European Geriatric Medicine最新文献

{"title":"Awareness of national dementia guidelines and management of oldest-old and frail people living with dementia: a European survey of geriatricians.","authors":"Elke De Bondt, Phaedra Locquet, María González López, Pinar Soysal, Tomas Welsh, Susan D Shenkin, Jos Tournoy","doi":"10.1007/s41999-025-01165-4","DOIUrl":"10.1007/s41999-025-01165-4","url":null,"abstract":"<p><strong>Background: </strong>Management of dementia, particularly the use of pharmacological treatments, in the oldest old and those with frailty is complex because of the multiple types of dementia, comorbidities, polypharmacy, and side effects. Current national dementia guidelines lack recommendations for this group. This study assessed guideline awareness, usage, and pharmacological management practices for dementia in the oldest old and frail across Europe.</p><p><strong>Methods: </strong>An online anonymous survey was distributed in 2023 to the European Geriatric Medicine Society Dementia Special Interest Group and their contacts to investigate guideline awareness and pharmacological practices for the oldest old and frail. The CHERRIES checklist was followed for reporting. Responses were summarized using descriptive statistics and quotations of free text responses.</p><p><strong>Results: </strong>Forty-nine responses from fourteen countries were received. A total of 76.6% were aware of a national dementia guideline and 86.9% applied it frequently. Acetylcholinesterase inhibitors (AChEIs) were generally used as a first-line treatment in mild-to-moderate Alzheimer's disease (AD) (91.6% and 93.4%). Memantine was added or replaced AChEIs as dementia severity progresses. Gingko biloba was considered in mild and moderate AD (23.6% and 22.7%, respectively). Off-label drug use was common in other types of dementia. 88.5% of respondents reported no difference in treatment compared with a younger population.</p><p><strong>Conclusion: </strong>There was awareness of various dementia guidelines, but none addressed the management of the oldest old and frail. Most respondents did not adapt their practices for this group, but many reported off-label treatments which resulted in non-evidence-based prescribing, overprescribing, and a lack of deprescribing. European consensus to guide the management of dementia in this complex population is needed.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"527-539"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dexamethasone on the prevalence of delirium in older COVID-19 patients: a retrospective cohort study.","authors":"Chris van der Laan, Kristel Goossens, Sarah H M Robben, Mariette H W Kappers","doi":"10.1007/s41999-024-01033-7","DOIUrl":"10.1007/s41999-024-01033-7","url":null,"abstract":"<p><strong>Purpose: </strong>Corticosteroids decrease mortality in patients with COVID-19 in need of oxygen therapy. However, corticosteroids are known to increase the risk of delirium in older patients. We studied whether dexamethasone increased the risk of delirium in older patients hospitalized with COVID-19.</p><p><strong>Methods: </strong>Single centre, retrospective cohort study including patients ≥ 70 years hospitalized in a large teaching hospital with COVID-19 during the first (control group) and second wave (dexamethasone group, receiving dexamethasone) of the COVID-19 pandemic. Only patients on regular (non-ICU) wards were included. Delirium was defined as having a mean delirium observation screening (DOS)-score of ≥ 3 or having an altered mental state on day 3 of admission.</p><p><strong>Results: </strong>We included 233 patients. The mean age in the dexamethasone group was 78.83 years [SD 6.5] compared to 79.43 years [SD 6.3] in the control group. In the dexamethasone group (n = 114), less patients developed delirium compared to the control group (n = 119) on day 3 of admission (5.3% vs 15.1%; p = 0.01). The Odds ratio of dexamethasone use for delirium was 0.23 (95% CI 0.08-0.64).</p><p><strong>Conclusion: </strong>In this study, dexamethasone did not increase the risk of delirium in older patients with COVID-19.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"665-672"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the circadian timing system in sarcopenia in old age: a scoping review.","authors":"Francesco Palmese, Ylenia Druda, Rossella Del Toro, Giorgio Bedogni, Marco Domenicali, Alessandro Silvani","doi":"10.1007/s41999-024-01129-0","DOIUrl":"10.1007/s41999-024-01129-0","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process.</p><p><strong>Methods: </strong>We developed a scoping review protocol following the PRISMA-ScR guidelines. Searches were conducted on PubMed, Scopus, Web of Science, RESULTS: We identified 373 papers from three online databases, screened 97 for full-text analysis. and selected 37 papers for inclusion. These papers included 17 primary research studies on human persons, focusing on cortisol and melatonin secretion, rest-activity rhythms, chrono-exercise, and chrono-dietary regimens, 9 primary research studies on animal models (mice, rats, fruit flies) focusing on direct expression measurement or mutations of core clock genes, and 11 narrative reviews.