Cleft Palate-Craniofacial Journal最新文献

{"title":"Prevalence of Malnutrition in Children with Cleft Conditions in Madagascar: A Cross-Sectional Study.","authors":"Daniel D Otobo, Charlotte Steppling, Ashley Myles, Natalie Torres, Emily M Jones, Anthony Dwyer, Caroline Yao","doi":"10.1177/10556656261426268","DOIUrl":"10.1177/10556656261426268","url":null,"abstract":"<p><p>ObjectiveThis study aims to assess the prevalence, patterns, and distribution of malnutrition among pediatric patients evaluated for cleft surgery in Madagascar.MethodologyDesign/Setting: This Retrospective cross-sectional study assessed 658 patients who presented for cleft care between 2020 and 2023 during surgical programs of an International Cleft Surgical Non-Profit Organization in Madagascar.Intervention/Outcome MeasuredPatient demographics and anthropometry of all patients were measured. The weight-for-length <i>Z</i> score/weight-for-height <i>Z</i> score World Health Organization Growth Chart <i>Z</i> scores, as well as mid-upper arm circumference for patients aged > 6 months to 59 months, were measured and recorded. Patients were grouped based on gender and age.ResultsOf the 658 patients screened for surgery, 96% were malnourished (mild to severe malnutrition), and 83% of the screened patients had to be enrolled in the nutrition program (<i>Z</i> scores ≤ -2standard deviation) for nutritional optimization before surgery could be considered. At the time of this study, 239 patients had received surgery, while 309 were awaiting surgery. The majority had combined cleft lip and palate (59%), and over half of the mothers were unable to breastfeed their children at all due to the cleft condition(s) (53%). The highest prevalence (52.4%) and severity (68.1%) of malnutrition was observed among infants under 6 months old.ConclusionThe malnutrition status among patients with a cleft lip and/or palate in Madagascar is high (96%, <i>p</i> < .001). When children with cleft conditions who were malnourished (96%) were compared with the under-5 malnutrition status among non-cleft patients (47%) in Madagascar, it was a ratio of 2:1.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3768-3774"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Outcomes of Porous Polyethylene Cranioplasty for Large Cranial Defects in Children: Assessment of Clinical Results and Cranial Growth.","authors":"Liliana Camison, Lucas A Dvoracek, Madeleine K Bruce, Justin W Beiriger, Erin E Anstadt, Mandeep S Tamber, Jesse A Goldstein, Joseph E Losee","doi":"10.1177/10556656261443448","DOIUrl":"10.1177/10556656261443448","url":null,"abstract":"<p><p>ObjectiveTo examine long-term outcomes and cranial growth after porous polyethylene (PPE) cranioplasty for large calvarial defects in children.DesignRetrospective review.SettingTertiary pediatric hospital.PatientsPediatric patients from 2006-2023 who underwent custom PPE cranioplasty (Medpor, Stryker) for large calvarial defects (>75 cm²) were identified. Twenty-six of 27 patients were included. Subset analysis was performed in 12 patients with CT scans obtained more than 5 years postcranioplasty to assess cranial growth.InterventionPPE cranioplasty.Outcome measuresPresurgical characteristics and clinical outcomes. For cranial growth, intracranial volume (ICV) and head circumference (HC) were calculated using CT at two time points.ResultsTwenty-six patients (mean age = 7.9 years; range = 2.4-21.3 years) with cranial defects averaging 152 cm² (range = 75-446 cm²) were included. The most common cause was traumatic brain injury (19 patients). Eighty-five percent had failed autologous cranioplasty, and 42% had prior infections. At last follow-up (mean = 6.5 years; range = 1.3-14.5 years), 25 patients had stable coverage and contour without complications. One patient required explantation because of iatrogenic causes. Growth analysis of 12 patients (mean follow-up = 9.3 years; range = 5.4-14.5 years) showed HC increased in all cases and remained within the same age-adjusted percentile range as pre-cranioplasty values. ICV increased or remained stable in 9 of 12 patients. In the remaining three patients, HC-ICV discrepancies resulted from inward calvarial thickening concurrent with intrinsic brain abnormalities.ConclusionsPPE cranioplasty appears to be safe for large cranial defects in select pediatric cases. Head circumference growth occurs over time and remains within normative ranges long term, whereas ICV changes do not always parallel HC. This growth pattern appears related to the extent of underlying brain injury rather than the reconstruction itself.