European Geriatric Medicine最新文献

{"title":"Effect of progressive chin tuck against resistance exercise on community-dwelling older adults with age-related dysphagia: a randomized controlled trial.","authors":"Lin Liu, Ran Hou, Lingli Zhang, Zhixing Qu, Siwen Tian","doi":"10.1007/s41999-025-01235-7","DOIUrl":"10.1007/s41999-025-01235-7","url":null,"abstract":"<p><strong>Background: </strong>Chin tuck against resistance (CTAR) exercise has been proven to be an effective intervention for improving swallowing function in older patients. However, most studies focus on fixed-resistance models and fail to fully incorporate the principle of progressive overload, a cornerstone of strength training. With this study, we explored the effects of progressive CTAR exercise on swallowing function in patients with age-related dysphagia.</p><p><strong>Methods: </strong>Sixty-four community-dwelling older adults (mean age = 81 ± 6 years; males, n = 28, females, n = 36) with age-related dysphagia were randomly assigned to either the experimental group (n = 32) or control group (n = 32) through cluster randomization. Both groups participated in an 8-week oral flexibility training program, with the experimental group receiving additional progressive CTAR exercise. Various outcome measures that included the Standardized Swallowing Assessment (SSA), the Swallowing Quality of Life (SWAL-QOL), and the Test of Mastication and Swallowing of Solids (TOMASS) were assessed at baseline (T0), after 4 weeks of intervention (T1), and after 8 weeks of intervention (T2).</p><p><strong>Results: </strong>Of the 64 participants, 61 completed the study protocol. Both groups showed significant differences in the SSA score, the SWAL-QOL score, and the total swallowing time at T1 and T2, but the experimental group demonstrated significantly greater improvement than the control group. However, no significant differences were found in the number of chews or swallows between groups, and the number of bites did not show a significant change compared with before the intervention.</p><p><strong>Conclusions: </strong>Progressive CTAR exercise significantly improves swallowing function and swallowing-related quality of life in patients with age-related dysphagia.</p><p><strong>Trial registration: </strong>This trial was registered with the Chinese Clinical Trial Registry in July 2024 under registration number ChiCTR2400087548.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1481-1492"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a nurse-led swallowing risk assessment tool in care-home residents: a prospective diagnostic accuracy study.","authors":"Patricia Heaney, Deborah Annis-Marley, William Gray, Louise Jones, Julia Scott, Miles D Witham","doi":"10.1007/s41999-025-01194-z","DOIUrl":"10.1007/s41999-025-01194-z","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and test a screening tool enabling care-home staff to identify residents with high-risk swallowing problems (dysphagia).</p><p><strong>Methods: </strong>The Nurse Dysphagia Screening Tool (NDST) was developed via an iterative, participatory process. A diagnostic evaluation study was performed in North-East of England care homes. We compared NDST with gold-standard speech and language therapist swallowing assessment risk category to derive sensitivity, specificity, and positive and negative predictive values.</p><p><strong>Results: </strong>One hundred and seventy two residents (101 women) were included from 14 care homes, mean age 82.1 years (SD 10.6). Residents known to SLT, or with Percutaneous Endoscopic Gastrostomy (PEG) were excluded. 18/172 (11%) had high-risk swallow by gold-standard assessment. NDST was completed successfully on all participants. Sensitivity, specificity, and positive and negative predictive values were 72%, 92%, 50%, and 97%, respectively. Sensitivity was higher (100%) in high-volume care homes and for those recruited late in the study, suggesting a learning curve.</p><p><strong>Conclusion: </strong>NDST requires additional testing but can potentially identify high-risk dysphagia in care homes.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1475-1479"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and care trajectories of older patients in temporary stays in Denmark.","authors":"Hanin Harbi, Carina Lundby, Peter Bjødstrup Jensen, Søren Post Larsen, Linda Grouleff Rørbæk, Lene Vestergaard Ravn-Nielsen, Jesper Ryg, Mette Reilev, Kasper Edwards, Anton Pottegård","doi":"10.1007/s41999-025-01209-9","DOIUrl":"10.1007/s41999-025-01209-9","url":null,"abstract":"<p><strong>Purpose: </strong>Temporary stays for patients requiring short-term care outside the home, often following hospital discharge, has gained increasing importance. This study aimed to describe the characteristics and care trajectories of older patients in Danish temporary stays to improve care delivery and patient safety.</p><p><strong>Methods: </strong>We conducted a descriptive study on a cohort of patients in temporary stays across 14 Danish municipalities from 2016 to 2023, using data from national health registries.