Cleft Palate-Craniofacial Journal最新文献

The Impact of Presurgical Nasoalveolar Molding on Midface Growth in Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis. 单侧唇腭裂患者术前鼻齿槽成型对中面部生长的影响：系统回顾与元分析

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-12-12 DOI: 10.1177/10556656241286386

T Moshal, I Roohani, M Jolibois, S Lasky, A Manasyan, P Naidu, N C O Munabi, M M Urata, J A Hammoudeh, W P Magee

{"title":"The Impact of Presurgical Nasoalveolar Molding on Midface Growth in Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis.","authors":"T Moshal, I Roohani, M Jolibois, S Lasky, A Manasyan, P Naidu, N C O Munabi, M M Urata, J A Hammoudeh, W P Magee","doi":"10.1177/10556656241286386","DOIUrl":"10.1177/10556656241286386","url":null,"abstract":"ObjectiveNasoalveolar molding (NAM) can optimize aesthetic outcomes in patients with cleft lip and palate (CLP), particularly in those with wider clefts. However, its impact on long-term postoperative sequelae such as midface hypoplasia (MFH) remains unclear. This study analyzed cephalometric data to evaluate NAM's effect on MFH in patients with complete unilateral CLP (UCLP).DesignSystematic Review and Meta Analysis.PatientsIncluded studies reported cephalometrics of patients ≥ 7 years old with repaired UCLP who underwent presurgical NAM versus no-NAM (control). Studies of bilateral cases or unoperated clefts were excluded.Main Outcome MeasuresMain outcomes were cephalometric angles (sella-nasion-A point (SNA), sella-nasion-B point (SNB), and A point-nasion-B point (ANB)) of patients treated with NAM vs. no-NAM.ResultsOf 2063 articles, three met inclusion criteria. Cephalometrics were reported for 171 patients (89 NAM, 82 no-NAM) at an average age of 8.5 ± 0.9 years. On pooled analysis, compared to the no-NAM cohort, the NAM cohort had insignificantly smaller SNA (78.8°±1.5° vs. 76.7°±1.5°, p = 0.169), SNB (75.5°±1.0° vs. 75.5°±1.0°, p = 0.954), and ANB (3.6°±1.4° vs. 1.23°±1.2°, p = 0.089) angles. Upon meta-analysis, compared to the no-NAM cohort, the NAM cohort had significantly smaller SNA (Mean Difference (MD) -1.96 [-3.31 to -0.61], p = 0.005) and ANB angles (MD -2.22 [-3.20 to -1.24], p < 0.001).ConclusionThis meta-analysis revealed that patients with UCLP who underwent presurgical NAM had significantly smaller SNA and ANB angles, possibly indicating worse MFH. Before choosing NAM, clinicians should consider CLP severity, potential sagittal growth restrictions, and feasibility, particularly in low-resource settings.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1939-1946"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthognathic Surgery Rates in Furlow Double-Opposing Z-Plasty Versus Straight-Line Repair: A Review of Three Decades of Experience. Furlow 双闭合 Z 形成形术与直线修复术的正颌手术率：三十年经验回顾

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-08-16 DOI: 10.1177/10556656241277395

Sasha Lasky, Tayla Moshal, Marah Jolibois, Idean Roohani, Artur Manasyan, Fatemah Husain, Samuel Harris, Eric S Nagengast, Mark M Urata, William P Magee, Jeffrey A Hammoudeh