</p><p><strong>Conclusion: </strong>While several reports supported the role of the circadian timing system in sarcopenia, specifically related to the aging process, the available evidence is fragmented and limited. The field is thus open to preclinical and clinical research that addresses the wide knowledge gaps in the available evidence, taking advantage of what has already been published to optimize and refine experimental and clinical protocols.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"447-460"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the FAB test associated with fall occurrence in older adults? A retrospective analysis of outpatient fall risk assessment.","authors":"Victoire Leroy, Yaohua Chen, Elisabeth Brocquet, Julien Labreuche, Cédric Gaxatte, Kelly Cotton, Jean Roche, Dominique Huvent-Grelle, François Puisieux","doi":"10.1007/s41999-024-01134-3","DOIUrl":"10.1007/s41999-024-01134-3","url":null,"abstract":"<p><strong>Methods: </strong>We conducted a single-center, retrospective cohort study of French older adults. Participants with Mini-Mental State Examination (MMSE) ≥ 24 were recruited from a fall clinic in a geriatrics department. We recorded history of falls in the preceding 6 months, as well as Timed Up and Go test and mobility assessment at baseline and at 6- and 12-month follow-up.</p><p><strong>Results: </strong>We included 199 participants at baseline (mean age 83.1 years; 70.3% of females), of which 50.8% (101) had abnormal FAB scores (indicating executive impairment). Participants with executive impairment were more likely to have a history of falls. 125 and 96 participants completed 6- and 12-month follow-up visits, respectively. There was no association between abnormal FAB score at baseline and any or serious falls. Abnormal baseline FAB score was only associated with repeated (≥ 2) falls at 6 months, after adjusting for age, education, and polypharmacy (OR = 3.1 95% CI [1.0, 9.9]). Moreover, participants with abnormal FAB scores had significantly lower Timed Up and Go test scores.</p><p><strong>Conclusion: </strong>Abnormal FAB score was associated with repeated falls at 6 months, but not with total incident falls during the follow-up period. Our results highlight the potential utility of FAB in fall risk assessment, particularly for repeated falls, but further studies are needed to clarify this association.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"655-663"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which screening tool performs best in identifying malnutrition risk among hospitalized older adults with cardiovascular disease? A diagnostic accuracy study comparing six different screening tools with GLIM criteria.","authors":"Kevser Tarı Selcuk, Sedat Arslan, Ayça Aydın, Duygu Durmaz","doi":"10.1007/s41999-025-01187-y","DOIUrl":"https://doi.org/10.1007/s41999-025-01187-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the performance of six different screening tools with the GLIM criteria in identifying malnutrition risk among older adults with cardiovascular diseases.</p><p><strong>Methods: </strong>In this diagnostic accuracy study, data from 669 patients aged 65 and older, hospitalized at Bandırma Training and Research Hospital diagnosed with cardiovascular disease, were evaluated. The data were obtained using a questionnaire that included a Demographic Information Form, Global Leadership Initiative on Malnutrition (GLIM) Criteria, Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), Short Nutritional Assessment Questionnaire (SNAQ), Mini Nutritional Assessment-Short Form (MNA-SF), Nutritional Risk Screening-2002 (NRS-2002), and Graz Malnutrition Screening (GMS) tool. GLIM criteria were used as gold standard and six screening tools were used as index tests. Receiver Operating Characteristic (ROC) curve analysis was conducted to calculate the Area Under the Curve (AUC), and the sensitivity, specificity, accuracy, and Cohen's Kappa (κ) coefficient of the index tests were assessed.</p><p><strong>Results: </strong>The mean age of the patients was 75.5 ± 7.7 years, 55.2% were female. According to the GLIM criteria, the prevalence of malnutrition was calculated as 22.0%. The AUC calculated by ROC indicated that MST (AUC: 0.905) had excellent predictive value, while MUST (AUC: 0.874), SNAQ (AUC: 0.851), MNA-SF (AUC: 0.842), and GMS (AUC: 0.820) demonstrated good predictive value. Among the screening tools, GMS had the highest sensitivity (92.5%), whereas MNA-SF exhibited the highest specificity (91.6%). MNA-SF also demonstrated the highest agreement with the GLIM criteria (Cohen's κ: 66.8) and the highest accuracy (88.3%).</p><p><strong>Conclusion: </strong>This study found that the MNA-SF tool outperformed other comprehensive screening tools when evaluating malnutrition risk in light of the GLIM criteria.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of antibiotic use in nursing homes for suspected urinary tract infections: comparison across five European countries.","authors":"Matilde Bøgelund Hansen, Jesper Lykkegaard, Malene Plejdrup Hansen, Carl Llor, Ana Garcia Sangenis, Pia Touboul-Lundgren, Bruno Pascale, Ruta Radzeviciene, Lina Jaruseviciene, Marilena Anastasaki, Christos Lionis, Anna Kowalczyk, Maciek Godycki-Ćwirko, Beatriz Gonzalez Lopez-Valcárcel, Fabiana Raynal Floriano, Athina Chalkidou, Lars Bjerrum, Jette Nygaard Jensen","doi":"10.1007/s41999-025-01185-0","DOIUrl":"https://doi.org/10.1007/s41999-025-01185-0","url":null,"abstract":"<p><strong>Purpose: </strong>Antibiotic use is the main driver of bacterial antimicrobial resistance. Urinary tract infections (UTIs), for which antibiotics are often prescribed, are among the most common infections among residents in nursing homes. This study aimed to estimate and compare the appropriateness of antibiotic use for suspected UTIs among nursing home residents across five European countries. Both the decision to treat and the choice of antibiotics used were explored.