European Geriatric Medicine最新文献

{"title":"Medication use patterns among older patients in temporary stays in Denmark.","authors":"Hanin Harbi, Carina Lundby, Peter Bjødstrup Jensen, Søren Post Larsen, Linda Grouleff Rørbæk, Lene Vestergaard Ravn-Nielsen, Jesper Ryg, Mette Reilev, Kasper Edwards, Anton Pottegård","doi":"10.1007/s41999-025-01210-2","DOIUrl":"10.1007/s41999-025-01210-2","url":null,"abstract":"<p><strong>Purpose: </strong>Patients in temporary stays are typically older individuals with frailty and multimorbidity. However, limited knowledge exists about their medication use. This study aimed to describe prescription drug use among patients in temporary stays in Denmark.</p><p><strong>Methods: </strong>We conducted a drug utilisation study on 11,424 patients in public healthcare-operated temporary stay units across 14 Danish municipalities between 2016 and 2023 (median age 81 years; 54% women). Prescription data were sourced from the Danish National Prescription Registry.</p><p><strong>Results: </strong>Patients used a median of six drug classes (interquartile range [IQR] 4-10) in the four months before moving into a temporary stay facility; 68% used ≥ 5 drug classes, and 26% used ≥ 10. The most commonly used drug classes were paracetamol (49%), statins (30%), and proton pump inhibitors (29%). The monthly rate of new drug use increased from 23/100 patients six months before move-in to a peak of 262/100 patients in the first month after move-in, driven primarily by laxatives, analgesics, and antibiotics. High-risk drug use increased from 70 to 83% following move-in, with 49% of patients initiating at least one new high-risk drug, most commonly opioids (28%), potassium (17%), and anticoagulants and platelet inhibitors (15%). General practitioners initiated 60-70% of treatments and maintained 80-90%. Hospital physician prescriptions increased around move-in, peaking at 55% for initiation and 25% for maintenance in the first month after move-in.</p><p><strong>Conclusion: </strong>Patients in temporary stays in Denmark demonstrate high medication use, including high-risk drugs, with a notable increase in treatment initiations around the time of move-in.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1427-1435"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the deprescribing timing on medicines optimisation in older cancer patients receiving hospice care at the end of life: a comparative cohort study.","authors":"Tahani Alwidyan, Omar Shamieh, Carole Parsons, Waleed Alrjoub, Ghadeer Alarjeh","doi":"10.1007/s41999-025-01217-9","DOIUrl":"10.1007/s41999-025-01217-9","url":null,"abstract":"<p><strong>Background: </strong>Deprescribing, the systematic discontinuation of potentially inappropriate medications, is essential for optimising end-of-life care in older cancer patients, particularly in hospice settings. While the benefits of deprescribing are recognised, the timing of these interventions and their impact on patient outcomes, such as survival, remain underexplored.</p><p><strong>Aim: </strong>This study aimed to compare the effects of deprescribing timing on medication appropriateness and survival time in older hospice cancer patients.</p><p><strong>Methods: </strong>A retrospective, observational cohort study that reviewed the medical records of all decedents aged 65 years and older who received palliative care consults in hospice settings was conducted between January 1 and December 31, 2022. Data collected included Palliative Performance Scale (PPS) scores and prescribed medications. Patients were categorised into early deprescribing (interventions initiated more than 30 days, but less than 180 days before death) and late deprescribing (within 30 days of death) groups. Unexpected deaths were excluded. Medication appropriateness was assessed using the OncPal deprescribing guideline.</p><p><strong>Results: </strong>Among 155 decedents, early deprescribing was associated with longer median survival time (81 versus 17 days; P < 0.001). Both early and late interventions significantly reduced preventive medications (4.6-1.6, 4.8-1.5, respectively; P < 0.001) and increased symptom control medications (3.6-6.0 and 3.7-5.5, respectively; P < 0.001). Late deprescribing was more common in patients with lower PPS scores (≤ 30%) and haematologic cancers.</p><p><strong>Conclusion: </strong>Early deprescribing in hospice care was associated with longer survival and improved symptom management, though this may reflect underlying patient characteristics rather than a direct effect of deprescribing.