European Geriatric Medicine最新文献

{"title":"eHealth in geriatric rehabilitation: an international consensus study.","authors":"Jules J M Kraaijkamp, Anke Persoon, Niels H Chavannes, Wilco P Achterberg, Mohamed-Amine Choukou, Frances Dockery, Hyub Kim, Laura M Pérez, José E Pompeu, Eva Topinkova, Mark A Vassallo, Andrea B Maier, Clemens Becker, Yoshiaki Amagasa, Marije S Holstege, Jolanda van Haastregt, Eléonore F van Dam van Isselt","doi":"10.1007/s41999-025-01170-7","DOIUrl":"10.1007/s41999-025-01170-7","url":null,"abstract":"<p><strong>Purpose: </strong>Current evidence on the use of eHealth in geriatric rehabilitation is limited. This aim of this study was to achieve international consensus on three key eHealth-related topics in geriatric rehabilitation: the use, domains, and scientific evaluation of eHealth. Additionally, we developed a model that provides insight into the use of eHealth in geriatric rehabilitation.</p><p><strong>Methods: </strong>An international, two-round Delphi study was conducted. Two models served as a framework for the initial statement draft, with a total of 28 statements based on our systematic review results, an international survey, and expert opinion. Eligible healthcare professionals working in geriatric rehabilitation facilities were recruited across 10 countries.</p><p><strong>Results: </strong>Eighty healthcare professionals participated in round one and 47 in round two. In the first round, consensus was obtained for 20 of the 28 statements (71%). Prior to round two, four statements were revised, two statements were combined, and one statement was removed. In round two, consensus was obtained on six statements, bringing the total to 26: three related to the use of eHealth, five to the domains of eHealth, and 18 related to the scientific evaluation of eHealth.</p><p><strong>Conclusion: </strong>International consensus has been reached on the use, domains, and scientific evaluation of eHealth in geriatric rehabilitation. This first step in generating reliable knowledge and understandable information will help promote a consistent approach to the development, implementation, and scientific evaluation of eHealth in geriatric rehabilitation.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"985-997"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geriatric syndrome burden on healthcare services utilization and mortality among community-dwelling older adults: is it still too late to do something?","authors":"Bilal Katipoglu, Suleyman Emre Kocyigit","doi":"10.1007/s41999-025-01189-w","DOIUrl":"10.1007/s41999-025-01189-w","url":null,"abstract":"<p><strong>Purpose: </strong>The increasing longevity of the population emphasizes the need for a deeper understanding of geriatric syndromes and their implications for healthcare usage and mortality among older adults. This study aimed to identify risk factors associated with healthcare service utilization and mortality of community-dwelling adults aged 80 and older in YASAM project.</p><p><strong>Methods: </strong>This prospective cohort study was part of the HEAT-YASAM trial, which focused on the community-based integrated healthy aging program for individuals aged 80 years and older in Balıkesir, Türkiye. The burden of geriatric syndromes was assessed based on a comprehensive evaluation at least two domains of the nutrition, cognitive, physcological and locomotor capacities. The study outcome was healthcare services utilization (inpatient, outpatient, emergency admission) and all-cause mortality data obtained during follow-up period (9 months).</p><p><strong>Results: </strong>The cohort consisted of 5018 participants with a mean age of 85.8 years, predominantly female (53.1%). On the multivariable analysis, geriatric syndrome burden and Deyo Charlson Comorbidity index (D-CCI) score significant on independent predictors of 9-month mortality (p = 0.01). Higher geriatric syndrome burden was linked to an approximately 10% lower risk for outpatient admissions (p = 0.01) and every point increase in the D-CCI score was associated with a 1.3-fold increased risk of utilizing outpatient services (p = 0.01). For multimorbidity, every point increase corresponded to a 2.6-fold higher risk of inpatient admissions (p = 0.01) and a 1.2-fold higher risk of emergency admissions (p = 0.01).</p><p><strong>Conclusions: </strong>This study demonstrate that a geriatric syndrome burden and multimorbidity has a significant impact on healthcare utilization and mortality in adults aged 80 years and older. Integrated comprehensive, coordinated, and patient-centered care models for this population facing multiple geriatric syndromes could positively impact the healthcare system.