Nature Reviews Neuroscience最新文献_第2页

The vascular contribution to cognitive decline in ageing and dementia 血管对衰老和痴呆认知能力下降的贡献。

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-08-04 DOI: 10.1038/s41583-025-00950-1

Silvia Anderle, Michael Dixon, Tania Quintela-Lopez, George Sideris-Lampretsas, David Attwell

{"title":"The vascular contribution to cognitive decline in ageing and dementia","authors":"Silvia Anderle, Michael Dixon, Tania Quintela-Lopez, George Sideris-Lampretsas, David Attwell","doi":"10.1038/s41583-025-00950-1","DOIUrl":"10.1038/s41583-025-00950-1","url":null,"abstract":"There is increasing evidence to suggest that vascular dysfunction can contribute to cognitive decline in ageing and dementia. This dysfunction can take the form of a reduction of cerebral blood flow (CBF), a loss of blood–brain barrier (BBB) function or a combination of the two. Indeed, CBF and BBB changes may be causally linked, although this possible causality and its directionality are understudied. Appreciation of the role of vascular dysfunction in initiating cognitive decline in ageing and dementia, as well as the mechanisms involved, is important because it opens up new avenues for the development of much-needed therapies for these conditions, which are becoming major causes of death. Here we assess the evidence for the importance of vascular contributions to dementia, draw parallels with changes that occur in normal ageing and discuss the initiating cells and signalling mechanisms involved. We suggest that attempting to maintain or restore CBF should be a central aim of therapeutic strategies. Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences of vascular dysfunction in ageing, Alzheimer disease and vascular dementia, and consider the implications for therapeutic interventions.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"591-606"},"PeriodicalIF":26.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A maturing view on interneuron development 关于中间神经元发育的成熟观点。

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-08-04 DOI: 10.1038/s41583-025-00955-w

Darran Yates

引用次数: 0

Prior learning governs human experience-based risk-taking 先前的学习支配着人类基于经验的冒险行为

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-31 DOI: 10.1038/s41583-025-00953-y

Jake Rogers

引用次数: 0

Sensory modality-specific wiring of thalamocortical circuits 丘脑皮层回路的感觉模式特异性布线

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-30 DOI: 10.1038/s41583-025-00945-y

Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Francisco J. Martini, Guillermina López-Bendito

{"title":"Sensory modality-specific wiring of thalamocortical circuits","authors":"Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Francisco J. Martini, Guillermina López-Bendito","doi":"10.1038/s41583-025-00945-y","DOIUrl":"10.1038/s41583-025-00945-y","url":null,"abstract":"The thalamus is an essential element for sensory information processing, serving as a link between peripheral sensory stimuli and cortical circuits. Consequently, the development of thalamocortical (TC) projections has been a central focus in systems neuroscience. Although substantial progress has been made in understanding the mechanisms guiding thalamic axon navigation from the diencephalon to the cortex, our understanding of the processes underlying sensory modality specificity in TC circuits remains incomplete. Modern genomic, physiological and imaging approaches have yielded exciting results, providing novel insights into the specialization of visual, somatosensory and auditory TC circuits. Recent findings have shed light on the genetic and spontaneous activity mechanisms involved in the formation of distinct sensory modalities, rekindling the interest in the thalamus and opening new research perspectives on the development of this diencephalic structure. The use of transcriptomic technologies has led to advances in our understanding of thalamocortical targeting during development. In this Review, Guillamón-Vivancos et al. discuss these advances in the context of how transcriptomic changes and neuronal activity work in concert to drive sensory modality specificity during the development of thalamic sensory nuclei.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"623-641"},"PeriodicalIF":26.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye movements provide insight into amnesia 眼球运动让我们了解健忘症

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-28 DOI: 10.1038/s41583-025-00952-z

Mariam Aly

引用次数: 0

Early adversity alters brain architecture and increases susceptibility to mental health disorders 早期的逆境改变了大脑结构，增加了对精神健康障碍的易感性

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-24 DOI: 10.1038/s41583-025-00948-9

