Iranian Journal of Public Health最新文献

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In-Silico Investigation and Intelligence Analysis of Particulate Matter and Pro-Oxidant-Antioxidant Balance. 对微粒物质和促氧化剂-抗氧化剂平衡的硅内调查和情报分析。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15576
Hee-Tae Roh, Taikyeong Jeong
{"title":"In-Silico Investigation and Intelligence Analysis of Particulate Matter and Pro-Oxidant-Antioxidant Balance.","authors":"Hee-Tae Roh, Taikyeong Jeong","doi":"10.18502/ijph.v53i4.15576","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15576","url":null,"abstract":"","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Injury Experience and Safety Regulations Compliance According to Korean College Students' Use of Shared Electric Kickboards. 韩国大学生使用共用电动脚踏板的身体伤害经历和安全法规遵守情况。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15577
Sang Soo Kim, Yu-Ree Yi, Sung Bum Ju
{"title":"Physical Injury Experience and Safety Regulations Compliance According to Korean College Students' Use of Shared Electric Kickboards.","authors":"Sang Soo Kim, Yu-Ree Yi, Sung Bum Ju","doi":"10.18502/ijph.v53i4.15577","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15577","url":null,"abstract":"","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing the Subjective Health and Physical Fitness Perceptions of Korean Adolescents. 影响韩国青少年主观健康和体能观念的因素。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15564
Jeonga Kwon, Yeon Taek Kwon
{"title":"Factors Influencing the Subjective Health and Physical Fitness Perceptions of Korean Adolescents.","authors":"Jeonga Kwon, Yeon Taek Kwon","doi":"10.18502/ijph.v53i4.15564","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15564","url":null,"abstract":"<p><strong>Background: </strong>Adolescence is an important period of growth and development. We aimed to analyz the factors affecting the subjective health and physical fitness perceptions of Korean adolescents.</p><p><strong>Methods: </strong>This cross-sectional study used data from 2,599 Korean adolescents who participated in the Korea National Life and Sports Surveys during 2020-2022, along with secondary data analysis. The study included frequency analysis of the demographic variables and chi-square tests to examine the relationship between the variables and subjective health and fitness perceptions. Multivariate logistic regression was also used to explore the factors affecting adolescent subjective perceptions.</p><p><strong>Results: </strong>The study revealed significant factors influencing health perceptions in Korean adolescents, including male gender, lack of regular physical activity, adequate rest, adherence to a consistent diet, and use of nutritional supplements (<i>P<</i>0.05).</p><p><strong>Conclusion: </strong>Key factors, such as rest, diet, and nutritional supplements should be considered while developing policies that support adolescent health. Unfortunately, there has been a decline in the physical activity of adolescents in Korea. Therefore, a variety of physical activity programs that consider the characteristics of each student need to be developed to address adolescent health issues.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence of Depression among the Global Public in the Context of the COVID-19 Epidemic: A Systematic Review and Meta-Analysis. COVID-19 流行病背景下全球公众的抑郁症患病率:系统回顾与元分析》。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15555
Jiaxian Shao, Yuncong Yu, Cheng Cheng, Min Gao, Xiaona Li, Dongping Ma, Wenqiang Yin, Zhongming Chen
{"title":"The Prevalence of Depression among the Global Public in the Context of the COVID-19 Epidemic: A Systematic Review and Meta-Analysis.","authors":"Jiaxian Shao, Yuncong Yu, Cheng Cheng, Min Gao, Xiaona Li, Dongping Ma, Wenqiang Yin, Zhongming Chen","doi":"10.18502/ijph.v53i4.15555","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15555","url":null,"abstract":"<p><strong>Background: </strong>We aimed to analyze the prevalence of depression among the global public during COVID-19, identify its influencing factors in order to provide reference, and help safeguard public mental health.</p><p><strong>Methods: </strong>A comprehensive literature on global public depression in various countries during the COVID-19 pandemic was obtained through electronic searches of PubMed, Web of Science, and other databases, combined with literature tracing from Dec 2019 to Mar 2023. Then a meta-analysis was conducted using the random effects model by Stata 16.0. The heterogeneity was evaluated by <i>I<sup>2</sup></i> . Subgroup analysis, sensitivity analysis, and meta-regression analysis were used to explore the sources of heterogeneity and the factors influencing public depression. Egger's test was used to test publication bias.