European Geriatric Medicine最新文献

{"title":"Shear-wave elastography for muscle assessment in geriatric outpatients at increased risk of falling.","authors":"Camilla Remuss, Josefine Oredson Krone, Ann-Kristine Weber Giger, Ditte Beck Jepsen, Karen Andersen-Ranberg, Kristoffer K Brockhattingen","doi":"10.1007/s41999-025-01333-6","DOIUrl":"https://doi.org/10.1007/s41999-025-01333-6","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia, defined by the loss of muscle strength, quantity, and quality, increases the risk of functional decline and adverse outcomes. Shear-wave elastography (SWE), a non-invasive ultrasound-based technique, quantifies muscle stiffness. However, its diagnostic value in sarcopenia remains unclear. This study investigated the relationship between rectus femoris (RF) stiffness and physical performance in geriatric outpatients with and without sarcopenia.</p><p><strong>Methods: </strong>This cross-sectional study, conducted in a geriatric outpatient clinic, included consecutive patients aged ≥ 65 years. Muscle stiffness was assessed using SWE, and muscle thickness was measured to estimate appendicular lean mass (ALM). Sarcopenia was diagnosed per EWGSOP2 criteria. Analyses included group comparisons, multivariable regression, and evaluating diagnostic accuracy using previously suggested SWE thresholds.</p><p><strong>Results: </strong>In total, 114 patients were included (mean age 80 ± 9.9 years; 65.8% female). The prevalence of sarcopenia was 20.1%. No significant difference in SWE was found between sarcopenic and non-sarcopenic participants (p = 0.78), nor was SWE associated with age (ρ = - 0.03, p = 0.72). Lower SWE was associated with poor physical performance (short physical performance battery ≤ 7; β = - 1.30, p = 0.025). At Q1 (4.062 kPa), the relative risk (RR) of sarcopenia was 0.83 (95% CI: 0.36-1.90); sensitivity 74%, specificity 22%. At Q3 (8.249 kPa), RR 2.33 (95% CI: 1.09-4.96); sensitivity 26%, specificity 90%. At Youden's (8.226 kPa), RR 2.68 (95% CI: 1.31-5.47); sensitivity 30.4%, specificity 90.1%.</p><p><strong>Conclusion: </strong>Lower SWE is associated with poor physical performance. SWE is not a reliable standalone marker for sarcopenia in geriatric outpatients. Until stronger evidence emerges, assessing ALM remains preferable.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and the health of older adults in Europe: a call for a geriatric climate medicine framework.","authors":"Isabel Lozano-Montoya, Claudia Ruiz-Huerta, Francisco J Gómez-Pavón","doi":"10.1007/s41999-025-01336-3","DOIUrl":"https://doi.org/10.1007/s41999-025-01336-3","url":null,"abstract":"<p><strong>Purpose: </strong>Climate change is a critical determinant of health that disproportionately affects older adults. This review synthesises recent evidence on climate-related health risks in older Europeans and proposes a geriatric climate medicine framework to guide clinical practice, health system preparedness and policy action.</p><p><strong>Methods: </strong>Narrative review of scientific literature and policy documents published between 2019 and 2025, with emphasis on European epidemiological data and adaptation frameworks. Studies were included if they reported health impacts or adaptation/mitigation strategies relevant to adults aged ≥ 65 years.</p><p><strong>Results: </strong>Heatwaves, chronic and acute exposure to air pollutants, flooding and the expanding range of climate-sensitive infectious diseases increase hospitalisation, cognitive decline, and mortality in older adults, especially in women, those aged ≥ 80 years, and individuals with comorbidities or frailty. These risks remain insufficiently addressed in geriatric clinical practice and health policy.</p><p><strong>Conclusions: </strong>In a Europe warming at twice the global rate, urgent integration of climate risk assessment into geriatric care, enhanced resilience of health and social care infrastructure and climate policies that prioritise older adults are essential to reduce inequities and improve health outcomes.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing urinary tract infection prevention and antibiotic stewardship in European nursing homes: an interview study with staff.","authors":"Marie Theut, Alexandra Jønsson, Jette Nygaard Jensen, Valeria Antsupova, Malene Plejdrup Hansen, Carl Llor, Ana Garcia-Sangenis, Ana Moragas, Lina Jaruseviciene, Nina Sodja, Anna Kowalczyk, Andras Balint, Helena Glasova, Agapi Angelaki, Jesper Lykkegaard","doi":"10.1007/s41999-025-01330-9","DOIUrl":"https://doi.org/10.1007/s41999-025-01330-9","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the perceptions of European nursing home staff regarding factors influencing the prevention of urinary tract infections and antimicrobial stewardship.