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The origins of freezing 冷冻的起源
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-10 DOI: 10.1038/s41583-024-00857-3
Philip Tovote
{"title":"The origins of freezing","authors":"Philip Tovote","doi":"10.1038/s41583-024-00857-3","DOIUrl":"https://doi.org/10.1038/s41583-024-00857-3","url":null,"abstract":"Philip Tovote describes the 1980 paper in which Michael Fanselow systematically investigated freezing as a defensive response in rodents","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural control of gut regulatory T cells 肠道调节性 T 细胞的神经控制
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-03 DOI: 10.1038/s41583-024-00863-5
Darran Yates
{"title":"Neural control of gut regulatory T cells","authors":"Darran Yates","doi":"10.1038/s41583-024-00863-5","DOIUrl":"https://doi.org/10.1038/s41583-024-00863-5","url":null,"abstract":"Activation of nociceptor neurons expressing TRPV1 downregulates gut regulatory T cells.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte antennae 星形胶质细胞触角
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-03 DOI: 10.1038/s41583-024-00864-4
Sian Lewis
{"title":"Astrocyte antennae","authors":"Sian Lewis","doi":"10.1038/s41583-024-00864-4","DOIUrl":"https://doi.org/10.1038/s41583-024-00864-4","url":null,"abstract":"Most astrocytes in the mouse brain have a primary cilium that transduces local cues to drive distinct astrocytic transcriptomic programmes that determine regional astrocytic subtypes, and, in turn, shape local circuits and influence behaviour.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping future locations. 绘制未来地点图。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-02 DOI: 10.1038/s41583-024-00861-7
Katherine Whalley
{"title":"Mapping future locations.","authors":"Katherine Whalley","doi":"10.1038/s41583-024-00861-7","DOIUrl":"https://doi.org/10.1038/s41583-024-00861-7","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disentangling human inference 解构人类推理
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-02 DOI: 10.1038/s41583-024-00860-8
Jake Rogers
{"title":"Disentangling human inference","authors":"Jake Rogers","doi":"10.1038/s41583-024-00860-8","DOIUrl":"https://doi.org/10.1038/s41583-024-00860-8","url":null,"abstract":"A study in humans reveals that the hippocampus encodes relevant task variables in abstract format during inferential reasoning, which enables the generalization needed for such complex cognition.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid hormone modulates exploration circuits. 甲状腺激素调节探索回路
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-09-02 DOI: 10.1038/s41583-024-00862-6
Katherine Whalley
{"title":"Thyroid hormone modulates exploration circuits.","authors":"Katherine Whalley","doi":"10.1038/s41583-024-00862-6","DOIUrl":"https://doi.org/10.1038/s41583-024-00862-6","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the labelling and selective manipulation of synapses. 突触标记和选择性操作的进展。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-08-22 DOI: 10.1038/s41583-024-00851-9
Binod Timalsina, Sangkyu Lee, Bong-Kiun Kaang
{"title":"Advances in the labelling and selective manipulation of synapses.","authors":"Binod Timalsina, Sangkyu Lee, Bong-Kiun Kaang","doi":"10.1038/s41583-024-00851-9","DOIUrl":"https://doi.org/10.1038/s41583-024-00851-9","url":null,"abstract":"<p><p>Synapses are highly specialized neuronal structures that are essential for neurotransmission, and they are dynamically regulated throughout the lifetime. Although accumulating evidence indicates that these structures are crucial for information processing and storage in the brain, their precise roles beyond neurotransmission are yet to be fully appreciated. Genetically encoded fluorescent tools have deepened our understanding of synaptic structure and function, but developing an ideal methodology to selectively visualize, label and manipulate synapses remains challenging. Here, we provide an overview of currently available synapse labelling techniques and describe their extension to enable synapse manipulation. We categorize these approaches on the basis of their conceptual bases and target molecules, compare their advantages and limitations and propose potential modifications to improve their effectiveness. These methods have broad utility, particularly for investigating mechanisms of synaptic function and synaptopathy.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal maturation and axon regeneration: unfixing circuitry to enable repair 神经元成熟与轴突再生：解除电路固定以实现修复
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-08-20 DOI: 10.1038/s41583-024-00849-3
Brett J. Hilton, Jarred M. Griffin, James W. Fawcett, Frank Bradke
{"title":"Neuronal maturation and axon regeneration: unfixing circuitry to enable repair","authors":"Brett J. Hilton, Jarred M. Griffin, James W. Fawcett, Frank Bradke","doi":"10.1038/s41583-024-00849-3","DOIUrl":"https://doi.org/10.1038/s41583-024-00849-3","url":null,"abstract":"<p>Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to 'The language network is topographically diverse and driven by rapid syntactic inferences'. 回复 "语言网络具有拓扑多样性，由快速句法推断驱动"。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-08-09 DOI: 10.1038/s41583-024-00853-7
Evelina Fedorenko, Anna A Ivanova, Tamar I Regev
{"title":"Reply to 'The language network is topographically diverse and driven by rapid syntactic inferences'.","authors":"Evelina Fedorenko, Anna A Ivanova, Tamar I Regev","doi":"10.1038/s41583-024-00853-7","DOIUrl":"https://doi.org/10.1038/s41583-024-00853-7","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The language network is topographically diverse and driven by rapid syntactic inferences. 语言网络具有拓扑多样性，由快速句法推断驱动。
IF 34.7 1区 医学
Nature Reviews Neuroscience Pub Date : 2024-08-09 DOI: 10.1038/s41583-024-00852-8
Elliot Murphy, Oscar Woolnough
{"title":"The language network is topographically diverse and driven by rapid syntactic inferences.","authors":"Elliot Murphy, Oscar Woolnough","doi":"10.1038/s41583-024-00852-8","DOIUrl":"https://doi.org/10.1038/s41583-024-00852-8","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":null,"pages":null},"PeriodicalIF":34.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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