Cancer Control最新文献

{"title":"Reversed Gender Burden of Pancreatic Cancer Attributable to High BMI: A GBD 2021 Analysis of 204 Countries with Projections to 2041.","authors":"Ruishuang Chen, Junping Wei","doi":"10.1177/10732748251372674","DOIUrl":"https://doi.org/10.1177/10732748251372674","url":null,"abstract":"<p><p>BackgroundPancreatic cancer (PC) is one of the most lethal cancers around the world. A high body mass index (BMI) is recognized as a significant and modifiable risk factor for this disease.MethodsData were obtained from the Global Burden of Disease (GBD) 2021 study. We used joinpoint regression and age-period-cohort (APC) models for trend analysis, and the Autoregressive Integrated Moving Average (ARIMA) model to forecast the burden of high BMI-related PC in 2022-2041. In addition, we used decomposition and health inequality analyses to examine causes and regional inequalities in the burden of high BMI-related PC.ResultsFrom 1990 to 2021, the total number of deaths from high BMI-related PC increased nearly tenfold. In the last 30 years, females consistently bore a greater burden of BMI-related PC, whereas the increase among males was more substantial. Deaths from high BMI-related PC escalated by 7 to 12 times in the 20-49 age group and by over sevenfold in low social development index (SDI) regions, reflecting increasing risk in younger populations and worsening global health inequalities. Furthermore, we predict that the global age-standardized mortality rate (ASMR) will continue to increase over the next 20 years.ConclusionOur findings generally revealed a sharply increased trend for the global burden of PC associated with high BMI during the past 30 years, as well as pronounced disparities by sex, age, and region. Hence, countries and nations should urgently advocate targeted public health initiatives in the future, especially in high-burden regions and populations.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251372674"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Events of Immune Checkpoint Inhibitors in Cancer Patients with Comorbid Diabetes: A Real-World Pharmacovigilance Analysis of the FDA Adverse Event Reporting System Database (2011-2025).","authors":"Minxia Yang, Di Qiu, Minguang Huang, Shengjian Yu, Feng Xuan","doi":"10.1177/10732748251381428","DOIUrl":"10.1177/10732748251381428","url":null,"abstract":"<p><p>IntroductionImmune checkpoint inhibitors (ICIs) have redefined cancer therapeutics. However, they may provoke immune-related adverse events (irAEs), with diabetes potentially altering their patterns. We aimed to investigate whether diabetic cancer patients exhibit a distinctive or intensified irAE pattern.MethodsWe performed a real-world, retrospective pharmacovigilance study of ICIs using the FDA Adverse Event Reporting System from 2011 to 2025. Reports listing anti-PD-1 (Nivolumab, Pembrolizumab, Cemiplimab), anti-PD-L1 (Atezolizumab, Avelumab, Durvalumab), and anti-CTLA-4 (Ipilimumab, Tremelimumab) agents as suspected drugs were extracted. Disproportionality signals were identified with 4 algorithms: Bayesian Confidence Propagation Neural Network, Reporting Odds Ratio, Proportional Reporting Ratio, and Multi-item Gamma Poisson Shrinker. Time-to-onset was calculated from therapy start to event date, modelled with Weibull distributions, and compared across subgroups with non-parametric tests.ResultsOf 22,775,812 FAERS reports, 1886 involved ICIs used in cancer patients with comorbid diabetes. 423 (22.4 %) were fatal and 1463 (77.6 %) non-fatal. Men predominated (71.5 %), and 63.0 % of patients were aged 65-85 years. Combination therapy (anti-CTLA-4 plus PD-1 or PD-L1) accounted for the highest death proportion (29.6 %). Disproportionality analysis revealed the strongest preferred-term signals for pneumonitis/interstitial lung disease, hypothyroidism, and colitis among all diabetic cancer patients receiving ICI therapy. At the system-organ-class level, endocrine, hepatobiliary, and blood/lymphatic disorders showed the most consistent risk across agents. Weibull modelling demonstrated an early-failure pattern (shape β < 1) with a median time-to-onset of 126.6 days overall, shortening to 90.9 days with combination therapy. Fatal subgroup occurred sooner than non-fatal subgroup (median 106.7 vs 132.5 days; <i>P</i> = 0.004).ConclusionDiabetic cancer patients experienced the full spectrum of ICI-associated toxicities, with combination treatments linked to greater lethality. Multidisciplinary surveillance during the first 3-4 months of therapy, glycemic control, and long-term follow-up may be essential to optimize benefit and minimize harm in this expanding population.