European Geriatric Medicine最新文献

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Characteristics and care trajectories of older patients in temporary stays in Denmark. 丹麦临时住院老年患者的特点和护理轨迹。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-11 DOI: 10.1007/s41999-025-01209-9
Hanin Harbi, Carina Lundby, Peter Bjødstrup Jensen, Søren Post Larsen, Linda Grouleff Rørbæk, Lene Vestergaard Ravn-Nielsen, Jesper Ryg, Mette Reilev, Kasper Edwards, Anton Pottegård
{"title":"Characteristics and care trajectories of older patients in temporary stays in Denmark.","authors":"Hanin Harbi, Carina Lundby, Peter Bjødstrup Jensen, Søren Post Larsen, Linda Grouleff Rørbæk, Lene Vestergaard Ravn-Nielsen, Jesper Ryg, Mette Reilev, Kasper Edwards, Anton Pottegård","doi":"10.1007/s41999-025-01209-9","DOIUrl":"10.1007/s41999-025-01209-9","url":null,"abstract":"<p><strong>Purpose: </strong>Temporary stays for patients requiring short-term care outside the home, often following hospital discharge, has gained increasing importance. This study aimed to describe the characteristics and care trajectories of older patients in Danish temporary stays to improve care delivery and patient safety.</p><p><strong>Methods: </strong>We conducted a descriptive study on a cohort of patients in temporary stays across 14 Danish municipalities from 2016 to 2023, using data from national health registries.</p><p><strong>Results: </strong>We identified 11,424 patients with a median age of 81 years (interquartile range [IQR] 73-87 years); 54% were women. Patients exhibited a high level of comorbidity, with a median Charlson Comorbidity Index of 1 (IQR 0-2), and a median of 3 hospital admissions (IQR 2-6) in the year preceding their move into temporary care. The majority (70%) transitioned to temporary stays following hospital discharge, while 30% were admitted directly from their homes. The median duration of temporary stays was 24 days (IQR 11-49 days), with 9.1% staying ≥ 90 days. Additionally, 7.0% of patients were hospitalised directly from the temporary stay facility, with a median time to hospital admission of 13 days (IQR 5-28 days). Median survival after admission to a temporary stay was 23 months (IQR 3.6-57 months). Predictors of mortality included male sex, older age, higher comorbidity burden, and increased number of hospital admissions prior to temporary stay.</p><p><strong>Conclusion: </strong>Patients in temporary stays are generally older individuals with multimorbidity and limited life expectancy. Most patients are admitted following hospital discharge, and their stays are often prolonged.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1437-1445"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frailty is associated with a history of falls among mobility-limited older adults-cross-sectional multivariate analysis from the BIOFRAIL study. 在行动受限的老年人中,虚弱与跌倒史有关——来自BIOFRAIL研究的横断面多变量分析。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-27 DOI: 10.1007/s41999-025-01239-3
Pernille Hansen, H Nygaard, M Schultz, F Dela, P Aagaard, Jesper Ryg, C Suetta
{"title":"Frailty is associated with a history of falls among mobility-limited older adults-cross-sectional multivariate analysis from the BIOFRAIL study.","authors":"Pernille Hansen, H Nygaard, M Schultz, F Dela, P Aagaard, Jesper Ryg, C Suetta","doi":"10.1007/s41999-025-01239-3","DOIUrl":"10.1007/s41999-025-01239-3","url":null,"abstract":"<p><strong>Aim: </strong>To identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling but who have not yet fallen.</p><p><strong>Findings: </strong>Frailty and muscle strength were characteristics distinguishing between older adults with a history of falls and those absent of falls despite an increased risk of falling.</p><p><strong>Message: </strong>Frailty should be incorporated alongside handgrip strength (HGS) and sit-to-stand (STS) tests into routine evaluations of mobility-limited older adults referred for fall assessment.</p><p><strong>Purpose: </strong>We aimed to identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling, and to identify the parameter with the strongest predictive value on the risk of falling.</p><p><strong>Methods: </strong>Data included anthropometry, HGS, 30-s and 5-reps STS tests, maximal isometric knee extensor strength, gait speed (6 m), postural balance (tandem test), and muscle mass (BIA). Frailty was assessed using the Clinical Frailty Scale (CFS) and sarcopenia was evaluated according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) guidelines. Outcomes of falls (past year), and depression (Geriatric Depression Scale 15) were self-reported.