</p><p><strong>Trial registration: </strong>The trial was prospectively registered at ClinicalTrials.gov. Identifier: NCT05993572 Registered on 15 July 2023.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1055-1061"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of long-term prognosis of older patients after a first fall according to economic status.","authors":"Ana García-Martínez, Lourdes Artajona, Sergio García-Rosa, Victoria Torres Machado, Adriana Gil-Rodrigo, Carmen Pérez-Fonseca, Javier Jacob, Pere Llorens, Pablo Herrero, Francisco J Martín-Sánchez, Andrea Bellido, Montserrat Lázaro Del Nogal, Òscar Miró","doi":"10.1007/s41999-025-01174-3","DOIUrl":"10.1007/s41999-025-01174-3","url":null,"abstract":"<p><strong>Purpose: </strong>Accidental falls are sentinel events of poor outcomes and future healthcare needs in older individuals. Understanding the effect of socioeconomic status (SES) on these needs is important for healthcare planning. The study aimed to investigate the association between SES and outcomes in a cohort of older fallers.</p><p><strong>Methods: </strong>A multicentre study was conducted including patients aged 65 years or older attending the emergency department (ED) of five Spanish hospitals after a first fall from September 1st, 2014, to August 31st, 2015. Sociodemographic features and past medical history were recorded. SES was evaluated using a proxy based on the mean income level at patients' zip code area. Outcomes after 5 years of the index fall included all-cause death, new fall-related visits to the ED, and fall-related fractures. Logistic regression was used to investigate the association between SES and outcomes.</p><p><strong>Results: </strong>The cohort included 716 patients (median age 79 years [IQR 72-85], 68% female). There were 439 patients (61.3%) with low and 277 (38.7%) with high SES. The group with low SES had significantly higher prevalence of depression (31.3% vs. 23%), polypharmacy (57.5% vs. 45.5%), or visual impairment (58.7% vs. 50.6%), whereas the percentage of patients with dependency (42.3% vs. 53.1%) or living alone (15.1% vs. 22.4%) was higher in the group with high SES. At the end of the 5-year follow-up, 250 patients (35.4%) died, 271 (49.3%) had a new fall-related visit, and 104 (20.6%) suffered a fall with fracture. None of these outcomes was associated with SES, irrespective of whether SES was considered as a dichotomous or a continuous variable.</p><p><strong>Conclusion: </strong>There are significant clinical differences based on SES in older patients attending the ED after a first fall. However, living in areas with lower SES was not associated with long-term outcomes in the context of a universal healthcare system. Further research is necessary to understand the interplay between SES and prognosis in this population.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"881-889"},"PeriodicalIF":3.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative sleep disturbances in older adults: a scoping review of epidemiology and treatment.","authors":"Hao Guo, Li-Heng Li, Fei Xiao, Yu-Bo Xie","doi":"10.1007/s41999-025-01238-4","DOIUrl":"https://doi.org/10.1007/s41999-025-01238-4","url":null,"abstract":"<p><strong>Purpose: </strong>Perioperative sleep disturbances are prevalent in older adults undergoing surgery, contributing to poor postoperative recovery, increased complications, and prolonged hospitalization. Despite their clinical significance, standardized assessment and management approaches remain insufficient.</p><p><strong>Methods: </strong>A scoping review conducted in accordance with PRISMA-ScR guidelines was performed using PubMed, Embase, and Web of Science. Studies focusing on perioperative sleep disturbances in older adults (aged ≥ 65 years) were included, covering prevalence, risk factors, and outcomes. No language restrictions were applied, and studies in English, Chinese, and Japanese were included. Both subjective (e.g., Pittsburgh Sleep Quality Index) and objective (e.g., actigraphy, polysomnography) assessment tools were reviewed, with data synthesized narratively to summarize evidence on prevalence, risk factors, and management strategies.