Nature Reviews Neuroscience最新文献_第4页

Ruminating on replay during the awake state 清醒状态下的回放反思

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-20 DOI: 10.1038/s41583-024-00885-z

Anna K. Gillespie

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Structural neural plasticity evoked by rapid-acting antidepressant interventions 速效抗抑郁剂干预诱发的结构性神经可塑性。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-18 DOI: 10.1038/s41583-024-00876-0

Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan

{"title":"Structural neural plasticity evoked by rapid-acting antidepressant interventions","authors":"Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan","doi":"10.1038/s41583-024-00876-0","DOIUrl":"10.1038/s41583-024-00876-0","url":null,"abstract":"A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of treatment with fairly rapid antidepressant effects (within days or a few weeks), such as ketamine, electroconvulsive therapy and non-invasive neurostimulation, seem to converge on enhancement of neural plasticity. However, the forms and mechanisms of plasticity that link antidepressant interventions to the restoration of excitatory synaptic function are still unknown. In this Review, we highlight preclinical research from the past 15 years showing that ketamine and psychedelic drugs can trigger the growth of dendritic spines in cortical pyramidal neurons. We compare the longitudinal effects of various psychoactive drugs on neuronal rewiring, and we highlight rapid onset and sustained time course as notable characteristics for putative rapid-acting antidepressant drugs. Furthermore, we consider gaps in the current understanding of drug-evoked in vivo structural plasticity. We also discuss the prospects of using synaptic remodelling to understand other antidepressant interventions, such as repetitive transcranial magnetic stimulation. Finally, we conclude that structural neural plasticity can provide unique insights into the neurobiological actions of psychoactive drugs and antidepressant interventions. Rapid-acting antidepressant interventions, such as ketamine and psilocybin, are thought to enhance neural plasticity. This Review outlines evidence of synaptic deficits in individuals with major depressive disorder before discussing in vivo longitudinal studies of antidepressant-evoked structural plasticity in rodents. Translational opportunities, research gaps and challenges are also considered.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 2","pages":"101-114"},"PeriodicalIF":28.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immune control of synapse development 突触发育的先天免疫控制

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-18 DOI: 10.1038/s41583-024-00887-x

Katherine Whalley

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Issues of parcellation in the calculation of structure–function coupling 结构-功能耦合计算中的解析问题。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-14 DOI: 10.1038/s41583-024-00877-z

Adam Turnbull, Feng Vankee Lin, Zhengwu Zhang

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Reply to ‘Issues of parcellation in the calculation of structure–function coupling’ 对 "结构-功能耦合计算中的分割问题 "的答复

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-14 DOI: 10.1038/s41583-024-00878-y

Panagiotis Fotiadis, Dani S. Bassett

引用次数: 0

A new target for leptin 瘦素的新目标

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-13 DOI: 10.1038/s41583-024-00884-0

Michael Attwaters

引用次数: 0

Opening the gate to regeneration 打开再生之门

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-10-28 DOI: 10.1038/s41583-024-00875-1

Sian Lewis

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Fly connectome over the wire 飞越铁丝网

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-10-28 DOI: 10.1038/s41583-024-00879-x

Jake Rogers

引用次数: 0

Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers 注意缺陷多动障碍的神经生物学：历史挑战与新兴前沿

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-10-24 DOI: 10.1038/s41583-024-00869-z

Sanju Koirala, Gracie Grimsrud, Michael A. Mooney, Bart Larsen, Eric Feczko, Jed T. Elison, Steven M. Nelson, Joel T. Nigg, Brenden Tervo-Clemmens, Damien A. Fair

{"title":"Neurobiology of attention-deficit hyperactivity disorder: historical challenges and emerging frontiers","authors":"Sanju Koirala, Gracie Grimsrud, Michael A. Mooney, Bart Larsen, Eric Feczko, Jed T. Elison, Steven M. Nelson, Joel T. Nigg, Brenden Tervo-Clemmens, Damien A. Fair","doi":"10.1038/s41583-024-00869-z","DOIUrl":"10.1038/s41583-024-00869-z","url":null,"abstract":"Extensive investigations spanning multiple levels of inquiry, from genetic to behavioural studies, have sought to unravel the mechanistic foundations of attention-deficit hyperactivity disorder (ADHD), with the aspiration of developing efficacious treatments for this condition. Despite these efforts, the pathogenesis of ADHD remains elusive. In this Review, we reflect on what has been learned about ADHD while also providing a framework that may serve as a roadmap for future investigations. We emphasize that ADHD is a highly heterogeneous disorder with multiple aetiologies that necessitates a multifactorial dimensional phenotype, rather than a fixed dichotomous conceptualization. We highlight new findings that suggest a more brain-wide, ‘global’ view of the disorder, rather than the traditional localizationist framework, which asserts that a limited set of brain regions or networks underlie ADHD. Last, we underscore how underpowered studies that have aimed to associate neurobiology with ADHD phenotypes have long precluded the field from making progress. However, a new age of ADHD research with refined phenotypes, advanced methods, creative study designs and adequately powered investigations is beginning to put the field on a good footing. Indeed, the field is at a promising juncture to advance the neurobiological understanding of ADHD and fulfil the promise of clinical utility. Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition that is poorly understood at a neurobiological level. In this Review, Fair and colleagues examine studies of ADHD neurobiology and provide a perspective on how the field may move forward.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 12","pages":"759-775"},"PeriodicalIF":28.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social and emotional learning in the cerebellum 小脑的社交和情感学习

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-10-21 DOI: 10.1038/s41583-024-00871-5

Frank Van Overwalle

{"title":"Social and emotional learning in the cerebellum","authors":"Frank Van Overwalle","doi":"10.1038/s41583-024-00871-5","DOIUrl":"10.1038/s41583-024-00871-5","url":null,"abstract":"The posterior cerebellum has a critical role in human social and emotional learning. Three systems and related neural networks support this cerebellar function: a biological action observation system as part of an extended sensorimotor integration network, a mentalizing system for understanding a person’s mental and emotional state subserved by a mentalizing network, and a limbic network supporting core emotional (dis)pleasure and arousal processes. In this Review, I describe how these systems and networks support social and emotional learning via functional reciprocal connections initiating and terminating in the posterior cerebellum and cerebral neocortex. It is hypothesized that a major function of the posterior cerebellum is to identify and encode temporal sequences of events, which might help to fine-tune and automatize social and emotional learning. I discuss research using neuroimaging and non-invasive stimulation that provides converging evidence for this hypothesized function of cerebellar sequencing, but also other potential functional accounts of the posterior cerebellum’s role in these social and emotional processes. The cerebellum’s canonical role in learning is expanding beyond movement coordination. In this Review, Van Overwalle details the systems and networks facilitating the cerebellum’s role in human social and emotional learning and discusses whether cerebellar temporal sequencing might account for this functionality.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"25 12","pages":"776-791"},"PeriodicalIF":28.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0