European Geriatric Medicine最新文献

{"title":"Epidemiology and assessments of delirium in nursing homes and rehabilitation facilities: a cross-country perspective.","authors":"Alice M Ornago, Elena Pinardi, Maria Cristina Ferrara, Suzanne Timmons, Chukwuma Okoye, Alberto Finazzi, Paolo Mazzola, Peter Nydahl, Rebecca von Haken, Heidi Lindroth, Keibun Liu, Alessandro Morandi, Giuseppe Bellelli","doi":"10.1007/s41999-025-01207-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01207-x","url":null,"abstract":"<p><strong>Purpose: </strong>Delirium represents a significant healthcare challenge in long-term care settings. This study aims to investigate the epidemiology of delirium in long-term care facilities (LTCFs) across various countries, examining point prevalence and assessment methods.</p><p><strong>Methods: </strong>This descriptive analysis included data from 94 surveys conducted in LTCFs on World Delirium Awareness Day (WDAD), March 15th, 2023. Group comparisons were made between rehabilitation facilities (RFs) and nursing homes (NHs).</p><p><strong>Results: </strong>Of the participating units/wards, primarily from Europe and Australia, 65 were RFs and 29 were NHs. The overall reported delirium point prevalence was approximately 12%, with higher rates in RFs than in NHs. While most units/wards reported using a validated delirium detection tool, notable differences emerged in the frequency of assessments, the personnel conducting them, and delirium awareness interventions across settings.</p><p><strong>Conclusion: </strong>Despite the well-documented impact of delirium on residents, the international variability in clinical practices within LTCFs highlights the current inadequacy in adopting effective and consistent strategies to address this condition.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a multifaceted intervention on antibiotic use for common infections in nursing homes in Spain. A before and after study.","authors":"Ramon Monfà, Ana García-Sangenís, Rosa Morros, Carlota Manuela Zárate Sáez, Jesús Mateos-Nozal, María N Vaquero Pinto, Carmen Sáez Bejar, Elena López Pérez, Consuelo Rodríguez Jiménez, Rosa Magallón-Botaya, Priscila Matovelle, Alicia Navarro Sanmartín, Carl Llor","doi":"10.1007/s41999-025-01193-0","DOIUrl":"https://doi.org/10.1007/s41999-025-01193-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to assess the impact of a multifaceted intervention aimed at nursing home staff on antibiotic use and hygiene elements for nursing home residents with common infections.</p><p><strong>Methods: </strong>Before-and-after study carried out in nursing homes in five areas of Spain. Nursing staff registered residents with common infections and documented hygiene practices over three months, before and after a 2-h educational intervention in autumn 2023. The intervention focused on the initial registration results, antibiotic guidelines, infection prevention, and management strategies for nursing homes. Indicators for potentially unnecessary antibiotic use and non-first-line antibiotics were developed, and results from both registration periods (Feb-Apr 2023 and Feb-Apr 2024) were compared to assess impact.</p><p><strong>Results: </strong>Of 34 nursing homes, 23 completed the intervention and the two registrations (67.6%). Staff reported 1003 infections in the first registration and 789 in the second. The overall antibiotic prescription rate was 84.6%. Potentially inappropriate antibiotic use for urinary tract infections decreased from 70.3 to 59.9% (P < 0.005) and use for respiratory infections dropped from 78.1 to 62.7% (P < 0.001), with inappropriate use decreasing from 46.3 to 31% (P < 0.001). The mean duration of antibiotics for cystitis reduced from 7 to 5.4 days (P < 0.05). The intervention had no impact on hygiene practices.</p><p><strong>Conclusion: </strong>Potentially unnecessary antibiotic use was lower after the intervention, whereas hygiene practices were unchanged. A more intensive, multifaceted educational approach is needed for a greater impact.