</p><p><strong>Methods: </strong>This qualitative descriptive study was conducted between July and September 2023. In each of eight European countries-Denmark, Greece, Hungary, Lithuania, Poland, Slovakia, Slovenia, and Spain-five semi-structured interviews were carried out with nursing home staff, resulting in a total of 40 interviews. All interviews were audio-recorded, transcribed verbatim, and analyzed using systematic text condensation.</p><p><strong>Results: </strong>Factors perceived to influence infection prevention and antibiotic stewardship were organized into five themes: (1) residents, including the respect for their autonomy, (2) relatives, including their demands for investigations and treatment, (3) physicians, including their attitudes towards antibiotics, (4) staff, including their challenging working conditions and lack of education, and (5) the nursing home environment in which these four actors navigate.</p><p><strong>Conclusion: </strong>Nursing home staff perceive multiple factors influencing infection prevention, including the challenge of balancing respect for residents' autonomy with maintaining high hygiene standards. A key barrier to effective antimicrobial stewardship appears to be a lack of staff awareness regarding their crucial role in the process.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating how different versions of ChatGPT align with expert opinions on geriatric script concordance tests.","authors":"Matthieu Lilamand, Théodore Decaix, Pierre-Antoine Gourraud, Richard Dufour, Gaëtan Gavazzi, Jacques Boaddaert, Claire Roubaud-Baudron, Hélène Vallet, Cédric Annweiler, Guillaume Chapelet","doi":"10.1007/s41999-025-01334-5","DOIUrl":"https://doi.org/10.1007/s41999-025-01334-5","url":null,"abstract":"<p><strong>Purpose: </strong>Large Language Models (LLMs), such as ChatGPT, are increasingly used in medical education, particularly for training clinical reasoning. Script Concordance Tests (SCTs) are valuable tools for assessing reasoning under uncertainty. Our objective was to evaluate the performance of four ChatGPT versions (3.5, 4, 4o, and 5) on SCTs compared to Geriatric Medicine experts.</p><p><strong>Methods: </strong>Twenty validated SCT questions covering diverse geriatric topics were administered to ChatGPT-3.5, 4, 4o, and 5, as well as a panel of 43 experts. SCTs assess responses on a five-point Likert scale, and scores were calculated using aggregate expert answers as the reference. Performance was analyzed based on alignment with expert majority responses.</p><p><strong>Results: </strong>ChatGPT-3.5 achieved a score of 8/20, aligning with the majority of experts on 15% of responses. ChatGPT-4 and -5 demonstrated significantly improved performance, scoring 15.6/20 and 15.2/20, respectively, and aligning with the majority on 45% of responses. ChatGPT 4o scored 13.6/20, slightly underperforming GPT-4, potentially due to differences in its architecture or training data. While GPT-4 and 5 excelled in reasoning and coherence, GPT-3.5 struggled with nuanced clinical scenarios.</p><p><strong>Conclusion: </strong>ChatGPT-4 and -5 performed comparably to geriatric experts in SCT-based reasoning, highlighting its potential for medical education. It can simulate case discussions, enhance autonomous learning, and support formative assessments. However, limitations such as variability across versions and question-specific challenges emphasize the need for further evaluation of LLMs across broader clinical domains. These findings support the integration of advanced LLMs into medical education to complement traditional teaching methods.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekend discharge after hip fracture surgery is associated with increased 30-day mortality. A retrospective observational study of 35,138 hip fractures reported to the Norwegian Hip Fracture Register.","authors":"Andrea Toft Boutera, Eva Dybvik, Geir Hallan, Torbjørn Berge Kristensen, Jan-Erik Gjertsen","doi":"10.1007/s41999-025-01329-2","DOIUrl":"https://doi.org/10.1007/s41999-025-01329-2","url":null,"abstract":"<p><strong>Purpose: </strong>The influence of discharge timing after hip fracture surgery has been sparsely investigated. We aimed to investigate whether time of discharge influence 30-day mortality, and secondarily 1-year mortality and 30-day readmission risk after hip fracture surgery.