Cleft Palate-Craniofacial Journal最新文献

{"title":"A Scoping Review of Socioeconomic Factors in Orofacial Cleft Research.","authors":"Erli Sarilita, Wisnu Fadila, Sri Susilawati, Peter Anthony Mossey","doi":"10.1177/10556656251379342","DOIUrl":"https://doi.org/10.1177/10556656251379342","url":null,"abstract":"<p><p>ObjectiveTo map and synthesize evidence on the relationship between socioeconomic status (SES) and orofacial clefts (OFC), identifying key SES indicators, study designs, and evidence gaps to inform future research and policy.DesignScoping review following Arksey and O'Malley's framework and reported per PRISMA-ScR guidelines.SettingSystematic searches of PubMed, Scopus, and Web of Science with no date or language restrictions.Patients/ParticipantsPeer-reviewed studies of individuals with non-syndromic OFC that explicitly measured at least one SES indicator (income, education, occupation, insurance status, area-level deprivation index, or composite SES index).InterventionsNot applicable.Main Outcome Measure(s)Identification and charting of SES measures, study characteristics (design, setting, sample size), and domains of SES-OFC associations (eg, access to care, OFC risk).ResultsOf 259 retrieved records, 42 studies met inclusion criteria. Publications increased over time, with 78.6% conducted in high-income countries (50.0% in North America). Retrospective designs predominated (59.5%). The most common SES indicators were demographic factors (61.9% of studies; race/ethnicity in 52.4%) and household income (42.9%). Two principal domains emerged: SES impact on access to multidisciplinary OFC care (45.2% of studies; all reporting greater barriers for low-SES groups) and SES as a risk factor for OFC (33.3%; most finding increased risk with lower SES).ConclusionsSES research in OFC is expanding but remains concentrated in high-income settings with diverse measures. Harmonized core indicators-LMICs included-and longitudinal, registry-based studies are needed. Findings support targeted policy interventions (eg, subsidies, resource allocation) and routine SES screening in OFC care pathways to promote equitable access.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251379342"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Step-by-Step Guide for Implementing Digital Scanning in Presurgical Infant Orthopedics (PSIO).","authors":"Juan Pablo Gomez, Puneet Batra, Cinthya Echeverry, Monica Dominguez, Dhruv Ahuja, Binita Saha","doi":"10.1177/10556656251380611","DOIUrl":"https://doi.org/10.1177/10556656251380611","url":null,"abstract":"<p><p>ObjectiveTo present a comprehensive guide for integrating digital scanning into the presurgical infant orthopedics (PSIO) workflow, enhancing precision and efficiency in cleft lip and palate (CLP) treatment.DesignDescriptive studyMethodsThe guide emphasizes the use of high-precision intraoral scanners and essential armamentarium for effective scanning. Key aspects include infant and operator positioning, secure infant stabilization, and ergonomic considerations for clinicians. Different scanning trajectories are recommended to ensure complete anatomical capture.ResultsHigh-resolution digital models generated through meticulous preparation and iterative scanning techniques mitigate potential pitfalls, such as motion artifacts and incomplete scans. These models enable the development of a digital workflow for creating patient-specific appliances.ConclusionIntegrating digital scanning into the PSIO workflow improves the accuracy, efficiency, and effectiveness of CLP treatment in clinical settings.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251380611"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical Study of Microtia Risk Factors in Indonesia.","authors":"Jilvientasia Godive Lilihata, Imaniar Fitri Aisyah, Magda Rosalina Hutagalung, Pudji Lestari, Indri Lakhsmi Putri","doi":"10.1177/10556656251378594","DOIUrl":"https://doi.org/10.1177/10556656251378594","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the characteristics and risk factors associated with microtia at Airlangga University Hospital.DesignA retrospective and unmatched case-control study involving 354 microtia patients and 354 controls, using convenience sampling from regions across western to eastern