Systemic inflammation is associated with gut microbiota diversity in post-stroke patients.

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

European Geriatric Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI:10.1007/s41999-025-01159-2

Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Kouki Yoneda, Keisuke Maeda

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引用次数: 0

Abstract

Background: There is growing interest in gut microbiota and health outcomes. However, the relationship between systemic inflammation and gut microbiota diversity in hospitalized patients remains unclear. This study aimed to investigate the association in post-stroke rehabilitation patients.

Methods: A cross-sectional study was conducted on post-stroke patients admitted to a rehabilitation hospital. Systemic inflammation was assessed using the modified Glasgow Prognostic Score (mGPS). Gut microbiota diversity was evaluated using three indices: Shannon index, Operational Taxonomic Unit (OTU) richness, and Faith's Phylogenetic Diversity (PD). Multiple linear regression analyses were performed to examine the relationship between mGPS and gut microbiota diversity indices, adjusting for potential confounders.

Results: A total of 156 patients (mean age 78.4 years; 55.7% men) were analyzed. The median mGPS was 0 (interquartile range: 0-1), with GPS distribution: 61.8% scored 0, 25.7% scored 1, and 12.5% scored 2. After adjusting for confounders, mGPS was significantly and negatively associated with the Shannon index (B = -0.143, 95% CI -0.288 to -0.002, β = -0.177) and OTU richness (B = -17.832, 95% CI -24.349 to -3.951, β = -0.208). However, no significant association was observed between mGPS and Faith's PD (B = -1.155, 95% CI -2.464 to 0.189, β = -0.155).

Conclusion: This study demonstrates a significant negative association between systemic inflammation and both quantitative and qualitative gut microbiota diversity in post-stroke patients.

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卒中后患者全身炎症与肠道菌群多样性相关。

背景：人们对肠道菌群和健康结果的兴趣越来越大。然而，住院患者全身性炎症与肠道菌群多样性之间的关系尚不清楚。本研究旨在探讨脑卒中后康复患者的相关性。方法：对某康复医院收治的脑卒中后患者进行横断面研究。采用改良格拉斯哥预后评分（mGPS）评估全身性炎症。采用Shannon指数、Operational Taxonomic Unit （OTU）丰富度和Faith’s Phylogenetic diversity (PD) 3个指标评价肠道微生物群的多样性。采用多元线性回归分析来检验mGPS与肠道微生物群多样性指数之间的关系，并对潜在的混杂因素进行调整。结果：共156例患者，平均年龄78.4岁；55.7%男性)。mGPS中位数为0（四分位数间距为0-1），GPS分布：61.8%为0分，25.7%为1分，12.5%为2分。调整混杂因素后，mGPS与Shannon指数（B = -0.143, 95% CI -0.288 ~ -0.002, β = -0.177）和OTU丰富度（B = -17.832, 95% CI -24.349 ~ -3.951, β = -0.208）呈显著负相关。然而，mGPS和Faith PD之间没有显著的相关性（B = -1.155, 95% CI -2.464 ~ 0.189, β = -0.155）。结论：本研究表明卒中后患者全身炎症与定量和定性肠道菌群多样性之间存在显著负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Geriatric Medicine GERIATRICS & GERONTOLOGY-

CiteScore

6.70

自引率

2.60%

发文量

114

审稿时长

6-12 weeks

期刊介绍： European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine. The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.