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the acutely presenting older patient screener for short term mortality prediction in older patients hospitalized for COVID-19.","authors":"Rosalinde A L Smits, Bas F M van Raaij, Steffy W M Jansen, Jessica M van der Bol, Carolien M J van der Linden, Harmke A Polinder-Bos, Hanna C Willems, Ewout W Steyerberg, Maarten van Smeden, Jacobijn Gussekloo, Simon P Mooijaart, Stella Trompet","doi":"10.1007/s41999-025-01200-4","DOIUrl":"https://doi.org/10.1007/s41999-025-01200-4","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to validate the acutely presenting older patient (APOP) screener, routinely used on the Emergency Department to predict risk of adverse outcomes in older people, for prediction of in-hospital mortality and 30-days-mortality in older patients hospitalized for COVID-19.</p><p><strong>Methods: </strong>Patients ≥ 70 years from a multicenter cohort hospitalized for COVID-19 with measured APOP risk were included. External validation analysis of the APOP screener for in-hospital mortality and 30-days-mortality was performed including discrimination and calibration.</p><p><strong>Results: </strong>389 patients (median age 80 (IQR 75-85) years, 41.4% female, 138 APOP high risk) were included. APOP high risk patients more often lived institutionalized, (26% vs. 4%; p < 0.001), had more comorbidities (Charlson Comorbidity Index 2 (1-3) vs. 2 (0-3); p = 0.002) and were less often fit (Clinical Frailty Scale 1-3 17% vs. 62%; p < 0.001). 84 patients died in hospital and 114 within 30 days. APOP high risk patients had a higher risk of in-hospital-death [OR 1.6 (95% CI 1.0-2.6)] and death within 30 days [OR 2.7 (95% CI 1.7-4.2)]. The APOP screener discriminated poorly for in-hospital mortality [AUC 0.56 (95% CI 0.48-0.63)] and for 30-days-mortality [AUC 0.62 (95% CI 0.55-0.68)]. Calibration plots revealed overestimation of the screener for both mortality risks.</p><p><strong>Conclusion: </strong>The APOP screener had a poor predictive performance for in-hospital mortality and 30-days-mortality in older people hospitalized for COVID-19. Screening tools routinely used on the ED may not be useful to predict mortality in different than usual clinical circumstances such as during a pandemic of a novel disease.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyspepsia in nonagenarian women.","authors":"Ersin Kuloglu, Ilker Sengul, Demet Sengul, Ali Muhtaroglu, Sefer Aslan, Kubilay Issever, Ahmet Cumhur Dulger","doi":"10.1007/s41999-025-01197-w","DOIUrl":"https://doi.org/10.1007/s41999-025-01197-w","url":null,"abstract":"<p><strong>Purpose: </strong>Dyspeptic complaints are common across all age groups, but limited research explores their characteristics and underlying pathologies in nonagenarians. This pioneering study aims to investigate the clinical, laboratory, and histopathological features in women nonagenarians vs. middle-aged.</p><p><strong>Methods: </strong>A cross-sectional study included 93 female nonagenarians and 90 under 65 years (control), all presenting with dyspeptic complaints to general surgery, internal medicine, and gastroenterology outpatient clinics. Both groups underwent comprehensive evaluations, including laboratory parameters, upper gastric endoscopic examinations, and histopathological assessments of gastric biopsies. Statistical analysis compared the two groups' demographic, laboratory, and histopathological findings.</p><p><strong>Results: </strong>Of the patients included in the study, 49.8% were under 65 years, and 50.2% were nonagenarians. The mean age of the control group was 54.8 years, while nonagenarians had a mean age of 92.7 years. Significant differences were observed in several laboratory biomarkers such as leukocytes, neutrophils, glucose, creatinine, sodium, potassium, albumin, alanine transaminase, C-reactive protein, etc. between the groups (p < 0.05). Nonagenarians were less infected with Helicobacter pylori, whereas they had a higher frequency of intestinal metaplasia.</p><p><strong>Conclusions: </strong>Nonagenarians group has a higher rate of intestinal metaplasia and displasia, while a lower rate of Helicobacter pylori infection in their gastric mucosal specimens. More extensive randomized controlled trials should illuminate the possible pathophysiological mechanisms for this association.