European Geriatric Medicine最新文献

{"title":"Critical appraisal of: the effect of intravenous vitamin C administration on postoperative pain and intraoperative blood loss in older patients after intramedullary nailing of trochanteric fractures.","authors":"Muhammad Zarrar","doi":"10.1007/s41999-025-01203-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01203-1","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening recovery: the impact of paired exercises in geriatric hip fracture rehabilitation-the PaLMe project.","authors":"Eyal Yaacobi, Shanny Gur, Adi Berliner Senderey, Ben Kapner, Tom Mushkat, Gili Golan, Smadar Pasand Van-Stee, Tova Farjun, Nissim Ohana","doi":"10.1007/s41999-025-01192-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01192-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of the PaLMe concept, which incorporates paired exercises into rehabilitation for old patients recovering from hip fracture surgery, and to assess the feasibility of implementing an online rehabilitation program in this population.</p><p><strong>Methods: </strong>A prospective, randomized interventional study was conducted in a hospital setting. A total of 93 participants (mean age: 80.5 years, 66% women) were enrolled and randomized into an intervention group (PaLMe, paired exercises, n = 44) or a control group (individual exercises, n = 49). The study intervention lasted for the duration of the hospital stay, with an average length of 5.6 days. In the PaLMe group, participants were paired using a custom algorithm developed to match patients based on similar clinical and demographic characteristics, fostering interaction and mutual motivation during synchronized exercises. Walking ability was measured by distance walked and level of assistance required, while self-efficacy and motivation were assessed using validated scales. Feasibility was evaluated through recruitment and retention rates, adherence to prescribed sessions, and participant feedback on usability and satisfaction. Data were analyzed using independent t-tests and qualitative feedback.</p><p><strong>Results: </strong>The PaLMe group demonstrated significantly greater improvements in walking distance, with 66% achieving ≥ 21 m at discharge compared to 43% in the control group (p < .05). Self-efficacy and motivation also improved more in the PaLMe group. Feasibility metrics indicated high program acceptability, with recruitment and retention rates of 37% and 89%, respectively. Adherence to the program was moderate, with 47% of PaLMe participants completing more than 50% of prescribed sessions. Participant feedback highlighted increased confidence, motivation, and satisfaction with the paired exercise format, despite logistical challenges such as scheduling conflicts.</p><p><strong>Conclusion: </strong>The PaLMe program significantly enhances physical and psychological recovery in senior patients after hip fracture surgery, demonstrating its potential as an effective rehabilitation strategy. Feasibility findings indicate strong acceptability but highlight logistical barriers, such as scheduling conflicts and adherence challenges, which must be addressed to optimize implementation. Further research is warranted to explore long-term outcomes and scalability across broader settings.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which screening tool performs best in identifying malnutrition risk among hospitalized older adults with cardiovascular disease? A diagnostic accuracy study comparing six different screening tools with GLIM criteria.","authors":"Kevser Tarı Selcuk, Sedat Arslan, Ayça Aydın, Duygu Durmaz","doi":"10.1007/s41999-025-01187-y","DOIUrl":"https://doi.org/10.1007/s41999-025-01187-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the performance of six different screening tools with the GLIM criteria in identifying malnutrition risk among older adults with cardiovascular diseases.</p><p><strong>Methods: </strong>In this diagnostic accuracy study, data from 669 patients aged 65 and older, hospitalized at Bandırma Training and Research Hospital diagnosed with cardiovascular disease, were evaluated. The data were obtained using a questionnaire that included a Demographic Information Form, Global Leadership Initiative on Malnutrition (GLIM) Criteria, Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), Short Nutritional Assessment Questionnaire (SNAQ), Mini Nutritional Assessment-Short Form (MNA-SF), Nutritional Risk Screening-2002 (NRS-2002), and Graz Malnutrition Screening (GMS) tool. GLIM criteria were used as gold standard and six screening tools were used as index tests. Receiver Operating Characteristic (ROC) curve analysis was conducted to calculate the Area Under the Curve (AUC), and the sensitivity, specificity, accuracy, and Cohen's Kappa (κ) coefficient of the index tests were assessed.