Cancer Control最新文献

{"title":"Letter re: Blood-Based Multi-Cancer Early Detection Tests (MCEDs) as a Potential Approach to Address Current Gaps in Cancer Screening.","authors":"K P Ameya, Durairaj Sekar","doi":"10.1177/10732748251317688","DOIUrl":"10.1177/10732748251317688","url":null,"abstract":"","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251317688"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Surgical Resection for Non-small-cell Lung Cancer Patients Comorbid With Minimal Pleural Effusion.","authors":"Haibo Wang, Tao Lu, Xinlong Zheng, Kan Jiang, Longfeng Zhang, Xiaobin Zheng, Qian Miao, Shiwen Wu, Zihua Zou, Shanshan Yang, Yujing Li, Sihui Chen, Yiquan Xu, Gen Lin","doi":"10.1177/10732748241311223","DOIUrl":"10.1177/10732748241311223","url":null,"abstract":"<p><strong>Background: </strong>The proportion and impact of minimal pleural effusion (PE) on prognosis remain blurred in operable non-small cell lung cancer (NSCLC) patients who reported minimal PE on imaging.</p><p><strong>Methods: </strong>Clinical and prognostic data of operable NSCLC patients who presented no distant metastasis, no direct pleural invasion, but minimal PE on preoperative imaging were retrospectively analyzed. The patients were divided into surgical (81 cases) and non-surgical (10 cases) cohorts. Potential or suspected malignant PE or pleural metastases were confirmed by surgery. The overall survival (OS) was analyzed by Kaplan-Meier curve and prognostic factors by multivariate Cox regression.</p><p><strong>Results: </strong>The surgical cohort reported no pleural invasion on preoperative imaging and no pleural metastases by postoperative pathology, with an overall median disease-free survival of 36.7 (28.6, 44.7) months and a median OS of 59.8 (45.7, 73.2) months, with the latter significantly longer in the surgical cohort than in the non-surgical cohort (59.8 months vs 20.37 months, <i>P</i> < 0.001). Multivariate analysis indicated surgical treatment as an independent prognostic factor for OS.</p><p><strong>Conclusion: </strong>Malignant PE is rare in operable NSCLC patients who report the presence of minimal PE but no distant metastasis or direct pleural invasion on preoperative imaging. Surgery may be the preferred treatment for these patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748241311223"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Features of Sinonasal Adenocarcinoma and Prognostic Nomogram: A Study Based on the SEER Database.","authors":"Lu Yang, Yufeng Gu, Lei Yu, Qiang Zhou, Li Liu, Ying Mao, Ji Ma, Yong Li, Na Li","doi":"10.1177/10732748241303423","DOIUrl":"10.1177/10732748241303423","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).</p><p><strong>Methods: </strong>Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival. A prognostic nomogram was then created based on these factors and assessed via concordance index, ROC analysis, and calibration curves.</p><p><strong>Results: </strong>Analysis of 488 SNAC patients indicated a rising incidence, peaking among 60-69-year-olds, with a male predominance and the highest occurrence in White populations. Common sites of occurrence included the nasal cavity, and the maxillary and ethmoid sinuses. The nomogram, developed with 184 patients, highlighted older age (≥70), male sex, advanced T stages (T4b, T4a), distant metastasis, larger tumors (≥5 cm), and lack of surgery as poor prognostic indicators. Nomogram performance demonstrated strong predictive capabilities in both training and validation cohorts.</p><p><strong>Conclusion: </strong>This investigation, leveraging the SEER database, elucidates the epidemiology of SNAC and pinpoints key adverse prognostic determinants: age ≥70, male gender, T stages T4b and T4a, presence of distant metastasis, tumor size exceeding 5 cm, and absence of surgical intervention. Moreover, it introduces a novel nomogram capable of accurately forecasting 1-, 3-, and 5-year OS for SNAC patients, thereby enhancing disease comprehension and facilitating the formulation of tailored therapeutic strategies by clinicians.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748241303423"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Artery Embolization in the Setting of Prostate Cancer: Review and Opinion.","authors":"Nainesh Parikh, Kosj Yamoah, Peter Johnstone, Javier Torres-Roca, Julio Pow-Sang, Daniel Fernandez, Anupam Rishi, G Daniel Grass","doi":"10.1177/10732748251317691","DOIUrl":"10.1177/10732748251317691","url":null,"abstract":"<p><p>Prostate Artery Embolization (PAE) is a novel minimally invasive angiographic technique that has been used effectively to treat men with lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH). However, applications of PAE for men with prostate cancer have been minimally studied. This review serves as an update on the status of PAE in men with prostate cancer, as well as a discussion of emerging indications.