{"title":"Orthognathic Surgery Rates in Furlow Double-Opposing Z-Plasty Versus Straight-Line Repair: A Review of Three Decades of Experience.","authors":"Sasha Lasky, Tayla Moshal, Marah Jolibois, Idean Roohani, Artur Manasyan, Fatemah Husain, Samuel Harris, Eric S Nagengast, Mark M Urata, William P Magee, Jeffrey A Hammoudeh","doi":"10.1177/10556656241277395","DOIUrl":"10.1177/10556656241277395","url":null,"abstract":"ObjectiveThe influence of different surgical techniques on maxillary growth remains unclear. This study investigates the long-term impact of Furlow double-opposing Z-plasty versus straight-line repair (SLR) techniques on midface growth and subsequent orthognathic surgery.DesignRetrospective cohort study.SettingTertiary children's hospital.Patients/participantsThis study evaluated patients who underwent primary palatoplasty with Furlow or SLR techniques from 1994-2023. Patients were >14 years old at their most recent follow-up.InterventionsNo interventions were performed.Main Outcome Measure(s)Primary outcomes were orthognathic surgery and orthognathic surgery recommendation rates to correct midface hypoplasia (MFH). Cephalometrics at the time of orthognathic surgery recommendation were traced to validate MFH.ResultsIn total, 1857 patients underwent palatoplasty, of which 335 met inclusion criteria (49 SLR, 286 Furlow). Average age at last follow-up was 18.5±2.6 years. Patients who underwent Furlow versus SLR showed no significant difference in orthognathic surgery rates (p=0.428) or recommendation for orthognathic surgery rates (p=0.900). Patients recommended to undergo orthognathic surgery had more negative ANB angles (p<0.001) and smaller SNA angles (p<0.001) than patients not recommended for orthognathic surgery, demonstrating maxillary hypoplasia. Upon multivariate regression, patients with Veau III and IV clefts had an increased need for orthognathic surgery, p=0.047 and p=0.008, respectively.ConclusionsOur findings suggest that higher cleft severity contributes to future orthognathic surgery. However, palatoplasty technique did not influence orthognathic surgery rates. Our results provide valuable data when surgeons are considering the impact of palatoplasty technique on sagittal growth restriction.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1825-1834"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Source of Nasal Rustle (Nasal Turbulence): An Overview of Current Evidence. 鼻啸声（鼻湍流）的来源：当前证据概述。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-08-28 DOI: 10.1177/10556656241278935

Michael Rollins, Ann Kummer

引用次数: 0

Cleft Lip Repair Comparison Between Inpatient and Outpatient Surgeries: A Multi-Surgeon Experience. 唇裂修复住院手术与门诊手术的比较：多位外科医生的经验

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-08-28 DOI: 10.1177/10556656241278569

Haven M Howell, Laura I Galarza, Laura S Humphries, Ian C Hoppe

{"title":"Cleft Lip Repair Comparison Between Inpatient and Outpatient Surgeries: A Multi-Surgeon Experience.","authors":"Haven M Howell, Laura I Galarza, Laura S Humphries, Ian C Hoppe","doi":"10.1177/10556656241278569","DOIUrl":"10.1177/10556656241278569","url":null,"abstract":"ObjectiveGreat variability exists as to whether cleft lip (CL) repair is performed as an inpatient or outpatient surgery. This study's aim is to investigate the authors' institutional experience to see if there is an increase in complications, emergency department (ED) visits, or readmissions to the hospital when performed as outpatient.DesignThis study reviewed patients who underwent CL repair between 2012 and 2023 at the authors' institution. Data collected included patient demographics, perioperative details, ED visits and readmissions within thirty days of surgery, and complications.ResultsOne hundred forty-five patients met inclusion measures. When the surgery was performed as outpatient, there was no significant difference in returning to the ED (p = 0.767) or readmission to the hospital (p = 0.447) within thirty days as compared to inpatient surgeries. Outpatients did not have more postoperative complications (p = 0.698). Bilateral cleft lips were more likely to be performed as inpatient (p = 0.001). Inpatients had a lower weight at time of repair (p = 0.033). Patients with a respiratory (p = .006), gastrointestinal (p = 0.003), or hematologic (p = 0.013) comorbidity had a higher readmission rate. Patients were more likely to be readmitted if they had a younger gestational age (p = 0.005).ConclusionThere was no increased return to the ED or readmission for patients undergoing inpatient versus outpatient CL repair. CL repair can be performed safely in an outpatient setting with careful patient selection.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1861-1864"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharyngeal Flap Versus Combined Pharyngeal Flap with Submucosal Injection of Phenytoin for Palatal Fistula Repair. 咽瓣与咽瓣联合粘膜下注射苯妥英修复腭瘘的比较。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2025-09-10 DOI: 10.1177/10556656241286722

Hoda Ismail Abdelhamid, Mohammad Waheed El-Anwar, Nasser Elnakib, Ali Mohammad Mohammad Awad, Ashraf El-Hussiny, Ibrahim Ahmed Khaled, Amany Mohamed Abd Albadea

