Thicker perineuronal nets disrupt insulin signalling

IF 28.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2024-09-26 DOI:10.1038/s41583-024-00872-4

Sian Lewis

引用次数: 0

Abstract

Diet-induced obesity in mice is accompanied by hypothalamic inflammation, which is shown here to result in thickened perineuronal nets in arcuate nucleus neurons, insulin resistance and metabolic disease.

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增厚的神经元周围网会干扰胰岛素信号传导

饮食诱发的小鼠肥胖伴随着下丘脑炎症，而下丘脑炎症会导致弓状核神经元的神经元周围网增厚、胰岛素抵抗和代谢疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.