Nature Reviews Neuroscience最新文献_第2页

Targeting TYK2 to target tau 以 TYK2 为靶标瞄准 tau

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-28 DOI: 10.1038/s41583-024-00890-2

Caroline Barranco

引用次数: 0

Neural circuit basis of pathological anxiety 病态焦虑的神经回路基础

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-27 DOI: 10.1038/s41583-024-00880-4

Teddy J. Akiki, Jenna Jubeir, Claire Bertrand, Leonardo Tozzi, Leanne M. Williams

{"title":"Neural circuit basis of pathological anxiety","authors":"Teddy J. Akiki, Jenna Jubeir, Claire Bertrand, Leonardo Tozzi, Leanne M. Williams","doi":"10.1038/s41583-024-00880-4","DOIUrl":"10.1038/s41583-024-00880-4","url":null,"abstract":"Anxiety disorders are the most prevalent mental health conditions worldwide. Unfortunately, the understanding of the precise neurobiological mechanisms that underlie these disorders remains limited. Current diagnostic classifications, based on observable symptoms rather than underlying pathophysiology, do not capture the heterogeneity within and across anxiety disorders. Recent advances in functional neuroimaging have provided new insights into the neural circuits implicated in pathological anxiety, revealing dysfunctions that cut across traditional diagnostic boundaries. In this Review, we synthesize evidence that highlights abnormalities in neurobehavioural systems related to negative valence, positive valence, cognitive systems and social processes. We emphasize that pathological anxiety arises not only from heightened reactivity in acute threat (‘fear’) circuits but also from alterations in circuits that mediate distant (potential) and sustained threat, reward processing, cognitive control and social processing. We discuss how circuit vulnerabilities can lead to the emergence and maintenance of pathological anxiety. Once established, these neural abnormalities can be exacerbated by maladaptive behaviours that prevent extinction learning and perpetuate anxiety disorders. By delineating the specific neural mechanisms in each neurobiological system, we aim to contribute to a more comprehensive understanding of the neurobiology of anxiety disorders, potentially informing future research directions in this field. Delineating the neurobiology of pathological anxiety remains challenging. In this Review, Akiki et al. synthesize task-based functional MRI evidence for how vulnerabilities within circuits that mediate acute, distant and sustained threat, reward processing, cognitive control and social processing can lead to its emergence and maintenance.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 1","pages":"5-22"},"PeriodicalIF":28.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echolocation over long distances 远距离回声定位

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-26 DOI: 10.1038/s41583-024-00891-1

Michael Attwaters

引用次数: 0

An interoceptive circuit regulating energy balance 调节能量平衡的感知回路

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-26 DOI: 10.1038/s41583-024-00889-9

Sian Lewis

引用次数: 0

Ruminating on replay during the awake state 清醒状态下的回放反思

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-20 DOI: 10.1038/s41583-024-00885-z

Anna K. Gillespie

引用次数: 0

Structural neural plasticity evoked by rapid-acting antidepressant interventions 速效抗抑郁剂干预诱发的结构性神经可塑性。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-18 DOI: 10.1038/s41583-024-00876-0

Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan

{"title":"Structural neural plasticity evoked by rapid-acting antidepressant interventions","authors":"Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan","doi":"10.1038/s41583-024-00876-0","DOIUrl":"10.1038/s41583-024-00876-0","url":null,"abstract":"A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of treatment with fairly rapid antidepressant effects (within days or a few weeks), such as ketamine, electroconvulsive therapy and non-invasive neurostimulation, seem to converge on enhancement of neural plasticity. However, the forms and mechanisms of plasticity that link antidepressant interventions to the restoration of excitatory synaptic function are still unknown. In this Review, we highlight preclinical research from the past 15 years showing that ketamine and psychedelic drugs can trigger the growth of dendritic spines in cortical pyramidal neurons. We compare the longitudinal effects of various psychoactive drugs on neuronal rewiring, and we highlight rapid onset and sustained time course as notable characteristics for putative rapid-acting antidepressant drugs. Furthermore, we consider gaps in the current understanding of drug-evoked in vivo structural plasticity. We also discuss the prospects of using synaptic remodelling to understand other antidepressant interventions, such as repetitive transcranial magnetic stimulation. Finally, we conclude that structural neural plasticity can provide unique insights into the neurobiological actions of psychoactive drugs and antidepressant interventions. Rapid-acting antidepressant interventions, such as ketamine and psilocybin, are thought to enhance neural plasticity. This Review outlines evidence of synaptic deficits in individuals with major depressive disorder before discussing in vivo longitudinal studies of antidepressant-evoked structural plasticity in rodents. Translational opportunities, research gaps and challenges are also considered.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"26 2","pages":"101-114"},"PeriodicalIF":28.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immune control of synapse development 突触发育的先天免疫控制

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-18 DOI: 10.1038/s41583-024-00887-x

Katherine Whalley

引用次数: 0

Issues of parcellation in the calculation of structure–function coupling 结构-功能耦合计算中的解析问题。

IF 28.7 1区医学

Nature Reviews Neuroscience Pub Date : 2024-11-14 DOI: 10.1038/s41583-024-00877-z

Adam Turnbull, Feng Vankee Lin, Zhengwu Zhang