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3822-3834"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Alcohol Dehydrogenase Mutations and Cleft Lip/Palate: A Scoping Review.","authors":"Theodore S Hyman, Esperanza Mantilla-Rivas, Liara Ortiz Ocasio, Athena Zhang, Sofia Finestone, Perry Bradford, Monica Manrique, Gary F Rogers, Natasha Shur, Albert K Oh","doi":"10.1177/10556656261438751","DOIUrl":"10.1177/10556656261438751","url":null,"abstract":"<p><p>BackgroundThe incidence of cleft lip with or without cleft palate (CL ± P) varies significantly according to genetic ancestry. The alcohol dehydrogenase (ADH) family comprises several enzymes with polymorphisms that are also highly disparate between genetic backgrounds. A small number of heterogeneous studies have linked <i>ADH</i> variants with risk of CL ± P. Therefore, the authors conducted a scoping review to better understand these potential associations.MethodsThis review was conducted following PRISMA 2020 guidelines, screening for studies published in PubMed and Medline databases. Case-control, cohort, case-series, and cross-sectional studies published in English between 1966 and 2024 that reported associations between ADH polymorphisms and CL ± P were included.ResultsFive studies met inclusion criteria, accounting for 1630 cases of CL ± P. Despite significant variation in study design and results, four studies linked polymorphisms in the maternal and/or fetal genotype <i>ADH1C</i> to CL ± P risk. Two also examined whether <i>ADH1C</i> genotype modifies the risk that prenatal alcohol exposure imparts for fetal CL ± P; one found that high-activity <i>ADH1C</i> polymorphisms in mother and child together reduced this alcohol-attributable CL ± P risk, while the other found no effect of <i>ADH1C</i> genotype on this risk. The fifth study reported a novel duplication in <i>ADH7</i> in a family with CL ± P cases.ConclusionsCurrent evidence, though limited, suggests that certain maternal and fetal ADH polymorphisms may influence risk of fetal CL ± P. Existing data have been primarily limited to demographically homogenous cohorts, and ancestry was not analyzed in concert with ADH polymorphisms. The interaction of ancestry, ADH mutations, and CL ± P remains an important, open question.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3977-3986"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cleft Care India Study: A National Audit on Patients with Non-Syndromic Unilateral Cleft Lip and Palate: Surgical Procedures and Outcomes.","authors":"Panchali Batra, Deborah Sybil, Krishnamurthy Bonanthaya, Subodh Kumar Singh, Srinivas Gosla Reddy, Puneet Batra, Suryakant Das, Syed Altaf Hussain, Ravi K Mahajan, Raj Gopal Reddy, Vinay Chugh, Gayatri Moghe, Nandlal Bhojraj, Krishna Shama Rao, K Chethana, Sukhdeep Singh Kahlon, Kamlesh Singh, Ranjit H Kamble, Shruti Bijapur, Charanya Vijaykumar, H Hari Kishore Bhat, Sakshi Katyal, Manoj Prathap, Karthika Nambiar, Badri Thiruvenkatachari","doi":"10.1177/10556656261436188","DOIUrl":"10.1177/10556656261436188","url":null,"abstract":"<p><p>ObjectiveTo assess the surgical protocols followed in the treatment of non-syndromic UCLP across Indian cleft centres and identify factors influencing secondary surgical outcomes.DesignProspective cross sectional design.SettingThe study was conducted in 14 sary/tertiary care comprehensive cleft centres.ParticipantsThe study included 307 patients with non-syndromic UCLP across three age groups (5, 12, and 20 years) from 14 centres nationwide.OutcomesData was collected through a standardized web-based form. Variables recorded included surgeon specialty and experience, surgical sequence, presurgical orthopaedics, primary surgical techniques, and their association with the need for secondary procedures such as lip/nose revision, velopharyngeal surgery, fistula repair, and alveolar bone grafting. Descriptive statistics were generated, and associations between variables were analysed using Fisher's exact test.ResultsMillard's technique was the most commonly used approach for primary lip repair across all age groups. Presurgical orthopedic plates, nasal conformers, and the specific lip repair technique were not significantly associated with the need for lip or nasal revision surgery, although the wide confidence intervals indicate considerable uncertainty in these estimates. Similarly, the type of palatal repair and use of intravelar veloplasty were not significantly associated