Biomedical Microdevices最新文献_第8页

Ultra-Sensitive and direct detection of MiRNAs in real samples via duplex-specific nuclease-mediated signal amplification 通过双链特异性核酸酶介导的信号放大，超灵敏和直接检测真实样品中的mirna。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-01-12 DOI: 10.1007/s10544-025-00789-4

Chun-Guang Yang, Yi Han, Jing-Jing Zhang, Li-Wen Xu, Jin Li

{"title":"Ultra-Sensitive and direct detection of MiRNAs in real samples via duplex-specific nuclease-mediated signal amplification","authors":"Chun-Guang Yang, Yi Han, Jing-Jing Zhang, Li-Wen Xu, Jin Li","doi":"10.1007/s10544-025-00789-4","DOIUrl":"10.1007/s10544-025-00789-4","url":null,"abstract":"<div><p>The expression levels of miRNAs in cells or biological fluids are closely associated with the onset and progression of many diseases, making the detection of miRNAs in serum and plasma increasingly important. However, due to the low levels of miRNAs in biological fluids and the complexity of their surrounding environment, their analysis faces challenges related to accuracy and reproducibility. We developed a duplex-specific nuclease (DSN)-mediated detection method for the direct detection of miRNA-21 in real samples. This method eliminates the need for total RNA extraction from real samples using commercial kits, a key advantage over traditional methods requiring pre-treatment. As verified by performance evaluation, this method exhibits a linear range of 5.00 fmol·L<sup>− 1</sup> to 500 pmol·L<sup>− 1</sup> and a limit of detection (LOD) of 2.66 fmol·L<sup>− 1</sup> for miRNA-21. Direct detection of miRNA-21 in real samples yielded favorable results. These findings confirm that the method holds great application potential for the direct detection of miRNA-21 in real biological samples and exhibits promising prospects in clinical cancer diagnosis and drug screening.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of physicochemical alterations in 3D-printed biodegradable implants under biomimetic conditions for cranial defect repair 3d打印生物可降解植入物在仿生条件下修复颅骨缺损的理化变化评估。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2026-01-07 DOI: 10.1007/s10544-025-00788-5

Eungtae Lee, Yeonguk Seong, Jihee Jeong, Yeji Cheon, Joonho Eom, Jinhyun Kim, Sangbae Park, Jong Hoon Chung

{"title":"Assessment of physicochemical alterations in 3D-printed biodegradable implants under biomimetic conditions for cranial defect repair","authors":"Eungtae Lee, Yeonguk Seong, Jihee Jeong, Yeji Cheon, Joonho Eom, Jinhyun Kim, Sangbae Park, Jong Hoon Chung","doi":"10.1007/s10544-025-00788-5","DOIUrl":"10.1007/s10544-025-00788-5","url":null,"abstract":"<div><p>Once implanted, biodegradable devices gradually deteriorate, potentially compromising clinical performance. Consequently, evaluating the alterations in physicochemical characteristics after implantation is crucial. Nonetheless, there is currently no established methodology for precisely assessing these alterations. This study sought to develop accurately simulated cranial defect physiological conditions (SCDPC) and examine the physicochemical modifications in biodegradable cranioplasty plates (BCP) to anticipate their performance changes following implantation in humans. We analyzed the physicochemical property alterations of BCP following 24 weeks of exposure to SCDPC. Following 24 weeks under SCDPC, the BCP showed a notable reduction in mass (− 0.79%) and tensile strength (− 69.30%). A decrease in molecular weight was noted after 12 weeks of implantation in rabbits (− 9.67%) and following 12 weeks of exposure to SCDPC (− 4.73%). The physicochemical alterations identified under simulated <i>in vitro</i> cranial defect conditions closely mirrored those found in the <i>in vivo</i> setting. In summary, assessing BCP under SCDPC offers an innovative and dependable approach for precisely forecasting performance shifts after implantation. This strategy could provide meaningful guidance for the advancement of BCP and various other biodegradable medical devices.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-025-00788-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balanced-armature-based, electromagnetic actuator for round window stimulation of the inner ear with static pre-load 基于平衡电枢的电磁执行器，用于静态预载荷的内耳圆窗刺激

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-12-29 DOI: 10.1007/s10544-025-00766-x

Maren S. Prediger, Eileen Müller, Anatoly Glukhovskoy, Konrad Bethmann, András Bernát Berta, Marc C. Wurz, Hannes Maier