</p><p><strong>Methods: </strong>This cross-sectional study used the Audit Project Odense (APO) method. The appropriateness of the treatment decision for UTIs was evaluated according to symptom presentation in residents without indwelling urinary catheters. The choice of antibiotic used for treatment was evaluated according to the first-line antibiotic recommended for the treatment of UTIs in the respective countries. Data were collected through an institutional sign-up questionnaire and a clinical case registration chart. All residents in new or ongoing treatment with systemic antibiotics were registered during a 6-week period between February and April 2022.</p><p><strong>Results: </strong>A total of 70 nursing homes or wards registered 508 antibiotic treatments for suspected UTIs. The proportion of antibiotics prescribed for UTIs to nursing home residents with no specific UTI symptoms varied from 10% in Poland to 68% in Spain. The proportion of treatments with the first-line choice of antibiotics for UTIs also varied from 28% in France and Poland to 55% in Spain.</p><p><strong>Conclusion: </strong>There was a substantial proportion of potentially inappropriate antibiotic treatments, with notable variation among the countries studied.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of different physical performance assessment methods for falls in older adults: a 3-year longitudinal study in China.","authors":"Fei Lu, Xiaohong Liu, Jiaojiao Li, Xiaohong Sun, Shan Jiang","doi":"10.1007/s41999-025-01184-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01184-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the predictive value of different physical performances including short physical performance battery (SPPB), time-up and go test (TUGT), gait speed (GS), five times sit-to-stand test (FTSST) and handgrip strength (HGS) on the incidence of falls among community-dwelling older adults and to propose the cut-off values for predicting the incidence of falls.</p><p><strong>Methods: </strong>This 3-year longitudinal observational study continuously recruited community-dwelling older adults in 2018, assessing baseline physical performances and recording fall incidence (at least one fall) after 3 years.</p><p><strong>Results: </strong>Of the 215 older adults (mean age, 84.0 ± 4.4 years; 123 [57.2%] females) included in this study, 98 (45.6%) fell. After adjusting for age, sex, and comorbidity, decreased SPPB score (odds ratio [OR] = 0.84, 95% confidence interval [CI], 0.75-0.94), increased TUGT time (OR = 1.07, 95% CI, 1.03-1.12), and lower GS (OR = 0.11, 95% CI, 0.03-0.37) were significantly associated with higher risk of fall and had similar predictive values, while the FTSST and HGS were not. To predict the incidence of falls, the areas under the curve for SPPB, TUGT, and GS were 0.71 (95% CI: 0.65-0.77), 0.73 (95% CI: 0.67-0.79), and 0.71 (95% CI: 0.64-0.77), whereas the cut-offs were 7 points, 14.8 s, and 0.75 m/s, according to the Youden index, respectively.</p><p><strong>Conclusion: </strong>As physical performance indicators, SPPB, TUGT, and GS may be more effective in assessing fall risk, and the threshold values proposed in this study can be used as a reference for stratified fall risk management among community-dwelling older residents.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of concern about falling after hospital discharge among older adults with fragility hip fractures: a prospective cohort study.","authors":"Suphawita Pliannuom, Phichayut Phinyo, Nida Buawangpong, Nopakoon Nantsupawat, Pichitchai Atthakomol, Tanawat Vaseenon, Nitchanant Kitcharanant, Peerasak Lerttrakarnnon, Kanokporn Pinyopornpanish","doi":"10.1007/s41999-025-01188-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01188-x","url":null,"abstract":"<p><strong>Purpose: </strong>Concern about falling [CaF] is common among older adults, particularly after fragility hip fracture. This condition is associated with adverse health outcomes and a reduced quality of life. The aim of this study is to explore predictors of CaF among older patients with fragility hip fractures 2 weeks after hospital discharge.</p><p><strong>Methods: </strong>A prospective observational cohort study was conducted at a Tertiary Care Hospital in Thailand. Participants were patients aged 60 years and above who had fragility hip fractures and were admitted to the hospital from March 2023 to March 2024. CaF was assessed using the short Falls Efficacy Scale-International 2 weeks after hospital discharge. Predictors examined pre-fall characteristics, fall-related data, surgery-related data, and postoperative data. In the full model approach, the multivariable Gaussian regression was employed to identify predictive factors.