{"title":"Pharyngeal Flap Versus Combined Pharyngeal Flap with Submucosal Injection of Phenytoin for Palatal Fistula Repair.","authors":"Hoda Ismail Abdelhamid, Mohammad Waheed El-Anwar, Nasser Elnakib, Ali Mohammad Mohammad Awad, Ashraf El-Hussiny, Ibrahim Ahmed Khaled, Amany Mohamed Abd Albadea","doi":"10.1177/10556656241286722","DOIUrl":"10.1177/10556656241286722","url":null,"abstract":"ObjectiveTo compare between L pharyngeal flap alone and combined L pharyngeal flap with phenytoin for repair of palatal fistula and velopharyngeal insufficiency (VPI).MethodsTwenty patients with soft palate fistula and persistent VPI who were divided into two groups. In the first group, superiorly based L pharyngeal flap was harvested from the oropharynx and inserted into the soft palate to close the fistula after fistula trimming. In the second group, the same L flap was done plus submucosal injection of phenytoin. Patients were evaluated before and after surgery using video-nasoendoscopy, and speech analysis.ResultsIn all patients, the palatal fistula could be closed. The nasal emission, intraoral pressure, resonance and articulation defects improved significantly after surgery, according to postoperative speech evaluation. All patients achieved grade 4 velopharyngeal valve closure (complete closure) in both groups. There were no reports of obstructive sleep apnea or flap dehiscence (partial or total).Both groups showed significant improvement of speech postoperatively with more improvement with topical phenytoin.ConclusionSubmucosal injection of phenytoin during repair of VPI and palatal fistula using L pharyngeal flap as a single stage surgery appears safe and seems to enhance healing, helping to close palatal fistula and correct velopharyngeal functions (closure and speech) in patients with persistent VPI with no reported significant complication.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1835-1841"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Man vs. Machine: 3D Milling of Auricular Frameworks". “人与机器：耳廓框架的3D铣削”。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-12-05 DOI: 10.1177/10556656241286732

Jina Yom, Jose F Palacios, Allison Neuwirth, Elisa K Atamian, Todd Goldstein, Nicholas Bastidas

{"title":"\"Man vs. Machine: 3D Milling of Auricular Frameworks\".","authors":"Jina Yom, Jose F Palacios, Allison Neuwirth, Elisa K Atamian, Todd Goldstein, Nicholas Bastidas","doi":"10.1177/10556656241286732","DOIUrl":"10.1177/10556656241286732","url":null,"abstract":"ObjectiveAutologous rib harvest with manual framework production is the current gold standard for microtia reconstruction. Recent clinical success with implantation of cadaveric costal cartilage grafts opens the possibility of point of care auricular framework production. This paper assesses the feasibility and efficiency of 3D milling of cadaveric costal cartilage for auricular framework production.DesignA Nagata/Firmin style auricular framework was manually carved en bloc out of soap and 3D scanned to design a milling toolpath on a desktop 3-axis computer numerical control (CNC) machine. An en bloc framework was then milled from cadaveric costal cartilage. Time to mill a complete framework was recorded. The dimensional/volumetric analyses were performed.Main Outcome Measure(s)The main outcome measures were total time to mill a complete auricular framework out of cadaveric cartilage and dimensional/volumetric comparisons to the model ear.ResultsTotal milling time for the cartilage framework was approximately 7 min. Finalizing steps took an extra 20 min. Total time to produce a final framework ready for implantation was approximately 27 min, compared to the traditional 1-2 h by manual carving. All dimensional comparisons were within 2 mm to the manually carved model. Volumetric analysis showed 71% similarity.ConclusionsEn bloc cadaveric costal cartilage framework milling is both feasible and efficient. 3D milling significantly reduces framework production time and allows for accurate reconstruction of the complex ear geometry, which can translate to cost savings, optimized patient safety, and potential for patient-specific reconstruction. The next step toward achieving clinical application is ensuring framework sterility.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1986-1991"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caring for a Child with a Cleft Lip and/or Palate: A Narrative Review. 照顾唇腭裂儿童：叙事回顾。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-09-09 DOI: 10.1177/10556656241280071