with fistula formation or the need for secondary velopharyngeal or fistula repair procedures. Across centres, wide variation existed in techniques used, but no one approach showed superiority in reducing secondary surgery needs.ConclusionDespite the observed variability in surgical weak associations were found between specific surgical techniques or surgeon-related factors and the need for secondary surgical interventions. The wide confidence intervals highlight the uncertainty of these findings and the need for further national-level audits, underscoring the challenge of establishing best practices in cleft care without robust systems for comprehensive data collection and consolidation.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3941-3952"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprazygomatic Maxillary Nerve Block is Associated with Reduced Postoperative Inpatient Opioid Requirement in Patients Undergoing Palatoplasty.","authors":"Artur Manasyan, Rachel Donaldson, Priyanka Naidu, Diba Nayeri, Mark M Urata, Jeffrey A Hammoudeh, William P Magee","doi":"10.1177/10556656261429798","DOIUrl":"10.1177/10556656261429798","url":null,"abstract":"<p><p>ObjectiveThe objective of this study was to evaluate the efficacy of the suprazygomatic maxillary nerve block in reducing postoperative inpatient opioid requirements in patients undergoing palatoplasty for cleft palate repair.DesignRetrospective cohort studySettingTertiary care children's hospitalPatients, ParticipantsPatients with isolated cleft palate or cleft lip and palate who underwent palatoplasty at our institution between 2006 and 2025.InterventionsPatients who received the suprazygomatic maxillary nerve block and a controlled cohort of patients who underwent cleft palate repair during the same time period without receiving a nerve block were assessed. Patient demographics, perioperative data, and opioid requirements within the immediate eight hours (in morphine milliequivalents [MME]) following surgery were recorded. Multivariate regression analysis was performed, with significance defined as <i>p</i> < .05.Main Outcome MeasuresInpatient opioid requirement eight hours following surgeryResultsA total of 470 patients were included, with 235 (50.0%) in the nerve block group and 235 (50.0%) in the group without nerve block. When adjusting for age, sex, Veau class, and surgical approach, use of nerve block was associated with a significantly lower amount of MME administered in the first eight hours following palatoplasty (OR = 0.54, 95% CI [0.34-0.87], <i>p</i> = .011).ConclusionsThe suprazygomatic maxillary nerve block appears to be an effective technique for reducing postoperative inpatient opioid requirements in children undergoing cleft palate repair.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3817-3821"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An RCT Evaluating the Efficacy of Using Platelet-Rich Fibrin (PRF) with Conventional Technique of Cleft Palate Repair.","authors":"Soujanya M, Rajesh S Powar","doi":"10.1177/10556656261422847","DOIUrl":"10.1177/10556656261422847","url":null,"abstract":"<p><p>ObjectiveTo evaluate the effectiveness of platelet-rich fibrin (PRF) in the repair of cleft palate (CP), with a primary goal of reducing the occurrence of postoperative palatal fistula formation.DesignAn RCT was conducted with a 1:1 allocation ratio.SettingSingle-center study conducted in the Department of Plastic & Reconstructive Surgery at a tertiary care center.Participants100 CP repair patients enrolled based on the following inclusion criteria: Non-syndromic CPAge between 1 and 3 yearsInformed consent.InterventionsParticipants were randomized using a computer-generated sequence into 2 groups (<i>n</i> = 50 each). The intervention group received PRF, prepared by Choukroun's method from a 5 to 7 mL blood sample, and applied during surgery. The control group underwent standard CP repair without PRF. Both groups received identical pre & postoperative care.Main OutcomesPalatal-fistula formation, wound dehiscence, and postoperative bleeding were assessed.No cases of wound dehiscence or postoperative bleeding were observed in either group.Palatal fistula occurred in 3 patients (6%) in the control group (non-PRF), while no cases were observed in the PRF group.ResultsThree palatal fistula cases were observed (3%; <i>n</i> = 100), 0% in the PRF group (<i>n</i> = 50), and 6% in the non-PRF group (<i>n</i> = 50).ConclusionsWhile PRF appears to be safe, biologically promising, and cost-effective adjunct in CP repair; the study was inconclusive as the small number of fistula occurrence limited ability to statistically substantiate its efficacy in reducing palatal fistula.