Cleft Palate-Craniofacial Journal最新文献

{"title":"Applying Latent Profile Analysis to CLEFT-Q Data: A Framework for Understanding Patient Reported Outcomes in Cleft Care.","authors":"Nicholas A Han, Philip D Tolley, Jing Huang, Leanne Magee, Allison C Hu, Isabel A Ryan, Oksana A Jackson, David W Low, Scott P Bartlett, Jesse A Taylor, Eric C Liao, Jordan W Swanson","doi":"10.1177/10556656251396633","DOIUrl":"10.1177/10556656251396633","url":null,"abstract":"<p><p>ObjectiveTo describe characteristic CLEFT-Q response profiles and patterns in patients with cleft palate and/or lip (CP ± L).DesignRetrospective analysis using latent profile analysis (LPA) to categorize patient-reported outcome responses into distinct profiles.SettingTertiary care pediatric hospital with multidisciplinary cleft team.Patients, ParticipantsPatients aged 8-29 years with CP ± L completing CLEFT-Q questionnaires from September 2021 to June 2025 (<i>n</i> = 596). Total of 923 responses analyzed after excluding 94 responses from patients under 8 years.InterventionsAdministration of the 119-item CLEFT-Q questionnaire prior to clinic visits, measuring appearance, function, and quality of life.Main Outcome Measure(s)Six latent profiles identified through LPA based on CLEFT-Q scores. Secondary outcomes included profile stability and surgical effects.ResultsSix profiles of CLEFT-Q responses emerged among subjects: Universally Affected-Moderate (UA1, <i>n</i> = 228, 24.7%), Universally Affected-Severe (UA2, <i>n</i> = 119, 12.9%), Facial Appearance-Moderate (FA1, <i>n</i> = 183, 19.8%), Facial Appearance-Severe (FA2, <i>n</i> = 56, 6.1%), Social/School/Speech distress (SSS, <i>n</i> = 95, 10.3%), and Minimally Distressed (MD, <i>n</i> = 242, 26.2%). Patients in severe profiles (UA2 and FA2) were older (<i>P</i> < .001) and more likely to have complete cleft lip (<i>P</i> < .001), while patients in the MD profile were younger and more likely to have isolated cleft palate (<i>P</i> < .001). Among 279 patients with longitudinal CLEFT-Q data, 47.5% remained in the same profile at subsequent CLEFT-Q response, with longer follow-up intervals predicting profile change (<i>P</i> = .049).ConclusionsLatent profile analysis categorizes CLEFT-Q responses into six clinically meaningful profiles correlating with demographics and treatment outcomes. This approach may guide personalized cleft care, though additional studies are needed for validation.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2909-2919"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric Evaluation of the Pterygomaxillary Suture in Patients with Unilateral and Bilateral Cleft Lip and Palate Using Cone-Beam Computed Tomography.","authors":"Salma Tabatabaei, Hamid Reza Heidari, Maryam Paknahad","doi":"10.1177/10556656251408756","DOIUrl":"10.1177/10556656251408756","url":null,"abstract":"<p><p>ObjectiveTo evaluate and compare the morphology of the pterygomaxillary suture (PMS) in unilateral cleft lip and palate (UCLP), bilateral cleft lip and palate (BCLP), and non-cleft (NC) individuals using cone-beam computed tomography (CBCT), focusing on side-specific differences relevant to Le Fort I osteotomy planning.DesignRetrospective cross-sectional study.SettingOral and maxillofacial radiology clinic of a university-affiliated center, where CBCT data were originally obtained for diagnostic purposes.PatientsOne hundred and fifty-six subjects-57 UCLP, 21 BCLP, and 78 NC-matched for age and sex (<i>P</i> > .25). Inclusion required complete records and high-quality CBCT scans; patients with syndromic anomalies or prior orthognathic surgery were excluded.InterventionsCBCT scans were retrospectively analyzed using standardized NNT software (v 6.2). Anatomical landmarks were referenced to the midsagittal plane for reproducibility.Main Outcome MeasuresSeven PMS parameters-thickness, width, length, angulation, lateral pterygoid plate (LPP) length, medial pterygoid plate (MPP) length, and distance to the greater palatine foramen (GPF)-were compared using ANOVA, paired-sample <i>t</i>-tests, and Tukey post-hoc analyses (α = 0.05).ResultsPMS angulation was higher in UCLP (79.82 ± 7.96°) and BCLP (79.84 ± 9.11°) compared with NC (75.90 ± 8.07; <i>P</i> < .001). In UCLP, the cleft side showed greater angulation and shorter LPP (<i>P</i> = .027; <i>P</i> = .001). Other parameters did not differ significantly.ConclusionsCLP patients show increased PMS angulation and cleft-side LPP shortening compared with controls. These variations may be relevant to surgical planning; however, the present study did not assess surgical outcomes. Future research should determine whether such differences influence intraoperative complexity.