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251317691"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness of Contraindications Among Cancer Patients in Riyadh, Saudi Arabia: A Cross-Sectional Study.","authors":"Mansour Almuqbil, Rama Abdulhamid Mohammed Alobaid, Amouna Abdulrahim Mazal Alhamad, Noor Hussam Eddin, Nora Al Yahya, Walaa F Alsanie, Abdulhakeem S Alamri, Majid Alhomrani, Amal F Alshammary, Rafiulla Gilkaramenthi, Syed Mohammed Basheeruddin Asdaq","doi":"10.1177/10732748251313498","DOIUrl":"10.1177/10732748251313498","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer patients often face challenges in managing their disease, particularly with regard to contraindications related to medications, foods, and physical activity, which can negatively affect treatment outcomes. This study aimed to evaluate cancer patients' awareness of these contraindications and to explore the influence of sociodemographic factors, support systems, comorbidities, and medication use on their knowledge.</p><p><strong>Methods: </strong>A cross-sectional prospective study was conducted with 125 cancer patients in Saudi Arabia between December 2022 and February 2023. Participants were selected using purposive sampling, and data were collected through a validated questionnaire. Multinomial regression analysis was employed to identify the predictors of awareness of contraindicated medications, foods, and other environmental factors.</p><p><strong>Results: </strong>Nationality, co-morbidities, and cancer duration were significant predictors of awareness regarding contraindicated drugs. Saudi patients were more likely to be aware of contraindicated medications (<i>P</i> = 0.010), and those without chronic diseases were 15 times more likely to know about drug contraindications (OR = 15.076, 95% CI: 3.442-66.042). Cancer diagnosis (<i>P</i> = 0.033) and cancer duration (<i>P</i> = 0.022) were also significant for food contraindications. Over 58% were unaware of the need to regulate body temperature during treatment. Location influenced exercise awareness (<i>P</i> = 0.064) and complementary and alternative medicine (CAM) awareness, with rural participants showing higher CAM knowledge (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This study emphasizes the need to improve cancer patients' awareness of contraindications, particularly regarding medications and foods. Key factors influencing awareness include nationality, co-morbidities, and cancer duration. While family support is beneficial, it doesn't directly enhance knowledge, highlighting the importance of targeted educational interventions to improve patient outcomes and safety.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251313498"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Age-Based Nomogram as the Best Predictor for Long-Term Overall Survival in Head and Neck Mucosa-Associated Lymphoid Tissue Lymphoma.","authors":"Chaoxin Fan, Aimin Jiang, Rui Zhao, Miaomiao Chen","doi":"10.1177/10732748251321661","DOIUrl":"10.1177/10732748251321661","url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck mucosa-associated lymphoid tissue (MALT) lymphoma, a rare subtype of non-Hodgkin lymphoma, has received limited attention regarding its prognosis. This study aimed to illuminate the clinical characteristics and identify prognostic factors for head and neck MALT lymphoma, intending to develop an accessible tool for clinicians to predict long-term survival probabilities and inform therapeutic strategies.</p><p><strong>Methods: </strong>This multicentre retrospective study enrolled 424 head and neck MALT lymphoma patients from the Surveillance, Epidemiology, and End Results Program (SEER) database. Least absolute shrinkage and selection operator (LASSO)-Cox regression analysis identified independent prognostic factors for overall survival (OS), leading to the development of an age-based nomogram predicting OS probabilities at 5, 10, and 15 years. Evaluation included time-dependent receiver operating curve (ROC), calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Multivariate Cox analysis highlighted age exceeding 65 years [hazards ratio (HR): 2.97, 95% confidence interval (CI): 1.94-4.57; <i>P</i> < 0.001] and unmarried status (HR: 1.58, 95% CI: 1.07-2.33, <i>P</i> = 0.023) as significantly associated with shorter OS, while black race correlated with longer OS (HR: 0.25, 95% CI: 0.09-0.69, <i>P</i> = 0.007). The age-based nomogram, integrating these factors, demonstrated efficacy in predicting 5-year [area under the curve (AUC): 0.640] and 10-year OS (AUC: 0.705), with an impressive AUC of 0.842 for the 15-year OS probability in the training cohort. Decision curve analysis affirmed the nomogram's clinical utility, surpassing individual factors. Consistent results were observed in validation cohorts.</p><p><strong>Conclusion: </strong>Our study provides crucial insights into head and neck MALT lymphoma, filling gaps in understanding its clinical landscape. The validated age-based nomogram serves as a practical tool for clinicians, offering enhanced prognostic precision and guiding personalized treatment strategies in this understudied lymphoma subtype.