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of falls with risk of dementia and all-cause mortality: a cohort study of Japanese older adults with a 9-year follow-up.","authors":"Xiangbin Zhong, Keyang Liu, Yao Yao, Honglin Cai, Baoqing Huang, Xiaojing Yuan, Kokoro Shirai, Katsunori Kondo, Liqi Guan, Qiqing Chen, Xinlei Wang, Yuting Li","doi":"10.1007/s41999-024-01149-w","DOIUrl":"10.1007/s41999-024-01149-w","url":null,"abstract":"<p><strong>Objective: </strong>Many risk factors affect dementia and all-cause mortality. However, whether falls are a risk factor for dementia and all-cause mortality is unclear. The study examines the association of falls with the risk of dementia and all-cause mortality, and whether dementia mediates the association of falls with all-cause mortality.</p><p><strong>Methods: </strong>Data were taken from the Japanese Gerontological Evaluation Study (JAGES) with a 9-year follow-up. Falls information was collected through a questionnaire and categorized into no falls, single and multiple falls. Dementia and all-cause mortality data were obtained from the long-term care insurance (LTCI) system. The Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs), and causal mediation analysis (CMA) was used to assess the mediating effects of dementia.</p><p><strong>Results: </strong>A total of 52,076 participants were included in the study. Compared to participants with no falls, participants with single and multiple falls had an increased risk of dementia (single fall, HRs = 1.18, 95% CIs 1.12-1.24; multiple falls, HRs = 1.66, 95% CIs 1.56-1.77) and all-cause mortality (single fall, HRs = 1.09, 95% CIs 1.04-1.15; multiple falls, HRs = 1.34, 95% CIs 1.26-1.43), and the risk increased with the number of falls (P for trend < 0.01). In addition, dementia significantly mediated the association between falls and risk of all-cause mortality (NIE: HRs = 1.02, 95% CIs 1.00-1.04, PM = 15.0%).</p><p><strong>Conclusion: </strong>Falls are associated with the risk of dementia and all-cause mortality. Dementia has important mediating effects in the association between falls and the risk of all-cause mortality.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"645-654"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of determining gait independence using adductor pollicis muscle thickness and skeletal muscle mass index in community-dwelling older adults undergoing outpatient rehabilitation.","authors":"Taisei Ishimoto, Takehiro Fujimoto, Ken Hisamatsu, Nozomi Matsudaira, Hikaru Hayashi, Risako Hashimoto, Yoshio Toyota, Naoki Akazawa","doi":"10.1007/s41999-024-01145-0","DOIUrl":"10.1007/s41999-024-01145-0","url":null,"abstract":"<p><strong>Objective: </strong>The accuracy of determining gait independence using adductor pollicis muscle thickness (APMT) and skeletal muscle mass index (SMI) in community-dwelling older adults undergoing outpatient rehabilitation remains unclear. The purpose of this study was to compare the accuracy of determining gait independence using APMT and SMI in community-dwelling older adults undergoing outpatient rehabilitation.</p><p><strong>Methods: </strong>This study included 98 older adults (mean age: 85.2 years). Participants received outpatient rehabilitation one to three times a week. The main outcomes were gait independence (functional independence measure gait score: 6 or 7), skeletal muscle mass index (SMI), and APMT. Receiver operating characteristic (ROC) curves of APMT and SMI for gait independence were created, and cut-off values were calculated using the Youden index. Additionally, the area under the curve (AUC) s of the APMT model and the SMI model were compared using the Delong test.</p><p><strong>Results: </strong>Among the 98 participants (male; 19, female; 79), 53 (54.1%) were in the gait independent group. The cut-off value of APMT calculated from the ROC curve was 13 mm; the sensitivity and specificity were 67.9% and 86.7%, respectively; and the AUC was 0.800. The cut-off value of SMI calculated from the ROC curve was 4.6 kg/m²; the sensitivity and specificity were 90.6% and 26.7%, respectively; and the AUC was 0.582. The AUC for the APMT model was significantly higher than the SMI model (P < 0.001).</p><p><strong>Conclusions: </strong>The results of this study show that the cut-off value of APMT for determining the gait independence was 13 mm. In addition, APMT had a higher accuracy of determining gait independence than SMI. This indicates that measuring APMT is more useful for predicting gait independence than SMI in community-dwelling older adults undergoing outpatient rehabilitation.