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2996-3005"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prerepair Mortality in Cleft Lip and/or Palate: A Retrospective Analysis of Early Childhood Deaths.","authors":"Rou Wan, Elameen A Adam, Ethylin W Jabs, Pavel N Pichurin, Samir Mardini, Waleed Gibreel","doi":"10.1177/10556656251394073","DOIUrl":"10.1177/10556656251394073","url":null,"abstract":"<p><p>ObjectiveThis study aimed to identify specific causes, clinical features, and contributing factors associated with early childhood mortality in a vulnerable subset of patients with cleft lip and/or palate (CL/P) who did not survive to undergo surgical repair.DesignThis was a retrospective chart review study.SettingThe study was conducted at a single tertiary medical center.Patients/ParticipantsWe identified 26 liveborn CL/P patients who died without cleft repair from 1970 to 2024. Their data was compared to a control group of 2070 surgically repaired CL/P patients from the same institution.Main Outcome MeasuresOur primary goal was to characterize the clinical profile of patients experiencing prerepair mortality. Secondary outcomes included identifying causes of death, maternal and prenatal risk factors, and comparing these findings with the surgically repaired patients.ResultsAll 26 unrepaired patients (100%) had genetic syndromes or isolated severe congenital anomalies, a significant difference compared to 24% in the surgically repaired group (<i>P</i> < .0001). Trisomy 13 (30.8%), holoprosencephaly (23.1%), congenital cardiac defects (11.5%), and trisomy 18 (11.5%) were the leading causes of death. The median age at death for unrepaired patients was 25 days (interquartile range 4-125 days), significantly lower than the 61.9 years in the control group (<i>P</i> < .0001). Multivariable logistic regression showed that genetic syndromes or severe congenital anomalies were strongly associated with early mortality (<i>P</i> < .0001). Notably, all unrepaired patients who were born in the United States after 2005 had accurate prenatal diagnoses, which allowed clinical planning before the patients were born.ConclusionsPrerepair mortality in CL/P is significantly driven by underlying genetic syndromes or congenital anomalies. For surgeons, this highlights the importance of genetic testing and prenatal care to guide appropriate surgical management. Considering a wait in surgical intervention until patients are approximately 4 months old may allow for better survival assessment and informed decisions for these high-risk individuals.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2841-2848"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgically Assisted Rapid Palatal Expansion in Patients With Cleft and Craniofacial Diagnoses.","authors":"Allison C Hu, Philip D Tolley, Isabel A Ryan, Nicholas A Han, Hyun-Duck Nah-Cederquist, Lawrence M Levin, Joseph A Napoli, Jordan W Swanson, Scott P Bartlett, Jesse A Taylor","doi":"10.1177/10556656251396635","DOIUrl":"10.1177/10556656251396635","url":null,"abstract":"<p><p>ObjectiveTo evaluate the indications, techniques, outcomes, and complications associated with surgically assisted rapid palatal expansion (SARPE) in patients with cleft and craniofacial diagnoses.DesignRetrospective chart review.SettingSingle tertiary care craniofacial center.Patients and ParticipantsAll patients undergoing SARPE between 2008 and 2024 were reviewed. Of the 65 patients identified, 23 (35.4%) had cleft or craniofacial conditions.InterventionsSARPE was performed in all patients. Expansion was achieved using custom-fabricated appliances.Main Outcome MeasuresIndications for SARPE, amount of palatal expansion, complications, and need for future orthognathic surgery, including segmental Le Fort I osteotomies.ResultsOf 65 SARPE patients, 23 (35.4%) had cleft or craniofacial conditions. The mean age was 17.2 ± 3.2 years. Indications included closed mid-palatal suture (<i>n</i> = 14, 60.9%) and failed expansion (<i>n</i> = 7, 30.4%). Expansion averaged 7.0 ± 1.7 mm over 14.7  ± 6.3 days. Sagittal maxillary osteotomies were performed with Piezotome in 19 (82.6%) patients and were most commonly midline (<i>n</i> = 12, 52.5%) and unilateral parasagittal (<i>n</i> = 9, 39.1%). Complications were minimal (4.3% each for root injury, fistula, and debonding). Seventeen patients (73.9%) proceeded to orthognathic surgery, with only 2 (18.2%) requiring segmental Le Fort I osteotomies.ConclusionsSARPE is a safe and effective treatment for transverse maxillary deficiency in cleft and craniofacial patients, offering reliable expansion with minimal morbidity. Its successful application in this complex population may reduce the need for segmental Le Fort I osteotomies during future orthognathic procedures. These findings support broader adoption of SARPE in craniofacial care, with potential to streamline surgical management and improve long-term outcomes.