{"title":"Balanced-armature-based, electromagnetic actuator for round window stimulation of the inner ear with static pre-load","authors":"Maren S. Prediger, Eileen Müller, Anatoly Glukhovskoy, Konrad Bethmann, András Bernát Berta, Marc C. Wurz, Hannes Maier","doi":"10.1007/s10544-025-00766-x","DOIUrl":"10.1007/s10544-025-00766-x","url":null,"abstract":"<div><p>Roughly 5% of the population is affected by hearing loss. In case of a functional middle ear impairment with decreased transmission, different types of active middle ear implants may restore hearing. To drive the round window membrane (RWM) for example, bone anchored actuators or floating mass transducer (FMT) have been used in clinics. Bone anchored devices are usually too big for the round window niche and FMTs display low displacement and force at low frequencies. This paper focuses on the stimulation of the RWM by a stator-based actuator that combines small size and bone anchoring. The design features a rotational-symmetric balanced armature core with flexible membrane parts manufactured micro technologically. Membranes and assembled prototypes were evaluated on the bench in the range of 0.1 kHz – 10 kHz and prototypes tested in human temporal bones. We demonstrate the feasibility of a balanced armature actuator of appropriate size for RW placement. With 1.4 mm outer diameter and 4.9 mm length, the actuator fits the anatomical constraints. Acoustic stimulation of the RWM resulted in a maximum output of approximately 80 eq. dB SPL at 300 Hz increasing to > 100 eq. dB SPL above 5 kHz. The measured output is comparable to clinically used devices. The design lacked sufficient robustness leading to a low yield in manufacturing and failures in experiments, although the output level was insensitive to static force loading up to 30 mN. Future developments require an increased maximum output level and improved robustness.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-025-00766-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145845732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Au-MnOx nanozyme-based multifunctional hydrogel for NIR-II laser triggered tumor radiotherapy sensitization 基于Au-MnOx纳米酶的多功能水凝胶用于NIR-II激光触发肿瘤放疗增敏。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-12-04 DOI: 10.1007/s10544-025-00780-z

Zhan Xiao, Xiaolong Zhou, Lingbo Zhang, Defang Zhao, Wei Cai, Jiancheng Wang

{"title":"Au-MnOx nanozyme-based multifunctional hydrogel for NIR-II laser triggered tumor radiotherapy sensitization","authors":"Zhan Xiao, Xiaolong Zhou, Lingbo Zhang, Defang Zhao, Wei Cai, Jiancheng Wang","doi":"10.1007/s10544-025-00780-z","DOIUrl":"10.1007/s10544-025-00780-z","url":null,"abstract":"<div><p>Radiotherapy (RT) is widely used for malignant tumors ablation in the clinic. However, redundant doses of X-rays might cause irreversible side effects in the periphery of tumor sites. To address this, the convergence of low-dose RT with a novel therapeutic method is promising. Here, a hydrogel system was created that combines nanozymes with NIR-II photothermal therapy and RT sensitization. Meteor hammer-like nanozyme Au-MnOx and agarose hydrogel were mixed to form multifunctional nanozyme hydrogel (MNH). The system experienced a reduction in MNH hardness when exposed to 1064 nm laser irradiation, allowing the release of Au-MnOx to react with H<sub>2</sub>O<sub>2</sub> in the tumor microenvironment, resulting in the production of <b>·</b>OH, which destroys bioactive substances and increases oxidative stress. This process also improves the effectiveness of hyperthermia in photothermal therapy (PTT). In addition, MNH-baed PTT enhances the RT sensitivity. Additionally, Au, with a high atomic number emits X-rays, leading to the generation of reactive oxygen species (ROS) through preexisting processes, which enhances radiation-induced DNA damage. Notably, the in vivo results indicated that MNH + NIR + RT could achieve a potent tumor inhibition rate with negligible side effects to normal tissues. This work paves a new avenue for novel nanozyme-based radiosensitization.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-Printed CRISPR-based detection system powered by a reusable handwarmer 基于crispr的3d打印检测系统，由可重复使用的暖手器提供动力。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-11-22 DOI: 10.1007/s10544-025-00782-x

Daniel Schreiber, Rui Yang, Xin Guan, Kurt T. Schalper, Chengyu Hou, Ziyue Li, Poornima Hegde, Changchun Liu

{"title":"3D-Printed CRISPR-based detection system powered by a reusable handwarmer","authors":"Daniel Schreiber, Rui Yang, Xin Guan, Kurt T. Schalper, Chengyu Hou, Ziyue Li, Poornima Hegde, Changchun Liu","doi":"10.1007/s10544-025-00782-x","DOIUrl":"10.1007/s10544-025-00782-x","url":null,"abstract":"<div><p>Nucleic acid-based molecular diagnostics are essential for the prevention, early detection, and treatment of cancer and infectious diseases. In this study, we developed a 3D-printed, electricity-free detection system for CRISPR-based nucleic acid detection. To eliminate the need for costly electrical heaters, we developed a reusable heating platform powered by a sodium acetate-based handwarmer. To maintain optimal temperatures for the CRISPR reaction, we designed and fabricated a 3D-printed heatsink filled with docosane wax to regulate the temperature. The fully 3D-printed microfluidic chip integrates finger-activated fluid transport <i>via</i> a 3D-printed flexible blister, a CRISPR reaction chamber, and a lateral flow strip for visual readout. We demonstrated the system’s analytical performance by detecting HPV-16 DNA with a sensitivity as low as 1 femtomolar. Additionally, we validated its clinical pilot feasibility using clinical cervical samples, achieving results consistent with standard PCR assays. Overall, this low-cost, reusable, and electricity-free detection system offers a practical solution for point-of-care molecular testing, particularly in resource-limited settings.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145581704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automation of electrothermal cell sheet manipulator for seamless tissue assembly and handling 用于无缝组织装配和处理的电热细胞片机械手的自动化