</p><p><strong>Results: </strong>Preoperative sleep disturbances prevalence ranges from 0 to 91%, while postoperative sleep disturbances affect 6.7% to 93% of patients. Most included studies enrolled participants aged 65-75 years, limiting generalizability to older adults ≥ 80 years. sleep disturbances are associated with increased postoperative pain sensitivity, heightened risk of delirium, cognitive decline, and prolonged recovery. Additionally, sleep disturbances correlate with worsened emotional states, including anxiety and depression, which further impair functional recovery. Key risk factors include pain, anesthesia, hospital environmental factors, and preexisting psychological distress. Management strategies involve multimodal analgesia, psychological interventions, environmental modifications, and pharmacologic treatments (e.g., dexmedetomidine, melatonin).</p><p><strong>Conclusion: </strong>Perioperative sleep disturbances significantly impact postoperative recovery by affecting pain levels, cognitive function, emotional stability, and overall rehabilitation progress. Standardized assessment and targeted interventions are needed to mitigate these effects. Future research should refine diagnostic criteria and explore individualized treatment approaches to optimize perioperative sleep management.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between plant-based diets and disability in daily activities in older Chinese individuals.","authors":"Huanting Zhang, Jianan He, Xianwen You, Xingyou Liu, Wenhao Zhou, Jie Shen","doi":"10.1007/s41999-025-01234-8","DOIUrl":"https://doi.org/10.1007/s41999-025-01234-8","url":null,"abstract":"<p><strong>Introduction: </strong>To investigate the independent and comprehensive association between plant-based diets and activities of daily living (ADL) in older Chinese individuals, we conducted a longitudinal study to evaluate the relationship between the plant-based diet index (PDI) and ADL in this population.</p><p><strong>Methods: </strong>This study included 18,670 participants (women [proportion]: 9899 [53.0%]) who were able to independently conduct ADL at baseline in the 1998-2018 China Longitudinal Survey of Health and Longevity (CLHLS). The Cox proportional hazard model was used to test the association between a plant-based diet and activities of daily living-related disabilities.</p><p><strong>Results: </strong>At baseline, the median age of all participants was 83 years old. Taking Q1 as the reference value, the hazard ratios (HR) for quartiles Q2, Q3, and Q4 were 1.080 [95% confidence interval (CI) 1.018-1.147], 1.086 (95% CI 1.007-1.181), and 1.110 (95% CI 1.038-1.187), respectively. This indicated that a higher PDI might have had adverse effects on ADL. Adjustments have been made to the potential inclusion population and data processing strategies, as well as to the frequency of intake based on nutritional factors. Subsequently, it was found that the obtained results were consistent with the preliminary analysis.</p><p><strong>Conclusion: </strong>This study found that a higher plant-based diet was associated with an increased risk of disability in daily activities, while the intake of meat and fish was associated with a decreased risk. These findings highlight the importance of dietary balance in plant-based diets.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of Montreal cognitive assessment combined with olfactory tests for mild cognitive impairment in older adult patients with type 2 diabetes.","authors":"Ni Wang, Xiao Chen","doi":"10.1007/s41999-025-01223-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01223-x","url":null,"abstract":"<p><strong>Purpose: </strong>The study aims to explore the diagnostic value of the Montreal Cognitive Assessment (MoCA) combined with olfactory tests for identifying mild cognitive impairment (MCI) in older adult patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>This prospective study enrolled older adult T2DM patients from Jiulongpo District People's Hospital, Chongqing, China, between August 2018 and January 2023. Diagnostic criteria proposed by Petersen served as the gold standard for MCI. The Mini-Mental State Examination (MMSE), MoCA, and olfactory assessments were employed to evaluate cognitive function.</p><p><strong>Results: </strong>A total of 192 patients were included, of which 94 (49.0%) were diagnosed with MCI (68.5 ± 5.5 years; 31.9% male) and 98 (51.0%) with normal cognitive function (NMCI) (68.4 ± 4.9 years; 45.9% male). Compared to the NMCI group, the MCI group showed significant differences in MMSE (25.6 ± 2.5 vs. 28.7 ± 1.3, P < 0.001), MoCA (20.7 ± 2.5 vs. 26.3 ± 2.4, P < 0.001), olfactory (23.9 ± 7.2 vs. 26.4 ± 8.4, P = 0.027), and olfactory impairment degree (P = 0.004). The area under the ROC curve (AUC) for the olfactory test was 0.620 (95%CI: 0.541-0.699), for MMSE 0.838 (95%CI: 0.779-0.897), and for MoCA 0.948 (95%CI: 0.918-0.977). For the combination of MoCA with olfactory tests, the AUC of the parallel test was 0.955 (95%CI: 0.929-0.982).