</p><p><strong>Results: </strong>The mean age of the patients was 75.5 ± 7.7 years, 55.2% were female. According to the GLIM criteria, the prevalence of malnutrition was calculated as 22.0%. The AUC calculated by ROC indicated that MST (AUC: 0.905) had excellent predictive value, while MUST (AUC: 0.874), SNAQ (AUC: 0.851), MNA-SF (AUC: 0.842), and GMS (AUC: 0.820) demonstrated good predictive value. Among the screening tools, GMS had the highest sensitivity (92.5%), whereas MNA-SF exhibited the highest specificity (91.6%). MNA-SF also demonstrated the highest agreement with the GLIM criteria (Cohen's κ: 66.8) and the highest accuracy (88.3%).</p><p><strong>Conclusion: </strong>This study found that the MNA-SF tool outperformed other comprehensive screening tools when evaluating malnutrition risk in light of the GLIM criteria.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of antibiotic use in nursing homes for suspected urinary tract infections: comparison across five European countries.","authors":"Matilde Bøgelund Hansen, Jesper Lykkegaard, Malene Plejdrup Hansen, Carl Llor, Ana Garcia Sangenis, Pia Touboul-Lundgren, Bruno Pascale, Ruta Radzeviciene, Lina Jaruseviciene, Marilena Anastasaki, Christos Lionis, Anna Kowalczyk, Maciek Godycki-Ćwirko, Beatriz Gonzalez Lopez-Valcárcel, Fabiana Raynal Floriano, Athina Chalkidou, Lars Bjerrum, Jette Nygaard Jensen","doi":"10.1007/s41999-025-01185-0","DOIUrl":"https://doi.org/10.1007/s41999-025-01185-0","url":null,"abstract":"<p><strong>Purpose: </strong>Antibiotic use is the main driver of bacterial antimicrobial resistance. Urinary tract infections (UTIs), for which antibiotics are often prescribed, are among the most common infections among residents in nursing homes. This study aimed to estimate and compare the appropriateness of antibiotic use for suspected UTIs among nursing home residents across five European countries. Both the decision to treat and the choice of antibiotics used were explored.</p><p><strong>Methods: </strong>This cross-sectional study used the Audit Project Odense (APO) method. The appropriateness of the treatment decision for UTIs was evaluated according to symptom presentation in residents without indwelling urinary catheters. The choice of antibiotic used for treatment was evaluated according to the first-line antibiotic recommended for the treatment of UTIs in the respective countries. Data were collected through an institutional sign-up questionnaire and a clinical case registration chart. All residents in new or ongoing treatment with systemic antibiotics were registered during a 6-week period between February and April 2022.</p><p><strong>Results: </strong>A total of 70 nursing homes or wards registered 508 antibiotic treatments for suspected UTIs. The proportion of antibiotics prescribed for UTIs to nursing home residents with no specific UTI symptoms varied from 10% in Poland to 68% in Spain. The proportion of treatments with the first-line choice of antibiotics for UTIs also varied from 28% in France and Poland to 55% in Spain.</p><p><strong>Conclusion: </strong>There was a substantial proportion of potentially inappropriate antibiotic treatments, with notable variation among the countries studied.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of different physical performance assessment methods for falls in older adults: a 3-year longitudinal study in China.","authors":"Fei Lu, Xiaohong Liu, Jiaojiao Li, Xiaohong Sun, Shan Jiang","doi":"10.1007/s41999-025-01184-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01184-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the predictive value of different physical performances including short physical performance battery (SPPB), time-up and go test (TUGT), gait speed (GS), five times sit-to-stand test (FTSST) and handgrip strength (HGS) on the incidence of falls among community-dwelling older adults and to propose the cut-off values for predicting the incidence of falls.</p><p><strong>Methods: </strong>This 3-year longitudinal observational study continuously recruited community-dwelling older adults in 2018, assessing baseline physical performances and recording fall incidence (at least one fall) after 3 years.</p><p><strong>Results: </strong>Of the 215 older adults (mean age, 84.0 ± 4.4 years; 123 [57.2%] females) included in this study, 98 (45.6%) fell. After adjusting for age, sex, and comorbidity, decreased SPPB score (odds ratio [OR] = 0.84, 95% confidence interval [CI], 0.75-0.94), increased TUGT time (OR = 1.07, 95% CI, 1.03-1.12), and lower GS (OR = 0.11, 95% CI, 0.03-0.37) were significantly associated with higher risk of fall and had similar predictive values, while the FTSST and HGS were not. To predict the incidence of falls, the areas under the curve for SPPB, TUGT, and GS were 0.71 (95% CI: 0.65-0.77), 0.73 (95% CI: 0.67-0.79), and 0.71 (95% CI: 0.64-0.77), whereas the cut-offs were 7 points, 14.8 s, and 0.75 m/s, according to the Youden index, respectively.