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3690-3698"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Secondary Alveolar Cleft Reconstruction With Labial and Palatal Lateral Ramus Cortical Grafts: A Case-Series Study.","authors":"Osama Bahaa Khidr, Maged Seleet, Kareem Samir El-Tabarany, Amr Gibaly","doi":"10.1177/10556656261431472","DOIUrl":"10.1177/10556656261431472","url":null,"abstract":"<p><p>ObjectiveThe study aims to evaluate a lateral ramus cortical graft technique for secondary alveolar bone grafting (SABG) in alveolar clefts.DesignThis study is a prospective case series.SettingsFrom October 2024 to October 2025.Patients/ParticipantsSeven patients of both sexes with unilateral alveolar clefts with an age range of 11 to 15 years old.Main Outcome Measure(s)The radiographic 3-dimensional volumetric calculation of graft fill, bone-bridge formation, and graft resorption rates.InterventionThe cleft defects were reconstructed by the harvest of the mandibular lateral ramus cortical plate, which was cut and adapted to frame the labial and palatal cleft boundaries, while obliterating the intercancellous space with a mixture of cancellous particulates and allogenic demineralized bone matrix (DBM), covered by a collagen membrane.ResultsAll grafts were consolidated with acceptable volume. The calculation of the generated models counted: 3.94 ± 0.30 cm³ for volume cleft, 4.41 ± 0.38 cm³ for volume graft, and 3.77 ± 0.36 cm³ for volume bone bridge, with a graft fill rate of 1.12, bone bridge formation rate of 95.6%, and graft resorption rate of 14.51%.ConclusionThe lateral ramus plate enabled a nearby intramembranous graft to achieve structural integrity and minimal morbidity, with favorable graft fill, bone bridge formation, and resorption rates. Mixing cancellous particulates with allogenic DBM and collagen membrane coverage compensated for the limited cancellous abundance at the donor site and enhanced the graft's osteogenic potential.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3835-3844"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What We Learnt in Unilateral Cleft Lip Repair Between Millard's and Tennison-Randall's Techniques: Comparison of the Outcomes in Adult Patients.","authors":"Angelica Pistoia, Maria Ida Rizzo, Francesca R Grippaudo, Marta Cajozzo, Francesca Grussu, Francesco Molinaro, Francesca Nascimben, Mario Zama","doi":"10.1177/10556656261422855","DOIUrl":"10.1177/10556656261422855","url":null,"abstract":"<p><p>ObjectiveTo compare long-term esthetic and morphological outcomes of unilateral cleft lip (UCL) repair using the Millard rotation-advancement versus the Tennison-Randall triangular flap technique, testing whether Millard provides superior lip symmetry.DesignRetrospective cohort study.SettingSingle tertiary cleft center.Patients, ParticipantsForty adults aged 18-25 were selected from 168 patients treated between 1988 and 1995. Inclusion criteria: complete UCL, primary cheiloplasty, absence of secondary lip revisions, complete frontal photographic documentation, and no syndromic diagnoses. Twenty underwent Millard repair and twenty Tennison-Randall repair.InterventionsPrimary UCL reconstruction performed using either Millard rotation-advancement or Tennison-Randall triangular flap. All operations were carried out by the same senior cleft surgeon under comparable operative conditions.Main Outcome Measure(s)Long-term lip symmetry quantified through a Symmetry Index derived from predefined anthropometric landmarks on standardized images. Subjective esthetic satisfaction assessed using the esthetic Units Satisfaction Questionnaire and the Cleft esthetic Rating Scale, completed by patients, the operating surgeon, and a blinded observer.ResultsMillard repair showed significantly greater medial lip width symmetry (<i>p</i> = .014). No significant differences were found for vermilion height, prolabial height, lateral lip width, or lip area. Subjective assessments consistently favored Millard, showing higher satisfaction and fewer negative ratings. Inter-rater reliability across evaluators was high (ICC = 0.82).ConclusionsBoth techniques produced stable long-term outcomes, but Millard yielded superior medial lip symmetry and higher esthetic satisfaction. These findings support its continued clinical preference and highlight the importance of long-term evaluations. Larger prospective studies are needed to confirm these results.