</p><p><strong>Results: </strong>We identified 11,424 patients with a median age of 81 years (interquartile range [IQR] 73-87 years); 54% were women. Patients exhibited a high level of comorbidity, with a median Charlson Comorbidity Index of 1 (IQR 0-2), and a median of 3 hospital admissions (IQR 2-6) in the year preceding their move into temporary care. The majority (70%) transitioned to temporary stays following hospital discharge, while 30% were admitted directly from their homes. The median duration of temporary stays was 24 days (IQR 11-49 days), with 9.1% staying ≥ 90 days. Additionally, 7.0% of patients were hospitalised directly from the temporary stay facility, with a median time to hospital admission of 13 days (IQR 5-28 days). Median survival after admission to a temporary stay was 23 months (IQR 3.6-57 months). Predictors of mortality included male sex, older age, higher comorbidity burden, and increased number of hospital admissions prior to temporary stay.</p><p><strong>Conclusion: </strong>Patients in temporary stays are generally older individuals with multimorbidity and limited life expectancy. Most patients are admitted following hospital discharge, and their stays are often prolonged.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1437-1445"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty is associated with a history of falls among mobility-limited older adults-cross-sectional multivariate analysis from the BIOFRAIL study.","authors":"Pernille Hansen, H Nygaard, M Schultz, F Dela, P Aagaard, Jesper Ryg, C Suetta","doi":"10.1007/s41999-025-01239-3","DOIUrl":"10.1007/s41999-025-01239-3","url":null,"abstract":"<p><strong>Aim: </strong>To identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling but who have not yet fallen.</p><p><strong>Findings: </strong>Frailty and muscle strength were characteristics distinguishing between older adults with a history of falls and those absent of falls despite an increased risk of falling.</p><p><strong>Message: </strong>Frailty should be incorporated alongside handgrip strength (HGS) and sit-to-stand (STS) tests into routine evaluations of mobility-limited older adults referred for fall assessment.</p><p><strong>Purpose: </strong>We aimed to identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling, and to identify the parameter with the strongest predictive value on the risk of falling.</p><p><strong>Methods: </strong>Data included anthropometry, HGS, 30-s and 5-reps STS tests, maximal isometric knee extensor strength, gait speed (6 m), postural balance (tandem test), and muscle mass (BIA). Frailty was assessed using the Clinical Frailty Scale (CFS) and sarcopenia was evaluated according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) guidelines. Outcomes of falls (past year), and depression (Geriatric Depression Scale 15) were self-reported.</p><p><strong>Results: </strong>Totally, 505 mobility-limited older adults (mean age 79.7 ± 6.3 years, 64.8% females) were included. Of these, 400 (79.2%) had experienced one or more falls within the past year (fallers), while 105 (20.8%) had not experienced a fall (at risk). Patients with experienced falls were more likely to feel depressed, had reduced handgrip strength, and reduced performance in both STS tests compared to those who had not fallen. Frailty was the strongest individual parameter associated with a history of prior falls, even after adjusting for covariates such as depression and 30-s STS (aOR 3.80; 95% CI 1.70-8.50).</p><p><strong>Conclusions: </strong>Present study identified frailty as a key factor independently associated with a history of falls in this population. Additionally, handgrip strength and STS performance were key characteristics distinguishing between older adults with a history of falls within the past 12 months and those at risk of falling.</p><p><strong>Trial registration: </strong>NCT05795556.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1283-1293"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between frailty and hospital-related adverse events in older hospitalised patients: a systematic literature review.","authors":"Faris Alotaibi, Abdullah Alshibani, Jay Banerjee, Brad Manktelow","doi":"10.1007/s41999-025-01242-8","DOIUrl":"10.1007/s41999-025-01242-8","url":null,"abstract":"<p><strong>Introduction: </strong>Studies have shown that hospital-related adverse events (AEs) affect older hospitalised patients. Frailty is an age-related syndrome of increased vulnerability, the risk of abrupt and extreme health changes, and the risk of suffering an adverse event (AE). Most of the published work focuses on the relationship between age alone and AEs' incidence. We aim to examine the association between frailty and the incidence of hospital-related AEs among hospitalised older adults in the published literature.</p><p><strong>Methods: </strong>A comprehensive search of Ovid MEDLINE, CINAHL, Scopus, and Web of Science databases was conducted between January and February 2024. Studies were included if they provide original data in English, regardless of methodology. In addition, the reference lists of all included studies were manually screened to identify any further eligible studies. The narrative synthesis followed the Cochrane methodology.