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"615-623"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation is associated with gut microbiota diversity in post-stroke patients.","authors":"Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Kouki Yoneda, Keisuke Maeda","doi":"10.1007/s41999-025-01159-2","DOIUrl":"10.1007/s41999-025-01159-2","url":null,"abstract":"<p><strong>Background: </strong>There is growing interest in gut microbiota and health outcomes. However, the relationship between systemic inflammation and gut microbiota diversity in hospitalized patients remains unclear. This study aimed to investigate the association in post-stroke rehabilitation patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on post-stroke patients admitted to a rehabilitation hospital. Systemic inflammation was assessed using the modified Glasgow Prognostic Score (mGPS). Gut microbiota diversity was evaluated using three indices: Shannon index, Operational Taxonomic Unit (OTU) richness, and Faith's Phylogenetic Diversity (PD). Multiple linear regression analyses were performed to examine the relationship between mGPS and gut microbiota diversity indices, adjusting for potential confounders.</p><p><strong>Results: </strong>A total of 156 patients (mean age 78.4 years; 55.7% men) were analyzed. The median mGPS was 0 (interquartile range: 0-1), with GPS distribution: 61.8% scored 0, 25.7% scored 1, and 12.5% scored 2. After adjusting for confounders, mGPS was significantly and negatively associated with the Shannon index (B = -0.143, 95% CI -0.288 to -0.002, β = -0.177) and OTU richness (B = -17.832, 95% CI -24.349 to -3.951, β = -0.208). However, no significant association was observed between mGPS and Faith's PD (B = -1.155, 95% CI -2.464 to 0.189, β = -0.155).</p><p><strong>Conclusion: </strong>This study demonstrates a significant negative association between systemic inflammation and both quantitative and qualitative gut microbiota diversity in post-stroke patients.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"689-699"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonious ageing: a narrative review of music therapy in the biomedical literature.","authors":"Shaz Raja, Ciara Barry, Rohit Upadhyay, Rana Alash, Méabh O'Raghallaigh, Róisín Hayes, Roman Romero-Ortuno","doi":"10.1007/s41999-024-01146-z","DOIUrl":"10.1007/s41999-024-01146-z","url":null,"abstract":"<p><strong>Purpose: </strong>As the global population of older adults rises, the United Nations Decade of Healthy Ageing (2021-2030) advocates for disease prevention, management, and enhancing overall wellbeing in older adults. We reviewed the MEDLINE literature under the MeSH term \"music therapy\" (MT), for its role in promoting healthy ageing.</p><p><strong>Methods: </strong>A systematic search of the MEDLINE biomedical database (Ovid) was conducted using \"MT\" and \"Ageing\" as keywords, retrieving relevant full-text studies in English. Preference was given to more recent studies with higher levels of evidence. The studies were categorised according to the biopsychosocial framework into physical, cognitive and social domains, and further subcategorised based on their relevance to disease prevention and management.</p><p><strong>Results: </strong>The initial search identified 1147 articles, of which 75 met inclusion criteria. Studies encompassed both MT and music interventions delivered by non-music therapists. Overall, studies showed benefits in the promotion of physical health, including enhancing exercise capacity and improving fitness among older adults. Results were promising in managing conditions such as Parkinson's disease and frailty. In the area of brain health, studies showed cognitive benefits, particularly in attention and processing speed among older adults. Socially, there was evidence of enhanced quality of life, reduced anxiety and depression, and improved social engagement, including in people living with dementia, underscoring the role of music in fostering emotional connections and mitigating caregiver stress.