</p><p><strong>Results: </strong>Of the 165 patients included in the study (mean age 78.76 ± 8.72 years), 79.39% were female. In the full model approach, pre-fracture activities of daily living (ADL) < 20 (adjusted mean difference [aMD] 3.44, 95% CI 1.04-5.85, p = 0.005) and shorter in-hospital duration of walking training (aMD - 0.66, 95% CI - 1.10 to - 0.22, p = 0.004) were identified as predictors of CaF at 2 weeks after hospital discharge.</p><p><strong>Conclusions: </strong>The findings of this study emphasize the importance of assessing pre-fracture functional status and the shorter duration of in-hospital walking training as key predictors of CaF in older adults with fragility hip fractures. Enhancing functional capacity and extending the duration of walking training during hospitalization are crucial steps in reducing CaF in this population.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in sarcopenia prevalence and muscle-related outcomes among post-stroke inpatients.","authors":"Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Takenori Hamada, Kouki Yoneda","doi":"10.1007/s41999-025-01186-z","DOIUrl":"https://doi.org/10.1007/s41999-025-01186-z","url":null,"abstract":"<p><strong>Background: </strong>Sex differences in sarcopenia prevalence and recovery patterns among post-stroke patients remain poorly understood. This study aimed to investigate sex differences in sarcopenia prevalence, improvement rates, and changes in muscle-related indices among post-stroke patients in rehabilitation settings.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a post-acute rehabilitation hospital. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. The primary outcomes were sarcopenia status and muscle-related indices (handgrip strength and skeletal muscle mass index) at discharge. Propensity score-adjusted logistic regression analysis was performed to examine the association between sex and non-sarcopenia at discharge.</p><p><strong>Results: </strong>A total of 598 patients (274 women) with a mean age of 71.6 years were analyzed. Women showed higher sarcopenia prevalence at admission compared to men (47.4% vs 34.2%, p = 0.001). After adjusting for confounders, male sex was positively associated with non-sarcopenia at discharge (OR 1.046, 95% CI 1.009-1.104, p < 0.001) and greater improvements in handgrip strength (B = 1.93, p = 0.031) and skeletal muscle mass index (B = 0.322, p = 0.019).</p><p><strong>Conclusion: </strong>This study revealed significant sex differences in sarcopenia among post-stroke rehabilitation patients. While women showed higher sarcopenia prevalence at admission, men demonstrated better improvements in muscle-related outcomes.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geriatric syndrome burden on healthcare services utilization and mortality among community-dwelling older adults: is it still too late to do something?","authors":"Bilal Katipoglu, Suleyman Emre Kocyigit","doi":"10.1007/s41999-025-01189-w","DOIUrl":"https://doi.org/10.1007/s41999-025-01189-w","url":null,"abstract":"<p><strong>Purpose: </strong>The increasing longevity of the population emphasizes the need for a deeper understanding of geriatric syndromes and their implications for healthcare usage and mortality among older adults. This study aimed to identify risk factors associated with healthcare service utilization and mortality of community-dwelling adults aged 80 and older in YASAM project.</p><p><strong>Methods: </strong>This prospective cohort study was part of the HEAT-YASAM trial, which focused on the community-based integrated healthy aging program for individuals aged 80 years and older in Balıkesir, Türkiye. The burden of geriatric syndromes was assessed based on a comprehensive evaluation at least two domains of the nutrition, cognitive, physcological and locomotor capacities. The study outcome was healthcare services utilization (inpatient, outpatient, emergency admission) and all-cause mortality data obtained during follow-up period (9 months).</p><p><strong>Results: </strong>The cohort consisted of 5018 participants with a mean age of 85.8 years, predominantly female (53.1%). On the multivariable analysis, geriatric syndrome burden and Deyo Charlson Comorbidity index (D-CCI) score significant on independent predictors of 9-month mortality (p = 0.01). Higher geriatric syndrome burden was linked to an approximately 10% lower risk for outpatient admissions (p = 0.01) and every point increase in the D-CCI score was associated with a 1.3-fold increased risk of utilizing outpatient services (p = 0.01). For multimorbidity, every point increase corresponded to a 2.6-fold higher risk of inpatient admissions (p = 0.01) and a 1.2-fold higher risk of emergency admissions (p = 0.01).</p><p><strong>Conclusions: </strong>This study demonstrate that a geriatric syndrome burden and multimorbidity has a significant impact on healthcare utilization and mortality in adults aged 80 years and older. Integrated comprehensive, coordinated, and patient-centered care models for this population facing multiple geriatric syndromes could positively impact the healthcare system.</p><p><strong>Trial registration: </strong>The trial was prospectively registered at ClinicalTrials.gov. Identifier: NCT05993572 Registered on 15 July 2023.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}