Risk Factors for Otitis Media in Pediatric Patients With Cleft Lip and/or Cleft Palate: Systematic Review and Meta-analysis.

IF 1.1 4区医学 Q2 Dentistry

Cleft Palate-Craniofacial Journal Pub Date : 2025-06-30 DOI:10.1177/10556656251352708

Arshbir Aulakh, Arshroop Khaira, Murad Husein, Julie E Strychowsky, M Elise Graham

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引用次数: 0

Abstract

Objective: To evaluate risk factors for otitis media (OM) in children with cleft lip and/or palate (CL/P).

Design: Systematic review of MEDLINE, Embase, Cochrane, CINAHL, and Web of Science using PRISMA guidelines. Meta-analysis was performed using RevMan5.4.1.

Setting: Eligible studies included cross-sectional, retrospective, and prospective studies.

Patients/participants: Pediatric patients with CL/P who develop OM.

Interventions: OM risk factors including age, gender, and cleft type and size.

Main outcome measure(s): Incidence of OM.

Results: Eighteen studies involving 2272 children with CL/P were included. Pooled results showed no statistically significant difference in OM incidence between male and female children with CL/P (OR: 1.16; 95% CI: 0.80-1.60; P = .44). There was no significant difference in OM incidence between patients aged 2 years and below and those aged above 2 years (OR: 2.14; 95% CI: 0.33-13.83; P = .42). Cleft lip and palate (CLP) patients demonstrated significantly higher incidences of OM than cleft palate (CP) (OR: 1.58; 95% CI: 1.09-2.29; P = .02) and cleft lip (CL) patients (OR: 8.26; 95% CI: 2.21-30.90; P = .002). CP-only patients also demonstrated significantly higher OM incidences than CL-only patients (OR: 22.30; 95% CI: 8.40-59.21; P < .00001). Moreover, CPs classified as Veau III and IV showed higher OM incidences than those classified as Veau I and II (OR: 0.32; 95% CI: 0.18-0.58; P = .0001 and OR: 0.51; 95% CI: 0.33-0.77; P = .001, respectively).

Conclusion: CLP and CP alone are significant risk factors for developing OM in children, but not age and sex.

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唇裂和/或腭裂患儿中耳炎的危险因素：系统回顾和荟萃分析

目的：探讨唇裂/腭裂儿童中耳炎（OM）的危险因素。设计：使用PRISMA指南对MEDLINE、Embase、Cochrane、CINAHL和Web of Science进行系统评价。meta分析采用RevMan5.4.1软件。条件：符合条件的研究包括横断面、回顾性和前瞻性研究。患者/参与者：发生OM的儿科CL/P患者。干预措施：OM危险因素包括年龄、性别、唇裂类型和大小。主要结局指标：OM的发生率。结果：纳入18项研究，涉及2272例CL/P患儿。合并结果显示，男性和女性CL/P患儿的OM发病率无统计学差异(OR: 1.16；95% ci: 0.80-1.60；p = .44)。2岁及以下患者与2岁以上患者的OM发病率差异无统计学意义(OR: 2.14；95% ci: 0.33-13.83；p = .42)。唇腭裂（CLP）患者OM的发生率明显高于腭裂（CP） (OR: 1.58；95% ci: 1.09-2.29；P = .02)和唇裂（CL）患者(OR: 8.26；95% ci: 2.21-30.90；p = .002)。单纯cp患者的OM发生率也明显高于单纯cl患者(OR: 22.30；95% ci: 8.40-59.21；p =。0001和OR: 0.51；95% ci: 0.33-0.77；p =。001年,分别)。结论：CLP和CP是儿童发生OM的重要危险因素，而年龄和性别无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cleft Palate-Craniofacial Journal DENTISTRY, ORAL SURGERY & MEDICINE-SURGERY

CiteScore

2.20

自引率

36.40%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.