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251381428"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and Intermediate-Term Morbidity Following Total Pelvic Exenteration in Colorectal Cancer.","authors":"Christopher Guske, Nusheen Immen, Devon Conant, Jose Laborde, Joshua Linscott, Mitchell Hayes, Seyed Behzad Jazayeri, Adnan Fazili, Erin Siegel, Sophie Dessureault, Julian Sanchez, Amalia Stefanou, Brandon Manley, Seth Felder","doi":"10.1177/10732748251316598","DOIUrl":"10.1177/10732748251316598","url":null,"abstract":"<p><strong>Introduction: </strong>Total pelvic exenteration (TPE) for clinical T4b colorectal cancer (CRC) is associated with significant morbidity. Short (0-30 days)- and intermediate (31-90 days)-term temporal analysis of complication onset is not well described, yet needed, to better counsel patients considering TPE.</p><p><strong>Methods: </strong>A retrospective cohort study of consecutive patients with primary or recurrent clinical T4b pelvic CRC undergoing open TPE between 2014 and 2023 was conducted. Clinicopathologic variables were collected for each patient. Postoperative morbidity was classified according to the Clavien-Dindo (CD) grade system and stratified by time of onset within 90 days of surgery. Pearson's Chi-square test, Fisher's Exact test, and the Mann-Whitney U test were used to compare primary vs recurrent patient groups, and logistic regression assessed predictors of postoperative morbidity. Statistical analysis was performed using R with two-sided significance set at <0.05.</p><p><strong>Results: </strong>Twenty-seven patients were identified of which 24 (88.9%) were male with a median age of 60.4 years (interquartile range [IQR]: 56.3-70.5). Seventeen (63.0%) patients had primary disease and 10 (37.0%) had recurrent CRC. Twenty-three (85.2%) patients experienced at least one complication within 90 days of surgery, but no mortality was observed. Ten (37.0%) patients experienced a CD ≥ 3 event, of which 40% took place beyond 30 days. The most common complication overall was anemia requiring transfusion, while the most common major complication was pelvic abscess. No clinicopathologic variables analyzed were predictive of major postoperative complication within 90 days of TPE.</p><p><strong>Conclusion: </strong>TPE for clinical T4b CRC carries a high risk of postoperative morbidity in both the short- and intermediate-term after surgery, with a significant proportion of complications occurring after 30 days. Given the magnitude of operation, an extended recovery with high risk for complications is common. Although a single-center series, this annotated postoperative complication profile may assist patients and clinicians when reviewing informed consent for TPE.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251316598"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis Challenges in Adult Leukemia: Insights From a Single-Center Retrospective Study in Qatar (2016-2021).","authors":"Hesham A B Aboelkhir, Yousra El Alaoui, Regina Padmanabhan, Majed Hadid, Adel Elomri, Tanvir Alam, Mohamed Amine Rejeb, Halima El Omri, Ruba Y Taha, Hesham Elsabah, Abdelfatteh El Omri","doi":"10.1177/10732748241275026","DOIUrl":"10.1177/10732748241275026","url":null,"abstract":"<p><p>ObjectivesWhile delays in leukemia detection remain an ongoing challenge in hematologic cancer care, little is known about the factors associated with these delays. This article focuses on identifying the barriers hindering timely diagnosis of leukemia through a cohort analysis (2016-2021) of 220 Acute Myeloid Leukemia (AML), 161 Chronic Myeloid Leukemia (CML), 90 Acute Lymphocytic Leukemia (ALL), and 121 Chronic Lymphocytic Leukemia (CLL) patients in Qatar.MethodsOf the 592 patients used for the study, subsets were identified and analyzed for delay (423), risk stratification (437), and leukemia stage (282).ResultsThere was an increasing trend in leukemia cases, with 32% of patients being diagnosed in the high-risk category. Out of 423 (median delay = 28 days) patients, 45% reported delayed diagnosis (median delay = 44 days). Further analysis of the association of delayed leukemia diagnosis using the univariate <math><mrow><mi>χ</mi></mrow></math>2 independence test revealed significant associations to patient referral type, and the presence of certain comorbidities and symptoms.ConclusionSignificant delays in leukemia diagnosis were identified, though the exact cause remains unclear. These delays can be attributed to factors such as patient, primary care, referral, system, and physician delays. Therefore, further investigation is imperative for improving the detection, diagnosis, and referral processes in hematologic cancers.