</p><p><strong>Results: </strong>Totally, 505 mobility-limited older adults (mean age 79.7 ± 6.3 years, 64.8% females) were included. Of these, 400 (79.2%) had experienced one or more falls within the past year (fallers), while 105 (20.8%) had not experienced a fall (at risk). Patients with experienced falls were more likely to feel depressed, had reduced handgrip strength, and reduced performance in both STS tests compared to those who had not fallen. Frailty was the strongest individual parameter associated with a history of prior falls, even after adjusting for covariates such as depression and 30-s STS (aOR 3.80; 95% CI 1.70-8.50).</p><p><strong>Conclusions: </strong>Present study identified frailty as a key factor independently associated with a history of falls in this population. Additionally, handgrip strength and STS performance were key characteristics distinguishing between older adults with a history of falls within the past 12 months and those at risk of falling.</p><p><strong>Trial registration: </strong>NCT05795556.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1283-1293"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between frailty and hospital-related adverse events in older hospitalised patients: a systematic literature review. 老年住院患者虚弱与医院相关不良事件之间的关系:系统文献综述
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1007/s41999-025-01242-8
Faris Alotaibi, Abdullah Alshibani, Jay Banerjee, Brad Manktelow
{"title":"The association between frailty and hospital-related adverse events in older hospitalised patients: a systematic literature review.","authors":"Faris Alotaibi, Abdullah Alshibani, Jay Banerjee, Brad Manktelow","doi":"10.1007/s41999-025-01242-8","DOIUrl":"10.1007/s41999-025-01242-8","url":null,"abstract":"<p><strong>Introduction: </strong>Studies have shown that hospital-related adverse events (AEs) affect older hospitalised patients. Frailty is an age-related syndrome of increased vulnerability, the risk of abrupt and extreme health changes, and the risk of suffering an adverse event (AE). Most of the published work focuses on the relationship between age alone and AEs' incidence. We aim to examine the association between frailty and the incidence of hospital-related AEs among hospitalised older adults in the published literature.</p><p><strong>Methods: </strong>A comprehensive search of Ovid MEDLINE, CINAHL, Scopus, and Web of Science databases was conducted between January and February 2024. Studies were included if they provide original data in English, regardless of methodology. In addition, the reference lists of all included studies were manually screened to identify any further eligible studies. The narrative synthesis followed the Cochrane methodology.</p><p><strong>Results: </strong>This review includes 19 observational studies, with the USA being the most common study location. Various frailty tools and definitions were used, with the frailty index (FI) being the most frequently employed tool. Hospital-acquired infections, including pneumonia, urinary tract infections (UTIs), sepsis and wound infections, were the most frequently reported adverse events, followed by delirium. In addition, falls, pressure ulcers and venous thromboembolism were also commonly documented.</p><p><strong>Conclusion: </strong>This review found that frailty is associated with an increased risk of hospital-acquired infections, in-hospital delirium, falls and pressure ulcers. More extensive and comprehensive studies are needed to focus on patient safety incidents among frail hospitalised individuals.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1303-1318"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Better survival of older patients with stroke managed in a collaborative stroke pathway. 协作卒中途径管理老年卒中患者更好的生存率。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-27 DOI: 10.1007/s41999-025-01225-9
Bruno Oquendo, Witold Jarzebowski, Charlotte Nouhaud, Anne Leger, Christel Oasi, Charlotte Havreng-Thery, Carmelo Lafuente-Lafuente, Joel Belmin
