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Rhythms alone cannot explain subjective time 节奏本身不能解释主观时间
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-26 DOI: 10.1038/s41583-026-01024-6
Carmelo Mario Vicario
{"title":"Rhythms alone cannot explain subjective time","authors":"Carmelo Mario Vicario","doi":"10.1038/s41583-026-01024-6","DOIUrl":"10.1038/s41583-026-01024-6","url":null,"abstract":"","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"236-236"},"PeriodicalIF":26.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cracking the code of gut–brain sensing 破解肠道-大脑感知的密码
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-23 DOI: 10.1038/s41583-026-01023-7
Lihua Ye
{"title":"Cracking the code of gut–brain sensing","authors":"Lihua Ye","doi":"10.1038/s41583-026-01023-7","DOIUrl":"10.1038/s41583-026-01023-7","url":null,"abstract":"In this Journal Club, Lihua Ye highlights a 2016 paper that characterized the vagal sensory neuron subtypes that transmit different sensory signals from the digestive tract, advancing our understanding of gut–brain communication.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"158-158"},"PeriodicalIF":26.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A roadmap for conducting more inclusive research on brain resilience in ageing and dementia 在衰老和痴呆症中开展更具包容性的大脑恢复力研究的路线图
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-23 DOI: 10.1038/s41583-025-01021-1
M. Natasha Rajah, Roger A. Dixon, Gillian Einstein, Yaakov Stern, The Brain Resilience and Diversity in Aging and Dementia Collaboratory
{"title":"A roadmap for conducting more inclusive research on brain resilience in ageing and dementia","authors":"M. Natasha Rajah, Roger A. Dixon, Gillian Einstein, Yaakov Stern, The Brain Resilience and Diversity in Aging and Dementia Collaboratory","doi":"10.1038/s41583-025-01021-1","DOIUrl":"10.1038/s41583-025-01021-1","url":null,"abstract":"The variability in cognitive and brain ageing trajectories may be influenced by inter-individual and community-level differences in resilience that result from differential exposures to social and structural determinants of health and be affected by an individual’s sex and gender. However, no clear guidance exists on how to best integrate these diversity-related factors (that is, sex, gender and social and structural determinants of health) into clinical and cognitive neuroscience research on resilience in ageing and dementia. The international Brain Resilience and Diversity in Aging and Dementia (BReDAD) Collaboratory was established in 2024 with the goals of synthesizing knowledge, identifying knowledge gaps and developing recommendations for conducting more inclusive research on resilience in this area. On the basis of a focused review of the literature, and discussions held and recommendations made by the Collaboratory, in this Roadmap article, we present a way forward for integrating diversity in future resilience research. This proposal comprises: (i) developing trust and meaningful long-term relationships with communities historically excluded from research; (ii) diversifying who is engaged in all aspects of the research process; (iii) adopting a life-course perspective; (iv) improving and expanding research designs and measurement tools; and (v) using sensitive computational analytics and mixed methods for testing complex, intersectional models. We conclude by recommending a transdisciplinary approach in resilience research to better reflect the complexities inherent in studying diversity and developing precision medicine outcomes. Guidance is lacking on how to best integrate sex, gender and social and structural determinants of health into neuroscience research on brain resilience in ageing and dementia. In this Roadmap article, Rajah et al. propose a way forward for conducting more inclusive research in this field.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 4","pages":"278-288"},"PeriodicalIF":26.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory neuron signals drive bone repair 感觉神经元信号驱动骨修复。
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-22 DOI: 10.1038/s41583-026-01027-3
Katherine Whalley
{"title":"Sensory neuron signals drive bone repair","authors":"Katherine Whalley","doi":"10.1038/s41583-026-01027-3","DOIUrl":"10.1038/s41583-026-01027-3","url":null,"abstract":"In mice, the sensory neurons that innervate the skeleton signal via FGF9 to promote bone repair after fracture.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 4","pages":"242-242"},"PeriodicalIF":26.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146021428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental decision neuroscience connects the brain to climate action 环境决策神经科学将大脑与气候行动联系起来。
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-21 DOI: 10.1038/s41583-026-01026-4
Daria Knoch, Annika M. Wyss
