Biomedical Microdevices最新文献_第9页

On-chip construction of a fully structured scaffold-free vascularized renal tubule 芯片上构建全结构无支架的血管化肾小管

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2023-02-24 DOI: 10.1007/s10544-023-00648-0

Yuntian Zhu, Zhengdi Shi, Weiping Ding, Chengpan Li

{"title":"On-chip construction of a fully structured scaffold-free vascularized renal tubule","authors":"Yuntian Zhu, Zhengdi Shi, Weiping Ding, Chengpan Li","doi":"10.1007/s10544-023-00648-0","DOIUrl":"10.1007/s10544-023-00648-0","url":null,"abstract":"<div><p>Renal tubule chips have emerged as a promising platform for drug nephrotoxicity testing. However, the reported renal tubule chips hardly replicate the unique structure of renal tubules with thick proximal and distal tubules and a thin loop of Henle. In this study, we developed a fully structured scaffold-free vascularized renal tubule on a microfluidic chip. On the chip, the renal epithelial cell-laden hollow calcium-polymerized alginate tube with thick segments at both ends and a thin middle segment was U-shaped embedded in collagen hydrogel, parallel to the endothelial cell-laden hollow calcium-polymerized alginate tube with uniform tube diameter. After the alginate tubes were on-chip degraded, the renal epithelial cells and endothelial cells automatically attached to the collagen hydrogel and proliferated to form the renal tubule with proximal tubule, loop of Henle and distal tubule as well as peritubular blood vessel. We evaluated the viability of cells on the hollow alginate tubes, characterized the distribution and morphology of cells before and after the degradation of the alginate tube, and confirmed the proliferation of cells and the metabolic function of cells in terms of ATP synthesis, fibronectin secretion and VEGFR2 expression on the chip. The enhanced metabolic functions of renal epithelial cells and endothelial cells were preliminarily demonstrated. This study provides new insights into designing a more biomimetic renal tubule on a microfluidic chip.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-023-00648-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5267012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-asperity adhesive contact model for catheter and vascular artery contact in endovascular surgery 一种用于血管内手术中导管与血管动脉接触的多粗糙度黏附接触模型

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2023-01-31 DOI: 10.1007/s10544-023-00646-2

Yang Xu, Sundeep Mangla, Paul Gschneidner, Yong Shi

{"title":"A multi-asperity adhesive contact model for catheter and vascular artery contact in endovascular surgery","authors":"Yang Xu, Sundeep Mangla, Paul Gschneidner, Yong Shi","doi":"10.1007/s10544-023-00646-2","DOIUrl":"10.1007/s10544-023-00646-2","url":null,"abstract":"<div><h2>Abstract\u0000</h2><div><p>Contact behaviors of medical devices, such as guidewires and catheters, are critical in endovascular surgeries. In this work, a new method to predict adhesive contact force between catheter and vascular artery is presented. Multi-asperity adhesion on the surface of vascular artery, deformation of asperity and deformation of vascular substrate are all considered. The single asperity behavior is described with Johnson-Kendall-Roberts (JKR) contact model. The multi-asperity behavior is based on Greenwood–Williamson (GW) asperity model. Vascular substrate is considered as elastic bulk substrate and its deformation is determined with Hertzian pressure from asperity on a circular region on the elastic half space. The model shows that the deformation of vascular substrate accounts for the majority of the total contact deformation and significantly affects the predicted contact force. The model is verified with published experimental data. The comparison shows that the model produces very accurate prediction of contact force between catheter and vascular artery when the contact force is compressive. Parametric analysis based on asperity topography is carried out. The analysis shows that the diameter of the circular region of the interface between asperity and vascular substrate has more significant effect on the estimation of contact force than the radius of asperity. Further validation of prediction accuracy of the model under experiment is needed.</p></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-023-00646-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5176530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An intelligent intestinal bleeding diagnosis and treatment capsule system based on color recognition 一种基于颜色识别的智能肠出血诊治胶囊系统

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2023-01-25 DOI: 10.1007/s10544-022-00642-y