Nicola M Stock, Debora Blaso, Matthew Hotton

{"title":"Caring for a Child with a Cleft Lip and/or Palate: A Narrative Review.","authors":"Nicola M Stock, Debora Blaso, Matthew Hotton","doi":"10.1177/10556656241280071","DOIUrl":"10.1177/10556656241280071","url":null,"abstract":"Raising a child with healthcare needs places additional demands on caregivers. In 2012, Nelson and colleagues authored a review of 57 papers pertaining to parents' experiences of caring for a child with cleft lip and/or palate (CL/P). Thanks in large part to this review, available literature on this topic has grown considerably. The aim of the present review was to update and critically appraise recent literature, with the wider goal of assessing progress in the field and setting recommendations for future work. All original, peer-reviewed articles pertaining to the psychological adjustment of parents of children with CL/P living in high-income countries (published May 2009 to May 2024) were examined. A total of 126 articles were included. Findings were narratively synthesised according to three salient themes: Emotional Impact; Social Experiences; and Care Delivery. Recent research has built on Nelson et al.'s recommendations, addressing some prior gaps in knowledge. Nonetheless, some areas remained largely unexplored and critical methodological limitations were still evident. Recommendations for clinical practice include: improved informational resources for parents and non-specialist health professionals, regular audit of services in collaboration with parents and families, routine psychological screening for known risk factors and integrated psychological support from diagnosis onward. Recommendations for future research include the design of multicentre, prospective, longitudinal studies with sufficient sample sizes and appropriate control/reference groups, inclusion of families from diverse ethnic and socioeconomic backgrounds, further examination of factors contributing to psychological growth, the development and evaluation of psychological interventions, and cross-condition learning.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1947-1974"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Correction of Secondary Bilateral Cleft lip and Nasal Deformities Using the Delaire-Precious Technique. 利用德莱尔-普利斯技术对继发性双侧唇裂和鼻畸形进行手术矫正。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-10-17 DOI: 10.1177/10556656241287079

Akira Watanabe, Kenichiro Suga, Jean-Charles Doucet, Shuji Yoshida, Masato Narita, Katsuya Kanno, Takeshi Uchiyama

{"title":"Surgical Correction of Secondary Bilateral Cleft lip and Nasal Deformities Using the Delaire-Precious Technique.","authors":"Akira Watanabe, Kenichiro Suga, Jean-Charles Doucet, Shuji Yoshida, Masato Narita, Katsuya Kanno, Takeshi Uchiyama","doi":"10.1177/10556656241287079","DOIUrl":"10.1177/10556656241287079","url":null,"abstract":"ObjectiveThis study aimed to determine the efficacy of the surgical correction of secondary bilateral cleft lip and nasal deformities using the Delaire-Precious technique for Asian patients with bilateral cleft lip +/- palate (BCL+/-P).DesignRetrospective cohort study.SubjectsThirty-six patients with BCL+/-P in Japan, the Philippines, and Vietnam underwent secondary lip correction using the Delaire-Precious technique by a single surgeon.MethodsThe critical concepts of this surgical technique are discussed and clarified. A patient/parent satisfaction survey was carried out to evaluate the usefulness of this technique.ResultsThe Delaire-Precious technique improves Cupid's bow's symmetry and the central tubercule's volume. The scar tissue between lateral and medial philtrum incisions is excised. The orbicularis oris muscle is then reconstructed with a midline suture placed above the periosteum of the premaxilla. Most patients (90.9%) and all parents were at satisfied with the surgical result. The technique was highly satisfactory to patients and parents except at the level of scar correction.ConclusionThe secondary bilateral cleft lip and nasal repair using the Delaire-Precious technique is an adaptable technique that can be applied to various ethnic groups. It was found to be a satisfactory technique for Asian patients with BCL+/-P.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1881-1887"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding Accessibility in Cleft Care: The Role of Artificial Intelligence in Improving Literacy of Alveolar Bone Grafting Information. 扩大唇裂护理的可及性：人工智能在提高牙槽骨移植信息可读性中的作用。

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-09-09 DOI: 10.1177/10556656241281453

Artur Manasyan, Sasha Lasky, Marah Jolibois, Tayla Moshal, Idean Roohani, Naikhoba Munabi, Mark M Urata, Jeffrey A Hammoudeh