{"title":"Better survival of older patients with stroke managed in a collaborative stroke pathway.","authors":"Bruno Oquendo, Witold Jarzebowski, Charlotte Nouhaud, Anne Leger, Christel Oasi, Charlotte Havreng-Thery, Carmelo Lafuente-Lafuente, Joel Belmin","doi":"10.1007/s41999-025-01225-9","DOIUrl":"10.1007/s41999-025-01225-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the survival of stroke patients over 70 years old managed in the collaborative Stroke Pathway dedicated to the OLD patients (SPOLD) with those referred to conventional rehabilitation wards.</p><p><strong>Methods: </strong>This longitudinal observational retrospective cohort study involved over 70 years old patients referred from the same neurovascular emergency unit in a university hospital in France to a post-stroke geriatric unit within the SPOLD pathway, compared to patients referred to conventional rehabilitation ward during the same period. Initial stroke severity and comorbidities were assessed using the NIHSS score and the Charlson index, respectively. The primary endpoint was 2-year survival, analyzed using Cox models for both the entire cohort and a propensity score-matched cohort to control for referral bias.</p><p><strong>Results: </strong>The study included 262 patients with a mean age of 84.5 ± 6.7 years, of whom 122 (46.6%) were male. Patients in the SPOLD group (n = 101) had significantly higher age, NIHSS scores, and Charlson indices compared to those in the conventional rehabilitation ward (n = 161). Adjusted mortality was significantly lower in SPOLD patients (OR: 0.525, 95% CI: 0.298 to 0.924, p = 0.025). In the propensity score-matched cohort, mortality was also significantly lower for SPOLD patients (OR: 0.426, 95% CI: 0.212 to 0.857, p = 0.017).</p><p><strong>Conclusion: </strong>This study suggests that this collaborative organization between a neurovascular emergency unit and a rehabilitation geriatric unit may be associated with a better survival of older patients after stroke.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1551-1558"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study. 更正:住院的八旬高龄COVID-19患者的临床特征及并发症和死亡率预测因素:一项双透视研究。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 DOI: 10.1007/s41999-025-01249-1
Marta Arroyo-Huidobro, Natàlia Pallarès Fontanet, Cristian Tebé Cordomí, Antonella F Simonetti, Carlos Pérez-López, Gabriela Abelenda-Alonso, Alexander Rombauts, Isabel Oriol Bermudez, Elisenda Izquierdo, Vicente Díaz-Brito, Gemma Molist, Guadalupe Gómez Melis, Sebastian Videla, Alfons López Soto, Jordi Carratalà, Alejandro Rodriguez-Molinero
{"title":"Correction: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study.","authors":"Marta Arroyo-Huidobro, Natàlia Pallarès Fontanet, Cristian Tebé Cordomí, Antonella F Simonetti, Carlos Pérez-López, Gabriela Abelenda-Alonso, Alexander Rombauts, Isabel Oriol Bermudez, Elisenda Izquierdo, Vicente Díaz-Brito, Gemma Molist, Guadalupe Gómez Melis, Sebastian Videla, Alfons López Soto, Jordi Carratalà, Alejandro Rodriguez-Molinero","doi":"10.1007/s41999-025-01249-1","DOIUrl":"10.1007/s41999-025-01249-1","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1559"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches to characterising multimorbidity in older people accessing hospital care: a scoping review. 描述接受医院护理的老年人多病特征的方法:范围界定综述。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-03-01 DOI: 10.1007/s41999-025-01166-3
Jonathan G Bunn, Lewis Steell, Susan J Hillman, Miles D Witham, Avan A Sayer, Rachel Cooper
{"title":"Approaches to characterising multimorbidity in older people accessing hospital care: a scoping review.","authors":"Jonathan G Bunn, Lewis Steell, Susan J Hillman, Miles D Witham, Avan A Sayer, Rachel Cooper","doi":"10.1007/s41999-025-01166-3","DOIUrl":"10.1007/s41999-025-01166-3","url":null,"abstract":"<p><strong>Purpose: </strong>An increasing proportion of older adults accessing hospital care are living with multimorbidity, with a high degree of complexity of multimorbidity in older hospital populations expected. We aimed to assess approaches taken to characterise multimorbidity in older adults accessing hospital care, including how complexity is considered.</p><p><strong>Methods: </strong>Following established scoping review guidelines, all published studies that characterised multimorbidity in a hospital population, with average age ≥ 65 years, were identified via a prespecified search strategy. Six electronic databases were searched to identify peer-reviewed literature published to September 2023 meeting eligibility criteria. Screening was undertaken by two independent reviewers, and data extracted using a standard proforma.