Top-down and bottom-up neuroscience: overcoming the clash of research cultures

IF 26.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2025-07-21 DOI:10.1038/s41583-025-00946-x

Fernando E. Rosas, Andrea I. Luppi, Pedro A. M. Mediano, Morten L. Kringelbach, Luiz Pessoa, Federico Turkheimer

引用次数: 0

Abstract

As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research approaches in neuroscience that we describe as ‘top-down’ and ‘bottom-up’. Recognizing the validity of both approaches dispels misunderstandings and unnecessary tension and promotes constructive interactions.

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自上而下和自下而上的神经科学：克服研究文化的冲突

作为科学家，我们想要可靠的答案，但我们也想回答重要的问题。然而，大脑的复杂性迫使在这些期望之间进行权衡，在神经科学中产生了两种截然不同的研究方法，我们称之为“自上而下”和“自下而上”。认识到这两种方法的有效性可以消除误解和不必要的紧张关系，促进建设性的互动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.