</p><p><strong>Conclusion: </strong>As physical performance indicators, SPPB, TUGT, and GS may be more effective in assessing fall risk, and the threshold values proposed in this study can be used as a reference for stratified fall risk management among community-dwelling older residents.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of concern about falling after hospital discharge among older adults with fragility hip fractures: a prospective cohort study.","authors":"Suphawita Pliannuom, Phichayut Phinyo, Nida Buawangpong, Nopakoon Nantsupawat, Pichitchai Atthakomol, Tanawat Vaseenon, Nitchanant Kitcharanant, Peerasak Lerttrakarnnon, Kanokporn Pinyopornpanish","doi":"10.1007/s41999-025-01188-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01188-x","url":null,"abstract":"<p><strong>Purpose: </strong>Concern about falling [CaF] is common among older adults, particularly after fragility hip fracture. This condition is associated with adverse health outcomes and a reduced quality of life. The aim of this study is to explore predictors of CaF among older patients with fragility hip fractures 2 weeks after hospital discharge.</p><p><strong>Methods: </strong>A prospective observational cohort study was conducted at a Tertiary Care Hospital in Thailand. Participants were patients aged 60 years and above who had fragility hip fractures and were admitted to the hospital from March 2023 to March 2024. CaF was assessed using the short Falls Efficacy Scale-International 2 weeks after hospital discharge. Predictors examined pre-fall characteristics, fall-related data, surgery-related data, and postoperative data. In the full model approach, the multivariable Gaussian regression was employed to identify predictive factors.</p><p><strong>Results: </strong>Of the 165 patients included in the study (mean age 78.76 ± 8.72 years), 79.39% were female. In the full model approach, pre-fracture activities of daily living (ADL) < 20 (adjusted mean difference [aMD] 3.44, 95% CI 1.04-5.85, p = 0.005) and shorter in-hospital duration of walking training (aMD - 0.66, 95% CI - 1.10 to - 0.22, p = 0.004) were identified as predictors of CaF at 2 weeks after hospital discharge.</p><p><strong>Conclusions: </strong>The findings of this study emphasize the importance of assessing pre-fracture functional status and the shorter duration of in-hospital walking training as key predictors of CaF in older adults with fragility hip fractures. Enhancing functional capacity and extending the duration of walking training during hospitalization are crucial steps in reducing CaF in this population.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in sarcopenia prevalence and muscle-related outcomes among post-stroke inpatients.","authors":"Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Kouki Yoneda","doi":"10.1007/s41999-025-01186-z","DOIUrl":"https://doi.org/10.1007/s41999-025-01186-z","url":null,"abstract":"<p><strong>Background: </strong>Sex differences in sarcopenia prevalence and recovery patterns among post-stroke patients remain poorly understood. This study aimed to investigate sex differences in sarcopenia prevalence, improvement rates, and changes in muscle-related indices among post-stroke patients in rehabilitation settings.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a post-acute rehabilitation hospital. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. The primary outcomes were sarcopenia status and muscle-related indices (handgrip strength and skeletal muscle mass index) at discharge. Propensity score-adjusted logistic regression analysis was performed to examine the association between sex and non-sarcopenia at discharge.</p><p><strong>Results: </strong>A total of 598 patients (274 women) with a mean age of 71.6 years were analyzed. Women showed higher sarcopenia prevalence at admission compared to men (47.4% vs 34.2%, p = 0.001). After adjusting for confounders, male sex was positively associated with non-sarcopenia at discharge (OR 1.046, 95% CI 1.009-1.104, p < 0.001) and greater improvements in handgrip strength (B = 1.93, p = 0.031) and skeletal muscle mass index (B = 0.322, p = 0.019).</p><p><strong>Conclusion: </strong>This study revealed significant sex differences in sarcopenia among post-stroke rehabilitation patients. While women showed higher sarcopenia prevalence at admission, men demonstrated better improvements in muscle-related outcomes.