Cleft Palate-Craniofacial Journal最新文献

{"title":"Genetic Variability of <i>IRF6</i> Polymorphisms in Non-Syndromic Cleft Lip/Palate: A Meta-Analysis Across Diverse Populations.","authors":"Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran","doi":"10.1177/10556656241300841","DOIUrl":"https://doi.org/10.1177/10556656241300841","url":null,"abstract":"<p><p>Common congenital malformations known as orofacial clefts include cleft lip, cleft lip and palate, and cleft palate. They present significant public health challenges globally due to their medical, psychological, and socioeconomic impacts. Genetic and environmental factors mostly influence the genesis of nonsyndromic cleft lip with or without cleft palate.</p><p><p>A meta-analysis was carried out to evaluate the association between <i>IRF6</i> polymorphisms (rs2235371, rs2235373, and rs2235375) and NSCL/P. PubMed, Google Scholar, Scopus, and Embase were systematically searched for relevant articles. Studies meeting predefined inclusion criteria included case-control designs, genotype data, and statistical measures (odds ratios, 95% confidence intervals). Seventeen research papers were chosen based on the Newcastle-Ottawa Scale criteria for worth evaluation.</p><p><p>The meta-analysis included 1809 NSCL/P cases and 3164 controls from diverse populations, including Chinese Han, Brazilian, South Indian, Northeast Chinese, Uyghur, Indonesian, Vietnamese, Mesoamerican, and Iranian groups. However, in our analysis, only specific <i>IRF6</i> SNPs-rs2235371 and rs2235373-showed significant associations in the allelic and dominant models, respectively, while other SNPs, including rs2235375, showed no significant association. These findings underscore the genetic heterogeneity of NSCL/P across various ethnic groups.</p><p><p>This meta-analysis emphasizes the complex role of <i>IRF6</i> polymorphisms in the genetic susceptibility to NSCL/P. While significant associations were identified in several populations, the lack of association in others suggests that genetic factors contributing to NSCL/P vary widely. Further research is needed to elucidate additional genetic determinants and their interfaces with environmental factors in the pathogenesis of NSCL/P.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241300841"},"PeriodicalIF":1.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information Needs of Australian Families Living with Craniosynostosis: A Qualitative Study.","authors":"Amanda J Osborn, Rachel M Roberts, Diana S Dorstyn","doi":"10.1177/10556656241298813","DOIUrl":"https://doi.org/10.1177/10556656241298813","url":null,"abstract":"<p><strong>Objective: </strong>Craniosynostosis is considered a lifelong condition, yet relatively little focus has been directed toward ascertaining the information needs of Australian families. Thus, the aim of this study was to explore the information needs of Australian parents whose child has been diagnosed with nonsyndromic or syndromic craniosynostosis.</p><p><strong>Design: </strong>Twenty-one online narrative interviews were conducted with parents of children with craniosynostosis (aged between 4 months and 20 years). Transcripts were analyzed using reflexive thematic analysis and themes were developed.</p><p><strong>Results: </strong>Four themes were generated: (1) lots of information …. and quickly!; (2) the practicalities of hospital and surgery; (3) guidance on how to talk about my child's condition; and (4) the path is rarely clear. Parents of children with craniosynostosis discussed a range of information that was provided to them, or they would have liked to have been given, following their child's diagnosis. Parents noted that insufficient information was provided by the health system and that they faced considerable difficulties accessing credible information about their child's condition, relevant location-specific surgical options, the treatment process and outcomes.</p><p><strong>Conclusions: </strong>Narrative interviews provided detailed insight into the information needs of Australian parents of children diagnosed with craniosynostosis. Although parents were frequently challenged by a lack of information detailing their specific treatment and support options, suggestions relevant to craniofacial providers globally were offered. Further work is now needed to develop and provide these information resources in a timely and easily accessible way.