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748241275026"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival.","authors":"Meng-Han Tsai, Jorge Cortes, Kenneth J Vega","doi":"10.1177/10732748251357469","DOIUrl":"10.1177/10732748251357469","url":null,"abstract":"<p><p>IntroductionEarly-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for EOCRC across three age-at-diagnosis groups.MethodsWe conducted a retrospective cohort analysis using the 2006-2020 Surveillance, Epidemiology, and End Results (SEER) Program, using multivariable logistic and Cox proportional hazards models to examine the association of race/ethnicity and age with survival.ResultsAmong 46,956 EOCRC patients, racial minorities were diagnosed with EOCRC at age of 20-29 years while non-Hispanic White patients were more commonly diagnosed at age 40-49 years (<i>P</i>-value <0.001). In adjusted analysis, non-Hispanic Black (NHB) (AOR, 1.65; 95% CI, 1.24-2.18), Asian/Pacific Islander (AOR, 2.22; 95% CI, 1.60-3.08), and Hispanic (AOR, 1.56; 95% CI, 1.27-1.93) patients aged 20-29 years were more likely to be diagnosed at a late stage. These groups were also more likely to have mucinous adenocarcinoma or signet ring cell subtypes (NHB: AOR,1.46; 95% CI, 1.00-2.13; Asian/PI: AOR, 1.89; 95% CI, 1.28-2.77; Hispanic: AOR, 1.95: 95% CI, 1.48-2.59). Regardless of age groups, NHB patients were more likely to die from CRC by 34%-59% (20-29 years: AHR, 1.40; 95% CI, 1.11-1.76; 30-39 years: AHR, 1.59; 95% CI, 1.42-1.77; 40-49 years: AHR, 1.34; 95% CI, 1.26-1.41).ConclusionPrioritizing prevention strategies and enhancing access to screening for racial minorities and the 20-29 age group is warranted.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251357469"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Distinct Research Gaps that Complement Previous Critiques of Militaristic Language in Relation to Cancer and Other Non-Military Topics.","authors":"Kari Almendingen","doi":"10.1177/10732748251349935","DOIUrl":"10.1177/10732748251349935","url":null,"abstract":"<p><p>Militaristic language is pervasive in cancer discourse across media, fundraising, politics, healthcare, and science, despite longstanding critiques from both civilian and military perspectives. Critics argue that framing cancer as a war or battle can lead to feelings of shame and inadequacy, particularly for those with metastatic cancer. This language often diverts focus from prevention and early detection strategies, complicating public perception and understanding of cancer. Two distinct research gaps related to the use of militaristic language in cancer discourse remain unaddressed: the role of dual-use technologies and the perspectives of individuals with wartime experience. Dual-use technologies, initially developed for military applications, have significantly advanced cancer diagnosis and treatment. Yet, their historical and ethical implications are largely absent from public discourse and scientific literature. Awareness of the complex role that dual-use technologies play in cancer diagnostics and treatment, as well as in other societal areas, could influence the prevalence of militaristic language used to describe challenges like cancer, drugs, poverty, and other civil issues. Secondly, studies have not examined opinions on the use of militaristic language among individuals with firsthand wartime experience, - such as civilian victims, military personnel, veterans, pacifists, and aid workers - compared to those without such experience. Both of these omissions may skew findings and overlook diverse perceptions. Addressing these research gaps could foster a more respectful public cancer discourse that takes into account the experiences of affected individuals. This commentary expands on existing critiques, urging professionals to adopt nuanced and inclusive language for cancer and other peaceful topics. Militaristic language is outdated, ethically questionable, and should not be used in science, healthcare, politics, fundraising, or other public contexts.