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251321661"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Prediction of the Risk of Hepatocellular Carcinoma After DAA Treatment for Hepatitis C Patients.","authors":"Xinyan Ma, Lili Huang, Meijie Yu, Rui Dong, Yifan Wang, Hongbo Chen, Rongbin Yu, Peng Huang, Jie Wang","doi":"10.1177/10732748251316609","DOIUrl":"10.1177/10732748251316609","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to develop and internally validate a hepatocellular carcinoma (HCC) risk prediction model incorporating repeated-measures data (longitudinal model), and compare with baseline predictions.</p><p><strong>Methods: </strong>A total of 1097 participants with chronic hepatitis C after direct-acting antivirals (DAA) treatment were included in this prospective cohort study. The framework of joint models for longitudinal and survival data was used to construct the longitudinal prediction model. For comparison, a baseline model incorporating the same predictors was constructed through the multivariate Cox regression models. Model performance was evaluated using dynamic discrimination index (DDI), areas under the receiver-operating characteristics curves (AUROC), and Brier scores.</p><p><strong>Results: </strong>Over a median follow-up of 7.25 years, 60 patients (5.5%) developed HCC. Key risk factors identified were aspartate aminotransferase (AST), cholinesterase, gamma-glutamyl transferase (GGT), albumin, hemoglobin (Hb), platelet count, alpha-fetoprotein (AFP), antigen-125 (CA-125), and carcinoembryonic antigen (CEA). The final joint model, with GGT and CEA removed, showed superior average predictive performance (DDI = .871) compared to models with all predictors included. Validation showed high predictive accuracy for HCC, with AUROCs above .9 for 1-, 3-, 4-, and 5-year predictions. In comparison, the baseline Cox model only achieved mediocre AUROCs of .7 (.75, .67, .69, and .67, respectively).</p><p><strong>Conclusion: </strong>Compared to static models, our dynamic prediction model can predict the risk of HCC in patients after DAA treatment more accurately, providing better information to distinguish high-risk populations.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251316609"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness to Implement Narrative Communication Interventions: Mixed Methods Study Among Breast Cancer Patients and Survivors at the University College Hospital, Ibadan, Nigeria.","authors":"Oluwaponmile A Odukoya, Mojisola M Oluwasanu, Ndidi A Okunnuga, Omobolaji Ayandipo, Susan Duncan, Oyedunni S Arulogun, Olufunmilayo I Olopade, Atara Ntekim","doi":"10.1177/10732748251328413","DOIUrl":"10.1177/10732748251328413","url":null,"abstract":"<p><p>PurposeGlobally, black women experience poorer breast cancer outcomes suggesting the need for effective health promotion approaches to increase perceived susceptibility and improve screening practices. Although narrative communication by patients or survivors is increasingly considered an effective approach for better breast cancer outcomes, there is limited information on its use in Nigeria. This study assessed the perception, willingness and generalized self-efficacy of breast cancer patients and survivors at the University College Hospital, Ibadan, to implement narrative communication interventions.Material and MethodsThis was a cross-sectional study, and a mixed-method convergent parallel design was utilized for data collection. Written informed consent was obtained from each study participant for in-depth interviews and a semi-structured questionnaire. Five patients were recruited for in-depth interviews and a semi-structured questionnaire was used to obtain data from 102 patients. Data were analysed using thematic analysis for qualitative data, and descriptive and inferential statistics for quantitative data.ResultsThe mean age of the respondents was 49.3 ± 10.2 years. There was a good perception (97.1%) towards narrative communication interventions. Ninety-eight percent were willing to implement narrative communication interventions and 79.4% had a high generalized self-efficacy. Respondents' educational attainment was significantly associated with the generalized self-efficacy to implement narrative communication intervention programs (<i>P</i> < .05). Most of the in-depth interview participants opined that a pre-diagnosis discussion with a breast cancer patient or survivor would have increased their perceived susceptibility and motivation to screen.ConclusionThis study highlights the potential of breast cancer patients and survivors as breast health educators, sharing their lived experiences to empower and motivate women on prevention and screening. Findings could guide the design of population-level, breast cancer prevention and screening interventions.