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2920-2926"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Synostosis After Spring-Mediated Cranioplasty for Sagittal Synostosis.","authors":"Max Shrout, Trey D Watmore, Alma Jukic, Davinder J Singh","doi":"10.1177/10556656251405356","DOIUrl":"10.1177/10556656251405356","url":null,"abstract":"<p><p>ObjectiveTo evaluate the incidence and characteristics of secondary synostosis following spring-mediated cranioplasty (SMC) for nonsyndromic sagittal craniosynostosis.DesignRetrospective cohort study.SettingSingle tertiary pediatric hospital.Patients/ParticipantsTen patients with isolated sagittal craniosynostosis who underwent primary SMC between 2021 and 2023. Patients with syndromic diagnoses or prior cranial surgery were excluded.InterventionsSMC was performed using 2 to 3 stainless-steel springs following sagittal strip craniectomy. Springs were typically removed 3 to 4 months postoperatively. Follow-up included review of clinical photographs, radiographs, and operative records.Main Outcome MeasuresChange in cephalic index (CI) from preoperative to postoperative assessment and occurrence of secondary suture fusion, particularly coronal synostosis.ResultsMean age at surgery was 4 months (range, 3-6 months). Mean CI improved from 68.5 to 79 following expansion. Three patients (30%) developed left unicoronal synostosis (UCS) during the perioperative period prior to spring removal. One patient required secondary coronal suturectomy for significant frontal asymmetry, while 2 were observed without intervention.ConclusionsSecondary synostosis, particularly UCS, may represent an underrecognized sequela of SMC. Altered biomechanical forces or asymmetric cranial remodeling during distraction may contribute to this finding. Larger, multicenter studies with longitudinal imaging are warranted to determine incidence, risk factors, and preventive strategies.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2989-2995"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Electromyographic Activity of Orbicularis oris Muscle in Cleft Lip and Palate Patients: A Systematic Review and Meta-analysis.","authors":"Mahsa Ghorbani, Shirin Shahnaseri, Chung H Kau, Erfan Bardideh, Seyed A Mousavi, Hooman Shafaee, Reyhaneh Gholamifard","doi":"10.1177/10556656251391504","DOIUrl":"10.1177/10556656251391504","url":null,"abstract":"<p><p>ObjectiveThis systematic review and meta-analysis aimed to evaluate electromyographic (EMG) activity of the orbicularis oris muscle in children, adolescents, and young adults with repaired cleft lip and/or palate (CLP), compared to noncleft controls.DesignSystematic review and Meta-analysis.Patients and ExposuresPatients with CLP.ComparisonPatients without CLP.Main Outcome MeasuresElectrical activity of orbicularis oris muscle at rest and during swallowing salaiva, lip compression, and articulation of bilabial phonemes (/pa/, /ba/, and /ma/).Methods & MaterialsObservational studies reporting quantitative surface EMG outcomes of the orbicularis oris in participants with repaired CLP and noncleft controls were included. Data extraction and risk of bias assessment were performed independently by two reviewers; certainty of evidence was evaluated with Grading of Recommendations, Assessment, Development and Evaluation, and heterogeneity was assessed with <i>I</i>².ResultsA comprehensive literature search was conducted across five databases (MEDLINE, Web of Science, EMBASE, Scopus, CENTRAL) from their inception until February 2025. Eligible observational studies based on the PECO question were selected and assessed for bias using the ROBINS-E tool. Random-effects meta-analyses were used to pool mean differences. Finally, six studies met the inclusion criteria. Pooled findings showed significantly higher orbicularis oris EMG amplitudes in tasks requiring strong lip seal-saliva swallowing, lip compression, and the bilabial phenome /pa/-among participants with repaired CLP relative to controls. In contrast, EMG activity at rest and certain other bilabial phonemes (/ba/ and /ma/) showed borderline or nonsignificant differences. Heterogeneity was generally moderate to high, reflecting methodological diversity among studies.ConclusionsChildren with repaired CLP exhibit elevated orbicularis oris muscle activity during tasks demanding strong lip closure. This may represent a compensatory mechanism to overcome structural alterations or scarring. Although such hyperactivation can enhance oral function (eg, swallowing and speech), it might also have long-term implications for maxillary growth or soft-tissue scarring.