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"1415-1426"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International expert panel's potentially inappropriate prescribing cascades (PIPC) list.","authors":"Paula A Rochon, Denis O'Mahony, Antonio Cherubini, Graziano Onder, Mirko Petrovic, Kieran Dalton, Lisa M McCarthy, Shelley A Sternberg, Donna R Zwas, Nathan M Stall, Christina E Reppas-Rindlisbacher, Nathalie van der Velde, Sarah N Hilmer, Wei Wu, Joyce Li, Amy Ly, Jerry H Gurwitz","doi":"10.1007/s41999-025-01215-x","DOIUrl":"https://doi.org/10.1007/s41999-025-01215-x","url":null,"abstract":"<p><strong>Purpose: </strong>Prescribing cascades contribute to potentially inappropriate prescribing, especially among older adults. With the prescribing cascade framework maturation, it is important to distinguish potentially inappropriate from potentially appropriate prescribing cascades. The objective was to create a comprehensive consensus list of Potentially Inappropriate Prescribing Cascades (PIPCs).</p><p><strong>Methods: </strong>A prescribing cascade inventory was compiled using published lists. An international panel of 12 experts in geriatric medicine and pharmacology was selected. Panelists participated in a Delphi consensus process completing two questionnaire rounds and one discussion round.</p><p><strong>Results: </strong>A total of 107 proposed prescribing cascades were identified. After Questionnaire Round 1, 56 prescribing cascades achieved a rating of agree or strongly agree by ≥ 75% of the panelists and were included in the PIPC list. For 32 of the 107 proposed cascades, 50-74% of panelists provided a rating of agree or strongly agree, and were moved to Round 2. In Questionnaire Round 2, 9 of 32 proposed cascades achieved a rating of agree or strongly agree by ≥ 75% of panelists and were included in the final PIPC list. For 14 prescribing cascades, 50-74% of panelists provided a rating of agree or strongly agree, and were included in the Discussion Round. After discussion, no additional prescribing cascades were included.</p><p><strong>Conclusion: </strong>An explicit list of 65 PIPCs was created using a rigorous Delphi consensus process conducted by international experts on pharmacotherapy for older adults. The PIPC list provides a crucial tool for clinicians and researchers to detect potentially inappropriate prescribing patterns and to foster efforts to improve medication safety.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitudes toward delirium: a multi-centered survey in a sample of physicians and pre-registration house officers in Egypt.","authors":"Shaimaa Nabil Rohaiem, Maha Magdy Wahdan, Asmaa Fathy Abdellah Hassan","doi":"10.1007/s41999-025-01281-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01281-1","url":null,"abstract":"<p><strong>Background: </strong>Delirium is common in older adult population in hospitals. It increases morbidity, mortality, and healthcare cost. Worldwide studies showed that early recognition and proper management are deficient because of knowledge lack among physicians.</p><p><strong>Objective: </strong>In Egypt, there is a lack of studies assessing delirium knowledge and attitudes in physicians. We aim to assess delirium awareness and attitudes of physicians and pre-registration house officers in Egypt.</p><p><strong>Methods: </strong>We conducted an online survey evaluating delirium knowledge, diagnostic criteria, and management attitudes. Participants included physicians at various career stages and pre-registration house officers from university and Ministry of Health hospitals across Egypt.</p><p><strong>Results: </strong>From 1,000 surveys distributed, we obtained 649 responses. Approximately three-quarters of the participants underestimated the prevalence of delirium (77.6%). A few participants knew the outcomes. Knowledge of diagnostic criteria was better. 55.3% of participants use assessment tools as confusion assessment method (CAM). Only about a third had confidence in delirium diagnosis (32.2%) or management (19.4%) and a minority (22.1%) performed serial cognitive assessment in patients at risk of delirium. Only 23.7% reported adequate training. Likely delirium-oriented specialties as geriatrics together with physicians at Ain Shams University hospitals showed more significant knowledge and attitudes to delirium.</p><p><strong>Conclusion: </strong>We highlighted gaps in delirium awareness and practice among physicians and pre-registration house officers in a variety of hospitals in Egypt. This underlined the need for enhanced delirium education and training.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical estimation equation for appendicular skeletal muscle mass in stroke rehabilitation: validating diagnostic accuracy and predicting functional outcomes.","authors":"Kota Hori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ayaka Matsumoto, Fumihiko Nagano, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Aomi Kuzuhara, Takenori Hamada, Kouki Yoneda","doi":"10.1007/s41999-025-01280-2","DOIUrl":"https://doi.org/10.1007/s41999-025-01280-2","url":null,"abstract":"<p><strong>Background: </strong>The gold standard methods for assessing muscle mass in sarcopenia diagnosis are often impractical due to cost and accessibility, necessitating simpler tools. This study evaluates the validity of diagnosing sarcopenia using skeletal muscle mass estimated by a prediction equation in post-stroke rehabilitation patients.