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3699-3706"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cephalometric Comparison of Le Fort I Osteotomy in Growing and Non-Growing Patients With Clefts: A Retrospective Study.","authors":"Minna Merta, Roni Harjunpää, Junnu Leikola, Juho Suojanen, Nora Holmberg, Arja Heliövaara","doi":"10.1177/10556656261424586","DOIUrl":"10.1177/10556656261424586","url":null,"abstract":"<p><p>ObjectiveTo cephalometrically compare craniofacial morphology and maxillary advancement in growing versus non-growing patients with clefts undergoing Le Fort I osteotomy.DesignRetrospective cohort study.SettingAll patients underwent maxillary osteotomy at a single tertiary hospital.PatientsThe Pre-Growth-Completion group (PreGC) comprised 28 growing patients (18 males, 10 females; 9 BCLP, 18 UCLP, 1 CP) with a mean age at surgery of 13.5 years (SD = 1.22; range, 11.5-16.7). The Post-Growth-Completion group (PostGC) comprised 59 patients (28 males, 31 females; 15 BCLP, 23 UCLP, 21 CP) with a mean age at surgery of 18.3 years (SD = 4.38; range, 14.5-45.3). Patients with syndromes and those undergoing bimaxillary osteotomies were excluded.InterventionsEach patient underwent Le Fort I osteotomy. Osteotomies were fixed with patient-specific implants or miniplates.Main Outcome MeasuresCephalometric analysis was performed comparing preoperative lateral cephalometric radiographs or CT scans and immediate postoperative lateral cephalometric radiographs.ResultsPatients in PreGC group had more severe preoperative maxillary hypoplasia (SNA 74.2° vs 77.0°, <i>P</i> = .007; ANB -5.2° vs -1.9°, <i>P</i> = .0001), but no significant differences were observed postoperatively (SNA 80.7° vs 78.9°, ANB 2.7° vs 3.9°). Maxillary horizontal advancement was greater in the PreGC group (point A 6.4 mm vs 3.2 mm; <i>P</i> = .00002).ConclusionsPatients undergoing early Le Fort I osteotomy had more severe preoperative maxillary hypoplasia, required greater horizontal advancements, yet achieved significant corrections comparable to patients treated later. However, early osteotomy in growing patients may be considered a 2-stage approach as secondary correction is often required after growth is complete.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3931-3940"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Infection, Dehiscence, and Unplanned Reintubation Following Cleft Lip Repair.","authors":"Aidin Gharavi, Elizabeth B Habermann, Stephanie F Polites, Samir Mardini, Waleed Gibreel, Dawit Haile","doi":"10.1177/10556656261424581","DOIUrl":"10.1177/10556656261424581","url":null,"abstract":"<p><p>ObjectiveWe sought to characterize factors associated with postoperative complications in patients undergoing primary cleft lip repair (CLR).DesignThe National Surgical Quality Improvement Program-Pediatric database was queried to identify patients under 12 months old undergoing CLR using CPT codes. Multivariable analysis was conducted to characterize complications and associated comorbidities.SettingA multicenter sample.Patients/ParticipantsA total of 11 957 cases (81.9% unilateral CLR and 18.1% bilateral CLR) were identified.InterventionsNone.Main Outcomes/MeasuresThe postoperative outcomes of significance were surgical site infection (SSI), wound dehiscence, and unplanned reintubation within 30 days of CLR.ResultsThe cohort had a mean age of 4.7 ± 2.0 months and a median American Society of Anesthesiologists classification of 2. SSIs occurred in 0.6% of cases and were independently associated with bilateral cleft anatomy (OR 2.16, <i>P</i> = .003) and longer anesthesia time (OR per minute: 1.004, <i>P</i> = .009). Wound dehiscence occurred in 0.4% of patients and was independently associated with bilateral cleft anatomy (OR 4.03, <i>P</i> < .001) but was associated with shorter anesthesia duration (OR per minute: 0.991, <i>P</i> < .001). Unplanned reintubation occurred in 0.2% of cases, with these patients having significantly higher rates of multiple comorbidities.ConclusionWound dehiscence, SSI, and unplanned reintubation were rare complications following CLR. Patients with a bilateral cleft lip had increased odds of both SSI and wound dehiscence.</p>","PeriodicalId":49220,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":" ","pages":"3926-3930"},"PeriodicalIF":1.3,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147285936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}