{"title":"早发性结直肠癌诊断和生存的种族/民族和年龄相关差异。","authors":"Meng-Han Tsai, Jorge Cortes, Kenneth J Vega","doi":"10.1177/10732748251357469","DOIUrl":null,"url":null,"abstract":"<p><p>IntroductionEarly-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for EOCRC across three age-at-diagnosis groups.MethodsWe conducted a retrospective cohort analysis using the 2006-2020 Surveillance, Epidemiology, and End Results (SEER) Program, using multivariable logistic and Cox proportional hazards models to examine the association of race/ethnicity and age with survival.ResultsAmong 46,956 EOCRC patients, racial minorities were diagnosed with EOCRC at age of 20-29 years while non-Hispanic White patients were more commonly diagnosed at age 40-49 years (<i>P</i>-value <0.001). In adjusted analysis, non-Hispanic Black (NHB) (AOR, 1.65; 95% CI, 1.24-2.18), Asian/Pacific Islander (AOR, 2.22; 95% CI, 1.60-3.08), and Hispanic (AOR, 1.56; 95% CI, 1.27-1.93) patients aged 20-29 years were more likely to be diagnosed at a late stage. These groups were also more likely to have mucinous adenocarcinoma or signet ring cell subtypes (NHB: AOR,1.46; 95% CI, 1.00-2.13; Asian/PI: AOR, 1.89; 95% CI, 1.28-2.77; Hispanic: AOR, 1.95: 95% CI, 1.48-2.59). Regardless of age groups, NHB patients were more likely to die from CRC by 34%-59% (20-29 years: AHR, 1.40; 95% CI, 1.11-1.76; 30-39 years: AHR, 1.59; 95% CI, 1.42-1.77; 40-49 years: AHR, 1.34; 95% CI, 1.26-1.41).ConclusionPrioritizing prevention strategies and enhancing access to screening for racial minorities and the 20-29 age group is warranted.</p>","PeriodicalId":49093,"journal":{"name":"Cancer Control","volume":"32 ","pages":"10732748251357469"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217559/pdf/","citationCount":"0","resultStr":"{\"title\":\"Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival.\",\"authors\":\"Meng-Han Tsai, Jorge Cortes, Kenneth J Vega\",\"doi\":\"10.1177/10732748251357469\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>IntroductionEarly-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for EOCRC across three age-at-diagnosis groups.MethodsWe conducted a retrospective cohort analysis using the 2006-2020 Surveillance, Epidemiology, and End Results (SEER) Program, using multivariable logistic and Cox proportional hazards models to examine the association of race/ethnicity and age with survival.ResultsAmong 46,956 EOCRC patients, racial minorities were diagnosed with EOCRC at age of 20-29 years while non-Hispanic White patients were more commonly diagnosed at age 40-49 years (<i>P</i>-value <0.001). In adjusted analysis, non-Hispanic Black (NHB) (AOR, 1.65; 95% CI, 1.24-2.18), Asian/Pacific Islander (AOR, 2.22; 95% CI, 1.60-3.08), and Hispanic (AOR, 1.56; 95% CI, 1.27-1.93) patients aged 20-29 years were more likely to be diagnosed at a late stage. These groups were also more likely to have mucinous adenocarcinoma or signet ring cell subtypes (NHB: AOR,1.46; 95% CI, 1.00-2.13; Asian/PI: AOR, 1.89; 95% CI, 1.28-2.77; Hispanic: AOR, 1.95: 95% CI, 1.48-2.59). Regardless of age groups, NHB patients were more likely to die from CRC by 34%-59% (20-29 years: AHR, 1.40; 95% CI, 1.11-1.76; 30-39 years: AHR, 1.59; 95% CI, 1.42-1.77; 40-49 years: AHR, 1.34; 95% CI, 1.26-1.41).ConclusionPrioritizing prevention strategies and enhancing access to screening for racial minorities and the 20-29 age group is warranted.</p>\",\"PeriodicalId\":49093,\"journal\":{\"name\":\"Cancer Control\",\"volume\":\"32 \",\"pages\":\"10732748251357469\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217559/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Control\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10732748251357469\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Control","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10732748251357469","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Racial/Ethnic and Age-Related Disparities in Early-Onset Colorectal Cancer Diagnoses and Survival.
IntroductionEarly-onset colorectal cancer (EOCRC) patients are more likely to have advanced diagnoses across different race/ethnicity or age at diagnosis groups. Thus, we examined the relationship of racial/ethnic disparities with cancer diagnoses (tumor features and histologic types) and 5-year causes-specific survival for EOCRC across three age-at-diagnosis groups.MethodsWe conducted a retrospective cohort analysis using the 2006-2020 Surveillance, Epidemiology, and End Results (SEER) Program, using multivariable logistic and Cox proportional hazards models to examine the association of race/ethnicity and age with survival.ResultsAmong 46,956 EOCRC patients, racial minorities were diagnosed with EOCRC at age of 20-29 years while non-Hispanic White patients were more commonly diagnosed at age 40-49 years (P-value <0.001). In adjusted analysis, non-Hispanic Black (NHB) (AOR, 1.65; 95% CI, 1.24-2.18), Asian/Pacific Islander (AOR, 2.22; 95% CI, 1.60-3.08), and Hispanic (AOR, 1.56; 95% CI, 1.27-1.93) patients aged 20-29 years were more likely to be diagnosed at a late stage. These groups were also more likely to have mucinous adenocarcinoma or signet ring cell subtypes (NHB: AOR,1.46; 95% CI, 1.00-2.13; Asian/PI: AOR, 1.89; 95% CI, 1.28-2.77; Hispanic: AOR, 1.95: 95% CI, 1.48-2.59). Regardless of age groups, NHB patients were more likely to die from CRC by 34%-59% (20-29 years: AHR, 1.40; 95% CI, 1.11-1.76; 30-39 years: AHR, 1.59; 95% CI, 1.42-1.77; 40-49 years: AHR, 1.34; 95% CI, 1.26-1.41).ConclusionPrioritizing prevention strategies and enhancing access to screening for racial minorities and the 20-29 age group is warranted.
期刊介绍:
Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.