantly higher proportion in the MCI group (p < 0.001). Logistic regression analysis revealed a significant association between occupational gaps and MCI (odds ratio 1.44, 95% confidence interval 1.15-1.80).</p><p><strong>Conclusion: </strong>The findings suggest that occupational gaps may be associated with MCI in older workers.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a predictive nomogram for frailty based on thyroid function in older adults.","authors":"Xiaotian Shi, Huayu Yang, Shan Wang, Yifan Yang, Yuanyuan Li, Guoze Dou, Qing Ma","doi":"10.1007/s41999-025-01247-3","DOIUrl":"https://doi.org/10.1007/s41999-025-01247-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to develop and validate a frailty prediction model incorporating thyroid hormone levels in older adults with normal thyroid function.</p><p><strong>Methods: </strong>A total of 767 participants aged ≥ 65 years (566 males, 73.8%) were enrolled between December 2019 and December 2023. Participants were randomly assigned to training (n = 546) and internal validation (n = 235) sets; an external validation cohort was recruited between December 2023 and December 2024. Frailty was assessed using the FRAIL scale. Predictors were selected through LASSO and logistic regression analyses, and a nomogram was constructed for clinical application.</p><p><strong>Results: </strong>A total of 767 patients were included, with a median age of 81 years. Of these, 205 individuals (26.7%) were classified into the frailty group. The restricted cubic spline plot showed a negative correlation between the FT3/FT4 and frailty after adjusting for multiple confounding factors. Five predictors, age, polypharmacy, MNA.SF score, grip, and FT3/FT4 were incorporated to establish the model. The model performed well achieving AUC values of 0.92 and 0.80 in the development and external validation datasets, respectively. The Calibration curves and DCA results suggested that the model possesses satisfactory predictive performance.</p><p><strong>Conclusions: </strong>We developed a clinically applicable model to predict frailty in older adults with normal thyroid function, highlighting the relevance of thyroid hormone status in frailty risk assessment.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to light and noise at night, and sleep quality in community-dwelling older adults: a cross-sectional study.","authors":"Shuhui Dai, Wenqing Wang, Kaixuan Yang, Jiayi Li, Hazizi Duoliken, Lu Fang, Mingjuan Jin, Jianbing Wang, Kun Chen, Mengling Tang","doi":"10.1007/s41999-025-01254-4","DOIUrl":"https://doi.org/10.1007/s41999-025-01254-4","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate the levels and sources of nighttime light and noise exposure in community-dwelling older adults and explored their associations with sleep quality.</p><p><strong>Methods: </strong>A total of 2978 participants ≥ 65 years old from the 2023 survey of Yiwu Elderly Cohort were included in this cross-sectional study. Nighttime light and noise exposure and sleep quality information were collected by questionnaires. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Log-binomial regression models were performed to evaluate the associations between different levels and sources of nighttime light and noise and sleep quality.</p><p><strong>Results: </strong>Among the 2978 participants (median age 72.0 years (interquartile range [IQR], 68.0-76.0 years), 49.8% men), 39.7% (n = 1181) were classified as having poor sleep quality (PSQI > 5). Significant associations were found between nighttime light and noise and poor sleep, with prevalence ratio (PR) of 1.14 (95% confidence interval [95% CI] 1.04, 1.26) for light and 1.15 (95% CI 1.03, 1.30) for noise. Specifically, light or television on in the room, light outside the room, and noise from the room, traffic and public place, were negatively associated with sleep quality. Further exploring the associations with PSQI components, nighttime light tended to increase the risk of low sleep efficiency, long sleep latency and sleep disturbances.</p><p><strong>Conclusion: </strong>Nighttime light and noise exposure are associated with poor sleep quality in older adults. Further interventional studies should explore whether creating a dim and quiet sleeping environment can help maintain good sleep quality in older adults.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of cytomegalovirus with physical functioning and health-related quality of life in older adults.","authors":"Frances A Kirkham, Phu Sabei Shwe, Ekow Mensah, Chakravarthi Rajkumar","doi":"10.1007/s41999-025-01244-6","DOIUrl":"https://doi.org/10.1007/s41999-025-01244-6","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Cytomegalovirus (CMV) is a highly prevalent virus, known to be associated with cardiovascular morbidity. It has been hypothesised to play a role in the development of frailty, but its association with physical function and sarcopenia has yet to be fully understood. This study aimed to look at the relationship between CMV, sarcopenia and health-related quality of life in older adults.</p><p><strong>Methods: </strong>210 people in the south of England, UK, with median age 68 years (49% male, 51% female) underwent demographic and medical questionnaires, measures of body composition (bioimpedance analysis), handgrip strength and the short form 36 item survey of quality of life (SF36). All participants had CMV serology and inflammatory markers measured. Measures of sarcopenia were calculated using European Working Group definitions.</p><p><strong>Results: </strong>51.7% of participants were positive for CMV Immunoglobulin G (IgG). There were no significant differences between CMV positive and negative groups in age, gender, measures of sarcopenia or inflammatory markers. CMV positive groups had lower scores in all domains of the SF36, with significantly lower physical function score (88.7 vs 81.3, p = 0.003) as well as limitations due to physical health, energy/fatigue, social functioning and pain. On linear regression, CMV status was significantly associated with SF36 physical function score (p = 0.004) after adjustment for age, gender, body mass index, C-reactive protein and handgrip strength.</p><p><strong>Conclusions: </strong>CMV positivity is significantly associated with physical function and health-related quality of life in older adults, although its direct relationship to sarcopenia is yet to be fully ascertained.