</p><p><strong>Results: </strong>Of 5305 titles and abstracts screened, 75 papers, reporting on 72 unique study populations across 24 countries, met inclusion criteria. There was heterogeneity in most aspects of characterisation. Multimorbidity was defined in 43% (n = 31/72) of studies; most (n = 59/72, 82%) aimed to describe a multimorbidity-outcome association. Number of conditions considered ranged from 2 to 285 and weighted indices were used as a measure of multimorbidity in 75% (n = 54/72) of studies, with 56% (n = 40/72) using a version of the Charlson Comorbidity Index. Complexity was explicitly studied in 17% (n = 12/72) of studies.</p><p><strong>Discussion: </strong>Our review highlights heterogeneity in characterisation of multimorbidity in older adults accessing hospital care, with limited consideration of complexity. As the proportion of older adults accessing hospital care who are living with multimorbidity increases, better characterisation of their multiple conditions and associated complexity is a priority to ensure delivery of appropriately tailored care.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1099-1113"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of potentially inappropriate prescribing in community-dwelling older adults: an application of STOPP/START version 3 to The Irish Longitudinal Study on Ageing (TILDA). 在社区居住的老年人中潜在不适当处方的患病率:STOPP/START版本3在爱尔兰老龄化纵向研究(TILDA)中的应用。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1007/s41999-025-01201-3
Ann Sinéad Doherty, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Rose Anne Kenny, Denis O'Mahony, Emma Wallace
{"title":"Prevalence of potentially inappropriate prescribing in community-dwelling older adults: an application of STOPP/START version 3 to The Irish Longitudinal Study on Ageing (TILDA).","authors":"Ann Sinéad Doherty, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Rose Anne Kenny, Denis O'Mahony, Emma Wallace","doi":"10.1007/s41999-025-01201-3","DOIUrl":"10.1007/s41999-025-01201-3","url":null,"abstract":"<p><strong>Purpose: </strong>Potentially inappropriate prescribing includes prescribing potentially inappropriate medicines (PIMs), where risk of medication-related harm may outweigh the clinical benefit(s), and potential prescribing omissions (PPOs), whereby clinically indicated medications are unprescribed without good reason. This study aimed to assess prevalence of PIMs and PPOs (subset of STOPP/START version 3) in older community-dwelling adults and any association with healthcare utilisation and functional decline over time.</p><p><strong>Methods: </strong>Retrospective cohort study of a nationally representative longitudinal study of ageing in Ireland (n = 3619) (2016-2018). Logistic regressions examined association of patient characteristics with PIMs/PPOs and between prevalent PIMs/PPOs and functional decline. Negative binomial regressions examined association between PIM/PPO with healthcare utilisation over time.</p><p><strong>Results: </strong>Participants' mean age was 74.2 years (SD 6.99), 53.9% were female and were prescribed a mean of 4.02 (SD 3.16) medications. A total of 1123 (31.0%) participants experienced STOPP PIMs and 1309 (36.2%) START PPOs. STOPP PIMs were associated with increased hospital admissions (adjusted incident rate ratio (aIRR) 1.38, 95% confidence interval (CI) 1.08, 1.75), and functional decline (adjusted odds ratio (aOR) 1.46, 95% CI 1.11, 1.91) at follow-up. Age ≥ 75 years (aOR 1.32, 95% CI 1.10, 1.57) and three or more chronic conditions (aOR 5.19, 95% CI 3.69, 7.31) were significantly associated with START PPOs.</p><p><strong>Conclusion: </strong>Approximately one-third of study participants experienced STOPP PIMs, associated with an increased risk of hospital admissions and functional decline. START PPOs also occurred in over one-third, associated with increasing age and degree of multimorbidity. Balancing the risk: benefit of medications for older people with multimorbidity remains challenging.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1389-1402"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimorbidity and fluid biomarkers of Alzheimer's disease: a systematic review. 阿尔茨海默病的多发病和液体生物标志物:系统综述。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-20 DOI: 10.1007/s41999-025-01222-y
Martina Valletta, Marco Canevelli, Francesca Gasparini, Simona Buscarnera, Martina Salzillo, Federico Triolo, Amaia Calderón-Larrañaga, Alessandra Marengoni, Davide Liborio Vetrano, Giulia Grande