</p><p><strong>Results: </strong>This review includes 19 observational studies, with the USA being the most common study location. Various frailty tools and definitions were used, with the frailty index (FI) being the most frequently employed tool. Hospital-acquired infections, including pneumonia, urinary tract infections (UTIs), sepsis and wound infections, were the most frequently reported adverse events, followed by delirium. In addition, falls, pressure ulcers and venous thromboembolism were also commonly documented.</p><p><strong>Conclusion: </strong>This review found that frailty is associated with an increased risk of hospital-acquired infections, in-hospital delirium, falls and pressure ulcers. More extensive and comprehensive studies are needed to focus on patient safety incidents among frail hospitalised individuals.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1303-1318"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better survival of older patients with stroke managed in a collaborative stroke pathway.","authors":"Bruno Oquendo, Witold Jarzebowski, Charlotte Nouhaud, Anne Leger, Christel Oasi, Charlotte Havreng-Thery, Carmelo Lafuente-Lafuente, Joel Belmin","doi":"10.1007/s41999-025-01225-9","DOIUrl":"10.1007/s41999-025-01225-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the survival of stroke patients over 70 years old managed in the collaborative Stroke Pathway dedicated to the OLD patients (SPOLD) with those referred to conventional rehabilitation wards.</p><p><strong>Methods: </strong>This longitudinal observational retrospective cohort study involved over 70 years old patients referred from the same neurovascular emergency unit in a university hospital in France to a post-stroke geriatric unit within the SPOLD pathway, compared to patients referred to conventional rehabilitation ward during the same period. Initial stroke severity and comorbidities were assessed using the NIHSS score and the Charlson index, respectively. The primary endpoint was 2-year survival, analyzed using Cox models for both the entire cohort and a propensity score-matched cohort to control for referral bias.</p><p><strong>Results: </strong>The study included 262 patients with a mean age of 84.5 ± 6.7 years, of whom 122 (46.6%) were male. Patients in the SPOLD group (n = 101) had significantly higher age, NIHSS scores, and Charlson indices compared to those in the conventional rehabilitation ward (n = 161). Adjusted mortality was significantly lower in SPOLD patients (OR: 0.525, 95% CI: 0.298 to 0.924, p = 0.025). In the propensity score-matched cohort, mortality was also significantly lower for SPOLD patients (OR: 0.426, 95% CI: 0.212 to 0.857, p = 0.017).</p><p><strong>Conclusion: </strong>This study suggests that this collaborative organization between a neurovascular emergency unit and a rehabilitation geriatric unit may be associated with a better survival of older patients after stroke.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1551-1558"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical characteristics and predictors of complications and mortality in hospitalized octogenarian patients with COVID-19: an ambispective study.","authors":"Marta Arroyo-Huidobro, Natàlia Pallarès Fontanet, Cristian Tebé Cordomí, Antonella F Simonetti, Carlos Pérez-López, Gabriela Abelenda-Alonso, Alexander Rombauts, Isabel Oriol Bermudez, Elisenda Izquierdo, Vicente Díaz-Brito, Gemma Molist, Guadalupe Gómez Melis, Sebastian Videla, Alfons López Soto, Jordi Carratalà, Alejandro Rodriguez-Molinero","doi":"10.1007/s41999-025-01249-1","DOIUrl":"10.1007/s41999-025-01249-1","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1559"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to characterising multimorbidity in older people accessing hospital care: a scoping review.","authors":"Jonathan G Bunn, Lewis Steell, Susan J Hillman, Miles D Witham, Avan A Sayer, Rachel Cooper","doi":"10.1007/s41999-025-01166-3","DOIUrl":"10.1007/s41999-025-01166-3","url":null,"abstract":"<p><strong>Purpose: </strong>An increasing proportion of older adults accessing hospital care are living with multimorbidity, with a high degree of complexity of multimorbidity in older hospital populations expected. We aimed to assess approaches taken to characterise multimorbidity in older adults accessing hospital care, including how complexity is considered.</p><p><strong>Methods: </strong>Following established scoping review guidelines, all published studies that characterised multimorbidity in a hospital population, with average age ≥ 65 years, were identified via a prespecified search strategy. Six electronic databases were searched to identify peer-reviewed literature published to September 2023 meeting eligibility criteria. Screening was undertaken by two independent reviewers, and data extracted using a standard proforma.</p><p><strong>Results: </strong>Of 5305 titles and abstracts screened, 75 papers, reporting on 72 unique study populations across 24 countries, met inclusion criteria. There was heterogeneity in most aspects of characterisation. Multimorbidity was defined in 43% (n = 31/72) of studies; most (n = 59/72, 82%) aimed to describe a multimorbidity-outcome association. Number of conditions considered ranged from 2 to 285 and weighted indices were used as a measure of multimorbidity in 75% (n = 54/72) of studies, with 56% (n = 40/72) using a version of the Charlson Comorbidity Index. Complexity was explicitly studied in 17% (n = 12/72) of studies.