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-11-21 DOI: 10.1007/s10544-025-00781-y

Sehong Kang, Min Ku Kim, Chi Hwan Lee, Hyunjoon Kong

{"title":"Automation of electrothermal cell sheet manipulator for seamless tissue assembly and handling","authors":"Sehong Kang, Min Ku Kim,  Chi Hwan Lee, Hyunjoon Kong","doi":"10.1007/s10544-025-00781-y","DOIUrl":"10.1007/s10544-025-00781-y","url":null,"abstract":"<div><p>The manipulation of fragile biological tissues such as engineered cell sheets remains a major challenge for regenerative medicine and tissue engineering. Manual handling with tools like tweezers often induces wrinkling or tearing, compromising tissue integrity. Here, we present an automated cell sheet manipulator that integrates a thermoresponsive microchanneled poly(N-isopropylacrylamide) (PNIPAAm) hydrogel with an embedded microheater, mounted on a programmable three-axis motorized stage. Upon localized heating and cooling, the hydrogel undergoes rapid, reversible volumetric transitions that enable suction-based gripping and release of cell sheets within a few seconds. The custom LabVIEW interface synchronizes stage movement and thermal cycling, allowing reproducible, hands-free operation. A compliance-based Z-axis apparatus ensured uniform low-magnitude contact forces, preventing mechanical damage during transfer. Using this system, human iPSC-derived neural sheets were reliably transferred onto human brain microvascular endothelial cell (hBMEC) monolayers. Compared to manual transfer, the automated manipulator preserved cell sheet flatness and minimized micro-wrinkling, resulting in safe retention of intercellular architecture and structural integrity. This work demonstrates a robust, user-friendly platform for automated and gentle handling of delicate biological sheets. By enabling the precise stacking of engineered tissues while preserving their morphology, this system provides a promising tool for advanced biofabrication workflows, supporting defect-free 3D tissue assembly and implantation.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10544-025-00781-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145561709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-contact culturing of vascular endothelial cells on wall surface following retention using acoustic radiation force and lipid bubbles 利用声辐射力和脂质泡在管壁表面非接触培养血管内皮细胞

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-10-31 DOI: 10.1007/s10544-025-00771-0

Shunya Watanabe, Yuki Ichikawa, Kota Konishi, Ayako Noguchi, Konoha Saito, Yoshitaka Miyamoto, Daiki Omata, Ryo Suzuki, Kohji Masuda

{"title":"Non-contact culturing of vascular endothelial cells on wall surface following retention using acoustic radiation force and lipid bubbles","authors":"Shunya Watanabe, Yuki Ichikawa, Kota Konishi, Ayako Noguchi, Konoha Saito, Yoshitaka Miyamoto, Daiki Omata, Ryo Suzuki, Kohji Masuda","doi":"10.1007/s10544-025-00771-0","DOIUrl":"10.1007/s10544-025-00771-0","url":null,"abstract":"<div><p>For application in the fabrication of artificial blood vessels, we developed a method for non-contact culturing of vascular endothelial cells following a process of non-contact retention. Utilizing the propulsive force acting on cells under ultrasound exposure when the cells were surrounded by lipid bubbles, the conditions of the acoustic field were investigated. First, cells were cultured in the presence of lipids without ultrasound to derive the optimal concentration of lipids. Next, cells were retained on the inner surface of the flow path using various acoustic fields, which include single-focal, multifocal, and bar-shaped fields. After culturing the cells in the path without flow for 24 h, the cultured area of cells was measured to evaluate the series of performance. In the experiment of cell culturing without ultrasound, the cultured area decreased inversely proportional to the lipid concentration, thus deriving the optimal concentration of bubbles. When the bar-shaped fields were used for the retention process, significant cell engraftment was observed compared to other fields, even though the acoustic intensity of SATA (Spatial average temporal average) and the retained area of the cells were similar. Those results suggest that conditions of acoustic field, including the distribution and magnitude of sound pressure according to the flow direction, are dominant for non-contact culturing of cells following retention. We succeeded in culturing cells at desired position on inner wall of the path, regardless of the direction of gravity.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral flow immunoassay based on large-sized Au@Ag nanoparticles for stable colorimetric enhanced detection of D-dimer 横向流动免疫分析法基于大尺寸Au@Ag纳米颗粒稳定比色增强检测d -二聚体