{"title":"Environmental decision neuroscience connects the brain to climate action","authors":"Daria Knoch, Annika M. Wyss","doi":"10.1038/s41583-026-01026-4","DOIUrl":"10.1038/s41583-026-01026-4","url":null,"abstract":"Climate change is driven by individual behaviour, yet little is known about how people make environmental choices. Environmental decision neuroscience examines the neural processes behind consequential climate-relevant decisions, and has revealed three core mechanisms that are beginning to crystallize as central to sustainable action.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"151-152"},"PeriodicalIF":26.7,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behaviour without synapses: peptidergic signalling as a mode of behavioural coordination 没有突触的行为：作为行为协调模式的肽能信号。
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-16 DOI: 10.1038/s41583-026-01022-8
Arjen J. Boender
{"title":"Behaviour without synapses: peptidergic signalling as a mode of behavioural coordination","authors":"Arjen J. Boender","doi":"10.1038/s41583-026-01022-8","DOIUrl":"10.1038/s41583-026-01022-8","url":null,"abstract":"In this Journal Club, Arjen Boender describes a 2017 study that showed that diffusible peptidergic signals coordinate behaviour in Trichoplax adhaerens, a tiny marine animal that lacks a nervous system.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"157-157"},"PeriodicalIF":26.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diverse forms and roles of the neuronal endoplasmic reticulum 神经元内质网的多种形态和作用。
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-13 DOI: 10.1038/s41583-025-01016-y
Lia G. Carvalhais, Koen Kole, Marijn Kuijpers
{"title":"The diverse forms and roles of the neuronal endoplasmic reticulum","authors":"Lia G. Carvalhais, Koen Kole, Marijn Kuijpers","doi":"10.1038/s41583-025-01016-y","DOIUrl":"10.1038/s41583-025-01016-y","url":null,"abstract":"Neurons are structurally complex and highly compartmentalized, placing unique demands on organelles to adapt locally and support communication across long distances. The endoplasmic reticulum (ER) meets this challenge through a dynamic and versatile architecture that spans the entire neuron. While specialized ER structures in axons, dendrites and synapses have been recognized for some time, recent work has uncovered new insights into their local functions and interactions with other membranes. In this Review, we highlight how neuronal ER morphology is established in different subcellular domains, including somato-dendritic regions, axons, and presynaptic and postsynaptic sites. These distinct ER structures enable localized functions in Ca2+ signalling, biosynthesis, excitability, regeneration, synaptic transmission and plasticity. We also discuss how perturbations in the ER contribute to neurodegenerative diseases. The dynamic and versatile architecture of the neuronal endoplasmic reticulum (ER) enables it to support a wide range of functions. In this Review, Carvalhais, Kole and Kuijpers describe the mechanisms that shape ER morphology and its contributions to specific local functions within neuronal subcellular domains.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 4","pages":"260-277"},"PeriodicalIF":26.7,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psilocybin shapes neural plasticity in selective brain networks 裸盖菇素在选择性大脑网络中塑造神经可塑性
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-06 DOI: 10.1038/s41583-025-01019-9
Sian Lewis
{"title":"Psilocybin shapes neural plasticity in selective brain networks","authors":"Sian Lewis","doi":"10.1038/s41583-025-01019-9","DOIUrl":"10.1038/s41583-025-01019-9","url":null,"abstract":"A single dose of psilocybin is shown here to induce neural plasticity in specific large-scale networks in the mouse.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"154-154"},"PeriodicalIF":26.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peroxidation protectors 过氧化保护者
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-05 DOI: 10.1038/s41583-025-01020-2
Darran Yates
{"title":"Peroxidation protectors","authors":"Darran Yates","doi":"10.1038/s41583-025-01020-2","DOIUrl":"10.1038/s41583-025-01020-2","url":null,"abstract":"A new study shows that two variants of apolipoprotein E that offer some protection against Alzheimer disease extract oxidized phospholipids from neurons via the ABCA7 transporter, supporting neuronal function.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"155-155"},"PeriodicalIF":26.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composing cognition via neural subspaces 通过神经子空间构成认知
IF 26.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2026-01-05 DOI: 10.1038/s41583-025-01018-w
Jake Rogers
{"title":"Composing cognition via neural subspaces","authors":"Jake Rogers","doi":"10.1038/s41583-025-01018-w","DOIUrl":"10.1038/s41583-025-01018-w","url":null,"abstract":"To flexibly perform multiple tasks, non-human primates compose appropriate behavioural responses by sharing subspaces of neural activity from which representations of task-related sensory, motor and cognitive information can be reused.","PeriodicalId":49142,"journal":{"name":"Nature Reviews Neuroscience","volume":"27 3","pages":"153-153"},"PeriodicalIF":26.7,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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