</p><p><strong>Results: </strong>Overall, 68 articles with 234,678 samples were included in the study. Analysis revealed that the overall prevalence of depression among the population during COVID-19 was 32.0% (95% CI: 29.0%-35.0%). Of these, marital status (OR=0.65, 95% CI: 0.47-0.87), presence of infected cases (OR=2.45, 95% CI: 1.82-3.30), and fear of being infected by the virus (OR=9.31, 95% CI: 6.03-14.37) were the main factors influencing people's depression and the main source of heterogeneity.</p><p><strong>Conclusion: </strong>The prevalence of depression among the global public is at a high level during COVID-19. The prevalence of depression among people unmarried, divorced, or widowed, surrounded by infected cases, contact infection cases, and worried about being were higher than others.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hospital Managers' Decision-Making Puzzle. 医院管理者的决策难题。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15572
Yeganeh Hayati, Ali Mohammad Mosadeghrad, Mohammad Arab
{"title":"Hospital Managers' Decision-Making Puzzle.","authors":"Yeganeh Hayati, Ali Mohammad Mosadeghrad, Mohammad Arab","doi":"10.18502/ijph.v53i4.15572","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15572","url":null,"abstract":"<p><strong>Background: </strong>Decision-making is choosing one option from among different options. Most decision-making models were developed in the general industry. Specific decision-making models are needed due to the special nature of the hospital and its services. We aimed to propose and validate a decision-making model for hospital managers.</p><p><strong>Methods: </strong>This research used the modified Delphi technique to develop and validate a decision-making model for hospital managers. A data collection form was used to collect data. The search of English databases covered the period from 1990 to 2020. The first draft of the model was introduced through a scoping review and semi-structured interviews. Two rounds of Delphi were conducted with 33 experts to verify the proposed model.</p><p><strong>Results: </strong>Many factors affect the quality and outcome of a hospital manager's decision. The decision-making model developed in this study has 10 constructs grouped into three components (i.e., inputs, processes, and outputs). These constructs include decision maker, decision implementer, organization, client, subject, analysis, identification, evaluation & selection, implementation and control. This model provides a guide for each decision stage and determines the conditions necessary for a good decision.</p><p><strong>Conclusion: </strong>Using the decision-making puzzle and considering the set of inputs, processes, and outcomes of the decision making together alongside with specifying the details of each decision-making stage make it easy for hospital managers to decide. Such a scientific, objective and systematic approach in decision-making will result in desired results for staff, patients, managers and the hospital. This puzzle is also a good tool for pathology of hospital managers' decisions.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Significance of Laboratory Tests in Bacteremic Brucellosis. 布鲁氏菌病菌血症实验室检测的预测意义
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15556
Mehmet Çelik, Yeliz Çiçek, Ebru Atalay, Deniz Altındağ, Fethiye Akgül, Fatma Yekta Ürkmez, Esra Gürbüz, Ahmet Şahin, Sevda Özdemir Al, Seval Bilgiç Atlı, Sevil Alkan, Davut İpek, Serpil Oğuz Mızrakçı, Mehmet Reşat Ceylan, Pınar Yürük Atasoy, Mustafa Kasım Karahocagil
{"title":"Predictive Significance of Laboratory Tests in Bacteremic Brucellosis.","authors":"Mehmet Çelik, Yeliz Çiçek, Ebru Atalay, Deniz Altındağ, Fethiye Akgül, Fatma Yekta Ürkmez, Esra Gürbüz, Ahmet Şahin, Sevda Özdemir Al, Seval Bilgiç Atlı, Sevil Alkan, Davut İpek, Serpil Oğuz Mızrakçı, Mehmet Reşat Ceylan, Pınar Yürük Atasoy, Mustafa Kasım Karahocagil","doi":"10.18502/ijph.v53i4.15556","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15556","url":null,"abstract":"<p><strong>Background: </strong>Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis.</p><p><strong>Methods: </strong>Patients older than 18 years of age followed up with a diagnosis of brucellosis between 2012 and 2022 were included in this retrospective multicenter study. They were divided into two main subgroups according to their <i>Brucella</i> species reproductive status as bacteremic and non-bacteremic.</p><p><strong>Results: </strong>A total of 743 patients, 370 (49.80%) bacteremic and 373 (50.20%) non-bacteremic brucellosis patients, were enrolled. The mean age of the bacteremic group (36.74 years) was lower than the non-bacteremic group (43.18 yr). High fever, chills/cold, sweating, nausea, vomiting, and weight loss were more common in the bacteremic group. In the bacteremic group, white blood cell count, platelet count, hemoglobin level, mean platelet volume, eosinophil, and neutrophil counts were lower, and lymphocyte, erythrocyte sedimentation rate, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and ferritin levels were higher. According to the receiver operating characteristic (ROC) analysis, when the cut-off value of ferritin was considered 67, it was the parameter with the strongest predictive significance in <i>Brucella</i> bacteremia.</p><p><strong>Conclusion: </strong>High ferritin level, low eosinophil count, and increased erythrocyte sedimentation rate were determined as the most critical laboratory findings in predicting bacteremia in brucellosis.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Sociodemographic Factors and Depressive Symptoms among Adult Population in Serbia. 塞尔维亚成年人口中社会人口因素与抑郁症状之间的关系。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15563
