Nature Reviews Neuroscience最新文献

Molecular and functional diversity of the autonomic nervous system 自主神经系统的分子和功能多样性

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-03 DOI: 10.1038/s41583-025-00941-2

Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola, Yuki Oka

{"title":"Molecular and functional diversity of the autonomic nervous system","authors":"Tongtong Wang, Avedis Tufenkjian, Olujimi A. Ajijola, Yuki Oka","doi":"10.1038/s41583-025-00941-2","DOIUrl":"https://doi.org/10.1038/s41583-025-00941-2","url":null,"abstract":"The autonomic nervous system (ANS) plays a pivotal role in regulating organ functions through descending brain-to-body signalling. The pathways involved are broadly categorized into two major branches: the sympathetic nervous system, which mediates ‘fight or flight’ responses, and the parasympathetic nervous system, which governs ‘rest and digest’ functions. Historically, the ANS was considered to mediate simple motor functions with limited neurochemical diversity. However, recent advances in neurotechnology have shown that brain-to-body communication is more complex and dynamic than previously appreciated. This review synthesizes current knowledge about the molecular, anatomical and functional diversity of autonomic motor neurons. Here we present a comparative analysis of the cellular architecture of the ANS and the suggested roles of distinct neuron populations. Additionally, we explore the emerging view that the ANS interacts with diverse systems involving metabolism, immunology and ageing, which extends its role beyond simple brain–organ modulation. Finally, we emphasize the need for cell-type-specific and longitudinal studies of the ANS to uncover novel mechanisms underlying body–brain interactions and to identify new translational opportunities for therapeutic interventions.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"77 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repulsion in the human hippocampus is linked to internal beliefs 人类海马体中的排斥力与内在信念有关

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-07-01 DOI: 10.1038/s41583-025-00947-w

Caroline Barranco

引用次数: 0

A new myeloid cell migration route 一种新的髓细胞迁移途径

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-26 DOI: 10.1038/s41583-025-00944-z

Sian Lewis

引用次数: 0

A reality check 现实检查

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-26 DOI: 10.1038/s41583-025-00942-1

Katherine Whalley

引用次数: 0

Rethinking excitation/inhibition balance in the human brain 重新思考人脑的兴奋/抑制平衡

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-23 DOI: 10.1038/s41583-025-00943-0

Roi Cohen Kadosh

引用次数: 0

Three-photon microscopy: an emerging technique for deep intravital brain imaging 三光子显微镜：一种新兴的深部活体脑成像技术

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-20 DOI: 10.1038/s41583-025-00937-y

Robert Prevedel, Júlia Ferrer Ortas, Jason N. D. Kerr, Jack Waters, Michael O. Breckwoldt, Benjamin Deneen, Michelle Monje, Stella J. Soyka, Varun Venkataramani

{"title":"Three-photon microscopy: an emerging technique for deep intravital brain imaging","authors":"Robert Prevedel, Júlia Ferrer Ortas, Jason N. D. Kerr, Jack Waters, Michael O. Breckwoldt, Benjamin Deneen, Michelle Monje, Stella J. Soyka, Varun Venkataramani","doi":"10.1038/s41583-025-00937-y","DOIUrl":"https://doi.org/10.1038/s41583-025-00937-y","url":null,"abstract":"Understanding brain function and pathology requires observation of cellular dynamics within intact neural circuits. Although two-photon microscopy revolutionized mammalian in vivo brain imaging, its limitation to upper cortical layers has restricted access to many important brain regions. Three-photon microscopy overcomes this constraint, enabling minimally invasive yet high-resolution visualization of the deep cortical and subcortical structures that are crucial for higher-order brain functions. This emerging technology opens new avenues for investigating fundamental aspects of neuroscience, from circuit dynamics to disease mechanisms. Here, we examine how three-photon microscopy has started to transform our ability to investigate neural circuits, glial biology, and oncological and neuroimmune interactions in previously inaccessible brain regions, primarily in the mouse, but also in other model organisms. We discuss current technical challenges, recent innovations and future applications that promise to bring us greater understanding of the living brain.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"46 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the biological causes of eating disorders to inform treatment strategies 检查饮食失调的生物学原因，为治疗策略提供信息

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-20 DOI: 10.1038/s41583-025-00940-3

Claire J. Foldi, Kristi R. Griffiths

{"title":"Examining the biological causes of eating disorders to inform treatment strategies","authors":"Claire J. Foldi, Kristi R. Griffiths","doi":"10.1038/s41583-025-00940-3","DOIUrl":"https://doi.org/10.1038/s41583-025-00940-3","url":null,"abstract":"Despite their prevalence, eating disorders (EDs) are under-researched and often misunderstood. A recent focus of research on the biological underpinnings of EDs has helped to reframe our understanding of their origins, but there remain a lack of effective treatment options, high rates of relapse and, unfortunately, high mortality and morbidity. In this Review, we highlight the many facets of normal and pathological feeding behaviour and body weight regulation and suggest that these provide a framework with which to develop integrative methods to study, and ultimately treat, EDs. We propose that a better understanding of the biological causes of ED, and their crucial interactions with psychological and environmental factors, is necessary to progress the field. This can be achieved through a combination of preclinical and clinical investigations, which provide complementary information on these highly complex disorders. In the era of individualized medicine and with the advent of artificial intelligence tools that allow the amalgamation of multimodal data, we hope that a better understanding of the biology of EDs may hold the answer to effectively overcoming the debilitating effects of these conditions.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar circuit computations for predictive motor control 预测运动控制的小脑电路计算

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-16 DOI: 10.1038/s41583-025-00936-z

Katrina P. Nguyen, Abigail L. Person

引用次数: 0

An intriguing role of repeat-element RNAs in nerve injury repair 重复元件rna在神经损伤修复中的有趣作用

IF 34.7 1区医学

Nature Reviews Neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41583-025-00939-w

Sian Lewis

引用次数: 0

Value-free teaching in action 无价值教学的实践