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251349935"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Machine Learning for Early Mortality Prediction in Lung Adenosquamous Carcinoma: A Web-Based Prognostic Model.","authors":"Min Liang, Xiaocai Li, Shangyu Xie, Xiaoying Huang, Shifan Tan","doi":"10.1177/10732748251357449","DOIUrl":"10.1177/10732748251357449","url":null,"abstract":"<p><p>IntroductionCombined with the characteristics of adenocarcinoma and squamous cell carcinoma, lung adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer with more aggressive biological behavior. This study aimed to quantify the 90-day mortality rate in patients with ASC, identify associated features, and develop a predictive machine learning model.MethodsThis retrospective study obtained data from the Surveillance, Epidemiology, and End Results (SEER) program database, covering the period from 2000 to 2018. Through univariate logistic regression and Lasso analyses, significant prognostic features were determined. We developed predictive models using XGBoost, logistic regression, and AJCC staging algorithms, assessing their performance via metrics such as the Area Under the Receiver Operating Characteristic Curve (AUC), Decision Curve Analysis (DCA), Kolmogorov-Smirnov (KS) statistic, and calibration plots. Restricted Cubic Splines (RCS) were employed to assess potential non-linear relationships between continuous features and survival outcomes.ResultsOur analysis of 2820 eligible patients identified 6 clinical features significantly affecting outcomes. The XGBoost model exhibited exceptional discriminatory power, with AUC scores of 0.97 in the training set and 0.84 in the validation set, surpassing other models in all datasets according to AUC, KS score, DCA, and calibration analyses. RCS analysis showed a non-linear association between tumor size and prognosis, with a cutoff size of 44 mm. Moreover, we integrated the model into a web-based platform to enhance its accessibility.ConclusionsWe present a novel machine learning model, supported by an easily accessible web-based platform, to guide personalized clinical decision-making and optimize treatment strategies for patients with ASC.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251357449"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Role of Radiotherapy in Low-Grade Endometrial Stromal Sarcoma: A SEER-Based Study.","authors":"Huimin Jian, Jinju Guo, Wenxin Zhao, Wei Liu, Yuan Xiang, Xia Wang","doi":"10.1177/10732748251356935","DOIUrl":"10.1177/10732748251356935","url":null,"abstract":"<p><p>IntroductionLow-grade endometrial stromal sarcoma (LG-ESS) is a rare malignant mesenchymal neoplasm for which there is no consensus regarding the role of radiotherapy in treatment. This study aimed to evaluate the prognostic significance of external beam radiotherapy (EBRT) using data from the Surveillance, Epidemiology, and End Results (SEER) database.MethodsThis retrospective study evaluated the role of EBRT in 1254 patients with LG-ESS using SEER data (2000-2021). Propensity score matching (PSM) was applied to compare outcomes between EBRT and non-EBRT groups. Cox and competing risk models assessed overall survival (OS) and cancer-specific survival (CSS).ResultsEBRT showed no survival benefit in either unmatched or matched cohorts. Post-PSM, OS (HR = 1.21, 95% CI 0.61-2.39) and CSS (HR = 1.75, 95% CI 0.69-4.43) remained unaffected by EBRT (<i>P</i> > 0.05). Lymphadenectomy and bilateral salpingectomy and oophorectomy (BSO) also demonstrated no significant associations with survival outcomes. Key prognostic factors included older age, larger tumor size, advanced stage, and chemotherapy use, all linked to poorer OS and CSS.ConclusionEBRT, lymphadenectomy, and BSO do not offer significant survival benefits for patients with LG-ESS. Prognosis was independently influenced by age, tumor size, stage, and chemotherapy use (associated with poorer outcomes). These findings support a more individualized, risk-adapted approach to LG-ESS management and highlight the need for prospective studies to define the optimal role of comprehensive treatment strategies.