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241298813"},"PeriodicalIF":1.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Palatal Fistula Closure with Tongue Flap Using a Parachute Technique.","authors":"Neda Khalili, Seyed Esmail Hassanpour, Abdolreza Rouientan","doi":"10.1177/10556656241298869","DOIUrl":"https://doi.org/10.1177/10556656241298869","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of tongue flaps in closing large palatal fistulas secondary to cleft palate repair in terms of functionality, esthetics, and donor site morbidity.</p><p><strong>Design: </strong>Tertiary academic center.</p><p><strong>Setting: </strong>We report our 8-year surgical experience with tongue flaps, with our parachute suture technique in flap inset, and not using tongue fixation methods or feeding tubes.</p><p><strong>Participants: </strong>Nineteen patients having recurrent secondary palatal fistula, post-cleft treatment were treated with anteriorly based dorsal tongue flaps.</p><p><strong>Main outcome measure: </strong>Patients were evaluated for outcome in terms of flap uptake and effectiveness, correction of oronasal regurgitation, speech and nasality improvement, donor site morbidity, and esthetics.</p><p><strong>Results: </strong>A total of 19 patients in the age range of 1.5 to 34 years were treated with anteriorly based tongue flap. Detachment of the tongue flap was observed in 1 patient. Furthermore, tongue flap necrosis was not observed in any of the patients. Nasal regurgitation was resolved completely in 15 cases (78.9%), and 2 out of 4 failed cases were due to fistula presence in a position out of flap territory. In addition, fistula persists in the case of flap detachment and another case at the location of pedicle division. Speech intelligibility and hypernasality changes were reported as noticeable improvement in 9 (47.4%) and no obvious change in 10 patients (52.6%).</p><p><strong>Conclusion: </strong>Using parachute suturing technique can facilitate successful lingual tissue inset in palatal defects with negligible remnant fistula. Moreover, avoiding tongue fixation methods and nasogastric tube-assisted feeding wasn't associated with increased flap dehiscence or suture loosening.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241298869"},"PeriodicalIF":1.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of WHO's Surgical Safety Checklist-Based Program on Cleft-lip and Palate Repair Outcomes in LMICs-The CLEAN CLEFT Program.","authors":"Getaw Alamnie, Manuella Timo, Sedera Arimino, Mekonen Eshete, Abraham Gebreegziabher, Fikre Abate, Hillena Kebede, Felicity Mehendale, Manuela Ehua-Koua, Olivier Moulot, Roumanatou Bankole, Nichole Starr, Tihitena Negussie Mammo","doi":"10.1177/10556656241299187","DOIUrl":"https://doi.org/10.1177/10556656241299187","url":null,"abstract":"<p><strong>Background: </strong>\"Clean Cleft\" (CC) is an adaptation of the Lifebox Clean Cut program, designed to reduce surgical site infections (SSIs) in cleft lip and palate repairs. It focuses on 6 key processes: hand and site decontamination, surgical linen integrity, instrument sterility, timely antibiotic use, gauze counting, and WHO Surgical Safety Checklist compliance. The study explores CC's effectiveness in reducing infections, other complications, and enhancing early recovery.</p><p><strong>Methods: </strong>CC was piloted in 2 Ethiopian hospitals and 1 in Côte d'Ivoire, the primary public cleft care centers in each country. Baseline data were collected through direct observation in the operating room, with patients monitored postoperatively for infections and complications through daily ward visits and follow-up calls or clinic visits at 30 days. Post-intervention data were collected for 5 months. Data was captured in DHIS2 software and analyzed using SPSS version 26.</p><p><strong>Results: </strong>The program enrolled 275 patients, with 156 during baseline and 119 post-implementation. Complications significantly dropped from 21.7% to 8.7% (<i>P</i> = .008), a 60% decrease. SSI rates fell from 18.1% to 8.0% (<i>P</i> = .03), while palatal fistulas decreased from 13.0% to 6.1% (<i>P</i> = .1) and wound dehiscence from 18.0% to 8.0% (<i>P</i> = .03). Adherence to perioperative standards improved, except for hand and skin preparation while pain management remained effective throughout the program.