Indonesia.SettingAirlangga University Hospital, a national referral center for microtia in Indonesia.ParticipantsPatients and controls were recruited through online questionnaires.InterventionsNone; data were collected using Google Forms.Main Outcome MeasuresPrevalence, laterality, severity (Hunter's Classification), and potential risk factors, including parental health, smoking exposure, folic acid intake, TORCH vaccination, and family history.ResultsMicrotia was more prevalent in males (78%) with a male-to-female ratio of 3.53:1 (<i>P</i> < .001). Unilateral cases dominated (80.2%), mainly affecting the right ear (61.3%). Grade 3 microtia was most common (59%). After performing multiple unconditional logistic regression analyses, significant risk factors associated with the microtia group included maternal history of miscarriage/stillbirth (adjusted odds ratio [AOR] = 4.74-4.96), diabetes (AOR = 6.46), hypertension (AOR = 4.18), maternal smoking (AOR = 2.06), paternal smoking (AOR = 2.42-2.83), lack of TORCH vaccination (AOR = 1.59-2.02), and family history (AOR = 5.36), all with <i>P</i> value < .05.ConclusionsMicrotia in Indonesia reflects global patterns, with male predominance and right-sided unilateral cases. Associated risk factors include parental smoking, maternal comorbidities, lack of TORCH vaccination, and genetic predisposition. Public health strategies should promote smoking cessation, prenatal care, and vaccination. Further studies should ensure matching between the control and microtia groups, minimize recall bias, and explore genetic links.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251378594"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Transfusion Outcomes for Patients Undergoing Surgical Correction of Craniosynostosis: A Multicenter Retrospective Analysis.","authors":"Gwendolyn E Daly, Matthew K McIntyre, Trisha E Wong, Heike Gries, Paul A Stricker, Spencer T Hills, Lori K Howell, Nathan R Selden, Erik M Wolfswinkel","doi":"10.1177/10556656251379006","DOIUrl":"https://doi.org/10.1177/10556656251379006","url":null,"abstract":"<p><p>ObjectiveIntraoperative transfusion during corrective surgery for craniosynostosis is common. We sought to evaluate determinants of intraoperative transfusion for patients with nonsyndromic, single-suture craniosynostosis undergoing primary repair.DesignWe queried the multicenter Pediatric Craniofacial Surgery Perioperative Registry for patients undergoing correction of craniosynostosis between June 2012 and January 2023. Nonsyndromic patients who underwent primary repair of single suture craniosynostosis at <12 months of age were included. Univariate and multivariate logistic regressions were performed.Main Outcome MeasureIntraoperative transfusion requirement.ResultsA total of 3994 patients met inclusion criteria, and 2261 (56.6%) received an intraoperative blood transfusion. Those who received an intraoperative transfusion had longer surgery duration (93.8 ± 1.5 vs 180.1 ± 1.9 min, <i>P</i> < .001), increased weight (6.8 ± 0.04 vs 7.8 ± 0.03 kg, <i>P</i> < .001), and were older (4.1 ± 0.1 vs 6.6 ± 0.1 months, <i>P</i> < .001) and more likely female (odds ratio [OR] 1.18, 95% confidence interval [CI]:1.03-1.35, <i>P</i> = .018). For 144 (3.6%) patients who received preoperative iron supplementation, the incidence of intraoperative transfusion was decreased (OR 0.39; 95%CI: 0.27-0.57, <i>P</i> < .001). In multivariate analysis, factors independently associated with higher odds of intraoperative transfusion included longer surgery duration (<i>P</i> < .001), increasing age (<i>P</i> = .017), lower weight (<i>P</i> = .011), higher American Society of Anesthesiologists class (<i>P</i> < .001), procedure (<i>P</i> < .001) (especially nonendoscopic), lack of preoperative iron supplementation (<i>P</i> < .001), and lower preoperative hemoglobin (<i>P</i> = .038).ConclusionsVarious factors influence the incidence of transfusion in patients undergoing primary surgical correction of single suture craniosynostosis. Timing of surgery and optimization of preoperative hemoglobin with iron supplementation represent possible modifiable risk factors that warrant additional, prospective study.