</p><p><strong>Conclusion: </strong>MT and interventions can enhance biopsychosocial health outcomes in older adults. Research should prioritise isolating MT's specific effects, standardising definitions and methodologies, and exploring therapeutic mechanisms.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"461-472"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching Comprehensive Geriatric Assessment (CGA) in medical education: a scoping review.","authors":"Regina Roller-Wirnsberger, Carolin Herzog, Sonja Lindner-Rabl, Mathias Schlögl, Maddalena Illario, Maria Cristina Polidori, Katrin Singler","doi":"10.1007/s41999-025-01157-4","DOIUrl":"10.1007/s41999-025-01157-4","url":null,"abstract":"<p><strong>Purpose: </strong>To gather and summarize evidence on educational and training formats for medical doctors in performing Comprehensive Geriatric Assessment (CGA) in under- and postgraduate medical education.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using the databases Medline, CINAHL, Cochrane and Embase to identify educational intervention studies and cohort studies related to CGA education and training for medical professionals. Additional references were incorporated through reference tracking. Studies included were then grouped according to competence level addressed during CGA trainings to create a current competence-based framework on educational tools to teach CGA to medical students and doctors.</p><p><strong>Results: </strong>Sixty eligible studies were identified, with 42 addressing the full implementation of CGA and 18 focusing on specific CGA domains. High variability in duration, intervention design and evaluation methods was consistently observed across the included studies.</p><p><strong>Conclusion: </strong>The findings underscore the need for further coordinated research in CGA education and training to consolidate evidence and pave the way to more innovative, high-quality healthcare systems capable of addressing the complexities of an aging society.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"425-433"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between depression and cardiovascular disease in older people: results from a large-scale epidemiological cohort study in Japan.","authors":"Kaoruko Komuro, Jin Komuro, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro, Masaki Ieda, Norihiko Takeda","doi":"10.1007/s41999-024-01128-1","DOIUrl":"10.1007/s41999-024-01128-1","url":null,"abstract":"<p><strong>Background: </strong>Depression is known to be associated with a greater risk of developing cardiovascular disease (CVD) in middle-aged people. However, it is not certain how depression would influence incident CVD in older people aged ≥ 75 years. We investigated the association between depression and CVD in older people.</p><p><strong>Methods: </strong>We analyzed 146,085 individuals aged ≥ 75 years including 7581 individuals (5.2%) with depression registered in the DeSC database from April 2014 to November 2022. We excluded those with a prior history of CVD. The incidence of composite CVD events, comprising ischemic heart disease (IHD), heart failure, and stroke was documented. A Cox proportional hazard regression analysis was conducted to estimate hazard ratios (HR) associated with the presence of depression.</p><p><strong>Results: </strong>The median age was 79 years and 41.0% were men. During the mean follow-up period of 3.4 ± 1.5 years, 39,552 composite CVD events (IHD: n = 10,916; heart failure: n = 26,719; stroke: n = 13,090) were recorded. Multivariable Cox regression analyses showed that older individuals with depression had a greater risk of composite CVD events than those without (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.24-1.34). The HR (95% CI) of depression was 1.26 (1.17-1.37) for IHD, 1.25 (1.19-1.31) for heart failure, and 1.30 (1.21-1.39) for stroke, respectively. While considering the limitations of real-world data, we conducted multiple sensitivity analyses, which confirmed the results of the primary analysis.</p><p><strong>Conclusions: </strong>The presence of depression was independently associated with a greater risk of developing CVD even in older individuals.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"673-680"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}