Nature Reviews Neuroscience最新文献

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Glia of the heart's nervous system. 心脏神经系统的神经胶质。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-10-17 DOI: 10.1038/s41583-025-00974-7
Katharina Scherschel,Hanna Wolf,Olujimi A Ajijola,Kalyanam Shivkumar,Diana Lindner,Jose A Gomez-Sanchez,Christian Meyer
{"title":"Glia of the heart's nervous system.","authors":"Katharina Scherschel,Hanna Wolf,Olujimi A Ajijola,Kalyanam Shivkumar,Diana Lindner,Jose A Gomez-Sanchez,Christian Meyer","doi":"10.1038/s41583-025-00974-7","DOIUrl":"https://doi.org/10.1038/s41583-025-00974-7","url":null,"abstract":"The heart adapts to changing physiological demands through bidirectional interactions with the brain. These are mediated via extensive feedback loops of the cardiac autonomic nervous system, a complex network of neurons and glial cells. Although the presence of glia in the heart and its nervous system has been known for decades, only recently has an understanding of their contribution to cardiac physiology and pathophysiology emerged. As new types of cardiac glia are discovered, it becomes evident that they represent heterogeneous cell populations in distinct anatomical locations of the cardiac nervous system, contributing not only to autonomic control of the healthy heart but also to pathological changes in the diseased heart.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"12 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic modulation of the blood-brain barrier in the healthy brain. 健康大脑血脑屏障的动态调节。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-10-15 DOI: 10.1038/s41583-025-00976-5
Alon Friedman,Ofer Prager,Yonatan Serlin,Daniela Kaufer
{"title":"Dynamic modulation of the blood-brain barrier in the healthy brain.","authors":"Alon Friedman,Ofer Prager,Yonatan Serlin,Daniela Kaufer","doi":"10.1038/s41583-025-00976-5","DOIUrl":"https://doi.org/10.1038/s41583-025-00976-5","url":null,"abstract":"The blood-brain barrier (BBB) performs intricate and dynamic functions that extend far beyond its traditional role as a static protective barrier, playing a pivotal role in maintaining CNS homeostasis. These multifaceted functions are rooted in its specialized architectural and cellular composition. In this Review, we examine the dynamic modulation of BBB function during physiological conditions and the hypothesis that such modulation contributes directly to neural and glial plasticity. We provide an integrated examination of the BBB's diverse cellular components - endothelial cells, pericytes, astrocytes, microglia and vascular smooth muscle cells - across different CNS vascular segments. We discuss how physiological features and states, including circadian rhythms, physical activity, stress and hormonal fluctuations, dynamically alter BBB permeability and signalling, potentially shaping synaptic function, neuronal circuit dynamics and glial responsiveness. Understanding these mechanisms offers new insights into the neurovascular basis of synaptic plasticity and suggests that the BBB may be an under-recognized regulator and modulator of brain adaptability in both health and disease.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"9 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145296126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amplifying the signal: how the brain resolves cognitive conflict. 放大信号:大脑如何解决认知冲突。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-10-09 DOI: 10.1038/s41583-025-00984-5
Chenyan Zhang
{"title":"Amplifying the signal: how the brain resolves cognitive conflict.","authors":"Chenyan Zhang","doi":"10.1038/s41583-025-00984-5","DOIUrl":"https://doi.org/10.1038/s41583-025-00984-5","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"24 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical detection of high-frequency electrical oscillations in freely behaving animals. 自由行为动物高频电振荡的光学检测。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2025-10-07 DOI: 10.1038/s41583-025-00980-9
Simon Haziza
{"title":"Optical detection of high-frequency electrical oscillations in freely behaving animals.","authors":"Simon Haziza","doi":"10.1038/s41583-025-00980-9","DOIUrl":"https://doi.org/10.1038/s41583-025-00980-9","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"18 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145241091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Parkinson's disease. 了解帕金森病。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2019-12-11 DOI: 10.1038/s41583-019-0254-x
{"title":"Understanding Parkinson's disease.","authors":"","doi":"10.1038/s41583-019-0254-x","DOIUrl":"10.1038/s41583-019-0254-x","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":" ","pages":""},"PeriodicalIF":34.7,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37448781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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