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251379006"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 on Cleft Surgery in Guatemala: A Decade at Hospital de Obras Sociales del Santo Hermano Pedro.","authors":"Hector Caceres, Alexandra Savage, Manuel Caceres-Asturias, Nelson Mayen, Rene Myers, Clinton Morrison","doi":"10.1177/10556656251381629","DOIUrl":"https://doi.org/10.1177/10556656251381629","url":null,"abstract":"<p><p>ObjectiveTo assess the demographic patterns, surgical volume, and COVID-19 effect on cleft lip and/or palate (CL/P) patients at a mission-based hospital, providing insight into the burden of cleft care and the role of global outreach in resource-limited settings.DesignRetrospective cohort study.SettingSocial aid hospital in Guatemala.PatientsPatients undergoing CL/P surgery between July 2014 and December 2024.InterventionsSurgical missions for CL/P.Main Outcome MeasurePrimary outcomes included surgical volume, geographic distribution of patients, and age at primary surgery.ResultsOver 10 years, 2010 CL/P patients were treated by 98 surgeons. Patients ranged from 11 months to 73 years (mean age 7.4 years); 64% were male. The most common conditions were unilateral cleft lip (38.4%), cleft palate (28.2%), and cleft palate with unilateral cleft lip (19.2%). Patients came from 18 of Guatemala's 22 departments. Surgical volume declined during the pandemic but rebounded in 2021, reaching the highest volume of patients treated. The average age at primary surgery decreased significantly over time, from 9.9 years pre-COVID to 4.9 years during the pandemic and 3.8 years post-COVID (<i>P</i> < .001).ConclusionOur institution provides essential cleft care to underserved populations across Guatemala. Even with disruptions caused by the pandemic, surgical delivery continued to improve. These findings reflect the hospital's ability to adapt and illustrate how mission-based models can continue improving timely surgical access over time. Efforts to further reduce treatment delays and expand follow-up care remain essential to optimizing cleft outcomes.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251381629"},"PeriodicalIF":1.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nevoid Basal Cell Carcinoma Syndrome Associated With Cleft Lip and Palate: A Case Report and Literature Review.","authors":"Chenxi Yu, Guanru Wang, Bingzhi Li, Zhe Liu, Chunjie Li, Bing Yan","doi":"10.1177/10556656251372700","DOIUrl":"https://doi.org/10.1177/10556656251372700","url":null,"abstract":"<p><p>Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder characterized by multisystem anomalies. Although cleft lip and palate (CLP) have been reported in 5% to 8.5% of cases in patients with NBCCS, their pathogenesis and clinical significance remain unclear. The study reports a case of NBCCS with CLP and elucidates its clinical associations and molecular mechanisms through literature reviews. Cases of NBCCS with CLP were searched in PubMed, China National Knowledge Infrastructure (CNKI), and Web of Science databases. Clinical features, genetic data, and phenotypic patterns were retrospectively analyzed. A total of 14 cases were included in this study combined with a 16-year-old female patient we treated, who presented with unilateral CLP and multiple odontogenic keratocysts (OKCs). Among the 15 cases, the male-to-female ratio approaches 1:1. Skeletal anomalies were observed in 86.7% cases, hypertelorism in 53.3%, and nasal deformities in 46.7%. In contrast, classic NBCCS features such as OKCs (53.3%), basal cell carcinomas (BCCs) (20.0%), and palmar/plantar pits (13.3%) were less prevalent compared to classic NBCCS cohorts. All cases met the minor diagnostic criteria for NBCCS, while <i>PTCH1</i> mutations were detected in 13.3% of patients. This study confirms CLP as an associated symptom of NBCCS and summarizes its molecular mechanisms. The comprehensive analysis of cases suggests that clinicians should consider NBCCS screening in patients with CLP with concomitant skeletal/craniofacial anomalies, even in the absence of typical OKC/BCC phenotypes.