</p><p><strong>Conclusion: </strong>CC improved perioperative practices, significantly reducing infections, palatal fistulas, and wound dehiscence, supporting the broader program expansion to any subspecialty.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241299187"},"PeriodicalIF":1.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Trajectories of Adolescent Patients With Cleft Lip and/or Palate According to Health Insurance Coverage in Medellin, Colombia.","authors":"Ana María Cerón-Zapata, Ángela María Segura-Cardona, María Cecilia González-Robledo","doi":"10.1177/10556656241299200","DOIUrl":"https://doi.org/10.1177/10556656241299200","url":null,"abstract":"<p><p>To describe and compare the healthcare trajectories of patients with CL/P under two different income-based programs for health coverage in Colombia, known in Colombia as a health insurance regime (contributory and subsidized), in Medellín, 2021.</p><p><p>Non-experimental, cross-sectional questionnaire-based study.</p><p><p>Primary level of clinical care in Medellín, Colombia.</p><p><p>Twenty-eight 15- to 21-year-olds with CL/P and primary caregivers.</p><p><p>Individuals with CL/P answered the survey. Patients with syndromic CL/P and patients with cognitive disabilities were excluded. The calculation of the probabilistic sample was performed based on the formula for finite populations using databases from 2 health insurance companies. The analysis was descriptive and bivariate. Chi-square and Fisher tests were used to analyze the variables of interest.</p><p><p>Continuity of the care pathway was measured with proxy indicators: (1) access to comprehensive CL/P treatment; (2) timeliness of access to comprehensive CL/P treatment; (3) differences in access to and timeliness of comprehensive CL/P treatment between patients under both health insurance coverage.</p><p><p>No differences were found when comparing the healthcare trajectories of young patients with CL/P who were in both health coverage. Differences were observed in the timeliness of care for patients with CL/P under the subsidized coverage who were more economically vulnerable. Delays in care were mainly linked to administrative procedures required for orthodontic procedures, bone grafts, and maxillofacial surgeries.</p><p><p>Despite the health system's guarantee of equal care across income levels, differences in the timeliness of care persist for patients from lower-income families.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241299200"},"PeriodicalIF":1.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Mydriasis as an Immediate Complication After Orthognathic Surgery in a Patient with Cleft Lip and Palate.","authors":"Isabela Toledo Teixeira da Silveira, Bhárbara Marinho Barcellos, Bruno Gomes Duarte, Marina de Almeida Barbosa Mello, Fernanda Leite, Renato Yassutaka Faria Yaedú","doi":"10.1177/10556656241259889","DOIUrl":"https://doi.org/10.1177/10556656241259889","url":null,"abstract":"<p><p>This study aims to report a rare complication, anisocoria (mydriasis), in a patient with cleft lip and palate in the immediate postoperative period after orthognathic surgery and discuss the literature surrounding this event. Mydriasis after orthognathic surgery may be related to the separation of the pterygoid plate from the sphenoid bone, which can injure the cranial nerves. Therefore, knowledge of possible anatomical variations of the posterior region of the maxilla becomes extremely important to minimize complications in cleft patients. The reported case highlights the management of anisocoria as a complication as well as the importance of its knowledge.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241259889"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Nutritive Suck and Parent Report of Feeding Skills in Infants Born With Cleft Lip and/or Palate.","authors":"Alaina Martens, Carolyn R Rogers-Vizena, Emily Zimmerman","doi":"10.1177/10556656241299915","DOIUrl":"https://doi.org/10.1177/10556656241299915","url":null,"abstract":"<p><strong>Objective: </strong>To compare non-nutritive sucking (NNS) and caregiver-reported feeding skills in infants with cleft lip and/or palate (CL/P) to a control group of typically developing infants without CL/P. To examine differences in NNS patterns and feeding behavior between cleft phenotypes.