</p><p><strong>Conclusion: </strong>The MoCA scale is an effective screening tool for MCI in T2DM patients. Additionally, the combination of MoCA and olfactory testing is superior to MoCA alone in identifying MCI in T2DM patients. This combination approach offers a promising diagnostic tool for MCI in T2DM patients.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyspepsia in nonagenarian women.","authors":"Ersin Kuloglu, Ilker Sengul, Demet Sengul, Ali Muhtaroglu, Sefer Aslan, Kubilay Issever, Ahmet Cumhur Dulger","doi":"10.1007/s41999-025-01197-w","DOIUrl":"https://doi.org/10.1007/s41999-025-01197-w","url":null,"abstract":"<p><strong>Purpose: </strong>Dyspeptic complaints are common across all age groups, but limited research explores their characteristics and underlying pathologies in nonagenarians. This pioneering study aims to investigate the clinical, laboratory, and histopathological features in women nonagenarians vs. middle-aged.</p><p><strong>Methods: </strong>A cross-sectional study included 93 female nonagenarians and 90 under 65 years (control), all presenting with dyspeptic complaints to general surgery, internal medicine, and gastroenterology outpatient clinics. Both groups underwent comprehensive evaluations, including laboratory parameters, upper gastric endoscopic examinations, and histopathological assessments of gastric biopsies. Statistical analysis compared the two groups' demographic, laboratory, and histopathological findings.</p><p><strong>Results: </strong>Of the patients included in the study, 49.8% were under 65 years, and 50.2% were nonagenarians. The mean age of the control group was 54.8 years, while nonagenarians had a mean age of 92.7 years. Significant differences were observed in several laboratory biomarkers such as leukocytes, neutrophils, glucose, creatinine, sodium, potassium, albumin, alanine transaminase, C-reactive protein, etc. between the groups (p < 0.05). Nonagenarians were less infected with Helicobacter pylori, whereas they had a higher frequency of intestinal metaplasia.</p><p><strong>Conclusions: </strong>Nonagenarians group has a higher rate of intestinal metaplasia and displasia, while a lower rate of Helicobacter pylori infection in their gastric mucosal specimens. More extensive randomized controlled trials should illuminate the possible pathophysiological mechanisms for this association.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of falls with risk of dementia and all-cause mortality: a cohort study of Japanese older adults with a 9-year follow-up.","authors":"Xiangbin Zhong, Keyang Liu, Yao Yao, Honglin Cai, Baoqing Huang, Xiaojing Yuan, Kokoro Shirai, Katsunori Kondo, Liqi Guan, Qiqing Chen, Xinlei Wang, Yuting Li","doi":"10.1007/s41999-024-01149-w","DOIUrl":"10.1007/s41999-024-01149-w","url":null,"abstract":"<p><strong>Objective: </strong>Many risk factors affect dementia and all-cause mortality. However, whether falls are a risk factor for dementia and all-cause mortality is unclear. The study examines the association of falls with the risk of dementia and all-cause mortality, and whether dementia mediates the association of falls with all-cause mortality.</p><p><strong>Methods: </strong>Data were taken from the Japanese Gerontological Evaluation Study (JAGES) with a 9-year follow-up. Falls information was collected through a questionnaire and categorized into no falls, single and multiple falls. Dementia and all-cause mortality data were obtained from the long-term care insurance (LTCI) system. The Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs), and causal mediation analysis (CMA) was used to assess the mediating effects of dementia.</p><p><strong>Results: </strong>A total of 52,076 participants were included in the study. Compared to participants with no falls, participants with single and multiple falls had an increased risk of dementia (single fall, HRs = 1.18, 95% CIs 1.12-1.24; multiple falls, HRs = 1.66, 95% CIs 1.56-1.77) and all-cause mortality (single fall, HRs = 1.09, 95% CIs 1.04-1.15; multiple falls, HRs = 1.34, 95% CIs 1.26-1.43), and the risk increased with the number of falls (P for trend < 0.01). In addition, dementia significantly mediated the association between falls and risk of all-cause mortality (NIE: HRs = 1.02, 95% CIs 1.00-1.04, PM = 15.0%).</p><p><strong>Conclusion: </strong>Falls are associated with the risk of dementia and all-cause mortality. Dementia has important mediating effects in the association between falls and the risk of all-cause mortality.