Cleft Palate-Craniofacial Journal最新文献

{"title":"Partners in African Cleft Training (PACT): Evolution of a Partnership Supporting Sustainable Interdisciplinary Cleft Team Care in Sub-Saharan Africa.","authors":"Anne Hing, Craig Birgfeld, Richard Hopper, Mekonen Eshete Abebe, Shiferaw Degu Berbirssa, Oladapo Olasoji, Gyikua Plange-Rhule, Albert Paintsil, Solomon Obiri-Yeboah, Hitesh Kapadia, Kaylee Paulsgrove, Olawunmi Fatusi, Jerry Fahnloe Brown, Ama A A Taplah, Cassandra Aspinall, Sean Flack, Emily Gallagher, Mariah Mazzaferri, Emily Nyamu, Mohammed Abullahi, Olurotimi Aaron, Lauren Beckett, Francis Tegete, Michael Cunningham, Peter Donkor","doi":"10.1177/10556656251319898","DOIUrl":"https://doi.org/10.1177/10556656251319898","url":null,"abstract":"<p><p>Partners in African Cleft Training (PACT) is a collaborative education program between cleft team providers from African countries and United States that focuses on interdisciplinary team care for children with orofacial clefting to improve outcomes and expand access to team care in Sub-Saharan Africa. In this paper, we describe the evolution of a partnership, initiated by an African surgeon, to determine how to support sustainable cleft team care in Africa and share the impact of the PACT program on participating teams. This narrative review discusses 3 major steps in the evolution of the PACT program. The initial step was a pilot study to identify requirements for sustainable team care in Africa. This study concluded that the identification of challenges and solutions for cleft team care must come from within the African continent and that training centers focused on team cleft care should be established. This led to a 3-year program to establish regional cleft training centers for surgery, anesthesiology, and speech. The partnership evolved to include in-person workshops focused on interdisciplinary team care with the addition of new teams. The current PACT program includes team workshops, virtual curriculum, and seminars. Since 2011, there have been 15 workshops. All teams have increased in size and composition and 90% of participants reported a positive impact of workshop on patient care and strengthening teams. The impact of the PACT program has included the establishment of regional training programs and team building resulting in improved access to comprehensive cleft team care in sub-Saharan Africa.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251319898"},"PeriodicalIF":1.1,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Preferences Toward Patient Education Materials for Children With Cleft Lip and/or Palate.","authors":"Lauren E Powell, Erica M Bien, Madison Kolbow, Ruth J Barta","doi":"10.1177/10556656251332213","DOIUrl":"https://doi.org/10.1177/10556656251332213","url":null,"abstract":"<p><p>ObjectiveTo determine caregiver preferences for education modalities.Design/SettingA cross-sectional study of caregivers of patients with cleft lip and/or palate (CL/P) seen at this American Cleft Palate-Craniofacial Association-approved center in the Midwest between January 2017 and September 2022 was conducted.Patients/ParticipantsThe population included parents of patients undergoing primary or secondary revision surgeries after a diagnosis of CL/P.Main Outcome MeasuresA phone interview gathered demographics, education preferences, familial research, and resources.ResultsOf the 81 families of CL/P patients, 42 families consented for interviews. Patients first presented to the clinic at an average age of 2.3 years of age (range 0-17) and had a mean age of 10.1 years (range 1-23) at the time of parental interview. The majority of interviewees identified as the patient's mother (90.5%), Caucasian (78.6%), and had completed a college education (81%). The majority (85.7%) of caregivers reported completing research prior to the first appointment. Most participants preferred electronic resources (35.7%), support groups (29%), books or written material (29%), with fewer preferring videos (12%), social media (7%), or podcasts (2%).ConclusionThe majority of families preferred having multiple resources available to learn about CL/P; however, the most common preferences were additional books, pamphlets, and online materials such as websites, videos, and audiobooks. With the multitude of options available for patient education materials, designing and providing high-quality materials that will be used by families and meet the health literacy of this diverse patient population is crucial.