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed hospitalized post-stroke patients. Skeletal muscle mass was assessed using bioelectrical impedance analysis (BIA) and a validated prediction equation (ASM = 0.485 × 0.998^age × 0.814^[female] × 1.006^height × weight^0.680). Sarcopenia was diagnosed following the Asian Working Group for Sarcopenia 2019 criteria. The accuracy of the prediction equation was assessed by correlation with BIA-derived skeletal muscle mass and diagnostic metrics (κ and AUC). Functional outcomes, including motor and cognitive scores from the Functional Independence Measure (FIM), were analyzed using multivariate regression to adjust for confounders.</p><p><strong>Results: </strong>A total of 748 participants were analyzed. The prediction equation demonstrated a strong correlation with BIA-derived skeletal muscle mass (R² = 0.84, RMSE = 2.04). Diagnostic accuracy for sarcopenia was moderate (men κ = 0.47, AUC = 0.74; women κ = 0.55, AUC = 0.75), with high sensitivity (men 83%, women 96%) and moderate specificity (men 55%, women 65%). Sarcopenia diagnosed using the prediction equation was independently associated with lower FIM motor (men: 87 vs. 78, p  < 0.001; women: 85 vs. 74, p < 0.001) and cognitive scores (men: 32 vs. 28, p  < 0.001; women: 33 vs. 27, p < 0.001) at discharge.</p><p><strong>Conclusions: </strong>The prediction equation offers a practical and accessible tool for estimating skeletal muscle mass and diagnosing sarcopenia, demonstrating strong correlations with established methods and associations with functional outcomes.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 12-week exercise on Meteorin-like levels, inflammation, and functional capacity in older adults: Korean national aging project randomized controlled study.","authors":"Parivash Jamrasi, Jun Hyun Bae, Wook Song","doi":"10.1007/s41999-025-01272-2","DOIUrl":"10.1007/s41999-025-01272-2","url":null,"abstract":"<p><strong>Purpose: </strong>Meteorin-like protein (Metrnl) is involved in regulating inflammation, metabolism, and muscle regeneration, making it a promising therapeutic target. Building on prior research, we investigated how exercise-induced changes in Metrnl relate to inflammatory markers, physical function, and cognitive performance. This randomized controlled trial examined the effects of a 12-week exercise intervention on circulating Metrnl, a novel biomarker, in 90 community-dwelling older adults (≥ 65 years).</p><p><strong>Methods: </strong>Participants were randomized into a walking group (WG), a combined resistance and walking group (RWG), or an active control group (CG). Intervention groups engaged in moderate-intensity exercise; walking based on age-specific step goals and resistance training twice weekly. Blood samples and assessments of physical and cognitive function were collected pre- and post-intervention.</p><p><strong>Results: </strong>79 participants successfully completed the study. After 12 weeks, serum Metrnl levels significantly increased in both RWG and WG compared to CG (WG vs. CG: p = .002; RWG vs. CG: p = .004). Metrnl changes were correlated with improvements in inflammatory markers (IL-6, p = .048; TNF-α, p = .040), physical activity (p = .041), and physical function (Timed Up & Go, p = .004; Five Times Sit to Stand Test, p = .008). Stronger associations were observed in the RWG, including cognitive gains (Stroop test, p = .040), enhanced handgrip strength (p = .036), and reduced fat mass (pp= .021). Timed Up & Go and Five Times Sit to Stand Test were the strongest predictors of Metrnl changes.</p><p><strong>Conclusion: </strong>These findings highlight Metrnl's potential as a biomarker linking exercise to reduced inflammation and improved physical and cognitive outcomes in older adults, supporting its relevance in developing targeted exercise-based therapies.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.","authors":"Ioannis Liampas, Silvia Demiri, Polyxeni Stamati, Lefteris Lazarou, Christos Michailides, Chrysoula Marogianni, Antonia Tsika, Vasileios Siokas, Efthimios Dardiotis","doi":"10.1007/s41999-025-01259-z","DOIUrl":"https://doi.org/10.1007/s41999-025-01259-z","url":null,"abstract":"<p><strong>Purpose: </strong>Motor signs are frequently observed over the clinical course of Alzheimer's disease (AD). We explored the potential clinical associations of motor manifestations in AD.</p><p><strong>Methods: </strong>Our sample consisted of older adults (≥ 60 years) with AD from NACC. Individuals with Parkinson's disease or other Parkinsonian syndrome or under anti-parkinsonian agents were excluded. UPDRS III was used to assess motor signs in nine domains: hypophonia; masked facies; resting tremor; action/postural tremor; rigidity; bradykinesia; impaired chair rise; impaired posture/gait; postural instability. A global motor variable assessed the presence of at least one motor sign. Binary logistic models were estimated for the global (primary) and individual motor domain variables (secondary outcomes).