{"title":"Multimorbidity and fluid biomarkers of Alzheimer's disease: a systematic review.","authors":"Martina Valletta, Marco Canevelli, Francesca Gasparini, Simona Buscarnera, Martina Salzillo, Federico Triolo, Amaia Calderón-Larrañaga, Alessandra Marengoni, Davide Liborio Vetrano, Giulia Grande","doi":"10.1007/s41999-025-01222-y","DOIUrl":"10.1007/s41999-025-01222-y","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aimed to summarize the evidence on the association between multimorbidity and fluid biomarkers of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>We systematically searched PubMed, Web of Science, and Embase for studies investigating the association between multimorbidity-defined as the co-occurrence of multiple chronic conditions in the same individual-and levels of cerebrospinal fluid (CSF) or blood biomarkers of AD, focusing on the most established AD biomarkers (amyloid-beta, phosphorylated-tau, total-tau, neurofilament light chain, and glial fibrillary acidic protein). Studies were selected following PRISMA guidelines.</p><p><strong>Results: </strong>Out of 3,104 records, we identified 10 cross-sectional studies. Four studies assessed CSF biomarkers in dementia-free participants with mean age between 61.8 and 66.6 years, yielding mixed findings with no consistent association between multimorbidity and CSF biomarkers. Six studies focused on blood biomarkers in participants with mean age ranging from 66.5 to 76.4 years, five of which included individuals with dementia. Most of these studies reported an association between multimorbidity and elevated blood biomarker levels.</p><p><strong>Conclusions: </strong>This review suggests a significant association between multimorbidity and AD blood biomarkers in older populations, while the results on CSF are mixed and inconsistent. Further research is needed, particularly longitudinal studies assessing both CSF and blood biomarkers within the same populations.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1121-1136"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. 老年人慢性利尿剂使用的有效性和安全性:近期发表的系统评价和随机对照试验的荟萃分析综述
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-25 DOI: 10.1007/s41999-025-01229-5
Eveline van Poelgeest, Konstantinos Prokopidis, Tuğba Erdogan, Min Ji Kwak, Karolina Piotrowicz, Luca Paoletti, Annette Eidam, Fatma Özge Kayhan Koçak, Birkan Ilhan, Alessia Beccacece, George Soulis, Serdar Özkök, Gulistan Bahat, Eva Topinková, Joost Daams, M Louis Handoko, Parag Goyal, Jerzy Gąsowski, Antonio Cherubini, Nicola Veronese, Giuseppe Dario Testa, Wade Thompson, Nathalie van der Velde
{"title":"Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials.","authors":"Eveline van Poelgeest, Konstantinos Prokopidis, Tuğba Erdogan, Min Ji Kwak, Karolina Piotrowicz, Luca Paoletti, Annette Eidam, Fatma Özge Kayhan Koçak, Birkan Ilhan, Alessia Beccacece, George Soulis, Serdar Özkök, Gulistan Bahat, Eva Topinková, Joost Daams, M Louis Handoko, Parag Goyal, Jerzy Gąsowski, Antonio Cherubini, Nicola Veronese, Giuseppe Dario Testa, Wade Thompson, Nathalie van der Velde","doi":"10.1007/s41999-025-01229-5","DOIUrl":"10.1007/s41999-025-01229-5","url":null,"abstract":"<p><strong>Background: </strong>Healthcare providers should balance the potential risks and benefits of chronic diuretic use, particularly in older adults, as with age, diuretic benefits may decline and risks increase. A comprehensive synthesis and critical evaluation of the available evidence on chronic diuretic treatment effects is currently lacking.</p><p><strong>Methods: </strong>We conducted an umbrella review of systematic reviews and meta-analyses published since 2018 on health outcomes associated with diuretic use in randomized-controlled trials (RCTs). We conducted random-effects meta-analysis for pooled effect estimates and narratively summarized data that could not be pooled.</p><p><strong>Results: </strong>We included 741 effect estimations from 117 systematic reviews (SRs) on 1566 RCTs in individuals aged 62 ± 6 years. Of our 33 meta-analyses, 11 provided convincing, high-quality evidence: finerenone reduced the risk of cardiovascular (CV) mortality and end-stage kidney disease in individuals with chronic kidney disease (CKD) and/or type 2 diabetes (T2D). Torasemide reduced the risk of heart failure-related hospitalization (HFH) more than furosemide in individuals with HF. Thiazides reduced CV events in individuals with hypertension. Mineralocorticoid receptor antagonists (MRAs) reduced HFH, but also increased hyperkalemia risk in individuals with HF. MRAs also reduced the risk of atrial fibrillation in those with HF or CVD, and reduced HFH, major adverse cardiovascular events (MACEs), > 40% eGFR decrease, and composite kidney outcomes in individuals with CKD and/or T2D. Lower quality evidence suggests that in older (≥ 65 years), but not in younger adults, diuretics may reduce CV mortality, but also increase adverse event (AE) risk.