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251332213"},"PeriodicalIF":1.1,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Psychosocial Impacts of Whole-Genome Sequencing Outcomes on Orofacial Cleft Caregivers in Nigeria: A Mixed-Methods Study.","authors":"Abimbola M Oladayo, Veronica Sule, Yewande Oshodi, Adegbayi A Adekunle, Wasiu L Adeyemo, Oluwagbemiga Ogunlewe, Oluwanifemi Ayelomi, Adejoke Babatunde, Boluwatife Aikomo, Abosede Ajadi, Shareef M Dabdoub, Chandler Pendleton, Tamara Busch, Azeez Alade, Mojisola Olujitan, Emmanuel Aladenika, Waheed Awotoye, Lord J J Gowans, Mekonen Eshete, Colleen Campbell, Daniel J Caplan, Oluwafemi Adeagbo, Peter A Mossey, Adebowale A Adeyemo, Jeffrey C Murray, Anya E R Prince, Azeez Butali","doi":"10.1177/10556656251332351","DOIUrl":"https://doi.org/10.1177/10556656251332351","url":null,"abstract":"<p><p>ObjectiveTo investigate the behavioral outcomes of children with clefts and the psychosocial impact and mental health experiences of their caregivers regarding unintended outcomes of genomic sequencing, that is, secondary genetic findings (SFs).DesignConvergent parallel mixed methods.<i>Setting</i>The cleft and immunization clinics at the Lagos University Teaching, Hospital, Nigeria.ParticipantsIn total, 127 cases and 158 control caregiver child dyads (quantitative) and 22 caregivers of children with clefts (qualitative).Main Outcome MeasuresStandardized questionnaires were used to assess caregiver-reported mental health, quality of life (QoL), and their children's behavioral difficulties. In 2 focus groups, participants shared their perspectives on genomic testing outcomes, including SFs, mental health, and expectations in the context of clefts.ResultsCompared to the control group, caregivers of children with clefts reported poorer mental health, lower QoL and more behavioral difficulties in their children. Also, they believed that introducing genomic testing outcomes, including SFs, may exacerbate existing burdens. Following qualitative data analyses, 5 themes emerged-genetics knowledge/awareness, stressors, cognitive appraisals, coping/support strategies, and negative impact/positive gains. Both qualitative and quantitative results showed that caring for children with clefts required significant financial resources placing substantial stress on caregivers.ConclusionsThese findings highlight the importance of addressing caregivers' psychosocial needs and the need for proactive measures to prepare for the return of genomic sequencing outcomes to patients and research participants, particularly in resource-limited settings like Africa, where such support may be lacking.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251332351"},"PeriodicalIF":1.1,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Transition to Adulthood in Patients with 22q11.2 Deletion Syndrome: A Comprehensive Literature Review and Transition Framework.","authors":"Molly F MacIsaac, Alexzandra Mattia, Luis A Montes, Ann Adair, Taryl O Crisp, Alyssa Fritz, S Alex Rottgers, Jordan N Halsey","doi":"10.1177/10556656251331392","DOIUrl":"https://doi.org/10.1177/10556656251331392","url":null,"abstract":"<p><p>22q11.2 deletion syndrome (22q11.2DS) is a complex genetic disorder characterized by a wide range of comorbidities requiring multidisciplinary care across the lifespan. As patients transition from pediatric to adult care, they face significant challenges, particularly with managing emerging psychiatric conditions such as schizophrenia, anxiety, and depression, alongside ongoing medical concerns involving cardiology, endocrinology, immunology, and other specialties. However, there is a lack of standardized transition protocols specifically designed for individuals with 22q11.2DS, leaving both caregivers and healthcare providers frustrated by inadequate coordination and communication during this critical period. This review addresses these gaps by presenting a framework for transition planning, drawing on existing literature and clinical practices. A comprehensive review used PubMed, Embase, and Web of Science to explore topics such as healthcare transitions, neuropsychiatric and cognitive developments, education, employment, social-sexual health, and caregiver challenges. Based on the findings, specialty-specific resources were developed and refined through a multidisciplinary 22q11.2DS clinic team. These resources