</p><p><strong>Methods: </strong>Data from 35,138 hip fracture patients aged ≥ 65 and with length of stay (LoS) ≤ 14 days reported to the Norwegian Hip Fracture Register 2008 to 2018 were analyzed. Cox regression analyses, adjusted for age groups, sex, ASA class, cognitive function, fracture type, and type of surgery were used to calculate mortality risk after discharge on weekdays compared to weekends (Friday 18:00 to Monday 08:00). Patients were grouped by age, cognitive function, ASA class, and discharge destination.</p><p><strong>Results: </strong>Mean age was 83 years, 71% were women, and 61% had ASA class ≥ 3. Patients discharged on weekends were marginally older, more often ASA class ≥ 3, cognitively impaired, and had shorter LoS than patients discharged on weekdays. Weekend discharge was associated with increased 30-day mortality (HRR 1.4, 95% CI 1.3-1.6; p < 0.001) and 1-year mortality (HRR 1.2, CI 1.2-1.3; p < 0.001) compared to weekday discharge. Sub-analyses showed increased 30-day mortality for all age groups except 65-74 years, all ASA groups, patients with and without cognitive impairment, patients discharged to nursing homes and the most common surgical methods. No statistically significant difference in 30-day readmission risk was found after weekend discharged compared to weekday discharge.</p><p><strong>Conclusion: </strong>Weekend discharge for hip fracture patients was associated with increased 30-day and 1-year mortality, but did not influence overall 30-day readmission risk.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness as a determinant of healthcare utilisation in older adults: a cross-sectional study in a Portuguese rural region.","authors":"Ângela Mira, Cristina Galvão, Paulo Santos","doi":"10.1007/s41999-025-01307-8","DOIUrl":"https://doi.org/10.1007/s41999-025-01307-8","url":null,"abstract":"<p><strong>Background: </strong>Loneliness is an increasingly recognised determinant of health in older adults, associated with adverse outcomes and higher healthcare utilisation.</p><p><strong>Purpose: </strong>This study aimed to evaluate the relationship between loneliness and healthcare use in an ageing rural population in southern Portugal.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted amongst community-dwelling individuals aged ≥ 65 years, randomly selected from primary care records in the Baixo Alentejo region. Data collection included the validated Portuguese version of the UCLA Loneliness Scale and self-reported use of healthcare services over the previous year (primary care and emergency visits, and the number of daily prescribed medicines).</p><p><strong>Results: </strong>A total of 318 participants were included (58.8% female), with a mean age of 75.5 years, 28.9% over 80. Mild loneliness was reported by 52.2% and severe loneliness by 14.8%. Severe loneliness was significantly associated with increased primary care visits (OR = 6.8; 95%CI: 5.8-7.7; p < 0.001), emergency department use (OR = 5.8; 95%CI: 4.4-7.1; p < 0.001), and polypharmacy (OR = 2.0; 95%CI: 1.3-2.6; p < 0.001). Depression, poor perceived health, family dysfunction, and urinary tract disease were associated with severe loneliness, whilst strong neighbourhood relationships appeared protective.</p><p><strong>Conclusion: </strong>Loneliness is a measurable and clinically relevant determinant of healthcare use in older adults. These findings support the integration of loneliness screening and intervention into routine clinical care, regardless of geographic setting.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of rehabilitation interventions for ESPEN/EASO-defined sarcopenic obesity: a scoping review.","authors":"Kosuke Suzuki, Masateru Hayashi, Yuichi Isaji, Hirotada Maeda, Katsuyoshi Tanaka, Takafumi Nasu, Koki Sasaki, Hayato Kunihara, Daisuke Sasaki, Wataru Okuyama, Yasuyuki Kurasawa, Takao Kaneko, Takashi Kitagawa","doi":"10.1007/s41999-025-01320-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01320-x","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenic obesity (SO) is a global concern characterized by the co-existence of sarcopenia and obesity. Although various interventions are recommended for SO, inconsistent definitions represent a barrier to clinical practice. This scoping review aimed to provide an overview of rehabilitation interventions for SO based on the definitions provided by the European Society for Clinical Nutrition and Metabolism and the European Association for the Study of Obesity.</p><p><strong>Methods: </strong>A systematic search was conducted across nine databases, with a final search conducted on February 27, 2024. The eligible studies included randomized controlled trials, prospective and retrospective cohort studies, and case-control studies without restrictions on language, country, sex, or publication date. The risk-of-bias assessment focused on muscle strength, physical function, and body composition. The risk of bias was assessed using the Risk of Bias 2 tool for randomized trials and the Newcastle-Ottawa scale for non-randomized studies.