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"645-654"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of determining gait independence using adductor pollicis muscle thickness and skeletal muscle mass index in community-dwelling older adults undergoing outpatient rehabilitation.","authors":"Taisei Ishimoto, Takehiro Fujimoto, Ken Hisamatsu, Nozomi Matsudaira, Hikaru Hayashi, Risako Hashimoto, Yoshio Toyota, Naoki Akazawa","doi":"10.1007/s41999-024-01145-0","DOIUrl":"10.1007/s41999-024-01145-0","url":null,"abstract":"<p><strong>Objective: </strong>The accuracy of determining gait independence using adductor pollicis muscle thickness (APMT) and skeletal muscle mass index (SMI) in community-dwelling older adults undergoing outpatient rehabilitation remains unclear. The purpose of this study was to compare the accuracy of determining gait independence using APMT and SMI in community-dwelling older adults undergoing outpatient rehabilitation.</p><p><strong>Methods: </strong>This study included 98 older adults (mean age: 85.2 years). Participants received outpatient rehabilitation one to three times a week. The main outcomes were gait independence (functional independence measure gait score: 6 or 7), skeletal muscle mass index (SMI), and APMT. Receiver operating characteristic (ROC) curves of APMT and SMI for gait independence were created, and cut-off values were calculated using the Youden index. Additionally, the area under the curve (AUC) s of the APMT model and the SMI model were compared using the Delong test.</p><p><strong>Results: </strong>Among the 98 participants (male; 19, female; 79), 53 (54.1%) were in the gait independent group. The cut-off value of APMT calculated from the ROC curve was 13 mm; the sensitivity and specificity were 67.9% and 86.7%, respectively; and the AUC was 0.800. The cut-off value of SMI calculated from the ROC curve was 4.6 kg/m²; the sensitivity and specificity were 90.6% and 26.7%, respectively; and the AUC was 0.582. The AUC for the APMT model was significantly higher than the SMI model (P < 0.001).</p><p><strong>Conclusions: </strong>The results of this study show that the cut-off value of APMT for determining the gait independence was 13 mm. In addition, APMT had a higher accuracy of determining gait independence than SMI. This indicates that measuring APMT is more useful for predicting gait independence than SMI in community-dwelling older adults undergoing outpatient rehabilitation.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"615-623"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation is associated with gut microbiota diversity in post-stroke patients.","authors":"Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Kouki Yoneda, Keisuke Maeda","doi":"10.1007/s41999-025-01159-2","DOIUrl":"10.1007/s41999-025-01159-2","url":null,"abstract":"<p><strong>Background: </strong>There is growing interest in gut microbiota and health outcomes. However, the relationship between systemic inflammation and gut microbiota diversity in hospitalized patients remains unclear. This study aimed to investigate the association in post-stroke rehabilitation patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on post-stroke patients admitted to a rehabilitation hospital. Systemic inflammation was assessed using the modified Glasgow Prognostic Score (mGPS). Gut microbiota diversity was evaluated using three indices: Shannon index, Operational Taxonomic Unit (OTU) richness, and Faith's Phylogenetic Diversity (PD). Multiple linear regression analyses were performed to examine the relationship between mGPS and gut microbiota diversity indices, adjusting for potential confounders.</p><p><strong>Results: </strong>A total of 156 patients (mean age 78.4 years; 55.7% men) were analyzed. The median mGPS was 0 (interquartile range: 0-1), with GPS distribution: 61.8% scored 0, 25.7% scored 1, and 12.5% scored 2. After adjusting for confounders, mGPS was significantly and negatively associated with the Shannon index (B = -0.143, 95% CI -0.288 to -0.002, β = -0.177) and OTU richness (B = -17.832, 95% CI -24.349 to -3.951, β = -0.208). However, no significant association was observed between mGPS and Faith's PD (B = -1.155, 95% CI -2.464 to 0.189, β = -0.155).</p><p><strong>Conclusion: </strong>This study demonstrates a significant negative association between systemic inflammation and both quantitative and qualitative gut microbiota diversity in post-stroke patients.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"689-699"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}