Vera Simic, Ivana Simic Vukomanovic, Svetlana Radevic, Vladimir Vukomanovic, Svetlana Djukic, Albert Darijan, Jovana Radovanovic, Viktor Selakovic, Milos Stepovic, Ermin Fetahovic, Snezana Radovanovic
{"title":"Association between Sociodemographic Factors and Depressive Symptoms among Adult Population in Serbia.","authors":"Vera Simic, Ivana Simic Vukomanovic, Svetlana Radevic, Vladimir Vukomanovic, Svetlana Djukic, Albert Darijan, Jovana Radovanovic, Viktor Selakovic, Milos Stepovic, Ermin Fetahovic, Snezana Radovanovic","doi":"10.18502/ijph.v53i4.15563","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15563","url":null,"abstract":"<p><strong>Background: </strong>Lower socioeconomic groups were more affected by depressive symptoms among adults of Serbia. In this study, we tested a model that examines association between sociodemographic factors and depressive symptoms among adult population in Serbia.</p><p><strong>Methods: </strong>The study was conducted within the National Health Survey of the Serbian population in 2019. The questionnaires used as instruments in this study were created in accordance with the questionnaires of the European Health Interview Survey -Third Wave. The Patient Health Questionnaire - 8 was used to evaluate the presence of depressive symptoms to the adult population aged 20 years and over. The relations between depression symptoms and a set of independent variables were examined with univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>The prevalence of mild depressive symptoms was 6.6%, %, the prevalence of depressive episodes was 2.2%, while 91.2% of respondents had no depressive symptoms. In the univariate regression model, depressive episodes is 1.9 times more frequent in women (OR=1.909), 6.6 times more frequent in persons over 80 years of age (OR=6.610 ), 3.1 times more frequent in divorced or without a partner (OR=3.143 ), 6.6 times more frequent in persons with low education (OR=6.609), 3.3 times more frequent in persons with a poor well-being index (OR=3.373), 3.6 times more frequent in persons inactive (OR=3.649) and 1.9 times more frequent in persons from Vojvodina (OR=1.902).</p><p><strong>Conclusion: </strong>Sociodemographic factors should be considered for policymaking and for the development of new interventions to lower prevalence of depressive symptoms in adults.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Burden of Type 2 Diabetes Mellitus and Attributable Risk Factors in Iran, 1990-2019: Results from the Global Burden of Disease Study 2019. 1990-2019 年伊朗 2 型糖尿病的负担和可归因风险因素:2019年全球疾病负担研究结果》。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15569
Maryam Peimani, Zahra Esfahani, Fatemeh Bandarian, Shahnaz Esmaeili, Sahar Saeedi Moghaddam, Nazli Namazi, Sogol Koolaji, Anita L Stewart, Narges Ebrahimi, Negar Rezaei, Nazila Rezaei, Farshad Farzadfar, Ensieh Nasli-Esfahani, Bagher Larijani
{"title":"The Burden of Type 2 Diabetes Mellitus and Attributable Risk Factors in Iran, 1990-2019: Results from the Global Burden of Disease Study 2019.","authors":"Maryam Peimani, Zahra Esfahani, Fatemeh Bandarian, Shahnaz Esmaeili, Sahar Saeedi Moghaddam, Nazli Namazi, Sogol Koolaji, Anita L Stewart, Narges Ebrahimi, Negar Rezaei, Nazila Rezaei, Farshad Farzadfar, Ensieh Nasli-Esfahani, Bagher Larijani","doi":"10.18502/ijph.v53i4.15569","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15569","url":null,"abstract":"<p><strong>Background: </strong>This study presents estimates for type 2 diabetes mellitus (T2DM) burden and attributable risk factors in Iran from 1990-2019, using data from the 2019 Global Burden of Disease study.</p><p><strong>Methods: </strong>This study reports prevalence, incidence, death, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) of T2DM in Iran, by sex, age, and province, from 1990 to 2019. We also present the T2DM burden attributable to risk factors. Results are reported in absolute number and age-standardized rates.</p><p><strong>Results: </strong>Overall, the burden of T2DM had increased greatly since 1990. In 2019, the T2DM incidence and prevalence cases were 291,482 (a 374% increase) and 5,035,012 (a 417% increase) respectively. Moreover, the number of death and DALYs were 14,191 (a 488% increase) and 716,457 (a 417% increase) respectively. DALYs and YLDs in women were consistently higher than men were, whereas women experienced slower increases in YLLs from 1990 to 2019. The age-standardized DALYs rate increased for all Iranian provinces during study period. High body-mass index, ambient particulate matter pollution, and low physical activity remained the three major attributable risk factors in all provinces in 2019.