{"title":"Expanding Accessibility in Cleft Care: The Role of Artificial Intelligence in Improving Literacy of Alveolar Bone Grafting Information.","authors":"Artur Manasyan, Sasha Lasky, Marah Jolibois, Tayla Moshal, Idean Roohani, Naikhoba Munabi, Mark M Urata, Jeffrey A Hammoudeh","doi":"10.1177/10556656241281453","DOIUrl":"10.1177/10556656241281453","url":null,"abstract":"ObjectiveThe American Medical Association (AMA) recommends patient education materials (PEMs) be written at or below a sixth grade reading level. This study seeks to determine the quality, readability, and content of available alveolar bone grafting (ABG) PEMs and determine if artificial intelligence can improve PEM readability.DesignReview of free online PEMs.SettingOnline ABG PEMs were retrieved from different authoring body types (hospital/academic center, medical society, or private practice).Patients, ParticipantsNoneInterventionsContent was assessed by screening PEMs for specific ABG-related topics. Quality was evaluated with the Patient Education Material Assessment Tool (PEMAT), which has measures of understandability and actionability. Open-access readability software (WebFX) determined readability with Flesch Reading Ease, Flesch-Kincaid Grade Level, and Gunning-Fog Index. PEMs were rewritten with ChatGPT, and readability metrics were reassessed.Main Outcome Measure(s)Quality, readability, and content of ABG PEMsResults34 PEMs were analyzed. Regarding quality, the average PEMAT-understandability score was 67.0 ± 16.2%, almost at the minimum acceptable score of 70.0% (p = 0.281). The average PEMAT-actionability score was low at 33.0 ± 24.1%. Regarding readability, the average Flesch Reading Ease score was 64.6 ± 12.8, categorized as \"standard/plain English.\" The average Flesch-Kincaid Grade Level was 8.0 ± 2.3, significantly higher than AMA recommendations (p < 0.0001). PEM rewriting with ChatGPT improved Flesch-Kincaid Grade Level to 6.1 ± 1.3 (p < 0.0001).ConclusionsAvailable ABG PEMs are above the recommended reading level, yet ChatGPT can improve PEM readability. Future studies should improve areas of ABG PEMs that are most lacking, such as actionability.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1873-1880"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Suppresses Mesenchymal Cell Proliferation and Migration Through miR-214-3p in Cleft Palate. 2,3,7,8-四氯二苯并对二恶英通过 miR-214-3p 抑制腭裂间充质细胞的增殖和迁移

IF 1.3 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2025-11-01 Epub Date: 2024-09-24 DOI: 10.1177/10556656241286314

Xiaobo Dong, Qiang Chen, Haojuan Du, Lin Qiu

{"title":"2,3,7,8-Tetrachlorodibenzo-p-Dioxin Suppresses Mesenchymal Cell Proliferation and Migration Through miR-214-3p in Cleft Palate.","authors":"Xiaobo Dong, Qiang Chen, Haojuan Du, Lin Qiu","doi":"10.1177/10556656241286314","DOIUrl":"10.1177/10556656241286314","url":null,"abstract":"ObjectiveThe aetiology of CL/P is complicated, with both genetic and environmental factors. This study aimed to investigate the association between TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposure and changes in the expression of miR-214-3p in the context of cleft palate.DesignIn this study, we established a fetal mouse cleft palate model using TCDD and differentially expressed miRNAs were analysed by microarray analysis and verified by qRT-PCR. Finally, we demonstrated the effects of TCDD and microRNAs on the proliferation and migration of mesenchymal cells by using CCK8, EDU, Transwell, and wound-healing assays.ResultsOur findings revealed significant upregulation of miRNAs such as miR-214-3p, miR-296-5p, and miR-33-5p in the TCDD intervention group, while miRNAs like miR-92a-3p, miR-126a-3p, and miR-411-5p were significantly downregulated. Notably, qRT-PCR testing confirmed a significant difference in miR-214-3P expression. Further investigations involved the overexpression of miR-214-3p, reducing cell proliferation and migration in primary mouse embryonic palatal mesenchymal (MEPM) cells.ConclusionsThese results are consistent with the finding that TCDD suppresses palatal mesenchymal cell proliferation and migration through miR-214-3p. In conclusion, miR-214-3p probably plays a role in TCDD-induced cleft palates in mice.","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"1930-1938"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0