</p><p><strong>Design: </strong>Prospective, cross-sectional study comparing infants born with CL/P to an age-matched control group with no congenital anomalies.</p><p><strong>Setting: </strong>Urban, academic, tertiary care children's hospital and academic department of speech-language pathology.</p><p><strong>Patients, participants: </strong>Forty-two infants (21 with CL/P; 21 without CL/P), 6 months of age and younger were included. Infants with syndromes or who underwent cleft repair were excluded.</p><p><strong>Main outcome measures: </strong>A 5min NNS sample was collected from the infant sucking on the lab's custom research pacifier. The infant's caregiver completed the Neonatal Eating Assessment Tool (NeoEAT) bottle-feeding section about their infant's feeding behaviors.</p><p><strong>Results: </strong>Infants with CL/P demonstrated slower NNS frequency (<i>P </i>= .04) and reduced suck amplitude (<i>P </i>= .04) compared to the control group. Caregivers of infants with CL/P reported a higher incidence of gastrointestinal symptoms (<i>P </i>= .04) and overall feeding difficulties (<i>P </i>= .03) relative to the control group. There were no significant differences between CL/P phenotypes for NNS or caregiver reported outcomes.</p><p><strong>Conclusions: </strong>Infants with CL/P demonstrate differences in NNS physiology and caregiver report measures of feeding compared to age-matched controls. These findings support the need for interventions to optimize sucking and feeding skill development in infants with CL/P.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241299915"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premaxillary Setback in the Management of Patients With Bilateral Cleft Lip: A 2 Decade Review.","authors":"Marah I Jolibois, Sasha Lasky, Eloise W Stanton, Idean Roohani, Tayla Moshal, Lacey Foster, Fatemah Husain, Naikhoba Co Munabi, Mark M Urata, William P Magee, Jeffrey A Hammoudeh","doi":"10.1177/10556656241298824","DOIUrl":"https://doi.org/10.1177/10556656241298824","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzes indications and outcomes of premaxillary setback (PS) and presents an algorithm for its use in patients with bilateral cleft lip and/or palate (BCL ± P).</p><p><strong>Design: </strong>Retrospective review.</p><p><strong>Setting: </strong>Children's Hospital Los Angeles.</p><p><p>A retrospective review was conducted evaluating patients with BCL ± P undergoing lip repair from 2003-2023. Patients were categorized as undergoing repair with (BCL + PS) or without (BCL-PS) simultaneous PS. Presurgical nasoalveolar molding (NAM), indications for PS, timing of surgery, and complications were collected.</p><p><strong>Interventions: </strong>BCL with PS, BCL + PS.</p><p><strong>Main outcome measures(s): </strong>Primary outcomes included rates of postoperative complications and revision surgeries. Secondary outcome was the need for orthognathic surgery to correct midface hypoplasia in patients at least 14 years old at their most recent follow-up.</p><p><strong>Results: </strong>Of 1193 patients, 262 met inclusion criteria. One hundred forty-nine patients (56.9%) were referred for NAM. Fifty-one patients (19.5%) underwent PS during primary BCL repair. Patients who failed repositioning of the premaxilla following presurgical NAM (n = 12) were not candidates for NAM (n = 31) or presented late with a protruding premaxilla (n = 8, 12.977 ± 8.196 months) underwent PS. Median age at surgery was 4.29 months. Complications included wound dehiscence (n = 3) and abscess formation (n = 2). No premaxillary necrosis occurred. Overall revision rates were 9.9%. Of 41 patients over 14 years old, 53.6% needed orthognathic surgery. BCL + PS had comparable rates of wound dehiscence (2.0% vs 4.0%; <i>P</i> = .790), lip revisions (7.8% vs 10.4%; <i>P</i> = .770), and orthognathic surgery (50.0% vs 56.3%; <i>P</i> > .999).</p><p><strong>Conclusion: </strong>PS is a safe and effective method to facilitate BCL repair in patients who are not candidates for NAM.