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251356935"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of HPV and NKG2D rs1049174 Polymorphism in Vietnamese Patients With Oropharyngeal Squamous Cell Carcinoma.","authors":"Nguyen Van Hung, Nguyen Hoang Viet, Do Trung Duc, Tran The Dieu, Nguyen Thanh Binh, Le Huy Hoang, Nguyen Quang Trung","doi":"10.1177/10732748251362943","DOIUrl":"10.1177/10732748251362943","url":null,"abstract":"<p><p>IntroductionOropharyngeal Squamous Cell Carcinoma (OPSCC) etiology involves environmental and genetic factors, with Human Papillomavirus (HPV) being a key ecological driver. This study evaluated the relative importance of environmental factors, particularly HPV status, and the genetic polymorphism NKG2D rs1049174 in OPSCC among a Vietnamese population.MethodsA retrospective case-control study was conducted with 279 OPSCC patients and 250 healthy controls. HPV DNA was screened and typed using PCR and Sanger sequencing. Genotyping of NKG2D rs1049174 was performed using TaqMan assays. Logistic regression, Kaplan-Meier survival analysis, Cox proportional hazards regression, and Random Forest analysis were employed to assess associations between risk factors, genotype, clinical stage, survival, and HPV status.ResultsHPV status strongly predicted overall survival (OS), with HPV-positive patients exhibiting significantly longer survival (adjusted Hazard Ratio (aHR) = 0.32, <i>P</i> < 0.001). Univariate Kaplan-Meier analysis further suggested differential survival among specific HPV types, with HPV16 infection trending toward prolonging OS. In predicting advanced-stage OPSCC, Random Forest analysis identified HPV status as the most critical predictor (Mean Decrease Accuracy = 5.47). Males constituted the vast majority of OPSCC patients in both HPV-negative (97.4%) and HPV-positive (84.6%) subgroups. A statistically significant difference in alcohol consumption patterns was also observed between HPV-positive and HPV-negative patients. Furthermore, the NKG2D rs1049174 polymorphism was significantly associated with OPSCC risk, though not with advanced-stage disease or OS.ConclusionHPV infection plays a critical role in OPSCC in this Vietnamese cohort, influencing patient characteristics, clinical presentation, and survival outcomes. The NKG2D rs1049174 polymorphism was identified as a significant factor in OPSCC risk; however, it did not appear to be a significant factor in disease progression or survival in this population. Further research is needed to explore the complex interplay of environmental and genetic factors in OPSCC etiology in Vietnam.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251362943"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Feedback for the Development of a Novel Brief Colon Cancer Screening Decision Aid for Adults ≥75 years at Risk for Limited Health Literacy: A Pilot Study.","authors":"Cadet Tj, Brown Ck, Hu M, Ahn Z, Siska M, Halmo R, M Schonberg","doi":"10.1177/10732748251372677","DOIUrl":"https://doi.org/10.1177/10732748251372677","url":null,"abstract":"<p><p>IntroductionAchieving health literacy is a primary goal of Healthy People 2030 due to the increasing recognition of its role to improve the health and well-being of all populations. Shared decision-making (SDM), a recognized process between patients and health care providers to discuss which health care decision is best for the patient considering the pros and cons, patient preferences, and circumstances, can improve health outcomes. Specifically, SDM can increase patient knowledge and the quality of decision-making, resulting in patients feeling more empowered, demonstrating less decisional regret, and more motivation. Yet, limited health literacy (LHL) can hinder a patient's ability to engage in the SDM process. Patients' ability to engage in SDM can be helped by improving health literacy levels, and by the suitability of the tools available to support them. Decision aids (DA) are educational tools that can help with SDM. SDM provides patients with the necessary skills, which, when paired with DAs designed with and for populations with LHL, can improve communication with health care providers.MethodsGuided by elements of the Ottawa Decision Framework and principles of human-centered design, in this retrospective study we aimed to develop a novel and current brief colon cancer screening DA, \"Making a Decision: Should I Stop or Continue Colon Cancer Screening - Ages 75-85,\" based on feedback from adults ≥75 years at risk for LHL in two focus groups and a comprehensive health literacy demand assessment of the \"Making a Decision About Colon Cancer Screening\" using four tools to determine its readability, understandability, and actionability.ResultsFindings include a DA that was viewed favorably by older adult participants who were at risk for LHL.ConclusionsWith feedback from older adults at risk for LHL, we have developed a DA that can be tested in a larger randomized control trial.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251372677"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}