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-10-31 DOI: 10.1007/s10544-025-00776-9

Jingfei Zhang, Xuanxu Nan, Li Yang, Yue Cui

引用次数: 0

Advances in microengineered platforms for 3D tumor production and modeling 三维肿瘤生成和建模微工程平台的进展。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-10-27 DOI: 10.1007/s10544-025-00778-7

Xufang Liu, Meilin Sun, Jinwei Zhang, Tingting Xuanyuan, Danyang Yu, Zheping Wang, Ying Wang, Zhenghao Deng, Wenming Liu

{"title":"Advances in microengineered platforms for 3D tumor production and modeling","authors":"Xufang Liu, Meilin Sun, Jinwei Zhang, Tingting Xuanyuan, Danyang Yu, Zheping Wang, Ying Wang, Zhenghao Deng, Wenming Liu","doi":"10.1007/s10544-025-00778-7","DOIUrl":"10.1007/s10544-025-00778-7","url":null,"abstract":"<div><p>The facile and large-scale construction of in vitro biomimetic three-dimensional (3D) tumor models has been pursued for cancer exploration, clinical/preclinical drug screening and discovery, as well as personalized therapy. The utilization of microengineering technologies in in vitro tumor fabrication and modeling is one of the most promising approaches and allows to create innovative outcomes being impractical or impossible to reach using conventional methods. Herein, an overview of technological and methodological development of microengineered systems for 3D tumor production and modeling is presented. The typical features of microengineering technologies are emphasized. The recent progress in the establishment of the miniaturized platforms based on multiple microfluidic and microarray methods for 3D tumor preparation and biomimetic construction are summarized. Their key advantages, achievements, and limitations with respect to cell manipulation and tumor formation are described and discussed. Finally, the challenges that need to be overcome to strengthen the functional performance of microengineered platforms are highlighted.</p></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mucoadhesive properties of Opuntia-carrageenan superporous hydrogel on gastrointestinal mucosa 欧普蒂-卡拉胶超多孔水凝胶对胃肠道粘膜黏附性能的评价。

IF 3.3 4区医学

Biomedical Microdevices Pub Date : 2025-10-27 DOI: 10.1007/s10544-025-00777-8

Itishree Jogamaya Das, Trishna Bal, Himansu Bhusan Samal, Abu Mohiuddin

{"title":"Evaluation of mucoadhesive properties of Opuntia-carrageenan superporous hydrogel on gastrointestinal mucosa","authors":"Itishree Jogamaya Das, Trishna Bal, Himansu Bhusan Samal, Abu Mohiuddin","doi":"10.1007/s10544-025-00777-8","DOIUrl":"10.1007/s10544-025-00777-8","url":null,"abstract":"<div><p>This study evaluates the mucoadhesive properties of <i>Opuntia</i>-carrageenan superporous hydrogel (OPM-CRG SPH) in vitro and in vivo, assessing its potential as a biomaterial for gastrointestinal (GI) mucoadhesive drug delivery systems. Mucoadhesive polymers are critical for anchoring drug delivery devices to specific mucosal sites, enabling localized and sustained drug presence. By prolonging residence time at the site of application, such biomaterials hold the potential to improve drug bioavailability and therapeutic outcomes, particularly in GI delivery platforms. This research explores the mucoadhesive performance of OPM-CRG SPH, which could advance the development of effective GI mucoadhesive drug delivery systems. In vitro mucoadhesion was tested using goat GI mucosa and a texture analyzer, measuring key parameters such as work of adhesion (W<sub>ad</sub>) and maximum detachment force (F<sub>max</sub>) under varying instrumental conditions. In vivo GI-retention studies were conducted on New Zealand rabbits, using X-ray radiography to monitor the formulation’s retention in the GI tract (GIT). Mucoadhesion increased with contact time and force but exhibited minimal change by withdrawal speed. Distinct mucoadhesive behaviors were observed across different GIT segments, with the highest F<sub>max</sub> and W<sub>ad</sub> values recorded in large intestinal tissues. In vivo studies confirmed maximum adherence at higher pH levels, consistent with in vitro findings. X-ray imaging demonstrated successful 8 to 10-h mucoadhesion in rabbits. The hydrogel exhibits promising mucoadhesive properties, making it a viable candidate for GI drug delivery systems. Its ability to adhere effectively across various GI segments and sustain prolonged retention highlights its potential for enhancing drug delivery efficiency.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0