Cancer Control最新文献

{"title":"Associations of County-Level Urbanicity With Overall Survival Across 19 Solid Tumor Groups, 2004-2023: A SEER Cohort Study of 5.5 Million Patients.","authors":"Lihui Liang, Jiancheng Huang, Qingbai Jiang","doi":"10.1177/10732748261491675","DOIUrl":"https://doi.org/10.1177/10732748261491675","url":null,"abstract":"<p><p>IntroductionWe evaluated whether county-level urbanicity at diagnosis was associated with overall survival (OS) across 19 solid tumor groups in SEER.MethodsThis retrospective, population-based cohort study included adults aged ≥18 years with first primary invasive solid tumors diagnosed during 2004-2023. County-level urbanicity at diagnosis was defined using the SEER-linked, year-specific Rural-Urban Continuum Code (RUCC) as nonmetropolitan (NM; RUCC 4-9), small/medium metropolitan (SMM; RUCC 2-3; metropolitan areas with <1 million residents), or large metropolitan (LM; RUCC 1; metropolitan areas with ≥1 million residents). Cancer-specific overlap-weighted Cox models estimated mortality hazard ratios (HRs), complemented by 36-month OS, restricted mean survival time (RMST), and sensitivity analyses.ResultsThe cohort included 5,486,535 patients: 664,872 in NM, 1,571,092 in SMM, and 3,250,571 in LM areas. In the primary adjusted model, SMM and LM residence were associated with significantly lower all-cause mortality than NM residence in 13 and 14 of 19 tumor groups, respectively, after false discovery rate (FDR) correction. For lung cancer, the HRs were 0.97 (95% CI, 0.96-0.98) for SMM versus NM and 0.93 (95% CI, 0.92-0.95) for LM versus NM; neither contrast was significant for esophageal cancer. Direct SMM-versus-LM comparisons differed significantly in 8 tumor groups, all favoring LM. Absolute differences were modest; the largest 36-month OS difference was 3.59 percentage points (stomach cancer, LM vs NM), and the largest 36-month RMST difference was 1.26 months (other digestive system/peritoneal tumors, LM vs NM).ConclusionsCompared with NM residence, SMM and LM residence were associated with more favorable OS in multiple solid tumor groups, with associations observed more broadly for LM residence. These observational findings do not establish causal effects of residence.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261491675"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Multidisciplinary Team Meetings and Short-Term Postoperative Outcomes in Gastrointestinal Malignancies: A Retrospective Cohort Study.","authors":"Hengbin Zhao, Bang Liu, Mingze Wu, Guozheng Ding, Yongjia Yan, Weihua Fu","doi":"10.1177/10732748261495563","DOIUrl":"https://doi.org/10.1177/10732748261495563","url":null,"abstract":"<p><p>IntroductionMultidisciplinary team meetings (MTMs) integrate expertise from different specialties to support individualized treatment planning. However, their association with short-term postoperative outcomes in high-risk patients with gastrointestinal malignancies remains unclear. This study evaluated the implementation of preoperative MTM discussion and its association with postoperative outcomes in patients with gastric cancer (GC) or colorectal cancer (CRC) complicated by diabetes mellitus and/or coronary heart disease.MethodsThis single-center retrospective cohort study included consecutive patients with histologically confirmed gastric or colorectal adenocarcinoma and concomitant diabetes mellitus and/or coronary heart disease who underwent radical resection between January 2020 and January 2024. Patients were divided into MTM and no-MTM groups according to whether they received preoperative MTM discussion. The primary outcome was the severity of postoperative complications during the hospitalization, categorized as no complication, Clavien-Dindo grade I-II, or grade III or higher. Multivariable ordinal logistic regression was used to estimate the association between the absence of preoperative MTM discussion and increasing complication severity. The secondary outcome was the occurrence of any postoperative complication and was analyzed using binary logistic regression. Firth penalized logistic regression for major postoperative complications was performed as a sensitivity analysis.ResultsA total of 477 patients were included, with 191 in the MTM group and 286 in the no-MTM group. The no-MTM group had a higher overall postoperative complication rate than the MTM group (19.2% vs. 12.0%, p=0.039), whereas ICU admission and hospitalization costs were higher in the MTM group. Multivariable ordinal logistic regression showed that absence of preoperative MTM discussion, longer operative time per 30-minute increase, and preoperative hypoalbuminemia were independently associated with increasing postoperative complication severity. Secondary analyses yielded generally consistent findings.ConclusionsPreoperative MTM discussion was associated with a lower occurrence and lower severity of postoperative complications during the hospitalization among high-risk patients with GC or CRC.