Maternal Fasting Plasma Glucose, Age and Body Mass Index as Prediction of Gestational Diabetes Mellitus in Iran.

IF 1.3 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Iranian Journal of Public Health Pub Date : 2024-10-01 DOI:10.18502/ijph.v53i10.16723

Sedigheh Hantoushzadeh, Mamak Shariat, Leyla Sahebi, Minor Lamiyan, Lida Moghaddam-Banaem, Raheleh Moradi

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Abstract

Background: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that can lead to adverse outcomes. In this retrospective cohort study, maternal fasting blood sugar (FBS) in the second trimester of pregnancy, body mass index (BMI), and age were assessed as potential screening indicators of later GDM.

Methods: The study population included information on 4007 Iranian pregnant women documented by the Integrated Health Record System (SIB) record system (2019-2020).

Results: In the adjusted analysis, FBS maintained a significant relationship with GDM (P ≤0.001). In the simple ROC analysis, the AUC (SE) of FBS for the prediction of GDM was 0.905(0.09), and considering the cut-off point as 85.95, sensitivity (Se) and specificity (Sp) were equal to 0.81 and 0.71, respectively, but by stillbirth, abortion, prematurity, neonatal weight, height, and head circumference not obtained acceptable AUC (≥.60) for detection of FBS cut-off point. The cut-off point of FBS in the presence of maternal age (AUC>0.6) and BMI (AUC>0.6) by GDM was 83.75(Se= 86.4%, Sp= 80.0%).

Conclusion: Based on the evidence presented, maternal weight and BMI are important in predicting hyperglycemia leading to GDM. It is necessary to conduct more precise national studies to standardize the FBS cut-off point by controlling age and BMI variables.

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伊朗孕妇空腹血浆葡萄糖、年龄和体重指数对妊娠糖尿病的预测作用。

背景：妊娠糖尿病（GDM）是一种常见的妊娠并发症，可导致不良后果。在这项回顾性队列研究中，孕妇在妊娠后三个月的空腹血糖（FBS）、体重指数（BMI）和年龄被评估为日后 GDM 的潜在筛查指标：研究对象包括由综合健康记录系统（SIB）记录系统（2019-2020年）记录的4007名伊朗孕妇的信息：在调整分析中，FBS与GDM保持显著关系（P≤0.001）。在简单ROC分析中，FBS预测GDM的AUC（SE）为0.905（0.09），考虑临界点为85.95，灵敏度（Se）和特异度（Sp）分别等于0.81和0.71，但通过死胎、流产、早产、新生儿体重、身高和头围检测FBS临界点未获得可接受的AUC（≥.60）。在 GDM 存在产妇年龄（AUC>0.6）和体重指数（AUC>0.6）的情况下，FBS 临界点为 83.75（Se= 86.4%，Sp= 80.0%）：根据所提供的证据，孕产妇体重和体重指数对预测导致 GDM 的高血糖非常重要。有必要开展更精确的全国性研究，通过控制年龄和体重指数变量来统一 FBS 临界点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

2.20

自引率

7.10%

发文量

300

审稿时长

3-8 weeks

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.