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-specific strength and its functional correlates in patients with osteosarcopenia.","authors":"G Şengül Ayçiçek, E Caran Karabacak, B Gökçe, E Oktay Oğuz, M Koca, P Ünsal","doi":"10.1007/s41999-025-01256-2","DOIUrl":"10.1007/s41999-025-01256-2","url":null,"abstract":"<p><strong>Methods: </strong>One hundred seventy patients were enrolled in this study and 141 patients were analyzed. Hand grip strength (HGS) was measured with Jamar dynamometer, muscle mass was measured with ultrasound, and sarcopenia diagnosis based on low muscle strength and low muscle mass. Muscle specific strength is calculated as HGS to muscle thickness (kg/cm) and cross-sectional area (kg/cm²). Osteoporosis is diagnosed if the T score was below - 2.5 or fragility fracture is present. The patients with both osteoporosis and sarcopenia were accepted as osteosarcopenia.</p><p><strong>Results: </strong>Mean age of the patients was 76.86 ± 6.74 and 121 (71.2%) were female. Ten percent of the patients was osteoporotic, 25.9% was sarcopenic and 27.1% was osteosarcopenic. In patients with osteosarcopenia, HGS/ Rectus femoris thickness (kg/cm) was 11.35 (2.47-37.5); HGS / Rectus femoris cross sectional area (kg/cm2) was 5.16 (0.82-27.3) and HGS/ Quadriceps femoris thickness (kg/cm) was 5.4 (1.43-13.04). When compared to control, osteoporosis and sarcopenia groups, muscle specific strength was lower in the osteosarcopenia group (p < 0.001, p = 0.009, p < 0.001, respectively). Linear regression analyses revealed that muscle specific strength was significantly associated with timed up and go (TUG) (β = - 0.236, p = 0.030) and L1-L4 T score (β = - 0.233, p = 0.032).</p><p><strong>Conclusion: </strong>Muscle specific strength- especially rectus femoris and quadriceps femoris thickness-is associated with TUG and L1-L4 scores in osteosarcopenia patients.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Tai Chi, Baduanjin, square dance, and Latin dance for cognitive and physical benefits in older adults: a randomized controlled trial.","authors":"Zhijian Wu, Fan Zhang","doi":"10.1007/s41999-025-01255-3","DOIUrl":"https://doi.org/10.1007/s41999-025-01255-3","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare the effects of four structured exercise interventions-Tai Chi, Baduanjin, square dance, and Latin dance-on cognitive function, physical health, body composition, and psychosocial outcomes in older adults.</p><p><strong>Methods: </strong>A 12-week randomized controlled trial (RCT) was conducted with 150 older adults aged 60 to 80 years (mean age: 69.7 ± 5.8 years; 62.7% female). Participants were assigned to one of five groups: Tai Chi, Baduanjin, square dance, Latin dance, or a health education control group. Pre- and post-intervention assessments included cognitive function (Montreal Cognitive Assessment, MoCA), upper limb strength (30-s arm curl test), flexibility (sit-and-reach test), balance (single-leg standing time), agility (2.4-m agility test), body fat percentage, and waist-to-hip ratio. Additionally, social interaction and psychological well-being were measured through standardized scales.</p><p><strong>Results: </strong>Significant improvements in cognitive function were observed in the square dance and Tai Chi groups (MoCA score increases of 4.2 and 3.7 points, respectively; p < 0.05). Square dance also led to notable improvements in grip strength (p < 0.01) and aerobic endurance (p < 0.05), while Latin dance showed the greatest benefits in flexibility and body fat percentage reduction. Psychological well-being improved across all intervention groups compared to the control group (p < 0.05), suggesting a broader impact on mental health and social engagement.</p><p><strong>Conclusion: </strong>These findings indicate that structured physical activity interventions significantly enhance cognitive and physical health in older adults, with variations in effectiveness based on exercise type. Furthermore, the inclusion of social components in certain activities, such as square dance, may amplify cognitive benefits through increased engagement and reduced social isolation.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait speed as a superior screening indicator for mild cognitive impairment compared to walk ratio and dual-task cost: a cross-sectional study.","authors":"Xiaoqin Wang, Jiani Wu, Qi Tian, Xintong Liu, Weihua Yu, Yang Lü","doi":"10.1007/s41999-025-01243-7","DOIUrl":"https://doi.org/10.1007/s41999-025-01243-7","url":null,"abstract":"<p><strong>Background: </strong>The accurate and sensitive quantitative indicator for screening patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) has not yet been established.</p><p><strong>Methods: </strong>Our study involved the measurement and comparison of clinical features and gait indicators among 96 patients with MCI, 66 patients with SCD, and 50 individuals with normal cognition (NC). Receiver operating characteristic (ROC) curve, multiple logistic regression, correlation clustering heatmap plot, and random forest modeling were used to evaluate the ability of gait indicators to differentiate disease.</p><p><strong>Results: </strong>No significant differences were observed in gait parameters between control and SCD groups [dual-task cost (DTC): p = 0.579; single-task gait speed: p = 0.656; dual gait speed: p = 0.951; single-task walk ratio: p = 0.683; dual-task walk ratio: p = 0.657]. Principal component analysis (PCA) revealed no distinct clustering patterns between these groups. For MCI discrimination, gait speed showed moderate predictive value (control vs. MCI: single-task AUC = 0.725, dual-task AUC = 0.726; SCD vs. MCI: single-task AUC = 0.733, dual-task AUC = 0.750). Both single-task (r = 0.36) and dual-task (r = 0.37) speeds correlated positively with MMSE scores. Multiple logistic regression identified single speed as a significant predictor of MCI (single-task: OR = 1.047; dual-task: OR = 1.05). Random forest analysis confirmed the importance of dual-task speed (mean decrease accuracy = 24.99).</p><p><strong>Conclusion: </strong>This study identifies gait speed as superior to walk ratio and DTC for MCI detection, supporting its clinical adoption as a frontline screening tool.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}