include transfer passports summarizing key medical information for adult providers, transition readiness assessments, and customized transition manuals. The proposed framework emphasizes early and ongoing preparation for transitions, collaboration among providers, and patient-centered care to promote independence. The goal is to equip families and healthcare professionals with practical tools and strategies to support seamless care continuity, improve outcomes, and address the complex needs of individuals with 22q11.2DS as they navigate adulthood. This work contributes to the growing body of knowledge on healthcare transitions and highlights the need for continued research and tailored guidelines for this population.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251331392"},"PeriodicalIF":1.1,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey of the Management of Submucous Cleft Palate Among Surgeons and Speech Pathologists in Australia and New Zealand.","authors":"Hyok Jun Kwon, Lachlan D M Farmer, Christina M Richards, Mark H Moore","doi":"10.1177/10556656251327822","DOIUrl":"https://doi.org/10.1177/10556656251327822","url":null,"abstract":"<p><p>BackgroundSubmucous cleft palate (SMCP) is a rare condition with a variable symptomatology. While in overt cleft palate, earlier repair is associated with superior speech outcomes, this is not always possible as many patients with SMCP present at an older age. There is controversy in how patients with SMCP who present at a young age should be treated because it is difficult to differentiate which patients will be symptomatic and which will be asymptomatic later in life. Because of this, we anticipate that even within a small population geographical region such as Australia and New Zealand, that there may be variation in SMCP is managed. We surveyed surgeons and speech pathologists in Australia and New Zealand to determine how SMCP is managed by different providers.MethodA web-based, 9 question survey was developed and sent to 52 cleft surgeons and 39 cleft speech pathologists in Australia and New Zealand, with questions about practice duration and location, preferred operative techniques, follow up duration and follow up type, and three clinical scenarios involving patients with SMCP.ResultsEighteen of 52 (35%) surgeons and 21 of 39 (54%) speech pathologists responded. There were differences in preferred surgical technique, follow-up duration, and indications for surgical intervention. There was disagreement in how to manage prelingual patients with SMCP, with 39% of surgeons repairing these patients early to prevent the development of cleft speech patterns, 22% of surgeons opting for early repair if there were other symptoms such as nasal regurgitation or otitis media with effusion, and 39% electing to wait for speech development. By contrast, only 10% of speech pathologists recommended early surgery, 40% recommended early surgery in the presence of other symptoms, and 50% recommended observation until speech development.ConclusionThere is a wide variation in the preferred management of SMCP in Australia and New Zealand. This may reflect the wide range in symptomology of this patient population, or the clinical equipoise between various management strategies based on the current body of evidence.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251327822"},"PeriodicalIF":1.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training Mechanisms for Healthcare Providers in Feeding Infants With Cleft Palate.","authors":"Katelyn J Kotlarek, Erin J Bush, Evy Loomis-Goltl, Jessica L Chee-Williams","doi":"10.1177/10556656251326748","DOIUrl":"https://doi.org/10.1177/10556656251326748","url":null,"abstract":"<p><p>ObjectiveThere is a lack of formal training documented for service providers across disciplines regarding patients with cleft palate, resulting in a variety of informal training mechanisms. The purpose of this study was to characterize the training interdisciplinary providers have received related to feeding infants with cleft palate and generate ideas for future training mechanisms.DesignProspective, mixed methods surveySettingFeeding providers from ACPA approved cleft palate teams in North AmericaParticipantsProviders of varying disciplines that regularly engaged in feeding services for infants with cleft palate and completed the first training-related question within the surveyMain Outcome MeasuresInformation on provider