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261495563"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Co-Creating Community-Living Interventions for Sustainable Cancer Control Programs: Meeting the Community Where They Are to Address Cancer Burden.","authors":"Folakemi T Odedina, Hayley Thompson, Kimlin Tam Ashing","doi":"10.1177/10732748251414201","DOIUrl":"10.1177/10732748251414201","url":null,"abstract":"<p><p><b>Background:</b> While much of cancer research has historically centered on innovations within clinical or laboratory settings, most of the factors shaping equity in cancer outcomes reside outside hospital walls-in neighborhoods, workplaces, and community networks. This reality underscores the need for community-involved and community-living interventions: <i>programs co-designed and delivered within communities to meet people where they live, work, and socialize</i>. Such interventions hold the greatest promise for sustainability because they are embedded in the daily lives, cultures, and resources of the populations they serve. <b>Methods:</b> This special collection brings together research that illuminates the power of community-centered and community co-led strategies for prevention, early detection, treatment, and survivorship across diverse settings. <b>Results:</b> The articles in this series illustrate how innovation, cultural humility, and local engagement can bridge persistent gaps in cancer care. <b>Conclusion:</b> Together, they highlight how communities themselves are essential partners in dismantling disparities and achieving lasting cancer control.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748251414201"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Outcomes With Inetetamab-Based Regimens for HER2-Positive Metastatic Breast Cancer: A Multicenter Retrospective Analysis in China.","authors":"Fangchao Zheng, Jiale Zhang, Dongdong Zhou, Guohua Ren, Ling Qiang, Ting Wang, Fei Pan, Changping Shan, Chongsheng Xia, Fan Yang, Hongjian Wang, Guozhu Liu, Jingfen Wang, Ruimin Hua, Xin Du, Baoxuan Zhang, Huihui Li","doi":"10.1177/10732748261419187","DOIUrl":"10.1177/10732748261419187","url":null,"abstract":"<p><p>IntroductionInetetamab has demonstrated favorable efficacy and safety in treating HER2-positive metastatic breast cancer (MBC).MethodsThe multicenter retrospective study enrolled 140 patients with HER2-positive MBC who received inetetamab-based regimens between November 2020 and April 2023. Primary endpoint was progression-free survival (PFS); secondary endpoints included objective response rate (ORR), disease control rate (DCR), and safety.ResultsThe median patient age was 53 (range: 27-90) years, with inetetamab-based regimens administered as first-, second-, or third-line (or later) therapy in 13 (9.3%), 29 (20.7%), and 98 (70.0%) patients, respectively. Median PFS was 6.1 months in the overall population, with an ORR of 35.0% and a DCR of 77.1%. Patients receiving inetetamab as first- or second-line therapy had significantly longer median PFS (14.5 months; 95% CI, 9.5-19.5) than those receiving it as third-line or later therapy (4.8 months; 95% CI, 4.2-5.3; <i>P</i> < 0.0001). First-line treatment resulted in a median PFS of 22.2 months. Patients previously treated with trastuzumab without HER2-TKIs had longer median PFS than those with prior TKI exposure (12.8 vs 5.7 months; <i>P</i> = 0.001). Multivariate analysis confirmed that treatment line (1-2 vs ≥3) was independently associated with PFS (hazard ratio = 0.330; 95% CI: 0.211-0.517). The most common grade 3 or 4 adverse events included leukopenia (16.4%) and neutropenia (12.9%). No treatment-related deaths were reported.ConclusionInetetamab-based regimens have shown promising efficacy and are well-tolerated for patients with HER2-positive MBC. These anti-HER2 regimens could be considered an alternative treatment option for this disease.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261419187"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Correcting Misinformation is Challenging\": Exploring Barriers and Facilitators of Health Care Providers' Responsiveness to Cervical Cancer Screening Literacy Needs of Rural Women Living With HIV in Eastern Uganda.","authors":"Juliana Namutundu, Edith Nakku-Joloba, Juliet Kiguli, Fredrick Makumbi, Fred C Semitala, Rhoda K Wanyenze, Miriam Laker-Oketta, Damalie Nakanjako, Miriam Nakalembe","doi":"10.1177/10732748261419591","DOIUrl":"10.1177/10732748261419591","url":null,"abstract":"<p><p>IntroductionCervical cancer screening literacy among rural women living with HIV (WLHIV), the ability to access, understand, appraise, and apply cervical cancer screening information to use cervical cancer screening services, is affected by individual factors including low educational attainment, low socioeconomic status, poor cervical cancer risk perception, fear, misconceptions, and beliefs, as well as interpersonal, community, and health facility barriers. However, rural public health facilities have limited