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251372700"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Recovery After Surgery in Patients With Cleft Lip and Palate Undergoing Alveolar Bone Grafting: A Review.","authors":"Selcen S Yuksel, Kant Y K Lin, Kristen Klement, Sameer Shakir","doi":"10.1177/10556656251377406","DOIUrl":"https://doi.org/10.1177/10556656251377406","url":null,"abstract":"<p><p>IntroductionEnhanced Recovery After Surgery (ERAS) protocols are evidence-based perioperative management pathways designed to optimize surgical outcomes. The American Society of Craniofacial Surgeons (ASCFS) Presidential Task Force has developed a series of ERAS protocols for patients with cleft and craniofacial anomalies. We outline an ERAS protocol for secondary alveolar bone grafting using cancellous bone graft from the iliac crest for patients with cleft lip and palate.Design and settingThe authors extracted information from existing peer-reviewed literature and our institutional experience at a large, tertiary pediatric hospital through retrospective chart review to guide surgeons in the pre-hospitalization, preoperative, intraoperative, and postoperative phases of care of alveolar bone grafting.ResultsIn the pre-hospitalization phase, our ERAS protocol emphasizes family education and expectation management, as well as minimization of preoperative fasting. In the preoperative phase, oral midazolam is recommended to reduce patient anxiety. In the intraoperative phase, we emphasize multimodal pain control with regional nerve blocks, bupivacaine-soaked absorbable sponge in the iliac crest, and ketorolac to minimize postoperative narcotic use. To prevent postoperative nausea and vomiting, we emphasize the use of an oropharyngeal pack prior to incision and nasogastric tube evacuation of the gastric contents at the completion of surgery, as well as a combination of ondansetron with dexamethasone intraoperatively. In the postoperative phase, we recommend dexmedetomidine, early postoperative oral feeding and hydration, and early ambulation with Physical Therapy consultation.ConclusionsThe present study sought to outline an ERAS protocol for secondary alveolar bone grafting in pediatric patients with cleft lip and/or palate to optimize surgical outcomes.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251377406"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Cupid's Bow Peak Placement on Nasolabial Formation in Unilateral Cleft Lip Repair.","authors":"Tadashi Yamanishi, Shoko Kirikoshi, Takahiro Nishio, Emi Fujibayashi, Takayuki Hara, Hokuto Yamazaki, Takahide Kondo, Yusuke Yokota","doi":"10.1177/10556656251377883","DOIUrl":"https://doi.org/10.1177/10556656251377883","url":null,"abstract":"<p><p>ObjectiveTo clarify how the preoperatively determined position of the Cupid's bow peak on the lateral lip element affects postoperative nasolabial formation in patients with unilateral cleft lip. We hypothesize that setting the proposed peak of the Cupid's bow close to the nostril floor causes the cleft-side nasal alar base to droop while positioning it near the oral commissure shortens the red lip, causing an elevated cleft-side oral commissure.DesignRetrospective study.SettingSingle institution.PatientsTwenty-seven patients with non-syndromic complete unilateral cleft lip and palate (UCLP) who received primary lip plasty at our department.InterventionsPrimary lip repair for patients with UCLP.Main outcome measuresWe tested our hypothesis using three-dimensional facial images taken before and 1 year after primary lip repair. Bilateral measurements included lip height (distance between the nasal alar base and the Cupid's bow peak), red lip length, and the vertical height of the nasal alar base and oral commissure.ResultsCorrelation analysis showed a significant relationship between preoperative cleft-side lip height and the postoperative position of the cleft-side nasal alar base (<i>P</i> = .0024, Pearson's correlation analysis). Preoperative short red lip remained short afterwards (<i>P</i> = .000036, Pearson's correlation analysis), causing a lip cant with an elevated cleft-side oral commissure (<i>P</i> = .012, Pearson's correlation analysis).ConclusionsPostoperative nasolabial formation is influenced by the preoperatively proposed position of the Cupid's bow peak. This study provides a comprehensive principle explaining the relationship between the location of the proposed Cupid's bow peak on the lateral lip elements and postoperative nasolabial formation in primary lip repair in patients with unilateral cleft lip.