Panpan Qiao, Luo Yu, Hongying Liu, Xueping Yan, Xitian Pi

{"title":"An intelligent intestinal bleeding diagnosis and treatment capsule system based on color recognition","authors":"Panpan Qiao, Luo Yu, Hongying Liu, Xueping Yan, Xitian Pi","doi":"10.1007/s10544-022-00642-y","DOIUrl":"10.1007/s10544-022-00642-y","url":null,"abstract":"<div><p>To our best knowledge, there are no non-invasive and painless means for the diagnosis and treatment of intestinal bleeding as of now, especially the segment of intestine that cannot be reached by endoscopy. We proposed an intelligent intestinal bleeding diagnosis and treatment capsule (IBDTC) system for the first time to diagnose and treat intestinal bleeding with low power consumption, estimated to be about 2.16mW. A hue-saturation-light (HSL) color space method was applied to diagnose bleeding according to H (hue) values of the film dyed by blood. A MEMS-based micro-igniter works as the critical component of the micro-thruster that houses the propellant (74.6% potassium nitrate, 11.9% sulfur, 13.5% charcoal) and the detonating agent (dinitrodiazophenol), to help release drug. Bleeding detection and ignition tests were performed to justify its feasibility and reliability. Results demonstrated that the bleeding diagnosis module of the IBDTC can effectively detect bleeding and the micro-igniter can successfully ignite the propellant. Owing to its simplicity and intelligence, the IBDTC system will pave a way for future accurate treatment of small intestinal bleeding with no injury, no pain, no complicated supporting equipment, no need for <i>in vitro</i> operation and positioning.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-022-00642-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4967987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezoelectric micropump with integrated elastomeric check valves: design, performance characterization and primary application for 3D cell culture 集成弹性止回阀的压电微泵:设计，性能表征和三维细胞培养的主要应用

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2023-01-17 DOI: 10.1007/s10544-022-00645-9

Joseph Benjamin Holman, Xiaolu Zhu, Hao Cheng

{"title":"Piezoelectric micropump with integrated elastomeric check valves: design, performance characterization and primary application for 3D cell culture","authors":"Joseph Benjamin Holman, Xiaolu Zhu, Hao Cheng","doi":"10.1007/s10544-022-00645-9","DOIUrl":"10.1007/s10544-022-00645-9","url":null,"abstract":"<div><p>This paper reports on the study of a piezoelectric actuated micropump with integrated elastomeric check valves that can transport small amounts of fluid in a highly controllable manner. The proposed micropump consists of a piezoelectric actuated fluid chamber with two integrated elastomeric check valves for regulating input and output flow direction, while restricting backflows. The actuation, fluid dynamic response and fluid–structure interactions at various working cycles are studied through a fully coupled multiphysics simulation (solid mechanics, electrostatic and fluid flow). The pump bodies are manufactured by micromachining of PMMA sheets, while the middle elastomeric membrane and diaphragm are fabricated by spin-coating PDMS. The experimental results confirm that the micropump can provide sufficiently low-velocity outflow for biomedical applications between 3.4 – 41.8 µl/min. The performance of the micropump is improved significantly through a convenient geometric modification of an off-the-shelf piezoelectric brass disc. Furthermore, the combination of this micropump with the 3D cell-culture microfluidic chip realizes the dynamic culture of cells encapsulated in 3D hydrogels with a continuous flowing medium, which offers the potential for changing the traditional mode of 3D cell culture with a static supply of nutrition and factors.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4682596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative application of microfluidic systems in circulating tumor cells and extracellular vesicles isolation; a review 微流控系统在循环肿瘤细胞和细胞外囊泡分离中的比较应用回顾

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-12-27 DOI: 10.1007/s10544-022-00644-w

Razieh Rezaei Adriani, Seyed Latif Mousavi Gargari

{"title":"Comparative application of microfluidic systems in circulating tumor cells and extracellular vesicles isolation; a review","authors":"Razieh Rezaei Adriani, Seyed Latif Mousavi Gargari","doi":"10.1007/s10544-022-00644-w","DOIUrl":"10.1007/s10544-022-00644-w","url":null,"abstract":"<div><p>Cancer is a prevalent cause of mortality globally, where early diagnosis leads to a reduced death rate. Many researchers' common strategies are based on personalized diagnostic methods with rapid response and high accuracy. This technology was developed by applying liquid biopsy instead of tissue biopsies in the case of tumor cell analysis that facilitates point-of-care testing for cancer diagnosis and treatment. In recent years, significant progress in microfluidic technology led to the successful isolation, analysis, and monitoring of cancer biomarkers in body liquid biopsy with merits like high sensitivity and flexibility, low sample usage, cost effective, and the ability of automation. The most critical and informative markers in body liquid refer to circulating tumor cells (CTCs) and extracellular vesicles derived from tumors (EVs) that carry various biomarkers in their structure (DNAs, proteins, and RNAs) as compared to ctDNA. The released ctDNA has a low half-life and decreased sensitivity due to large amounts of nucleic acid in serum. This review intends to highlight different cancer screening tests with a particular focus on the details regarding the only FDA-approved and awaiting technologies for FDA clearance to isolate CTCs and EVs based on microfluidics systems.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-022-00644-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5458859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Microfluidic isolation of aptamers with affinity towards multiple myeloma monoclonal immunoglobulins 具有多发性骨髓瘤单克隆免疫球蛋白亲和力的适配体的微流控分离

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-12-08 DOI: 10.1007/s10544-022-00643-x