resources that limit their ability mitigate these challenges. This research identified barriers and facilitators of healthcare providers' responsiveness to cervical cancer screening literacy needs of rural WLHIV in Eastern Uganda.MethodsThis was a descriptive qualitative study that involved conducting 15 Key Informant Interviews with all individuals involved in planning, communicating, and providing cervical cancer screening services at 4 purposively selected rural public health facilities in Eastern Uganda. Data were collected using a guide developed based on the organizational Health Literacy responsiveness framework. This framework was used to derive deductive categories (domains and sub-domains) during thematic analysis, and barriers and facilitators were inductively identified from the interviews.ResultsBarriers included non-involvement of health workers and affected women in planning, limited funding, few trained health workers, long waiting times, limited space, limited communication modalities, inadequate Information Education and Communication (IEC) materials, IEC materials not translated to the local language, challenges with addressing misconceptions, and language barriers. Facilitators included support from implementing partners, free cervical cancer screening services, integration of cervical cancer screening into HIV care, consumer-centered care, clear pathways and navigation support, using peers during health education, availability of IEC materials, using simple, local language during education sessions, and health worker facilitation.ConclusionStrategies targeted at the identified factors can improve health care providers' responsiveness to the cervical cancer screening literacy needs of rural WLHIV in Eastern Uganda.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261419591"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Text Messaging as a Tool to Address Language Barriers in Cervical Cancer Screening Among Spanish-Preferred Populations: A Quality Improvement Study.","authors":"Brittany A Strelow, Emmarie Byom, Haley Wangen, Julia Backlund, Faith Van Erp, Lydia Wilson, Cynthia Herrera, Rachel Olson, Angela J Fought, Matt Shelden, Danielle O'Laughlin","doi":"10.1177/10732748261478959","DOIUrl":"https://doi.org/10.1177/10732748261478959","url":null,"abstract":"<p><p>BackgroundDespite advances in cervical cancer screening, cervical cancer rates have been increasing in the last decade. Hispanic women have higher cervical cancer incidence and mortality rates compared to non-Hispanic women in the United States. These disparities are primarily due to language barriers experienced in this Spanish-preferred population. Our study aims to improve cervical cancer screening rates among Spanish-preferred patients through a Spanish-language multimedia presentation on cervical cancer screening.MethodsIn patients not adherent to U.S. cervical cancer screening guidelines, we conducted a non-randomized study comparing standard care in Family Medicine (FM) to standard care plus a multimedia presentation with Spanish voiceover intervention in Internal Medicine (IM). We evaluated whether baseline characteristics differed between the two study arms using the Wilcoxon rank sum test and either the Chi-Square test or Fisher's exact test. For the primary goal, we examined whether there was a difference in screening scheduling rates between the intervention and standard care groups using the Chi-Square test. Using descriptive statistics, we investigated whether there was a difference in characteristics for those who scheduled screening and those who did not.ResultsWe had 52 patients in IM and 58 in FM, differing in age and insurance status, with median ages of 45.5 and 40.0, and percent insured of 65.4% and 82.8%. Post-study, 25.0% (13/52) in IM and 15.5% (9/58) in FM scheduled cervical screening appointments, which was not significantly different, p=0.21. Patients who scheduled screening had higher rates of insurance coverage, at 95.5% compared to 69.3%.ConclusionNo statistically significant difference in scheduling rates among Spanish-preferred patients was observed in this study. Further efforts should include larger samples and randomization.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261478959"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in EGFR-TKI-Related Adverse Events: A Pharmacovigilance Study Based on the FAERS Database.","authors":"Shuman Wang, Tingting Wu, Yajing Liu, Chen Shi, Zhiwen Fu","doi":"10.1177/10732748261452789","DOIUrl":"10.1177/10732748261452789","url":null,"abstract":"<p><p>IntroductionBased on the FAERS database, this retrospective pharmacovigilance study analyzed gender-based reporting signals for adverse events associated with three EGFR-TKIs.MethodsAdverse drug reaction (ADR) data were collected from the FAERS database for three drugs: gefitinib (Q4 2003-Q4 2024), afatinib (Q4 2013-Q4 2024), and osimertinib (Q4 2015-Q4 2024). Reporting odds ratio (ROR) was used to detect the disproportionality