</p><p><strong>Conclusions: </strong>Our umbrella review offers a comprehensive and up-to-date evaluation of the benefits and harms of diuretics. However, further research is needed to establish their efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1353-1387"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Falls prevention in community-dwelling older adults and implementation of world falls guidelines: a call for action across Europe by the European Geriatric Medicine Society Special Interest Group on Falls and Fractures. 社区居住的老年人预防跌倒和实施世界跌倒指南:欧洲老年医学会跌倒和骨折特别兴趣小组呼吁全欧洲采取行动。
IF 3.6 3区 医学
European Geriatric Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1007/s41999-025-01206-y
Nathalie van der Velde, Lotta J Seppala, Alvaro Casas Herrero, Cedric Annweiler, Anna Björg Jónsdóttir, Hubert Blain, Yannis Dionyssiotis, Sofia Duque, James Frith, Bahaa N Francis, Tomasz Grodzicki, Alison Hay, Luisa Alejandra Hernández-Sánchez, Roope Jaatinen, Christof J Kadane, Marko Kolsek, Tomasz Kostka, Lisa McGarrigle, Stany Perkisas, Christoph Pertinatsch, Beatrice Pettersson, Jean-Yves Reginster, Carmelinda Ruggiero, Opinder Sahota, François-Xavier Sibille, Balamrit Singh Sokhal, Dawn A Skelton, Joke Spildooren, Emma Stanmore, Hana Vankova, Ellen Vlaeyen, Yelda Ozturk, Ozlem Yilmaz, Chris Todd, Caterina Trevisan, Hanna Willems, Manuel Montero-Odasso, Finbarr C Martin, Jesper Ryg, Tahir Masud
{"title":"Falls prevention in community-dwelling older adults and implementation of world falls guidelines: a call for action across Europe by the European Geriatric Medicine Society Special Interest Group on Falls and Fractures.","authors":"Nathalie van der Velde, Lotta J Seppala, Alvaro Casas Herrero, Cedric Annweiler, Anna Björg Jónsdóttir, Hubert Blain, Yannis Dionyssiotis, Sofia Duque, James Frith, Bahaa N Francis, Tomasz Grodzicki, Alison Hay, Luisa Alejandra Hernández-Sánchez, Roope Jaatinen, Christof J Kadane, Marko Kolsek, Tomasz Kostka, Lisa McGarrigle, Stany Perkisas, Christoph Pertinatsch, Beatrice Pettersson, Jean-Yves Reginster, Carmelinda Ruggiero, Opinder Sahota, François-Xavier Sibille, Balamrit Singh Sokhal, Dawn A Skelton, Joke Spildooren, Emma Stanmore, Hana Vankova, Ellen Vlaeyen, Yelda Ozturk, Ozlem Yilmaz, Chris Todd, Caterina Trevisan, Hanna Willems, Manuel Montero-Odasso, Finbarr C Martin, Jesper Ryg, Tahir Masud","doi":"10.1007/s41999-025-01206-y","DOIUrl":"10.1007/s41999-025-01206-y","url":null,"abstract":"<p><p>Falls among older adults represent a significant public health challenge due to their consequences, including serious injuries, increased morbidity and mortality, decreased quality of life, and heightened healthcare costs. The World Falls Guidelines (WFG), published in 2022, offer a robust framework for evidence-based interventions; however, the uptake of these guidelines into clinical practice across Europe remains inconsistent. Key barriers to implementation include insufficient resources, a lack of trained healthcare professionals, and limited integration into existing healthcare systems. This position paper by the EuGMS Special Interest Group (SIG) on Falls and Fractures addresses the implementation of the WFG among community-dwelling older adults and falls prevention across Europe by providing an overview of the current status of WFG adoption in Europe and discusses the challenges and opportunities for implementation. We provide an overview of the current resources to support the clinical practice of falls prevention, implementation guides, and educational programs. Additionally, we discuss what is necessary for the future development of these resources and for advancing research. The EuGMS SIG on Falls and Fractures advocates for a commitment of healthcare providers as well as insurers, policymakers, and other stakeholders to collaborative European initiatives-such as developing a standardised falls prevention strategy, promoting evidence-based implementation plans, establishing a European-wide research agenda, and creating under- and postgraduate curricula-which are essential for advancing falls prevention efforts across Europe.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1249-1268"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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