</p><p><strong>Results: </strong>Four randomized controlled trials involving 246 participants were included, all of which were conducted in communities. In addition, three studies comprised exclusively female participants, and all four studies employed resistance exercises. One study used a combination of resistance exercises and nutritional interventions. The overall risk of bias was high for all outcomes.</p><p><strong>Conclusion: </strong>The reported studies emphasized the limited number of studies covering diverse populations and settings. Further studies with improved methodological rigor are essential to identify effective rehabilitation strategies for SO.</p><p><strong>Registration: </strong>The study protocol was registered in the Open Science Framework ( https://osf.io/wak9n/ ) on January 31, 2024.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported geriatric syndromes and their association with quality of life: findings from a cross-sectional study in German older adults.","authors":"Aline Schönenberg, Konstantin G Heimrich, Annika Sternkopf, Paul Lochbihler, Tino Prell","doi":"10.1007/s41999-025-01332-7","DOIUrl":"https://doi.org/10.1007/s41999-025-01332-7","url":null,"abstract":"<p><strong>Purpose: </strong>Many older patients suffer from multimorbidity, rendering disease-specific approaches moot. Instead, overarching geriatric syndromes can be used to describe patients' experiences above and beyond concrete diagnoses. However, little is known about how patients themselves perceive these geriatric syndromes.</p><p><strong>Methods: </strong>We collected self-reported data on N = 511 (83.0 ± 5.96 years, 66% female) geriatric in- and N = 155 outpatients (79.0 ± 6.42 years, 60% female) on the occurrence of nine geriatric syndromes: reduced mobility, falls, problems with cognition, depressiveness, loneliness, pain, incontinence, problems with sleep, and problems with swallowing. We additionally asked about the perceived restriction and expectations regarding improvement of the geriatric syndromes. Using descriptive statistics, group comparisons, and linear regression, we describe how patients perceive and experience geriatric syndromes and their association with mental and physical quality of life (QoL) while controlling for cognition, functional status, and health.</p><p><strong>Results: </strong>On average, patients report 3.4 (SD = 1.8) of nine different geriatric syndromes, while 47.2% reported ≥ 4. The most frequent geriatric syndromes were mobility problems, falls, and pain; these were also perceived as most restrictive in daily life. A higher number of geriatric syndromes significantly reduces mental and physical QoL, above and beyond physical health. For physical QoL, mobility problems, falls, and pain are most influential, while mental QoL is linked with depressiveness, loneliness, and sleep problems. These associations were even stronger in outpatients than in inpatients.</p><p><strong>Conclusion: </strong>Geriatric syndromes are highly prevalent and lead to reduced mental and physical QoL. As they impact QoL above and beyond physical health and functionality, geriatric syndromes and their association with age-related expectations should be incorporated in clinical care to improve well-being.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145304157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional recovery in older adults following mild traumatic brain injury: a systematic review.","authors":"Lucas Tze Peng Tan, Claire Yi Jia Lim, Jin Hean Koh, Gobinathan Chandran, Li Feng Tan, Reshma A Merchant","doi":"10.1007/s41999-025-01326-5","DOIUrl":"https://doi.org/10.1007/s41999-025-01326-5","url":null,"abstract":"<p><strong>Aim: </strong>To determine the domain-specific functional, psychological, and cognitive recovery outcomes in older adults aged ≥ 65 years after mild traumatic brain injury.</p><p><strong>Findings: </strong>Across 18 studies (3549 participants), fewer than half of the older adults regained full functional independence by 6 months, and many had persistent mood symptoms and cognitive deficits up to 1 year. Global tools such as the GOSE reveal wide measurement heterogeneity and an under-recognized burden.</p><p><strong>Message: </strong>Mild traumatic brain injury is seldom \"mild\" in older adults. Geriatrics-tailored, multidimensional assessment and follow-up could improve rehabilitation and guide practice.