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2808-2821"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Autologous Bone Grafting With and Without PRP or PRF in Cleft Alveolus Reconstruction: A Prospective Randomized Study.","authors":"Abhilasha Yadav, Rajiv Borle, Suhas Jajoo, Anuj Jain","doi":"10.1177/10556656251386537","DOIUrl":"10.1177/10556656251386537","url":null,"abstract":"<p><p>ObjectiveTo evaluate the effectiveness of autologous bone grafting alone, with platelet-rich plasma (PRP), and with platelet-rich fibrin (PRF) in the treatment of cleft alveolus.DesignRandomized controlled clinical trial.SettingDepartment of Oral and Maxillofacial Surgery at a tertiary care center.Patients, ParticipantsSeventy-five patients aged 7 to 20 years with alveolar clefts, randomized (1:1:1) into 3 groups (<i>n</i> = 25 each).InterventionsGroup 1: Autologous bone graft alone. Group 2: Autologous bone graft + PRP. Group 3: Autologous bone graft + PRF.Main Outcome Measure(s)Primary-radiographic bone formation (bone density) and bone bridge quality (Bergland score). Secondary-postoperative pain (VAS), surgical site complications (composite SSC: infection, fistula, graft exposure), and donor-site morbidity.ResultsPRF demonstrated the highest radiographic bone density at 6 months and a more favorable Bergland distribution versus control (<i>P</i> < .05). Grade I Bergland success was highest in the PRF group (64%). Early postoperative VAS pain scores were significantly lower with PRF (Kruskal-Wallis <i>P</i> < .05). Overall postoperative complications were low and comparable across groups (SSC, nonsignificant). Age-stratified analyses (7-12 vs 13-20 years) preserved the direction of effect (PRF ≥ PRP > control) but were exploratory and underpowered.ConclusionsAdjunctive PRP/PRF with autologous bone grafting may improve clinical outcomes in alveolar cleft reconstruction, with PRF appearing to provide a modest advantage in bone formation and early pain reduction. Findings are preliminary and warrant confirmation in larger, blinded studies with longer follow-up.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2736-2743"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145543672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Microneedling With PRP Versus Vitamin C Serum in the Management of Post-Operative Cleft lip Scars.","authors":"Sameera Dawar, Manu Gupta, Varun Arya, Sanjeev Kumar","doi":"10.1177/10556656251395554","DOIUrl":"10.1177/10556656251395554","url":null,"abstract":"<p><p>ObjectiveThe present study was conducted with the objective of comparing the efficacy of microneedling with vitamin C serum versus platelet-rich plasma (PRP) in the management of the appearance of post-operative cleft lip scars.DesignThe study was conducted as a prospective, randomized comparative study.ParticipantsA total of 30 participants (<i>n</i> = 30) were included in the study, with each group comprising of 15 participants.SettingSmile train verified cleft center.InterventionEach patient underwent three sessions of microneedling combined with the assigned adjuvant, PRP in group A and vitamin C serum in group B. Follow-up evaluations were conducted at 1, 2, and 3 months post-operatively.Main Outcome MeasuresThe scar quality and improvements were assessed using the patient and observer scar assessment scale (POSAS), graded from 1 to 10 by each patient and a fixed outer observer from the department of oral and maxillofacial surgery. <i>p</i> ≤ 0.5 was considered statistically significant.ResultsResults indicated that while both modalities offer significant improvements in scar appearance, texture, and overall esthetic outcomes, PRP showed superior results in terms of scar reduction and patient-reported satisfaction (<i>p</i> < 0.05). However, pliability (<i>p</i> = 0.10) and pain (<i>p</i> = 0.28) scores did not show a statistically significant difference between the two groups.ConclusionThrough this study, we concluded that microneedling when combined with PRP offers far more superior results in terms of improvement of the scar appearance as compared to vitamin C serum.