Towards single-cell-resolution global maps of mammalian brains

IF 34.7 1区医学 Q1 Neuroscience

Nature Reviews Neuroscience Pub Date : 2025-07-16 DOI:10.1038/s41583-025-00949-8

Chengyu T. Li, Wu Wei

引用次数: 0

Abstract

Brain cell atlases are revolutionizing neuroscience by using single-cell and spatial genomics to reveal the brain’s cellular diversity across development, function and disease. Fully realizing the potential of these atlases requires continued technology improvement, multimodal data integration and strategies to address ethical challenges, paving the way for transformative discoveries in neuroscience and clinical applications.

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迈向哺乳动物大脑单细胞分辨率全球地图

通过使用单细胞和空间基因组学来揭示大脑细胞在发育、功能和疾病中的多样性，脑细胞图谱正在彻底改变神经科学。充分实现这些地图集的潜力需要持续的技术改进、多模式数据集成和应对伦理挑战的策略，为神经科学和临床应用的变革性发现铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience 医学-神经科学

CiteScore

35.00

自引率

0.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neuroscience is a journal that is part of the Nature Reviews portfolio. It focuses on the multidisciplinary science of neuroscience, which aims to provide a complete understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience have made it possible to tackle longstanding neurobiological questions. However, the wealth of knowledge generated by these advancements has created a need for new tools to organize and communicate this information efficiently. Nature Reviews Neuroscience aims to fulfill this need by offering an authoritative, accessible, topical, and engaging resource for scientists interested in all aspects of neuroscience. The journal covers subjects such as cellular and molecular neuroscience, development of the nervous system, sensory and motor systems, behavior, regulatory systems, higher cognition and language, computational neuroscience, and disorders of the brain. Editorial decisions for the journal are made by a team of full-time professional editors who are PhD-level scientists.