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251328413"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with <i>EGFR</i> or <i>KRAS</i> Mutation.","authors":"Jialiang Wang, Chang Guo, Jiexiao Wang, Xiaopeng Zhang, Jian Qi, Xiang Huang, Zongtao Hu, Hongzhi Wang, Bo Hong","doi":"10.1177/10732748241307363","DOIUrl":"https://doi.org/10.1177/10732748241307363","url":null,"abstract":"<p><strong>Introduction: </strong><i>EGFR</i> and <i>KRAS</i> mutations are frequently detected in lung adenocarcinoma (LUAD). Tumor mutational signature (TMS) determination is an approach to identify somatic mutational patterns associated with pathogenic factors. In this study, through the analysis of TMS, the underlying pathogenic factors of LUAD with <i>EGFR</i> and <i>KRAS</i> mutations were traced.</p><p><strong>Methods: </strong>This was a retrospective study. TMS of LUAD with <i>KRAS</i> and <i>EGFR</i> mutations from the TCGA, OncoSG, and MSK datasets was determined by two bioinformatics tools, namely the \"MutationalPatterns\" and \"FitMS\" packages. Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) of LUAD clinical specimens was analyzed using capillary electrophoresis.</p><p><strong>Results: </strong>In LUAD with <i>KRAS</i> mutations, TMS analysis indicated that the smoking-related SBS4 signature was enriched. For LUAD with <i>EGFR</i> L858R mutation, the smoking-related SBS4 signature was enriched in the Western population from the TCGA database; however, the smoking-related SBS4 signature was not obvious in Asian LUAD patients. LUAD with <i>EGFR</i> exon19 deletion (19Del) exhibited stronger SBS15 signature, which was related to defective DNA mismatch repair. Capillary electrophoresis analysis showed that an EMAST locus was frequently instable in LUAD with <i>EGFR</i> 19Del. Different from the Western population, Asian LUAD patients with <i>EGFR</i> mutations exhibited the enrichment of SBS1, SBS2, and SBS13 signatures, which were associated with the endogenous mutation process of cytidine deamination.</p><p><strong>Conclusions: </strong>TMS analysis reveals that smoking is associated with LUAD with <i>KRAS</i> mutations. Defective DNA mismatch repair and endogenous cytidine deamination are associated with LUAD with <i>EGFR</i> mutations, especially for the <i>EGFR</i> 19Del. The endogenous mutational process is stronger in Asian LUAD patients than Western LUAD patients.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748241307363"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the Use of Artificial Intelligence-Generated Content Bridge the Cancer Knowledge Gap? A Longitudinal Study With Health Self-Efficacy as a Mediator and Educational Level as a Moderator.","authors":"Zehang Xie, Ru Chen, Wenjuan Ding","doi":"10.1177/10732748251319487","DOIUrl":"10.1177/10732748251319487","url":null,"abstract":"<p><strong>Objectives: </strong>The cancer knowledge gap represents a significant disparity in awareness and understanding of cancer-related information across different demographic groups. Leveraging Artificial Intelligence-Generated Content (AIGC) offers a promising approach to personalize health education and potentially bridge this gap. This study aimed to evaluate the potential of AIGC to bridge the cancer knowledge gap, assessing the roles of health self-efficacy as a mediator and educational level as a moderator in this relationship.</p><p><strong>Methods: </strong>A 6-month longitudinal study was conducted using online surveys distributed to undergraduate students in non-medical disciplines at one university and graduate students in medical specialties at another university in China. The study assessed the frequency of AIGC use, health self-efficacy, and cancer knowledge at two time points.</p><p><strong>Results: </strong>The results indicated that AIGC use significantly enhanced cancer knowledge levels and health self-efficacy over time. Educational level notably moderated the effects of AIGC use, with non-medical undergraduate students showing greater gains in knowledge and self-efficacy. Additionally, health self-efficacy mediated the relationship between AIGC use and cancer knowledge, underscoring the importance of health self-efficacy. The study confirms the efficacy of AIGC in narrowing the cancer knowledge gap and enhancing health self-efficacy, particularly among students with lower initial medical knowledge.</p><p><strong>Conclusion: </strong>These findings highlight the potential of integrating AIGC tools in cancer education and public health interventions, particularly for individuals at different educational levels. By tailoring digital health resources to varying educational needs, these interventions could enhance cancer knowledge acquisition, improve health self-efficacy, and contribute to better cancer prevention and control outcomes.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251319487"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}