</p><p><strong>Results: </strong>A total of 4771 older, predominantly female, well-educated participants were analysed: 3556 without (75.4 ± 7.6 years, 45.6% males) and 1215 with motor manifestations (79.4 ± 7.8 years, 44.4% males). The most influential risk factor for motor manifestations in AD was the Clinical Dementia Rating stage: stage one increased the odds of motor signs by ~ 44%, stage two by ~ 168% and stage three by ~ 437%. Each additional point on the Geriatric Depression Scale elevated the odds of motor manifestations by ~ 5%, whereas each additional point on the Mini-Mental State Examination decreased these odds by ~ 2.5%. Cerebrovascular disease (by ~ 44%), diabetes mellitus (by ~ 25%), traumatic brain injury (by ~ 30%), alcohol abuse (by ~ 33%), anxiolytics (by ~ 36%), antidepressants (by ~ 31%), antipsychotics (by ~ 48%) and β-blockers (by ~ 33%) elevated the odds of motor manifestations. Angiotensin II receptor blockers decreased the odds of motor manifestations (by ~ 33%).</p><p><strong>Conclusion: </strong>Disease progression constitutes the most crucial clinical risk factor for motor manifestations in AD.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of the Short Physical Performance Battery (SPPB): a systematic review with meta-analysis.","authors":"Davide Eusepi, Leonardo Pellicciari, Alessandro Ugolini, Lorenzo Graziani, Andrea Coppari, Alessandra Carlizza, Serena Caselli, Fabio La Porta, Matteo Paci, Mauro Di Bari, Daniele Piscitelli","doi":"10.1007/s41999-025-01277-x","DOIUrl":"10.1007/s41999-025-01277-x","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a systematic review with meta-analysis on reliability of Short Physical Performance Battery (SPPB) in adult patients.</p><p><strong>Methods: </strong>Five databases were queried until March 2025 to identify studies evaluating SPPB intra- and inter-rater reliability and measurement error. Two independent reviewers performed study selection, data extrapolation and assessment of methodological quality and quality of evidence (QoE). Random effect meta-analyses were performed when at least two studies assessed the same property of the same subscale.</p><p><strong>Results: </strong>Twenty-two studies were included. Regarding total score, intra-rater (ICC = 0.88) and inter-rater reliability (ICC = 0.86) were rated sufficiently with high QoE, while the measurement error (MDC = 1.90) was rated insufficiently with high QoE. Regarding the balance subscale, intra-rater (ICC = 0.69) and inter-rater reliability (ICC = 0.77) were rated inconsistently with low QoE, while the measurement error (MDC = 1.32) was rated as indeterminate with high QoE. Regarding the walking subscale, intra-rater (ICC = 0.88) and inter-rater reliability (ICC = 0.86) were rated sufficiently with moderate and high QoE, respectively, while the measurement error (MDC = 0.51 points) was rated indeterminately with moderate QoE. Regarding the chair subscale, intra-rater (ICC = 0.83) and inter-rater reliability (ICC = 0.94) were rated sufficiently with moderate and high QoE, respectively. In contrast, the measurement error (MDC = 2.14 points, equal to 53.4% of the total score) was rated indeterminately with high QoE.</p><p><strong>Conclusion: </strong>Intra- and inter-reliability of the SPPB were supported for assessing physical performance in different populations. Measurement error of each subscale (except for the walking subscale) is higher than the measurement error of the total score; these results suggest using the total score in clinical practice. PROSPERO registration: CRD420251003320.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and sarcopenia: two sides of the same coin.","authors":"Stefano Cacciatore, Konstantinos Prokopidis, Mathias Schlögl","doi":"10.1007/s41999-025-01275-z","DOIUrl":"https://doi.org/10.1007/s41999-025-01275-z","url":null,"abstract":"","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study.","authors":"Dolores Sanchez-Rodriguez, Amelie Bellanger, Laura Iconaru, Felicia Baleanu, Anne-Sophie Hambye, Jeroen de Filette, Aude Mugisha, Florence Benoit, Murielle Surquin, Pierre Bergmann, Jean-Jacques Body","doi":"10.1007/s41999-025-01273-1","DOIUrl":"https://doi.org/10.1007/s41999-025-01273-1","url":null,"abstract":"<p><strong>Purpose: </strong>We assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.</p><p><strong>Methods: </strong>Retrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 \"probable\" and \"confirmed\"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.</p><p><strong>Results: </strong>As expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].</p><p><strong>Conclusions: </strong>Older women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}