</p><p><strong>Purpose: </strong>Mild traumatic brain injury (mTBI) in older adults is increasingly common and associated with long-term functional, psychological, and cognitive impairment, especially in those with frailty and multimorbidity. Traditional outcome measures may underestimate the long-term burden in this patient population. This systematic review synthesizes current evidence on domain-specific functional recovery outcomes in older adults with mTBI with emphasis on physical function, depression, and cognition.</p><p><strong>Methods: </strong>A systematic search of Medline/PubMed, Embase, and Cochrane Library was conducted through 6 October 2024. Observational studies reporting functional outcomes in older adults ≥ 65 years post-mTBI were included. Study quality was assessed using the Quality of Prognostic Studies (QUIPS) tool.</p><p><strong>Results: </strong>Eighteen studies (three thousand five hundred forty-nine participants) were included. Persistent impairments in activity and participation were observed in up to 66% at 6 months post-injury. Approximately 24% experienced at least mild depression, and 9% had moderate-to-severe anxiety. Cognitive recovery was heterogeneous, with residual deficits in processing speed, memory, and executive function. Standard global measures such as GOSE frequently failed to detect domain-specific impairments, especially in psychosocial and cognitive domains.</p><p><strong>Conclusion: </strong>Older adults with mTBI frequently experience prolonged and incomplete recovery across multiple domains, which often goes undetected by traditional outcome measures. Given the multidimensional burden observed, comprehensive geriatric assessment and interdisciplinary follow-up could help align care to patient needs. Future research should include adults aged ≥ 80 years, adopt multidimensional tools, and extend follow-up to better guide tailored rehabilitation strategies.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle strengthening activities: cross-sectional associations with skeletal muscle outcomes in adults aged 50-64 and 65 years and above.","authors":"Konstantinos Prokopidis, Stefano Cacciatore, Paolo Piaggi, Davide Liborio Vetrano, Mathias Schlögl","doi":"10.1007/s41999-025-01327-4","DOIUrl":"https://doi.org/10.1007/s41999-025-01327-4","url":null,"abstract":"<p><strong>Aim: </strong>To examine the association of muscle strengthening activities with knee extension strength, gait speed, and skeletal muscle index in adultsaged 50-64 and ≥65 years.</p><p><strong>Findings: </strong>Muscle strengthening activities are linked to better gait speed, knee extension strength, and skeletal muscle index mainly in middle-aged adults (50-64 years), with weaker or no associations in older adults except for higher activity frequency (≥8 sessions/month), benefi tingstrength in those ≥65 years.</p><p><strong>Message: </strong>Muscle strengthening activities are linked to better physical function and muscle health in middle-aged compared to older adults,although frequency may be a confounding parameter.</p><p><strong>Background: </strong>This study examined the association of muscle strengthening activities (MSA) with knee extension strength (KES) and gait speed (GS) (n = 2169), and skeletal muscle index (SMI; n = 765) in adults aged 50-64 and ≥ 65 years.</p><p><strong>Methods: </strong>Data were drawn from the National Health and Nutrition Examination Survey 1999-2018 cycles. MSA were self-reported based on engagement with weightlifting, push-ups, or sit-ups. MSA frequency was categorized as ≥ 8 or < 8 sessions/month. Linear and logistic regressions were performed, adjusting for demographic and clinical covariates.</p><p><strong>Results: </strong>MSA were associated with improved GS and KES across adults aged 50-64 years in fully adjusted models (GS: β = -0.24, 95% CI - 0.42 to - 0.07; KES: β = 31.7, 95% CI 18.9 to 44.5) but not in those ≥ 65 years (GS: p = 0.07; KES: p = 0.11). For SMI, a significant positive association emerged only in the 50-64-year old group after adjustments (β = 0.18, 95% CI 0.03 to 0.34; ≥ 65 years → p = 0.53). Age interaction (≥ 65 vs. 50-64 years) showed significant MSA associations with GS and KES, though SMI results were inconsistent. Finally, higher MSA frequency for ≥ 65 versus 50-64 years was linked to higher KES (β = 22.0, p = 0.03), but not GS (p = 0.05) or SMI (p = 0.64).</p><p><strong>Conclusions: </strong>MSA are associated with higher KES and GS in middle-aged, but not in older adults. Higher MSA frequency is linked to increased KES in older adults.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}