Charles A. Nelson, Eileen F. Sullivan, Viviane Valdes

{"title":"Early adversity alters brain architecture and increases susceptibility to mental health disorders","authors":"Charles A. Nelson, Eileen F. Sullivan, Viviane Valdes","doi":"10.1038/s41583-025-00948-9","DOIUrl":"10.1038/s41583-025-00948-9","url":null,"abstract":"Each year, millions of children around the world are exposed to a host of adverse experiences early in life. These include various forms of maltreatment, growing up in unsafe neighbourhoods, and witnessing intimate partner violence. These experiences exact a toll on the brain development and mental health of children. In this Review, we attempt to explain how brain architecture and circuitry are affected by exposure to such early adversity, which in turn increases susceptibility to mental health disorders later in life. We begin defining what we mean by early adversity and then summarize the experience-dependent nature of postnatal brain development. Within this context, we discuss times in development when the brain is particularly receptive to experience (critical periods) and, thus, is more vulnerable to adverse experiences. Drawing from studies with both rodent and non-human primate models and neuroimaging research with humans, we next discuss how the circuitry of the brain is affected by early-life adversity, with a focus on the subsequent effects upon neural network development. We then review the mental health consequences of adverse experiences in early life across mental health disorders and within specific dimensions of psychopathology. We conclude by offering a conceptual model of the pathway that links exposure to adversity early in life to these mental health outcomes later in life, and we provide suggestions for future research. Adverse experiences in early life affect brain development across species. In this Review, Nelson, Sullivan and Valdes discuss neuroimaging evidence for how these adversity-induced changes to human brain architecture alter developmental trajectories that may underpin adult psychopathology.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"642-656"},"PeriodicalIF":26.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Top-down and bottom-up neuroscience: overcoming the clash of research cultures 自上而下和自下而上的神经科学：克服研究文化的冲突

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-21 DOI: 10.1038/s41583-025-00946-x

Fernando E. Rosas, Andrea I. Luppi, Pedro A. M. Mediano, Morten L. Kringelbach, Luiz Pessoa, Federico Turkheimer

引用次数: 0

Reward encoded relative to experience 与经验相关的奖励编码

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-17 DOI: 10.1038/s41583-025-00951-0

Jake Rogers

引用次数: 0

Towards single-cell-resolution global maps of mammalian brains 迈向哺乳动物大脑单细胞分辨率全球地图

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-16 DOI: 10.1038/s41583-025-00949-8

Chengyu T. Li, Wu Wei

引用次数: 0

Molecular and functional diversity of the autonomic nervous system 自主神经系统的分子和功能多样性

IF 26.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-03 DOI: 10.1038/s41583-025-00941-2

Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola, Yuki Oka

{"title":"Molecular and functional diversity of the autonomic nervous system","authors":"Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola, Yuki Oka","doi":"10.1038/s41583-025-00941-2","DOIUrl":"10.1038/s41583-025-00941-2","url":null,"abstract":"The autonomic nervous system (ANS) plays a pivotal role in regulating organ functions through descending brain-to-body signalling. The pathways involved are broadly categorized into two major branches: the sympathetic nervous system, which mediates ‘fight or flight’ responses, and the parasympathetic nervous system, which governs ‘rest and digest’ functions. Historically, the ANS was considered to mediate simple motor functions with limited neurochemical diversity. However, recent advances in neurotechnology have shown that brain-to-body communication is more complex and dynamic than previously appreciated. This review synthesizes current knowledge about the molecular, anatomical and functional diversity of autonomic motor neurons. Here we present a comparative analysis of the cellular architecture of the ANS and the suggested roles of distinct neuron populations. Additionally, we explore the emerging view that the ANS interacts with diverse systems involving metabolism, immunology and ageing, which extends its role beyond simple brain–organ modulation. Finally, we emphasize the need for cell-type-specific and longitudinal studies of the ANS to uncover novel mechanisms underlying body–brain interactions and to identify new translational opportunities for therapeutic interventions. The autonomic nervous system has long been viewed as a simple motor system in brain-to-body signalling. In this review, Wang and colleagues highlight diversity within autonomic neurons and their dynamic roles across physiological systems and disease contexts.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 10","pages":"607-622"},"PeriodicalIF":26.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0