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geriatric syndrome burden on healthcare services utilization and mortality among community-dwelling older adults: is it still too late to do something?","authors":"Bilal Katipoglu, Suleyman Emre Kocyigit","doi":"10.1007/s41999-025-01189-w","DOIUrl":"https://doi.org/10.1007/s41999-025-01189-w","url":null,"abstract":"<p><strong>Purpose: </strong>The increasing longevity of the population emphasizes the need for a deeper understanding of geriatric syndromes and their implications for healthcare usage and mortality among older adults. This study aimed to identify risk factors associated with healthcare service utilization and mortality of community-dwelling adults aged 80 and older in YASAM project.</p><p><strong>Methods: </strong>This prospective cohort study was part of the HEAT-YASAM trial, which focused on the community-based integrated healthy aging program for individuals aged 80 years and older in Balıkesir, Türkiye. The burden of geriatric syndromes was assessed based on a comprehensive evaluation at least two domains of the nutrition, cognitive, physcological and locomotor capacities. The study outcome was healthcare services utilization (inpatient, outpatient, emergency admission) and all-cause mortality data obtained during follow-up period (9 months).</p><p><strong>Results: </strong>The cohort consisted of 5018 participants with a mean age of 85.8 years, predominantly female (53.1%). On the multivariable analysis, geriatric syndrome burden and Deyo Charlson Comorbidity index (D-CCI) score significant on independent predictors of 9-month mortality (p = 0.01). Higher geriatric syndrome burden was linked to an approximately 10% lower risk for outpatient admissions (p = 0.01) and every point increase in the D-CCI score was associated with a 1.3-fold increased risk of utilizing outpatient services (p = 0.01). For multimorbidity, every point increase corresponded to a 2.6-fold higher risk of inpatient admissions (p = 0.01) and a 1.2-fold higher risk of emergency admissions (p = 0.01).</p><p><strong>Conclusions: </strong>This study demonstrate that a geriatric syndrome burden and multimorbidity has a significant impact on healthcare utilization and mortality in adults aged 80 years and older. Integrated comprehensive, coordinated, and patient-centered care models for this population facing multiple geriatric syndromes could positively impact the healthcare system.</p><p><strong>Trial registration: </strong>The trial was prospectively registered at ClinicalTrials.gov. Identifier: NCT05993572 Registered on 15 July 2023.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"eHealth in geriatric rehabilitation: an international consensus study.","authors":"Jules J M Kraaijkamp, Anke Persoon, Niels H Chavannes, Wilco P Achterberg, Mohamed-Amine Choukou, Frances Dockery, Hyub Kim, Laura M Pérez, José E Pompeu, Eva Topinkova, Mark A Vassallo, Andrea B Maier, Clemens Becker, Yoshiaki Amagasa, Marije S Holstege, Jolanda van Haastregt, Eléonore F van Dam van Isselt","doi":"10.1007/s41999-025-01170-7","DOIUrl":"https://doi.org/10.1007/s41999-025-01170-7","url":null,"abstract":"<p><strong>Purpose: </strong>Current evidence on the use of eHealth in geriatric rehabilitation is limited. This aim of this study was to achieve international consensus on three key eHealth-related topics in geriatric rehabilitation: the use, domains, and scientific evaluation of eHealth. Additionally, we developed a model that provides insight into the use of eHealth in geriatric rehabilitation.</p><p><strong>Methods: </strong>An international, two-round Delphi study was conducted. Two models served as a framework for the initial statement draft, with a total of 28 statements based on our systematic review results, an international survey, and expert opinion. Eligible healthcare professionals working in geriatric rehabilitation facilities were recruited across 10 countries.</p><p><strong>Results: </strong>Eighty healthcare professionals participated in round one and 47 in round two. In the first round, consensus was obtained for 20 of the 28 statements (71%). Prior to round two, four statements were revised, two statements were combined, and one statement was removed. In round two, consensus was obtained on six statements, bringing the total to 26: three related to the use of eHealth, five to the domains of eHealth, and 18 related to the scientific evaluation of eHealth.</p><p><strong>Conclusion: </strong>International consensus has been reached on the use, domains, and scientific evaluation of eHealth in geriatric rehabilitation. This first step in generating reliable knowledge and understandable information will help promote a consistent approach to the development, implementation, and scientific evaluation of eHealth in geriatric rehabilitation.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association of frailty index with incidence of chronic kidney disease: China Health and Retirement Longitudinal Study.","authors":"Lisha Zhang, Yan Zhang, Yanru He, Fuxue Deng, Jiahong Xue","doi":"10.1007/s41999-025-01164-5","DOIUrl":"https://doi.org/10.1007/s41999-025-01164-5","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}