Nature Reviews Neuroscience最新文献_第5页

Reply to ‘Causal prominence for neuroscience’ 回复 "神经科学的因果关系"。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-20 DOI: 10.1038/s41583-024-00839-5

Lauren N. Ross, Dani S. Bassett

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Causal prominence for neuroscience 神经科学的因果关系突出。

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Nature Reviews Neuroscience Pub Date : 2024-06-20 DOI: 10.1038/s41583-024-00838-6

Philip Tseng, Tony Cheng

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The power of direct observation: discovery of REM sleep 直接观察的力量：快速眼动睡眠的发现。

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Nature Reviews Neuroscience Pub Date : 2024-06-20 DOI: 10.1038/s41583-024-00840-y

Danqian Liu

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Gene therapy for CNS disorders: modalities, delivery and translational challenges 中枢神经系统疾病的基因治疗：模式、传输和转化挑战

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Nature Reviews Neuroscience Pub Date : 2024-06-19 DOI: 10.1038/s41583-024-00829-7

Jingjing Gao, Swetharajan Gunasekar, Ziting (Judy) Xia, Kiruba Shalin, Christopher Jiang, Hao Chen, Dongtak Lee, Sohyung Lee, Nishkal D. Pisal, James N. Luo, Ana Griciuc, Jeffrey M. Karp, Rudolph Tanzi, Nitin Joshi

{"title":"Gene therapy for CNS disorders: modalities, delivery and translational challenges","authors":"Jingjing Gao, Swetharajan Gunasekar, Ziting (Judy) Xia, Kiruba Shalin, Christopher Jiang, Hao Chen, Dongtak Lee, Sohyung Lee, Nishkal D. Pisal, James N. Luo, Ana Griciuc, Jeffrey M. Karp, Rudolph Tanzi, Nitin Joshi","doi":"10.1038/s41583-024-00829-7","DOIUrl":"10.1038/s41583-024-00829-7","url":null,"abstract":"Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of recently approved gene therapies for the treatment of spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and active cerebral adrenoleukodystrophy are encouraging further development of this approach. However, most attempts to translate gene therapy to the clinic have failed to make it to market. There is an urgent need not only to tailor the genes that are targeted to the pathology of interest but to also address delivery challenges and thereby maximize the utility of genetic tools. In this Review, we provide an overview of gene therapy modalities for CNS diseases, emphasizing the interconnectedness of different delivery strategies and routes of administration. Important gaps in understanding that could accelerate the clinical translatability of CNS genetic interventions are addressed, and we present lessons learned from failed clinical trials that may guide the future development of gene therapies for the treatment and management of CNS disorders. Recent advances in the development of gene therapy tools provide hope that these approaches might modulate the altered gene expression that characterizes many CNS disorders. Gao et al. provide an overview of current gene therapy strategies, highlighting the interdependence of therapeutic modality, delivery vehicle and administration route for translational success.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 8","pages":"553-572"},"PeriodicalIF":28.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141425370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lessons on predictive learning from the honeybee 蜜蜂的预测学习经验

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-11 DOI: 10.1038/s41583-024-00835-9

Sabine Krabbe

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Fear, anxiety and the functional architecture of the human central extended amygdala 恐惧、焦虑和人类中央扩展杏仁核的功能结构。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-10 DOI: 10.1038/s41583-024-00832-y

Alexander J. Shackman, Shannon E. Grogans, Andrew S. Fox

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Reply to ‘Fear, anxiety and the functional architecture of the human central extended amygdala’ 对 "恐惧、焦虑和人类中央扩展杏仁核的功能结构 "的答复

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-10 DOI: 10.1038/s41583-024-00834-w

Liping Wang, Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Sheng He

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A pas de deux between the hippocampus and the cortex during sleep 睡眠时海马体与大脑皮层的双人舞

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-05 DOI: 10.1038/s41583-024-00828-8

Adrien Peyrache

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Pattern recognition using action potential timing 利用动作电位定时进行模式识别

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-06-03 DOI: 10.1038/s41583-024-00831-z

Izumi Fukunaga

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Common principles for odour coding across vertebrates and invertebrates 脊椎动物和无脊椎动物气味编码的共同原则。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-05-28 DOI: 10.1038/s41583-024-00822-0

Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta

{"title":"Common principles for odour coding across vertebrates and invertebrates","authors":"Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta","doi":"10.1038/s41583-024-00822-0","DOIUrl":"10.1038/s41583-024-00822-0","url":null,"abstract":"The olfactory system is an ideal and tractable system for exploring how the brain transforms sensory inputs into behaviour. The basic tasks of any olfactory system include odour detection, discrimination and categorization. The challenge for the olfactory system is to transform the high-dimensional space of olfactory stimuli into the much smaller space of perceived objects and valence that endows odours with meaning. Our current understanding of how neural circuits address this challenge has come primarily from observations of the mechanisms of the brain for processing other sensory modalities, such as vision and hearing, in which optimized deep hierarchical circuits are used to extract sensory features that vary along continuous physical dimensions. The olfactory system, by contrast, contends with an ill-defined, high-dimensional stimulus space and discrete stimuli using a circuit architecture that is shallow and parallelized. Here, we present recent observations in vertebrate and invertebrate systems that relate the statistical structure and state-dependent modulation of olfactory codes to mechanisms of perception and odour-guided behaviour. The detection, discrimination and categorization of odours are essential for survival across the animal kingdom. In this Review, Datta and co-workers describe and compare the neural circuits that mediate the processing of olfactory information and the key principles of olfactory coding in insects and mammals.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 7","pages":"453-472"},"PeriodicalIF":28.7,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0