</p><p><strong>Discussion: </strong>Our review highlights heterogeneity in characterisation of multimorbidity in older adults accessing hospital care, with limited consideration of complexity. As the proportion of older adults accessing hospital care who are living with multimorbidity increases, better characterisation of their multiple conditions and associated complexity is a priority to ensure delivery of appropriately tailored care.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1099-1113"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of potentially inappropriate prescribing in community-dwelling older adults: an application of STOPP/START version 3 to The Irish Longitudinal Study on Ageing (TILDA).","authors":"Ann Sinéad Doherty, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Rose Anne Kenny, Denis O'Mahony, Emma Wallace","doi":"10.1007/s41999-025-01201-3","DOIUrl":"10.1007/s41999-025-01201-3","url":null,"abstract":"<p><strong>Purpose: </strong>Potentially inappropriate prescribing includes prescribing potentially inappropriate medicines (PIMs), where risk of medication-related harm may outweigh the clinical benefit(s), and potential prescribing omissions (PPOs), whereby clinically indicated medications are unprescribed without good reason. This study aimed to assess prevalence of PIMs and PPOs (subset of STOPP/START version 3) in older community-dwelling adults and any association with healthcare utilisation and functional decline over time.</p><p><strong>Methods: </strong>Retrospective cohort study of a nationally representative longitudinal study of ageing in Ireland (n = 3619) (2016-2018). Logistic regressions examined association of patient characteristics with PIMs/PPOs and between prevalent PIMs/PPOs and functional decline. Negative binomial regressions examined association between PIM/PPO with healthcare utilisation over time.</p><p><strong>Results: </strong>Participants' mean age was 74.2 years (SD 6.99), 53.9% were female and were prescribed a mean of 4.02 (SD 3.16) medications. A total of 1123 (31.0%) participants experienced STOPP PIMs and 1309 (36.2%) START PPOs. STOPP PIMs were associated with increased hospital admissions (adjusted incident rate ratio (aIRR) 1.38, 95% confidence interval (CI) 1.08, 1.75), and functional decline (adjusted odds ratio (aOR) 1.46, 95% CI 1.11, 1.91) at follow-up. Age ≥ 75 years (aOR 1.32, 95% CI 1.10, 1.57) and three or more chronic conditions (aOR 5.19, 95% CI 3.69, 7.31) were significantly associated with START PPOs.</p><p><strong>Conclusion: </strong>Approximately one-third of study participants experienced STOPP PIMs, associated with an increased risk of hospital admissions and functional decline. START PPOs also occurred in over one-third, associated with increasing age and degree of multimorbidity. Balancing the risk: benefit of medications for older people with multimorbidity remains challenging.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1389-1402"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity and fluid biomarkers of Alzheimer's disease: a systematic review.","authors":"Martina Valletta, Marco Canevelli, Francesca Gasparini, Simona Buscarnera, Martina Salzillo, Federico Triolo, Amaia Calderón-Larrañaga, Alessandra Marengoni, Davide Liborio Vetrano, Giulia Grande","doi":"10.1007/s41999-025-01222-y","DOIUrl":"10.1007/s41999-025-01222-y","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aimed to summarize the evidence on the association between multimorbidity and fluid biomarkers of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>We systematically searched PubMed, Web of Science, and Embase for studies investigating the association between multimorbidity-defined as the co-occurrence of multiple chronic conditions in the same individual-and levels of cerebrospinal fluid (CSF) or blood biomarkers of AD, focusing on the most established AD biomarkers (amyloid-beta, phosphorylated-tau, total-tau, neurofilament light chain, and glial fibrillary acidic protein). Studies were selected following PRISMA guidelines.</p><p><strong>Results: </strong>Out of 3,104 records, we identified 10 cross-sectional studies. Four studies assessed CSF biomarkers in dementia-free participants with mean age between 61.8 and 66.6 years, yielding mixed findings with no consistent association between multimorbidity and CSF biomarkers. Six studies focused on blood biomarkers in participants with mean age ranging from 66.5 to 76.4 years, five of which included individuals with dementia. Most of these studies reported an association between multimorbidity and elevated blood biomarker levels.</p><p><strong>Conclusions: </strong>This review suggests a significant association between multimorbidity and AD blood biomarkers in older populations, while the results on CSF are mixed and inconsistent. Further research is needed, particularly longitudinal studies assessing both CSF and blood biomarkers within the same populations.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1121-1136"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}