Timothy R. Olsen, Claudia Tapia-Alveal, Kechun Wen, Tilla S. Worgall, Milan N. Stojanovic, Qiao Lin

{"title":"Microfluidic isolation of aptamers with affinity towards multiple myeloma monoclonal immunoglobulins","authors":"Timothy R. Olsen, Claudia Tapia-Alveal, Kechun Wen, Tilla S. Worgall, Milan N. Stojanovic, Qiao Lin","doi":"10.1007/s10544-022-00643-x","DOIUrl":"10.1007/s10544-022-00643-x","url":null,"abstract":"<div><p>Multiple myeloma (MM) is a bone marrow cancer of resident plasma cells that affects 125,000 patients in the U.S. with about 30,000 new cases per year. Its signature is the clonal proliferation of a single plasma cell that secretes a patient specific monoclonal immunoglobulin (M-Ig). Targeting the M-Ig in patient serum could allow sensitive and noninvasive identification of minimal residual disease in multiple myeloma. Aptamers, which are single-stranded oligonucleotides with affinity and specificity to a target molecule, have recently been introduced as affinity reagents for recognition of MM M-Igs. Here we exploit microfluidic SELEX technology to enable rapid and efficient generation of aptamers against M-Ig proteins from MM patients. We first characterize the technology by isolating aptamers with affinity towards the monoclonal antibody rituximab as a model M-Ig and then apply the technology to isolating aptamers specifically targeting M-Igs obtained from serum samples of MM patients. We demonstrate that high-affinity DNA aptamers (K<sub>D</sub> < 50 nM) for M-Ig proteins from a patient sample could be isolated via microfluidic SELEX within approximately 12 h and using less than 100 micrograms of patient M-Ig. Such aptamers can potentially be used in personalized monitoring of minimal residual disease in MM patients.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4331216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies 用于体外生命支持的硅膜:设计和制造方法的比较

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-12-06 DOI: 10.1007/s10544-022-00639-7

David G. Blauvelt, Benjamin W. Chui, Nicholas C. Higgins, Francisco J. Baltazar, Shuvo Roy

{"title":"Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies","authors":"David G. Blauvelt, Benjamin W. Chui, Nicholas C. Higgins, Francisco J. Baltazar, Shuvo Roy","doi":"10.1007/s10544-022-00639-7","DOIUrl":"10.1007/s10544-022-00639-7","url":null,"abstract":"<div><p>Extracorporeal life support is an advanced therapy that circulates blood through an extracorporeal oxygenator, performing gas exchange outside the body. However, its use is limited by severe complications, including bleeding, clotting, and hemolysis. Semiconductor silicon-based membranes have emerged as an alternative to traditional hollow-fiber semipermeable membranes. These membranes offer excellent gas exchange efficiency and the potential to increase hemocompatibility by improving flow dynamics. In this work, we evaluate two next-generation silicon membrane designs, which are intended to be mechanically robust and efficient in gas exchange, while simultaneously reducing fabrication complexity. The “window” design features 10 µm pores on one side and large windows on the back side. The “cavern” design also uses 10 µm pores but contains a network of interconnected buried caverns to distribute the sweep gas from smaller inlet holes. Both designs were shown to be technically viable and able to be reproducibly fabricated. In addition, they both were mechanically robust and withstood 30 psi of transmembrane pressure without breakage or bubbling. At low sweep gas pressures, gas transfer efficiency was similar, with the partial pressure of oxygen in water increasing by 10.7 ± 2.3 mmHg (mean ± standard deviation) and 13.6 ± 1.9 mmHg for the window and cavern membranes, respectively. Gas transfer efficiency was also similar at higher pressures. At 10 psi, oxygen tension increased by 16.8 ± 5.7 mmHg (window) and 18.9 ± 1.3 mmHg (cavern). We conclude that silicon membranes featuring a 10 µm pore size can simplify the fabrication process and improve mechanical robustness while maintaining excellent efficiency.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4241964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored calix[4]arene-gold nanoconjugate as a ultra-sensitive immunosensing nanolabel 定制杯[4]芳烃-金纳米缀合物作为超灵敏免疫传感纳米标记物

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-11-30 DOI: 10.1007/s10544-022-00640-0