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241298824"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Treatment Needs Among 16-Year-Old Patients with Cleft Lip and Palate: An Observational Study in Western Norway.","authors":"Paul K Saele, Anne N Åstrøm, Manal Mustafa","doi":"10.1177/10556656241286323","DOIUrl":"https://doi.org/10.1177/10556656241286323","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to a) assess intermaxillary sagittal relations, dental alignment, and occlusion among patients with Cleft Lip and/or Palate (CL/P) and b) evaluate the need for future dental treatment.</p><p><strong>Material/methods: </strong>Clinical assessment, lateral cephalogram, orthopantomogram, and study models from 1019 patients with CL/P collected at age 16 from the Bergen national CLP team in Norway. Records included the number of dental agenesis or hypoplasia, ANB angulation, dental alignment, occlusion, oronasal fistula, and indications for future dental treatment needs.</p><p><strong>Results: </strong>One-third required further treatment by an orthodontist, prosthodontist, or oral surgeon in adulthood, and complete bilateral or unilateral CLP had a significantly higher need than patients with isolated cleft of the lip or the palate. Missing teeth increased the risk for retrognathic maxilla (OR = 3,62), need for orthodontic and prosthodontic treatment (OR = 5.20), and a negative overjet and need for orthognathic surgery (OR = 4.86) (p < 0.001). Oronasal fistula was present in 4.7% of the participants, significantly worsening all clinical indicators (p < 0.001). Boys exhibited more adverse findings than girls, except regarding the need for dental porcelain bridges. A noticeable trend indicated increased dental treatment needs among 16-year-old patients with clefts born between 1990-2001, compared to patients born between 1980-1990.</p><p><strong>Conclusions/implications: </strong>The findings underscore the need for comprehensive, individualized treatment plans and interdisciplinary dental services for adult patients with CL/P. The original cleft pattern, male gender, presence of oronasal fistula, and a high number of missing teeth negatively influenced the dental status and treatment outcomes measured at the 16-year-old assessment.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241286323"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type of Cleft and Socioeconomic Determinants for Increased Caries Risk Among Young Patients With Cleft Lip and/or Palate.","authors":"L S van der Knaap-Kind, E B Wolvius, L Kragt","doi":"10.1177/10556656241299194","DOIUrl":"https://doi.org/10.1177/10556656241299194","url":null,"abstract":"<p><p>This study aimed to identify the predictive role of cleft type, ethnicity, adoption status, spoken language at home and parental education level on the caries risk in the primary dentition of patients with cleft lip and/or palate (CL/P). This knowledge is used to make an estimate on increased caries risk in young patients with CL/P.</p><p><p>A retrospective analysis of data concerning dental caries and basic characteristics of patients with CL/P was done. Patients were born and registered in 2016, 2017, or 2018 at the cleft team of the Erasmus Medical Center, Rotterdam, the Netherlands.</p><p><p>After Chi-square tests, the cleft type (<i>P </i>= .02), country of birth father (<i>P </i>< .001), country of birth mother (<i>P </i>= .002), parental educational level (<i>P </i>= .006), and spoken language at home (<i>P </i>= .002) were significantly different between 144 patients with CL/P with and without caries. Items were used in binary logistic regressions and after stepwise backward elimination resulting in most important determinants for caries in the primary dentition in patients with CL/P being: father born in another country than the Netherlands (odds ratio [OR]<i> </i>= 4.87, <i>P </i>= .001), a cleft lip alveolus and palate phenotype (OR<i> </i>= 3.54, <i>P </i>= .002), and a lower parental educational level (OR<i> </i>= 2.30, <i>P </i>= .04).</p><p><p>The recommendation for the dental care professional will be to use these 3 determinants as a first prediction on future dental caries. This helps the dental professional in clinical decisions as recall intervals, referral to specialized dental care and extensiveness of caries prevention strategies and thereby improves oral health of patients born with CL/P.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"10556656241299194"},"PeriodicalIF":1.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}