signals and to assess the presence of gender differences in reporting.ResultsA total of 6,618 adverse events were reported for gefitinib (3,917 in females and 2,701 in males), 5,073 for afatinib (3,110 in females and 1,963 in males), and 18,415 for osimertinib (12,007 in females and 6,408 in males). For all three medications, the annual number of adverse drug event (ADE) reports was higher in females than in males. The ROR value and number of ADE reports under the SOC distribution indicated predominant reporting signals of skin and gastrointestinal adverse reactions. Gender-specific analysis of skin and gastrointestinal ADEs revealed that: (i) Gefitinib showed higher reporting signals for intestinal pneumatosis and skin ulcers in females; (ii) Afatinib showed higher reporting signals for acneiform dermatitis and oral pain in females, while males showed a higher reporting frequency of stomatitis and glossitis; (iii) Osimertinib showed higher reporting signals for diarrhea in females. These observed reporting disparities generate hypotheses regarding potential contributing factors, such as gender-based differences in hormone levels, gastrointestinal tract anatomy, and skin barrier function.ConclusionsThis pharmacovigilance analysis suggests the presence of sex-based reporting disparities in adverse event reports for three EGFR-TKIs. Females showed overall stronger reporting signals, with notable differences observed in specific skin and gastrointestinal events. Although the analysis has certain limitations, these findings generate hypotheses to inform future focused investigations.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261452789"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13180208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of RAS Pathway Gene Mutations on Survival in Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis.","authors":"Yasmin Eslalakawi, Mohamed Omar Saad, Amin S Sanosi, Rowan Mesilhy, Abdulrahman F Al-Mashdali, Nabil E Omar, Ahmed O Saleh, Elmustafa Abdalla, Amal Elfatih, Shehab F Mohamed","doi":"10.1177/10732748261424957","DOIUrl":"10.1177/10732748261424957","url":null,"abstract":"<p><p>IntroductionMyelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenia, and risk of progression to acute myeloid leukemia. Somatic mutations in RAS pathway, including NRAS, KRAS, and PTPN11, are known contributors to leukemogenesis, yet their prognostic significance in MDS remains incompletely defined. This systematic review and meta-analysis assesses the impact of RAS pathway genes mutation on survival outcomes in adult patients with MDS.MethodsPubMed, Embase, Scopus, Web of Science, and Gene Expression Omnibus were systematically searched on January 2025. This review included English-language studies involving adults with MDS that examined the impact of RAS pathway mutations on survival, including either hazard ratios or Kaplan-Meier data. Studies were excluded if they included only specific treatments, narrow subgroups, secondary MDS, or were not original research. Sixteen papers eventually met the inclusion criteria. Data extraction and quality assessment were independently performed by multiple reviewers. The methodological quality of each study was assessed using the MASTER scale. Hazard ratios were pooled using a random-effects model.ResultsSixteen retrospective cohort studies involving 7969 patients tested for RAS pathway mutations were included. KRAS mutations were associated with poorer overall survival when compared to patients without the mutation (HR 1.66, 95% CI 1.32-2.08, <i>P</i> < 0.001). NRAS mutations were linked to worse overall survival (HR 1.73, 95% CI 1.46-2.04, <i>P</i> < 0.001) and leukemia-free survival (HR 2.48, 95% CI 1.47-4.18, <i>P</i> < 0.001) in comparison to those without the mutation. PTPN11 mutations were also associated with decreased overall survival (HR 1.36, 95% CI 1.01-1.85, <i>P</i> = 0.046) compared to individuals without the mutation.ConclusionMutations in the RAS pathway, particularly NRAS, KRAS, and PTPN11, are associated with inferior survival outcomes in adult patients with MDS. These findings underscore the prognostic relevance of RAS mutations and highlight their potential utility in refining current risk stratification models such as IPSS-M, WPSS, and MDAS.