demographics and trainingResultsMost respondents' (56.6%) academic program did not include information regarding feeding infants with cleft palate, which was significantly higher (<i>P</i> < .001) for disciplines outside of speech-language pathology. Of all respondents, 81.6% received on-the-job training while 69.7% attended continuing education to acquire this information; significantly more speech-language pathologists (<i>P</i> < .001) reported attending continuing education than other disciplines. Conventions or conferences (44.7%) and materials (47.4%) from the ACPA were considered very helpful by those who pursued continuing education. Inductive content analysis revealed themes related to collaborating with other professionals, available research to guide practice, and graduate and postgraduate/professional training.ConclusionsInconsistencies in academic training within and across disciplines exist related to feeding infants with cleft palate. There are several opportunities to expand continuing education.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251326748"},"PeriodicalIF":1.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graft Outcomes With or Without Use of Cortical Bone Graft for Nasal Floor Reconstruction in Unilateral Cleft Lip and Palate.","authors":"Jean-Charles Doucet, Amr Alsabbagh, Scott Martyna, Ana M Mercado, John Daskalogiannakis, Ronald R Hathaway, Ross E Long, Kathy A Russell","doi":"10.1177/10556656251322619","DOIUrl":"https://doi.org/10.1177/10556656251322619","url":null,"abstract":"<p><p><i>Objective</i>Evaluate the use of cortical bone grafts (CBGs) for nasal floor reconstruction on alveolar bone graft (ABG) outcomes in unilateral cleft lip and palate (UCLP).<i>Design</i>Retrospective cohort study.<i>Setting</i>North-American cleft centers.<i>Subjects</i>Fifty-three children with nonsyndromic UCLP treated with secondary ABG.<i>Methods</i>Center 1 (<i>n</i> = 23) utilized CBG for nasal floor reconstruction, while Centers 2 (<i>n</i> = 10), 3 (<i>n</i> = 10), and 4 (<i>n</i> = 10) did not. Occlusal radiographs, taken 6 to 18 months after ABG, were assessed by 6 calibrated raters using the Standardized Way to Assess Grafts (SWAG) Scale. Weighted kappa statistics measured intra and interrater reliabilities. SWAG scores comparisons in the apical, middle, and coronal thirds of the alveolar cleft were conducted between the centers. The Kruskal-Wallis test was used to determine significant differences, with a <i>P</i>-value of <.05 considered statistically significant.<i>Results</i>Intrarater reliability was very good (κ = 0.858), and interrater reliabilities were good (κ = 0.717). Significant differences were initially found in overall SWAG scores across centers (<i>P</i> = .003), with Center 1 achieving the highest mean overall SWAG score (5.16 ± 0.99) compared to Centers 2, 3, and 4 (4.48 ± 1.37, 4.58 ± 1.44, and 3.72 ± 0.65, respectively). Center 4 exhibited statistically significant lower scores compared to Centers1, 2, and 3, and was excluded from secondary analyses. After exclusion, no significant differences remained among Centers1, 2, and 3 (<i>P</i> = .135) for overall SWAG scores or apical third SWAG scores (where CBG is inserted). No significant differences were observed in the middle (<i>P</i> = .055) or coronal (<i>P</i> = .131) thirds across centers.<i>Conclusions</i>CBG in secondary ABG procedures for CUCLP patients showed outcomes comparable to cancellous-only grafts, with a trend toward improved apical scores in CBG-treated patients.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251322619"},"PeriodicalIF":1.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presurgical Infant Orthopedics Appliance in Complex Craniofacial Deformity Involving Complete Cleft Lip and Palate Patients: A Case Series.","authors":"Adi Basuki, Prasetyanugraheni Kreshanti, Julieta Pancawati, Jasmine Athiyya Wibowo, Roberto L Flores, Kristaninta Bangun","doi":"10.1177/10556656251316753","DOIUrl":"https://doi.org/10.1177/10556656251316753","url":null,"abstract":"<p><p>Tessier facial clefts are rare congenital abnormalities and among the most challenging deformities treated by craniofacial surgeons. Despite various surgical interventions, treatment outcomes remain limited, resulting in a higher burden of care and lower quality of life. PreSurgical Infant Orthopedics (PSIO) has shown benefits in cleft care, but its application to Tessier clefts is underreported. This report assesses the long-term surgical outcomes of 3 patients with Tessier clefts who underwent PSIO. The cleft width and premaxilla reduction were observed in all 3 patients.