Dolores Sanchez-Rodriguez, Amelie Bellanger, Laura Iconaru, Felicia Baleanu, Anne-Sophie Hambye, Jeroen de Filette, Aude Mugisha, Florence Benoit, Murielle Surquin, Pierre Bergmann, Jean-Jacques Body
{"title":"老年妇女骨骼肌减少症、肌肉减少症及其与新近证实的脆性骨折的关系：在FRISBEE 2研究中应用7种定义","authors":"Dolores Sanchez-Rodriguez, Amelie Bellanger, Laura Iconaru, Felicia Baleanu, Anne-Sophie Hambye, Jeroen de Filette, Aude Mugisha, Florence Benoit, Murielle Surquin, Pierre Bergmann, Jean-Jacques Body","doi":"10.1007/s41999-025-01273-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.</p><p><strong>Methods: </strong>Retrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 \"probable\" and \"confirmed\"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.</p><p><strong>Results: </strong>As expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].</p><p><strong>Conclusions: </strong>Older women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study.\",\"authors\":\"Dolores Sanchez-Rodriguez, Amelie Bellanger, Laura Iconaru, Felicia Baleanu, Anne-Sophie Hambye, Jeroen de Filette, Aude Mugisha, Florence Benoit, Murielle Surquin, Pierre Bergmann, Jean-Jacques Body\",\"doi\":\"10.1007/s41999-025-01273-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.</p><p><strong>Methods: </strong>Retrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 \\\"probable\\\" and \\\"confirmed\\\"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.</p><p><strong>Results: </strong>As expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].</p><p><strong>Conclusions: </strong>Older women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.</p>\",\"PeriodicalId\":49287,\"journal\":{\"name\":\"European Geriatric Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Geriatric Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s41999-025-01273-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Geriatric Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s41999-025-01273-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Osteosarcopenia, sarcopenia, and their associations with validated recent fragility fractures in older women: applying seven definitions in the FRISBEE 2 study.
Purpose: We assessed the associations between osteosarcopenia, sarcopenia (according to seven definitions), and the presence of radiologically validated recent osteoporotic fractures in community-dwelling older women from the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE2) study.
Methods: Retrospective cohort design. The FRISBEE2 study includes 907 community-dwelling women aged 77 (75-81) years. Sarcopenia (according to six consensual definitions: EWGSOP2 "probable" and "confirmed"; IWGS; SCWD; SDOC; FNIH, and as seventh, an exploratory, potential framework for the GLIS), osteoporosis (T-score ≤ - 2.5SD), and osteosarcopenia (osteoporosis plus each of the 7 sarcopenia definitions) were assessed at baseline. We recorded and radiologically validated recent (i.e., within 2 years before baseline) central or major osteoporotic fractures (MOFs). Multivariate regression models adjusted for age, BMI, sedentary lifestyle, and comorbidities, were used to evaluate associations between osteosarcopenia and sarcopenia at baseline with the presence of recent fractures.
Results: As expected, the prevalence of osteosarcopenia and sarcopenia varied widely depending on the definitions used. Out of the 907 included women, 47 (5.2%) had experienced a recent fracture. The crude analysis showed significant associations between osteosarcopenia, osteoporosis, and sarcopenia and the presence of recent fractures. In the multivariate analysis, only EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength) was associated with recent fractures [OR = 2.14 (1.05-4.35); p = 0.035].
Conclusions: Older women with a history of recent fracture had EWGSOP2-defined probable sarcopenia (i.e., low handgrip strength). A recent central or MOF should alert on probable sarcopenia. Further prospective studies are needed to explore the role of muscle strength as a modifiable risk factor for fractures.
期刊介绍：
European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine.
The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.
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