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261424957"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12979904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Exploration of HPV Vaccination Decisions Among Central American Immigrant Parents in the United States: A Socio-Ecological Perspective on Barriers and Facilitators.","authors":"Denisse Delgado, Denise Lima Nogueira, Virginia Arango Moreno, Madelyne J Valdez, Doris Lucero, Axel Hernandez Nieto, Nachalie Rodriguez-Cruz, Ana Cristina Lindsay","doi":"10.1177/10732748261433630","DOIUrl":"10.1177/10732748261433630","url":null,"abstract":"<p><p>IntroductionHPV vaccination is crucial for preventing HPV-related cancers, yet rates remain below target, particularly among ethnic and immigrant communities in the United States (U.S.), where systemic barriers contribute to disparities. While research on HPV vaccination in Latino populations is growing, immigrants from Northern Triangle-El Salvador, Guatemala, and Honduras-are underrepresented. This study explored multilevel barriers and facilitators to HPV vaccination among Central American immigrant parents, a largely understudied group in vaccine research.MethodsThis qualitative, descriptive, exploratory study used in-depth, semi-structured interviews, guided by the Social Ecological Model (SEM) and the Health Belief Model (HBM). These frameworks informed the interview guide and analysis, capturing multilevel influences (SEM) and individual perceptions of susceptibility, severity, benefits, and barriers (HBM). Thematic analysis, using inductive and deductive approaches in MAXQDA, was organized by SEM levels, with HBM constructs integrated to interpret intrapersonal beliefs shaping vaccination decisions.ResultsFifty-six parents (33 mothers, 23 fathers; mean age = 42.7 years) participated; nearly all (92.8%) were foreign-born (average U.S. residency = 17.3 years) from El Salvador, Guatemala, and Honduras. They had 77 children (ages 11-17). About 33% of children had received an HPV vaccine recommendation from a healthcare provider, and all who received a recommendation initiated vaccination (≥1 dose). Analysis revealed a complex interplay of intrapersonal, interpersonal, organizational, community, and policy-level factors. HBM constructs highlighted how perceived susceptibility, severity, benefits, and barriers influenced decisions. Key themes included knowledge gaps, cultural norms, institutional support, and systemic barriers impacting uptake.ConclusionsFindings underscore the need for multilevel approaches to vaccination decision-making among immigrant populations. Interventions should integrate SEM and HBM perspectives, combining culturally relevant education, family and provider support, community-driven initiatives, and supportive policies to enhance vaccine literacy, build trust, reduce barriers, and increase HPV vaccine acceptance and coverage among Central American immigrants in the U.S.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261433630"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Clinician-Patient Communication and the Quality of Life of Patients With Leukaemia: A Prospective Cross-Sectional Global Study.","authors":"Samantha Nier, Alan J Poots, Sarah Gunn, Esther Natalie Oliva, Tatyana Ionova, Sam Salek","doi":"10.1177/10732748261433287","DOIUrl":"10.1177/10732748261433287","url":null,"abstract":"<p><p>IntroductionThis study examined relationships between patient reported quality of life and demographic, disease related, and clinician-patient communication variables in people with leukaemia, using a validated haematological malignancy specific patient-reported outcome measure to provide insights to help improve care and enhance patient well-being.MethodsA prospective global cross-sectional online questionnaire study was conducted, with people self-identifying as patients with leukaemia, that included 100 items on demographics, information on communication, disease and treatment and the Haematological Malignancy Patient-Reported Outcome (HM-PRO) instrument. The HM-PRO scores were analysed using Kruskal-Wallis tests and Gradient Boosting Decision Trees (GBDTs) to identify key factors associated with patient outcomes.Results2,260 patients with leukaemia participated, from 64 countries, of whom 1,993 completed the HM-PRO Part-A (measure of QoL) and 1,951 completed Part-B (signs and symptoms). The HM-PRO scores varied significantly by demographic factors, with younger patients (18-25) and people with acute leukaemia reporting the highest scores. Communication about treatment decisions and side effects was significantly associated with HM-PRO scores (η²: 0.012-0.063). GBDT models had high Area Under Curve but low accuracy: isolation and depression emerged as key predictors of QoL classification.ConclusionImproved clinician-patient communication and psychosocial support may mitigate the burden of leukaemia. Tailored, person-centred approaches integrating medical and emotional care could improve QoL, treatment adherence, and outcomes, particularly for younger patients and people facing significant treatment challenges. However, given the cross-sectional design, causal inferences cannot be made. We note our findings are presented strictly as associations observed in cross-sectional data, and we acknowledge the potential for bidirectional relationships between QoL and the variables explored. The findings primarily reflect the experiences of individuals who are more engaged, digitally included, or connected to advocacy organisations, rather than the broader leukaemia population.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"33 ","pages":"10732748261433287"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}