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"2849-2859"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crouzon Syndrome and Craniosynostosis - A Review for the Twenty-First Century.","authors":"Eftychia Liampou, Aarushi Jain, Subhasis Howlader, Dirk Hamadziripi, Shahid Muhammad","doi":"10.1177/10556656261475439","DOIUrl":"https://doi.org/10.1177/10556656261475439","url":null,"abstract":"<p><p>Crouzon syndrome (CS) is a syndromic craniosynostosis most often caused by heterozygous activating variants in fibroblast growth factor receptor 2, leading to premature fusion of cranial sutures and progressive craniofacial dysmorphology. Premature suture fusion alters cranial growth patterns and modifies cranial base anatomy, increasing the risk of raised intracranial pressure, ventriculomegaly or hydrocephalus, and hindbrain crowding; shallow orbits cause ocular proptosis with exposure keratopathy, strabismus and amblyopia; midface (maxillary) hypoplasia results in class III malocclusion and nasopharyngeal narrowing, contributing to sleep-disordered breathing; and middle ear disease and external canal stenosis contribute to conductive or mixed hearing loss. This narrative review aims to highlight clinical features and treatment for patients with CS. This narrative review was formulated by critically evaluating and synthesising a range of existing literature, particularly focusing on review articles published between 2007 and 2026. Diagnosis is based on clinical and radiological assessment, confirmed by molecular testing. Management is staged and multidisciplinary: cranial vault expansion - posterior and/or fronto-orbital - is usually performed in late infancy to protect the brain and vision; midface advancement during later childhood or adolescence addresses ocular exposure, airway obstruction and malocclusion; ongoing ophthalmological, audiological, orthodontic and sleep-medicine management aims to reduce functional impairment. A rarer variant, CS with acanthosis nigricans, results from pathogenic variants in fibroblast growth factor receptor 3 and is characterised by distinctive skin findings and a higher risk of choanal anomalies. With timely diagnosis, structured surveillance and coordinated reconstruction within specialist craniofacial centres, long-term functional outcomes and life expectancy are generally positive.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656261475439"},"PeriodicalIF":1.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Mandibular Lingula Structure and Location in Pediatric Patients with Cleft Lip and Palate Using Cone-Beam Computed Tomography.","authors":"Yasemin Özant, Ayşe Çelik, Ceyda Özçakır Tomruk","doi":"10.1177/10556656261480646","DOIUrl":"https://doi.org/10.1177/10556656261480646","url":null,"abstract":"<p><p>ObjectiveTo evaluate mandibular lingula structure and location in children and adolescents with cleft lip and/or cleft palate (CL/P) compared with age- and sex-matched controls using cone-beam computed tomography (CBCT).DesignRetrospective cross-sectional study.SettingUniversity-based dentomaxillofacial radiology archive.Patients/ParticipantsCBCT scans of 120 patients aged 8-18 years (60 CLP, 60 controls; mean age 13.15 ± 3.02 years) were included in the study.InterventionsRetrospective evaluation of existing CBCT images.Main Outcome MeasuresLinear distances from the lingula to key anatomical landmarks, including the anterior (x) and posterior (y) ramus borders, inferior ramus border (w), sigmoid notch (z), mandibular foramen (h₁), and occlusal plane at the mesial aspect of the first permanent molar (t), along with the anteroposterior ratio [x/(x + y)] and lingula shape, assessed bilaterally with consideration of the cleft side.ResultsSignificant differences were observed between groups in several linear measurements, including x, y, z, and t, with reduced distances in the CL/P group. However, no significant differences were found for h₁ or the x/(x + y) ratio, indicating preservation of the relative anteroposterior position of the lingula. The assimilated form was the most common lingula shape in both groups, with no significant between-group difference. Although some side-based variations were detected, these were inconsistent and not specific to CL/P.ConclusionsDespite differences in certain linear dimensions, the relative position and morphology of the lingula are preserved in children and adolescents with CL/P. This structural consistency may support CBCT-based individualized planning for surgical and anesthetic procedures.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656261480646"},"PeriodicalIF":1.3,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}