</p><p><strong>Conclusion: </strong>T2DM constitutes a major health burden in Iran. The remarkable upsurge in the T2DM burden represents an ongoing challenge, given the rapidly aging population in Iran. Thus, integrated and multi-sectoral actions that decrease exposure to risk factors and improve the prevention and early diagnosis are needed.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis. 孕产妇孕期接触砷与早产风险之间的关系:系统回顾与元分析》。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15553
Yanwen Ding, Yuxin Xu, Xiujuan Tan, Mohammad Alizadeh, Hamzeh Alizadeh
{"title":"Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis.","authors":"Yanwen Ding, Yuxin Xu, Xiujuan Tan, Mohammad Alizadeh, Hamzeh Alizadeh","doi":"10.18502/ijph.v53i4.15553","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15553","url":null,"abstract":"<p><strong>Background: </strong>Several observational studies have suggested that maternal exposure during pregnancy to arsenic is associated with the risk of preterm birth (PTB); however, available evidence is inconsistent. Therefore, we aimed to explore the relation of maternal exposure to arsenic to PTB risk.</p><p><strong>Methods: </strong>A comprehensive systematic search was carried out from inception to April 2023 in PubMed and Scopus to retrieve all relevant studies. A pooled odds ratio (OR) with corresponding 95% confidence interval (CI) was employed using a random effects model to test the association.</p><p><strong>Results: </strong>As a result, 14 eligible studies, with 12,619 participants, were included in the meta-analysis. Overall, the pooled OR of all analyzed studies indicated that higher maternal arsenic exposure is significantly related to the 1.12-fold increased odds of PTB (OR = 1.12, 95% CI = 1.04-1.21), with a remarkable heterogeneity across studies (<i>P</i> = <0.001, I<sup>2</sup> = 70.9%). This association was found in prospective cohort studies (OR = 1.15, 95% CI = 1.05-1.26), but not in non-cohort studies. In the stratified analysis, the majority of subgroups supported the association of arsenic with PTB.</p><p><strong>Conclusion: </strong>Maternal exposure to arsenic during pregnancy is directly linked to the odds of PTB. Future studies are suggested to investigate the effectiveness of specific measures to decrease exposure to arsenic in high-risk communities, particularly in pregnant women.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long non-coding RNA UCA1 Knockdown Assisted by CRISPR/Cas9 in Female Cancer Cell Lines Increases Mir-143 Tumor-Suppressor. 通过 CRISPR/Cas9 在雌性癌症细胞系中敲除长非编码 RNA UCA1 可增加 Mir-143 肿瘤抑制因子。
IF 1.3 4区 医学
Iranian Journal of Public Health Pub Date : 2024-04-01 DOI: 10.18502/ijph.v53i4.15571
Behshad Montazeri-Najafabadi, Abbas Doosti, Jafar Kiani
{"title":"Long non-coding RNA <i>UCA1</i> Knockdown Assisted by CRISPR/Cas9 in Female Cancer Cell Lines Increases Mir-143 <i>Tumor-Suppressor</i>.","authors":"Behshad Montazeri-Najafabadi, Abbas Doosti, Jafar Kiani","doi":"10.18502/ijph.v53i4.15571","DOIUrl":"https://doi.org/10.18502/ijph.v53i4.15571","url":null,"abstract":"<p><strong>Background: </strong>The lncRNAs has been linked to several malignancies, including breast cancer. Our objective was to investigate the impact of urothelial carcinoma associated 1 (<i>UCA1</i>) on cellular growth and death by a CRISPR/Cas9 knockdown technique.</p><p><strong>Methods: </strong>In 2020, the CHOPCHOP program was utilized to design two sgRNAs targeting the <i>UCA ge</i>ne. sgRNA1 and sgRNA2 were inserted into two different CRISPR plasmids to produce two recombinant plasmids. These recombinant plasmids were simultaneously transfected into MCF-7 and MDA-MB 231 carcinoma of the breast cells. Proliferation and apoptosis were compared using the MTT test, CCK-8 assay, and flow cytometry evaluation. RNA-hybrid software, quantitative reverse transcription PCR, and luciferase assays were utilized to confirm the relationship between <i>UCA1</i> and miR-143.</p><p><strong>Results: </strong>Proliferated cells were less active in MTT and CCK-8 tests and fellow cytometry analysis. The PX459-sgRNA1,2 group had elevated levels of the cancer biomarker <i>Caspase-3</i> gene expression (<i>P</i><0.001). When WT-<i>UCA1</i> and miR-143 were co-transfected, the luciferase activity was drastically decreased.</p><p><strong>Conclusion: </strong>One very effective method of regulating cellular proliferation in vitro is the deletion of <i>UCA1</i>, which CRISPR/Cas9 accomplishes.</p>","PeriodicalId":49173,"journal":{"name":"Iranian Journal of Public Health","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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