Nidhi Verma, Pinkesh Sutariya, Tvarit Patel, Malvika Shukla, Alok Pandya

{"title":"Tailored calix[4]arene-gold nanoconjugate as a ultra-sensitive immunosensing nanolabel","authors":"Nidhi Verma, Pinkesh Sutariya, Tvarit Patel, Malvika Shukla, Alok Pandya","doi":"10.1007/s10544-022-00640-0","DOIUrl":"10.1007/s10544-022-00640-0","url":null,"abstract":"<div><p>The construction of highly sensitive and specific immunosensing nanolabels have attracted tremendous attention in the development of reliable point-of-care disease diagnostics. However, there are still challenges with traditional immunoassays, such as complicated and time-consuming procedure, the use of enzyme label, non-specificity, and require readers for detection. Therefore, we have designed and developed site-directed antibody-immobilized calix[4]arene-gold nanoconjugate based colorimetric immunosensing nanolabel to offer high sensitivity. The prepared nanolabel enabled oriented binding of the antibodies by providing full accessibility of Fab domain for antigen binding. The improved sensitivity of the developed nanolabel was evaluated using vertical flow immunoassay (VFIA) for detecting C-reactive protein (CRP) with a lower detection limit up to 1 ng/ml. Our developed nanolabel was found to be highly specific, easy, quick, and appropriate for onsite detection. The nanolabel is validated with spiked blood samples which exhibited ~90% recovery having a relative error of ~2%. Furthermore, the nanolabel was also used for screening of human blood real samples which showed relative error of ~0.6%. The developed nanolabel can be utilized as a potential nanolabel for the quantitative detection of various biomolecules in clinical samples.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"25 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5164136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A handheld electronic device with the potential to detect lung cancer biomarkers from exhaled breath 一种手持电子设备，具有从呼出的气体中检测肺癌生物标志物的潜力

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-11-18 DOI: 10.1007/s10544-022-00638-8

Shadi Emam, Mehdi Nasrollahpour, John Patrick Allen, Yifan He, Hussein Hussein, Harsh Shailesh Shah, Fariborz Tavangarian, Nian-Xiang Sun

{"title":"A handheld electronic device with the potential to detect lung cancer biomarkers from exhaled breath","authors":"Shadi Emam, Mehdi Nasrollahpour, John Patrick Allen, Yifan He, Hussein Hussein, Harsh Shailesh Shah, Fariborz Tavangarian, Nian-Xiang Sun","doi":"10.1007/s10544-022-00638-8","DOIUrl":"10.1007/s10544-022-00638-8","url":null,"abstract":"<div><p>Lung cancer is the leading cause of cancer death in the United States. It has the lowest 5-year survival rate among the most common cancers and therefore, early diagnosis is critical to improve the survival rate. In this paper, a new handheld electronic device is proposed to detect nine lung cancer biomarkers in the exhaled breath. An electrochemical gas sensor was produced through deposition of a thin layer of graphene and Prussian blue on a chromium-modified silicon substrate. Selective binding of the analyte was formed by molecular imprinting polymer (MIP). Subsequent polymerization and removal of the analyte yielded a layer of a conductive polymer on top of the sensor containing molecularly imprinted cavities selective for the target molecule. The sensors were tested over 1–20 parts per trillion (ppt) level of concentration while the sensor resistance has been monitored as the sensors react to the analyte by resistance change. Pentane sensor was also tested for selectivity. A printed circuit board was designed to measure the resistance of each sensor and send the data to a developed application in smartphone through Bluetooth. This handheld device has the potential to be used as a diagnostic method in the near future.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"24 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4735056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Fabrication and characterization of core–shell microparticles containing an aqueous core 含水核的核壳微粒的制备与表征

IF 2.8 4区医学

Biomedical Microdevices Pub Date : 2022-11-10 DOI: 10.1007/s10544-022-00637-9

Fariba Malekpour Galogahi, Abolfazl Ansari, Adrian J. T. Teo, Haotian Cha, Hongjie An, Nam-Trung Nguyen

{"title":"Fabrication and characterization of core–shell microparticles containing an aqueous core","authors":"Fariba Malekpour Galogahi, Abolfazl Ansari, Adrian J. T. Teo, Haotian Cha, Hongjie An, Nam-Trung Nguyen","doi":"10.1007/s10544-022-00637-9","DOIUrl":"10.1007/s10544-022-00637-9","url":null,"abstract":"<div><p>Core–shell microparticles containing an aqueous core have demonstrated their value for microencapsulation and drug delivery systems. The most important step in generating these uniquely structured microparticles is the formation of droplets and double emulsion. The droplet generator must meet the performance and reliability requirements, including accurate size control with tunability and monodispersity. Herein, we present a facile technique to generate surfactant-free core–shell droplets with an aqueous core in a microfluidic device. We demonstrate that the geometry of the core–shell droplets can be precisely adjusted by the flow rates of the droplet components. As the shell is polymerized after the formation of the core–shell droplets, the resulting solid microparticles ensure the encapsulation of the aqueous core and prevent undesired release. We then study experimentally and theoretically the behaviour of resultant microparticles under heating and compression. The microparticles demonstrate excellent stability under both thermal and mechanical loads. We show that the rupture force can be quantitatively predicted from the shell thickness relative to the outer shell radius. Experimental results and theoretical predictions confirm that the rupture force scales directly with the shell thickness.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"24 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-022-00637-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4433927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2