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251377883"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Liposomal Bupivacaine (Exparel^Ⓡ) in Pediatric Patients Undergoing Cleft Lip and Palate Repair: A Retrospective Review.","authors":"Ryan Korlewitz, Jason D'John, Kenneth Shaheen","doi":"10.1177/10556656251380539","DOIUrl":"https://doi.org/10.1177/10556656251380539","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the safety and effectiveness of lipsomal bupivacaine (Exparel) in reducing opioid use and facilitating same-day discharge in pediatric patients under age six undergoing cleft lip palate surgery. <b>Design:</b> Retrospective chart review. <b>Setting:</b> Corewell Health East William Beaumont University Hospital, Royal Oak, Michigan. <b>Patients, Participants:</b> Nineteen pediatric patients under age six who underwent primary cleft lip or palate repair by a single reconstructive plastic surgeon between February 2023 and February 2025. <b>Interventions:</b> All patients received intraoperative administration of weight-based Exparel (4 mg/kg) via peripheral nerve blocks (greater or infraorbital) and direct surgical site infiltration. <b>Main Outcome Measure(s):</b> Same day discharge rate, postoperative opioid requirement, and 30-day adverse events including readmission or pain-related follow-up. <b>Results:</b> Seventeen patients (89.5%) were discharged home on the day of surgery. No patients required postoperative opioid prescriptions and no readmissions or pain-related follow-ups occurred within 30 days. There were no immediate or delayed adverse reactions attributed to Exparel. <b>Conclusions:</b> Lipsomal bupivacaine appears to be a safe adjunct for postoperative pain management in cleft lip and palate surgery for pediatric patients under age six. Its use was associated with high same-day discharge rates, complete avoidance of postoperative opioids, and no adverse outcomes. These findings support further prospective studies to confirm Exparel's role in enhancing recovery and minimizing opioid exposure in pediatric craniofacial surgery.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251380539"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-Disordered Breathing in Children With Craniofacial Syndromes.","authors":"Ganeshraj Sivaram, Kahir Jawad, Karim El-Kersh, Kelly Betz, Mark Chariker, Egambaram Senthilvel","doi":"10.1177/10556656251378588","DOIUrl":"https://doi.org/10.1177/10556656251378588","url":null,"abstract":"<p><p>ObjectiveTo assess the prevalence of obstructive sleep apnea (OSA) in a cohort of children with craniofacial syndromes (CFS) within a single institution, and to describe their polysomnographic (PSG) characteristics and the overall management of OSA in this cohort.DesignA single-center retrospective study. Electronic healthcare records were used to access information regarding medical history, surgical history, and PSG details of patients with CFS.SettingThis study took place at a tertiary care center affiliated with a school of medicine.Patient, ParticipantsPatients with CFS under the age of 18 years with PSG data were assessed.InterventionsNo intervention was performed as it was retrospective study.Main Outcome MeasuresObstructive sleep apnea prevalence among children with CFS.ResultsA total of 46 patients were included in this study. In our study, 69.6% of the children with CFS had OSA, with 39.1% of them classified as severe. We performed mandibular distraction osteogenesis (MDO) to treat 26.5% of patients with OSA. The prevalence of OSA was 93.8% among a total of 16 Pierre Robin Sequence (PRS) patients. MDO substantially decreased apnea-hypopnea index (AHI), rapid eye movement AHI, and EtCO2 in PRS patients while simultaneously increasing SpO2 and total sleep time.ConclusionsObstructive sleep apnea is more prevalent in children with CFS than was previously recognized, and MDO is the most frequently employed treatment. Pierre Robin Sequence is the most prevalent pediatric CFS associated with OSA. Mandibular distraction osteogenesis significantly improves OSA and sleep quality in PRS patients.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251378588"},"PeriodicalIF":1.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}