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656251316753"},"PeriodicalIF":1.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interrater Reliability for Classifying Craniofacial Microsomia Severity: A Call for Objective Evaluation.","authors":"Elsa M Ronde, Jitske W Nolte, Alfred G Becking, Corstiaan C Breugem","doi":"10.1177/10556656231216557","DOIUrl":"10.1177/10556656231216557","url":null,"abstract":"<p><p>ObjectiveThe severity of craniofacial microsomia (CFM) is generally classified using the Orbit, Mandible, Ear, Soft tissue, Nerve (OMENS) classification score. The global assessment of the Phenotypic Assessment Tool for Craniofacial Microsomia (PAT-CFM), is a pictorial modification of the OMENS classification. The aim of this study was to assess the interrater reliability of the PAT-CFM global assessment score.DesignIn this prospective cohort study, three clinicians completed the global assessment form of the PAT-CFM. The mandible was classified based on orthopantomogram- and/or computed tomography images.ParticipantsConsecutive patients with CFM or microtia.<i>Main Outcome Measure</i>Interrater agreement was calculated using the weighted Krippendorff alpha (α), with 95% confidence intervals (CI).ResultsIn total, 53 patients were included (106 hemifaces). The reliabilities of the main classification components ranged from high for the mandible (α = 0.904 [95% CI 0.860-0.948]) and ear (α = 0.958 [95% CI 0.934-0.983]) subscales, to tentative for the orbital summary score (α = 0.682 [0.542-0.821]), and nerve summary score (α = 0.782 [0.666-0.900]) subscales.ConclusionsThe reliability of the ear and radiographic mandible scales of the PAT-CFM global classification were high, while the orbit, facial nerve and soft tissue subscales may have limited reliability. Research focusing on radiographic severity scores for hypoplasia of the orbits and soft tissues, as well as objective measures for overall facial hypoplasia using non-ionizing forms of imaging for early classification, are warranted.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"619-626"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Platelet Concentrates in the Reconstruction of the Alveolar Cleft Defect: A Systematic Review and Meta-Analysis.","authors":"Mariana Vásquez-Álvarez, Qian Wang, Uriel Zapata","doi":"10.1177/10556656231222076","DOIUrl":"10.1177/10556656231222076","url":null,"abstract":"<p><p>ObjectiveEvaluate quantitative and qualitative outputs when comparing the incidence of platelet concentrates (PCs) combined with autogenous bone grafts to an autograft control group for the reconstruction of alveolar cleft defects.DesignSystematic review and meta-analysis.Patients/ParticipantsRandomized and nonrandomized controlled clinical trials where PCs were used in the reconstruction of alveolar cleft defects.InterventionsUse of PCs in combination with autogenous bone graft in the experimental group and autogenous bone graft alone in the control group.Main Outcome Measure(s)Average bone formation and bone density were evaluated, mean differences were calculated and pooled by a meta-analysis technique. Additionally, clinical outcomes such as wound dehiscence, closure of the oronasal fistula, pain, swelling, discharges, infections, and bleeding were considered in the qualitative synthesis.ResultsAfter an evaluation of forty-nine articles, nineteen were considered for the review. The qualitative assessment of bone density, bone formation, and clinical outcomes showed no differences between groups in most of the included studies. The meta-analysis showed no statistical differences between PCs groups when compared to the control group in bone density at three months (mean difference 45.67 HU, <i>P</i> = .23) and six months (mean difference 48.57 HU, <i>P</i> = .64). Neither were statistical differences in the percentage of regenerated bone volume at six months (mean difference 6.39%, <i>P</i> = .15) and the volume of newly formed bone at 12 months (mean difference 0.37 mm3, <i>P</i> = .99).ConclusionsThere were no significant differences in terms of bone formation, bone density, and clinical outputs between groups.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"633-652"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}